The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival
Open accessAbstract
BACKGROUND: Anti-HLA antibodies hamper successful transplantation, and activation of the complement cascade is involved in antibody-mediated rejection. We investigated whether the complement-binding capacity of anti-HLA antibodies plays a role in kidney-allograft failure. METHODS: We enrolled patients who received kidney allografts at two transplantation centers in Paris between January 1, 2005, and January 1, 2011, in a population-based study. Patients were screened for the presence of circulating donor-specific anti-HLA antibodies and their complement-binding capacity. Graft injury phenotype and the time to kidney-allograft loss were assessed. RESULTS: The primary analysis included 1016 patients. Patients with complement-binding donor-specific anti-HLA antibodies after transplantation had the lowest 5-year rate of graft survival (54%), as compared with patients with non-complement-binding donor-specific anti-HLA antibodies (93%) and patients without donor-specific anti-HLA antibodies (94%) (P<0.001 for both comparisons). The presence of complement-binding donor-specific anti-HLA antibodies after transplantation was associated with a risk of graft loss that was more than quadrupled (hazard ratio, 4.78; 95% confidence interval [CI], 2.69 to 8.49) when adjusted for clinical, functional, histologic, and immunologic factors. These antibodies were also associated with an increased rate of antibody-mediated rejection, a more severe graft injury phenotype with more extensive microvascular inflammation, and increased deposition of complement fraction C4d within graft capillaries. Adding complement-binding donor-specific anti-HLA antibodies to a traditional risk model improved the stratification of patients at risk for graft failure (continuous net reclassification improvement, 0.75; 95% CI, 0.54 to 0.97). CONCLUSIONS: Assessment of the complement-binding capacity of donor-specific anti-HLA antibodies appears to be useful in identifying patients at high risk for kidney-allograft loss.
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Levey, A. S., Coresh, J., Bolton, K., Culleton, B. F., Harvey, K. S., Ikizler, T. A., Johnson, C. A., Kausz, A., Kimmel, P. L., Kusek, J. W., et al. (2002) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 11,633
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493
Banff 07 Classification of Renal Allograft Pathology: Updates and Future Directions
Solez, K., Colvin, R. B., Racusen, L. C., Haas, M., Sis, B., Mengel, M., Halloran, P. F., Baldwin, W., Banfi, G., Collins, A. B., et al. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02159.x · Cited by 1,857
Self-citationSellarés, J., de Freitas, D. G., Mengel, M., Reeve, J., Einecke, G., Sis, B., Hidalgo, L. G., Famulski, K., Matas, A., & Halloran, P. F. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03840.x · Cited by 1,590
Significance of the Positive Crossmatch Test in Kidney Transplantation
Patel, R., & Terasaki, P. I. (1969) · New England Journal of Medicine · doi:10.1056/nejm196904032801401 · Cited by 1,508
Pencina, M. J., & D'Agostino, R. B. (2004) · Statistics in Medicine · doi:10.1002/sim.1802 · Cited by 1,444
Doqi, K. (2002) · American Journal of Kidney Diseases · Cited by 1,285
Racusen, L. C., Colvin, R. B., Solez, K., Mihatsch, M. J., Halloran, P. F., Campbell, P. M., Cecka, M. J., Cosyns, J., Demetris, A. J., Fishbein, M. C., et al. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00072.x · Cited by 1,060
Self-citationLong-Term Renal Allograft Survival in the United States: A Critical Reappraisal
Lamb, K. E., Lodhi, S., & Meier-Kriesche, H.-U. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03283.x · Cited by 916
Wolf, G., Chen, S., Han, D. C., & Ziyadeh, F. N. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.29865 · Cited by 871
Cited by
Hoffman, W., Lakkis, F. G., & Chalasani, G. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09430915 · Cited by 482
IgG endopeptidase in highly sensitized patients undergoing transplantation
Jordan, S. C., Lorant, T., Choi, J., Kjellman, C., Winstedt, L., Bengtsson, M., Zhang, X., Eich, T., Toyoda, M., Eriksson, B.-M., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1612567 · Cited by 377
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Thorgersen, E. B., Barratt‐Due, A., Haugaa, H., Harboe, M., Pischke, S. E., Nilsson, P. H., & Mollnes, T. E. (2019) · Hepatology · doi:10.1002/hep.30508 · Cited by 240
Baker, R. J., Mark, P. B., Patel, R. K., Stevens, K. K., & Palmer, N. (2017) · BMC Nephrology · doi:10.1186/s12882-017-0553-2 · Cited by 211
Allorecognition and the spectrum of kidney transplant rejection
Callemeyn, J., Lamarthée, B., Koenig, A., Koshy, P., Thaunat, O., & Naesens, M. (2022) · Kidney International · doi:10.1016/j.kint.2021.11.029 · Cited by 189
Metadata
- Authors
- Loupy, A., Lefaucheur, C., Vernerey, D., Prugger, C., van Huyen, J.-P. D., Mooney, N., Suberbielle, C., Frémeaux-Bacchi, V., Méjean, A., Desgrandchamps, F., Anglicheau, D., Nochy, D., Charron, D., Empana, J.-P., Delahousse, M., Legendre, C., Glotz, D., Hill, G. S., Zeevi, A., & Jouven, X.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2013-09-26
- Volume
- 369
- Issue
- 13
- Pages
- 1215-1226
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2115660072
- Cited by
- 852
- References
- 30
- FWCI
- 60.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Loupy, A., Lefaucheur, C., Vernerey, D., Prugger, C., van Huyen, J.-P. D., Mooney, N., Suberbielle, C., Frémeaux-Bacchi, V., Méjean, A., Desgrandchamps, F., Anglicheau, D., Nochy, D., Charron, D., Empana, J.-P., Delahousse, M., Legendre, C., Glotz, D., Hill, G. S., Zeevi, A., & Jouven, X. (2013). Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1302506
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
