The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Influence of Rapid Malaria Diagnostic Tests on Treatment and Health Outcome in Fever Patients, Zanzibar—A Crossover Validation Study
Open accessAbstract
BACKGROUND: The use of rapid diagnostic tests (RDTs) for Plasmodium falciparum malaria is being suggested to improve diagnostic efficiency in peripheral health care settings in Africa. Such improved diagnostics are critical to minimize overuse and thereby delay development of resistance to artemisinin-based combination therapies (ACTs). Our objective was to study the influence of RDT-aided malaria diagnosis on drug prescriptions, health outcomes, and costs in primary health care settings. METHODS AND FINDINGS: We conducted a cross-over validation clinical trial in four primary health care units in Zanzibar. Patients of all ages with reported fever in the previous 48 hours were eligible and allocated alternate weeks to RDT-aided malaria diagnosis or symptom-based clinical diagnosis (CD) alone. Follow-up was 14 days. ACT was to be prescribed to patients diagnosed with malaria in both groups. Statistical analyses with multilevel modelling were performed. A total of 1,887 patients were enrolled February through August 2005. RDT was associated with lower prescription rates of antimalarial treatment than CD alone, 361/1005 (36%) compared with 752/882 (85%) (odds ratio [OR] 0.04, 95% confidence interval [CI] 0.03-0.05, p<0.001). Prescriptions of antibiotics were higher after RDT than CD alone, i.e., 372/1005 (37%) and 235/882 (27%) (OR 1.8, 95%CI 1.5-2.2, p<0.001), respectively. Reattendance due to perceived unsuccessful clinical cure was lower after RDT 25/1005 (2.5%), than CD alone 43/882 (4.9%) (OR 0.5, 95% CI 0.3-0.9, p = 0.005). Total average cost per patient was similar: USD 2.47 and 2.37 after RDT and CD alone, respectively. CONCLUSIONS: RDTs resulted in improved adequate treatment and health outcomes without increased cost per patient. RDTs may represent a tool for improved management of patients with fever in peripheral health care settings. TRIAL REGISTRATION: (Clinicaltrials.gov) NCT00549003.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Rapid Diagnostic Tests for Malaria Parasites
Moody, A. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.1.66-78.2002 · Cited by 1,418
Bhattarai, A., Ali, A. S., Kachur, S. P., Mårtensson, A., Abbas, A. K., Khatib, R., Al-mafazy, A.-W., Ramsan, M., Rotllant, G., Gerstenmaier, J. F., et al. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040309 · Cited by 647 · cited 1×
“By the time of the trial, malaria transmission in Zanzibar was generally considered endemic [23], with recorded malaria parasite rates between 10% and 50% in”
BackgroundSelf-citationMcMorrow, M. L., Masanja, M. I., Abdulla, S. M. K., Kahigwa, E., & Kachur, S. P. (2008) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2008.79.385 · Cited by 127 · cited 1×
“. High adherence by prescribers in relation to RDT results was, however, also reported in a recent study conducted in mainland Tanzania”
ResultSelf-citation
Cited by
Beyond Malaria — Causes of Fever in Outpatient Tanzanian Children
D'Acremont, V., Kilowoko, M., Kyungu, E., Philipina, S., Sangu, W., Kahama-Maro, J., Lengeler, C., Cherpillod, P., Kaiser, L., & Genton, B. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1214482 · Cited by 444
Lewnard, J. A., Charani, E., Gleason, A., Hsu, L. Y., Khan, W. A., Karkey, A., Chandler, C. I. R., Mashe, T., Khan, E. A., Bulabula, A. N. H., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00862-6 · Cited by 220
Mubi, M., Janson, A., Warsame, M., Mårtensson, A., Källander, K., Petzold, M. G., Ngasala, B., Maganga, G., Gustafsson, L. L., Massele, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019753 · Cited by 155
Self-citationAhiabu, M.-A., Tersbøl, B. P., Biritwum, R., Bygbjerg, I. C., & Magnussen, P. (2016) · Health Policy and Planning · doi:10.1093/heapol/czv048 · Cited by 85
Kyabayinze, D. J., Tibenderana, J. K., Nassali, M., Tumwine, L. K., Riches, C., Montague, M., Counihan, H., Hamade, P., Van Geertruyden, J.-P., & Meek, S. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-306 · Cited by 42
Metadata
- Authors
- Msellem, M. I., Mårtensson, A., Rotllant, G., Bhattarai, A., Strömberg, J., Kahigwa, E., Garcia, M., Petzold, M., Olumese, P., Ali, A., & Björkman, A.
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-04-28
- Volume
- 6
- Issue
- 4
- Pages
- e1000070
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- OpenAlex
- W2027366400
- Cited by
- 204
- References
- 3
- FWCI
- 24.08
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Influence of Rapid Malaria Diagnostic Tests on Treatment and Health Outcome in Fever Patients, Zanzibar—A Crossover Validation Study. https://app.cochat.ai/papers/10.1371/journal.pmed.1000070
- The paper
- Msellem, M. I., Mårtensson, A., Rotllant, G., Bhattarai, A., Strömberg, J., Kahigwa, E., Garcia, M., Petzold, M., Olumese, P., Ali, A., & Björkman, A. (2009). Influence of Rapid Malaria Diagnostic Tests on Treatment and Health Outcome in Fever Patients, Zanzibar—A Crossover Validation Study. PLoS Medicine. https://doi.org/10.1371/journal.pmed.1000070
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
