The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Incidence of Dementia over Three Decades in the Framingham Heart Study
Open accessAbstract
BACKGROUND: The prevalence of dementia is expected to soar as the average life expectancy increases, but recent estimates suggest that the age-specific incidence of dementia is declining in high-income countries. Temporal trends are best derived through continuous monitoring of a population over a long period with the use of consistent diagnostic criteria. We describe temporal trends in the incidence of dementia over three decades among participants in the Framingham Heart Study. METHODS: Participants in the Framingham Heart Study have been under surveillance for incident dementia since 1975. In this analysis, which included 5205 persons 60 years of age or older, we used Cox proportional-hazards models adjusted for age and sex to determine the 5-year incidence of dementia during each of four epochs. We also explored the interactions between epoch and age, sex, apolipoprotein E ε4 status, and educational level, and we examined the effects of these interactions, as well as the effects of vascular risk factors and cardiovascular disease, on temporal trends. RESULTS: The 5-year age- and sex-adjusted cumulative hazard rates for dementia were 3.6 per 100 persons during the first epoch (late 1970s and early 1980s), 2.8 per 100 persons during the second epoch (late 1980s and early 1990s), 2.2 per 100 persons during the third epoch (late 1990s and early 2000s), and 2.0 per 100 persons during the fourth epoch (late 2000s and early 2010s). Relative to the incidence during the first epoch, the incidence declined by 22%, 38%, and 44% during the second, third, and fourth epochs, respectively. This risk reduction was observed only among persons who had at least a high school diploma (hazard ratio, 0.77; 95% confidence interval, 0.67 to 0.88). The prevalence of most vascular risk factors (except obesity and diabetes) and the risk of dementia associated with stroke, atrial fibrillation, or heart failure have decreased over time, but none of these trends completely explain the decrease in the incidence of dementia. CONCLUSIONS: Among participants in the Framingham Heart Study, the incidence of dementia has declined over the course of three decades. The factors contributing to this decline have not been completely identified. (Funded by the National Institutes of Health.).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Higher childhood education levels and lifelong higher educational attainment reduce dementia risk.2, 35, 36, 37”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [36]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Another key issue is that air pollution levels have been dropping over time in many areas of the world, and dementia incidence, as well, appears to have declined in North America and Europe in recent decades (Satizabal et al. 2016; Wolters et al. 2020).”
From Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature (2021) · cites this paper as Satizabal et al. 2016
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The Lancet Commission on Dementia Prevention, Intervention, and Care suggested that lifestyle modifications may already have an influence on dementia risk decades before the onset of dementia.3-8”
From Awareness of dementia risk reduction among current and future healthcare professionals: A survey study (2021) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“Decades of efforts to reduce stroke and cardiovascular risks by the AHA/ASA and other health organizations and, more recently, to promote cardiovascular health are likely to have already contributed to the declining incidence of dementia.172”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [172]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01380.x · Cited by 4,946
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921
The projected effect of risk factor reduction on Alzheimer's disease prevalence
Barnes, D. E., & Yaffe, K. S. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70072-2 · Cited by 2,846
Epidemiological approaches to heart disease: the Framingham study
Dawber, T. R., Meadors, G. F., & Moore, F. E. (1951) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.41.3.279 · Cited by 2,148
Probability of stroke: a risk profile from the Framingham Study.
