The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke
Open accessAbstract
BACKGROUND: We aimed to assess the safety and efficacy of thrombectomy for the treatment of stroke in a trial embedded within a population-based stroke reperfusion registry. METHODS: During a 2-year period at four centers in Catalonia, Spain, we randomly assigned 206 patients who could be treated within 8 hours after the onset of symptoms of acute ischemic stroke to receive either medical therapy (including intravenous alteplase when eligible) and endovascular therapy with the Solitaire stent retriever (thrombectomy group) or medical therapy alone (control group). All patients had confirmed proximal anterior circulation occlusion and the absence of a large infarct on neuroimaging. In all study patients, the use of alteplase either did not achieve revascularization or was contraindicated. The primary outcome was the severity of global disability at 90 days, as measured on the modified Rankin scale (ranging from 0 [no symptoms] to 6 [death]). Although the maximum planned sample size was 690, enrollment was halted early because of loss of equipoise after positive results for thrombectomy were reported from other similar trials. RESULTS: Thrombectomy reduced the severity of disability over the range of the modified Rankin scale (adjusted odds ratio for improvement of 1 point, 1.7; 95% confidence interval [CI], 1.05 to 2.8) and led to higher rates of functional independence (a score of 0 to 2) at 90 days (43.7% vs. 28.2%; adjusted odds ratio, 2.1; 95% CI, 1.1 to 4.0). At 90 days, the rates of symptomatic intracranial hemorrhage were 1.9% in both the thrombectomy group and the control group (P=1.00), and rates of death were 18.4% and 15.5%, respectively (P=0.60). Registry data indicated that only eight patients who met the eligibility criteria were treated outside the trial at participating hospitals. CONCLUSIONS: Among patients with anterior circulation stroke who could be treated within 8 hours after symptom onset, stent retriever thrombectomy reduced the severity of post-stroke disability and increased the rate of functional independence. (Funded by Fundació Ictus Malaltia Vascular through an unrestricted grant from Covidien and others; REVASCAT ClinicalTrials.gov number, NCT01692379.).
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Cites
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
Berkhemer, O. A., Fransen, P. S. S., Beumer, D., van den Berg, L. A., Lingsma, H. F., Yoo, A. J., Schonewille, W. J., Vos, J. A., Nederkoorn, P. J., Wermer, M. J. H., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411587 · Cited by 6,657
Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke
Goyal, M., Demchuk, A. M., Menon, B. K., Eesa, M., Rempel, J. L., Thornton, J., Roy, D., Jovin, T. G., Willinsky, R. A., Sapkota, B. L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414905 · Cited by 6,083
Self-citationEndovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection
Campbell, B. C. V., Mitchell, P. J., Kleinig, T. J., Dewey, H. M., Churilov, L., Yassi, N., Yan, B., Dowling, R. J., Parsons, M. W., Oxley, T. J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414792 · Cited by 5,819
Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke
Saver, J. L., Goyal, M., Bonafe, A., Diener, H.-C., Levy, E. I., Pereira, V. M., Albers, G. W., Cognard, C., Cohen, D. J., Hacke, W., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1415061 · Cited by 5,193
Self-citationHacke, W., Kaste, M., Fieschi, C., von Kummer, R., Davalos, A., Meier, D., Larrue, V., Bluhmki, E., Davis, S., Donnan, G., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)08020-9 · Cited by 3,662
Self-citationWahlgren, N., Ahmed, N., Dávalos, A., Ford, G. A., Grond, M., Hacke, W., Hennerici, M. G., Kaste, M., Kuelkens, S., Larrue, V., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60149-4 · Cited by 2,379
Self-citationEndovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke
Broderick, J. P., Palesch, Y. Y., Demchuk, A. M., Yeatts, S. D., Khatri, P., Hill, M. D., Jauch, E. C., Jovin, T. G., Yan, B., Silver, F. L., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214300 · Cited by 1,820
Self-citationWilson, J. T. L., Hareendran, A., Grant, M., Baird, T., Schulz, U. G. R., Muir, K. W., & Bone, I. (2002) · Stroke · doi:10.1161/01.str.0000027437.22450.bd · Cited by 855
Prehospital Use of Magnesium Sulfate as Neuroprotection in Acute Stroke
Saver, J. L., Starkman, S., Eckstein, M., Stratton, S. J., Pratt, F. D., Hamilton, S., Conwit, R., Liebeskind, D. S., Sung, G., Kramer, I., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1408827 · Cited by 407
Saver, J. L. (2007) · Stroke · doi:10.1161/strokeaha.107.488536 · Cited by 177
Cited by
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596
Chamorro, Á., Dirnagl, U., Urra, X., & Planas, A. M. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00114-9 · Cited by 1,198
Self-citationAutomated deep-neural-network surveillance of cranial images for acute neurologic events
Titano, J. J., Badgeley, M., Schefflein, J., Pain, M., Su, A., Cai, M., Swinburne, N., Zech, J., Kim, J., Bederson, J., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0147-y · Cited by 458
Metadata
- Authors
- Jovin, T. G., Chamorro, A., Cobo, E., de Miquel, M. A., Molina, C. A., Rovira, A., San Román, L., Serena, J., Abilleira, S., Ribó, M., Millán, M., Urra, X., Cardona, P., López-Cancio, E., Tomasello, A., Castaño, C., Blasco, J., Aja, L., Dorado, L., Quesada, H., Rubiera, M., Hernandez-Pérez, M., Goyal, M., Demchuk, A. M., von Kummer, R., Gallofré, M., & Dávalos, A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-06-11
- Volume
- 372
- Issue
- 24
- Pages
- 2296-2306
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2143237216
- Cited by
- 4,898
- References
- 12
- FWCI
- 399.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jovin, T. G., Chamorro, A., Cobo, E., de Miquel, M. A., Molina, C. A., Rovira, A., San Román, L., Serena, J., Abilleira, S., Ribó, M., Millán, M., Urra, X., Cardona, P., López-Cancio, E., Tomasello, A., Castaño, C., Blasco, J., Aja, L., Dorado, L., . . . Dávalos, A. (2015). Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1503780
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