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Cited by 288

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Everolimus-Eluting Stents or Bypass Surgery for Multivessel Coronary Disease

Open access
Bangalore, Sripal, Guo, Yu, Samadashvili, Zaza, Blecker, Saul, Xu, Jinfeng, Hannan, Edward L.·2015·New England Journal of Medicine

Abstract

BACKGROUND: Results of trials and registry studies have shown lower long-term mortality after coronary-artery bypass grafting (CABG) than after percutaneous coronary intervention (PCI) among patients with multivessel disease. These previous analyses did not evaluate PCI with second-generation drug-eluting stents. METHODS: In an observational registry study, we compared the outcomes in patients with multivessel disease who underwent CABG with the outcomes in those who underwent PCI with the use of everolimus-eluting stents. The primary outcome was all-cause mortality. Secondary outcomes were the rates of myocardial infarction, stroke, and repeat revascularization. Propensity-score matching was used to assemble a cohort of patients with similar baseline characteristics. RESULTS: Among 34,819 eligible patients, 9223 patients who underwent PCI with everolimus-eluting stents and 9223 who underwent CABG had similar propensity scores and were included in the analyses. At a mean follow-up of 2.9 years, PCI with everolimus-eluting stents, as compared with CABG, was associated with a similar risk of death (3.1% per year and 2.9% per year, respectively; hazard ratio, 1.04; 95% confidence interval [CI], 0.93 to 1.17; P=0.50), higher risks of myocardial infarction (1.9% per year vs. 1.1% per year; hazard ratio, 1.51; 95% CI, 1.29 to 1.77; P<0.001) and repeat revascularization (7.2% per year vs. 3.1% per year; hazard ratio, 2.35; 95% CI, 2.14 to 2.58; P<0.001), and a lower risk of stroke (0.7% per year vs. 1.0% per year; hazard ratio, 0.62; 95% CI, 0.50 to 0.76; P<0.001). The higher risk of myocardial infarction with PCI than with CABG was not significant among patients with complete revascularization but was significant among those with incomplete revascularization (P=0.02 for interaction). CONCLUSIONS: In a contemporary clinical-practice registry study, the risk of death associated with PCI with everolimus-eluting stents was similar to that associated with CABG. PCI was associated with a higher risk of myocardial infarction (among patients with incomplete revascularization) and repeat revascularization but a lower risk of stroke. (Funded by Abbott Vascular.).

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Metadata

Authors
Bangalore, S., Guo, Y., Samadashvili, Z., Blecker, S., Xu, J., & Hannan, E. L.
Venue
New England Journal of Medicine
Published
2015-03-26
Volume
372
Issue
13
Pages
1213-1222
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2152735600
Cited by
288
References
21
FWCI
35.15
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Everolimus-Eluting Stents or Bypass Surgery for Multivessel Coronary Disease. https://app.cochat.ai/papers/10.1056/nejmoa1412168
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Bangalore, S., Guo, Y., Samadashvili, Z., Blecker, S., Xu, J., & Hannan, E. L. (2015). Everolimus-Eluting Stents or Bypass Surgery for Multivessel Coronary Disease. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1412168

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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