Wolf, P. A., D'Agostino, R. B., Belanger, A. J., & Kannel, W. B. (1991) · Stroke · doi:10.1161/01.str.22.3.312 · Cited by 1,782
Flagged first, then by citations
Research works printed but not linked: 2
- Harwood RH, 2004, Bull World Health Organ, 82, 251
- Manton KC, 2005, Adv Gerontol, 16, 30
Cited by
Sorted by citations
Items 601–700 of 1,000
Logroscino, G., & Zoccolella, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00159-6 · Cited by 10
Kuroda, Y., Fujita, K., Sugimoto, T., Uchida, K., Shimazu, T., Saito, J., Arai, H., & Sakurai, T. (2023) · Archives of Public Health · doi:10.1186/s13690-023-01205-0 · Cited by 9
A multinational cohort study of trends in survival following dementia diagnosis
Luo, H., Koponen, M., Roethlein, C., Becker, C., Bell, J. S., Beyene, K. A., Chai, Y., Chan, A. H. Y., Chui, C. S. L., Haenisch, B., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-00923-6 · Cited by 10
Zhu, W., Yu, X., Huang, C., Deng, S., Ren, M., Li, M., Zhou, X., Shen, Z., Cai, G., Zhu, X., et al. (2025) · BMC Public Health · doi:10.1186/s12889-025-24097-x · Cited by 9
Chiriboga, D. A., Park, N. S., Gilbert, K., Molinari, V., & Barnes, M. (2019) · Innovation in Aging · doi:10.1093/geroni/igz013 · Cited by 9
Degen, C., Frankenberg, C., Toro, P., & Schröder, J. (2022) · Brain Sciences · doi:10.3390/brainsci12020271 · Cited by 10
Dementia in Latin America and the Caribbean: Prevalence, Incidence, Impact, and Trends over Time
Pan American Health Organization (2023) · Pan American Health Organization eBooks · doi:10.37774/9789275126653 · Cited by 9
Concurrent nutrient deficiencies are associated with dementia incidence
van Soest, A. P. M., de Groot, C. P. G. M., Witkamp, R. F., van Lent, D. M., Seshadri, S. S., & van de Rest, O. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13884 · Cited by 9
Self-citationLucassen, P. J., Kőrösi, A., de Rooij, S. R., Smit, A. B., van Dam, A., Daskalakis, N. P., van Kesteren, R. E., Verheijen, M. H. G., Lesuis, S. L., Kessels, H. W. H. G., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.11.007 · Cited by 9
Incidence and risk factors of dementia and the primary subtypes in northern rural China
Gu, X., Shi, Z., Liu, S., Guan, Y., Lü, H., Zhang, Y., Zhang, M., Liu, S., Yue, W., Wu, H., et al. (2021) · Medicine · doi:10.1097/md.0000000000025343 · Cited by 9
Analysis of Time Trends in Alzheimer’s Disease and Related Dementias Using Partitioning Approach
Akushevich, I. V., Yashkin, A. P., Kravchenko, J. S., & Yashin, A. I. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210273 · Cited by 9
Postural Hypotension and Cognitive Function in Older Adults
McLeod, K. J., & Jain, T. (2017) · Gerontology and Geriatric Medicine · doi:10.1177/2333721417733216 · Cited by 10
Evans, S., McRae‐McKee, K., Hadjichrysanthou, C., Wong, M. M., Ames, D. J., López, O. L., de Wolf, F., Anderson, R. M., Initiative, A. D. N., ageing, A. I. B. A. L. F. S. O., et al. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.04.005 · Cited by 11
Ding, H., An, N., Au, R., Devine, S., Auerbach, S. H., Massaro, J. M., Joshi, P. S., Liu, X., Liu, Y., Mahon, E., et al. (2020) · Journal of Medical Internet Research · doi:10.2196/15376 · Cited by 9
Sleep, Breathing, and Neurologic Disorders
Chokroverty, S., & Provini, F. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_41 · Cited by 9
Clinical Study Designs and Sources of Error in Medical Research
Kacha, A. K., Nizamuddin, S. L., Nizamuddin, J., Ramakrishna, H., & Shahul, S. S. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2018.02.009 · Cited by 9
The times they are a-changin’: cohort effects in aging, cognition, and dementia
Ganguli, M. (2016) · International Psychogeriatrics · doi:10.1017/s1041610216001927 · Cited by 10
Population-Based Approaches to Dementia Prevention
