The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Stent Thrombogenicity Early in High-Risk Interventional Settings Is Driven by Stent Design and Deployment and Protected by Polymer-Drug Coatings
Open accessAbstract
Background—: Stent thrombosis is a lethal complication of endovascular intervention. Concern has been raised about the inherent risk associated with specific stent designs and drug-eluting coatings, yet clinical and animal support is equivocal. Methods and Results—: We examined whether drug-eluting coatings are inherently thrombogenic and if the response to these materials was determined to a greater degree by stent design and deployment with custom-built stents. Drug/polymer coatings uniformly reduce rather than increase thrombogenicity relative to matched bare metal counterparts (0.65-fold; P =0.011). Thick-strutted (162 μm) stents were 1.5-fold more thrombogenic than otherwise identical thin-strutted (81 μm) devices in ex vivo flow loops ( P <0.001), commensurate with 1.6-fold greater thrombus coverage 3 days after implantation in porcine coronary arteries ( P =0.004). When bare metal stents were deployed in malapposed or overlapping configurations, thrombogenicity increased compared with apposed, length-matched controls (1.58-fold, P =0.001; and 2.32-fold, P <0.001). The thrombogenicity of polymer-coated stents with thin struts was lowest in all configurations and remained insensitive to incomplete deployment. Computational modeling–based predictions of stent-induced flow derangements correlated with spatial distribution of formed clots. Conclusions—: Contrary to popular perception, drug/polymer coatings do not inherently increase acute stent clotting; they reduce thrombosis. However, strut dimensions and positioning relative to the vessel wall are critical factors in modulating stent thrombogenicity. Optimal stent geometries and surfaces, as demonstrated with thin stent struts, help reduce the potential for thrombosis despite complex stent configurations and variability in deployment.
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Cites
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Cited by
Palmerini, T., Biondi-Zoccai, G., Riva, D. D., Stettler, C., Sangiorgi, D., D'Ascenzo, F., Kimura, T., Briguori, C., Sabatè, M., Kim, H.-S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60324-9 · Cited by 959
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Bioresorbable Scaffolds versus Metallic Stents in Routine PCI
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Role of Endothelial Shear Stress in Stent Restenosis and Thrombosis
Koskinas, K. C., Chatzizisis, Y. S., Antoniadis, A. P., & Giannoglou, G. D. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.10.903 · Cited by 347
Bio-resorbable polymer stents: a review of material progress and prospects
McMahon, S., Bertollo, N., Cearbhaill, E. D. O., Salber, J., Pierucci, L., Duffy, P., Dürig, T., Bi, V., & Wang, W. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.05.002 · Cited by 194
Metadata
- Authors
- Kolandaivelu, K., Swaminathan, R., Gibson, W. J., Kolachalama, V. B., Nguyen-Ehrenreich, K.-L., Giddings, V. L., Coleman, L., Wong, G. K., & Edelman, E. R.
- Venue
- Circulation
- Published
- 2011-04-05
- Volume
- 123
- Issue
- 13
- Pages
- 1400-1409
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1595078900
- Cited by
- 802
- References
- 26
- FWCI
- 46.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kolandaivelu, K., Swaminathan, R., Gibson, W. J., Kolachalama, V. B., Nguyen-Ehrenreich, K.-L., Giddings, V. L., Coleman, L., Wong, G. K., & Edelman, E. R. (2011). Stent Thrombogenicity Early in High-Risk Interventional Settings Is Driven by Stent Design and Deployment and Protected by Polymer-Drug Coatings. Circulation. https://doi.org/10.1161/circulationaha.110.003210
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