Sexton, C. E., & Yaffe, K. S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190104 · Cited by 9
Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
Mohapatra, T. K., Nayak, R. R., Ganeshpurkar, A., Tiwari, P. K., & Kumar, D. (2025) · Ibrain · doi:10.1002/ibra.12197 · Cited by 8
Systemic medications and dementia risk: a systematic umbrella review
Belessiotis‐Richards, C., Hayes, J., Yap, Y. F., Talwar, S., Eskinazi, M., Li, W., Ward, H., Letrondo, P. A., Morelli‐Batters, M., Bruun, A., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03129-3 · Cited by 9
Sáez, M. E., González‐Pérez, A., Hernández‐Olasagarre, B., Beà, A., Moreno–Grau, S., de Rojas, I., Monté, G. C., Orellana, A., Valero, S., Comella, J. X., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52724-2 · Cited by 8
Kognitive Dysfunktion bei Herzinsuffizienz – Ursachen und Folgen
Wedegärtner, S. M., Böhm, M., & Kindermann, I. (2020) · Der Internist · doi:10.1007/s00108-020-00835-8 · Cited by 8
Napolioni, V., Scelsi, M. A., Khan, R. R., Altmann, A., & Greicius, M. D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.629373 · Cited by 8
Associations between primary care electrocardiography and non-Alzheimer dementia
Isaksen, J. L., Ghouse, J., Skov, M. W., OLESEN, M. S., Holst, A. G., Pietersen, A. H., Nielsen, J. B., Maier, A. M., Graff, C., Frikke‐Schmidt, R., et al. (2022) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2022.106640 · Cited by 8
Computer-based cognitive tests and cerebral pathology among Japanese older adults
Shimada, H., Makino, K., Kato, T., & Ito, K. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-03918-x · Cited by 8
Gao, Y.-F., Jin, T., Chen, Y., & Ding, Y.-H. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1071574 · Cited by 8
A novel neuroimaging signature for ADRD risk stratification in the community
Satizábal, C. L., Beiser, A., Fletcher, E. M., Seshadri, S. S., & DeCarli, C. S. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13600 · Cited by 8
Self-citationPeng, J., Zheng, G., Hu, M., Zhang, Z., Yuan, Z., Xu, Y., Shao, Y., Zhang, Y., Sun, X., Han, L., et al. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05293-7 · Cited by 8
Yang, X., Xiong, T., & Li, S. (2024) · Regenerative medicine reports . · doi:10.4103/regenmed.regenmed-d-24-00007 · Cited by 8
Blandi, L., Bertuccio, P., Clemens, T., Brand, H., & Odone, A. (2025) · Annals of Epidemiology · doi:10.1016/j.annepidem.2025.03.007 · Cited by 8
Okami, Y., Ueshima, H., Nakamura, Y., Okuda, N., Nakagawa, H., Sakata, K., Saitoh, S., Okayama, A., Yoshita, K., Choudhury, S. R., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.43075 · Cited by 8
The contribution of dementia to the disparity in family wealth between black and non-black Americans
Kaufman, J. E., Gallo, W. T., & Fahs, M. C. (2018) · Ageing and Society · doi:10.1017/s0144686x18000934 · Cited by 9
Role of Epidemiology in the Biopharmaceutical Industry
Oleske, D. M., & Islam, S. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-58116-5.00005-5 · Cited by 8
Fosnacht, A. M., Patel, S. S., Yucus, C. J., Pham, A. Q., Rasmussen, E., Frigerio, R., Walters, S. J., & Maraganore, D. M. (2017) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2017.3 · Cited by 8
Prince, M. J., Acosta, D. M., Guerra, M., Huang, Y., Jiménez‐Velázquez, I. Z., Rodríguez, J. J. L., Salas, A., Sosa, A. L., Dewey, M. E., Guerchet, M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195133 · Cited by 8
Joshi, P. S., Heydari, M., Kannan, S., Ang, T. F. A., Qin, Q., Liu, X., Mez, J., Devine, S., Au, R., & Kolachalama, V. B. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.11.006 · Cited by 8
Chireh, B., & D’Arcy, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0242911 · Cited by 8
Temporal Trends in Stroke-Related Memory Change
Eng, C. W., Mayeda, E. R., Gilsanz, P., Whitmer, R. A., Kim, A., & Glymour, M. M. (2021) · Stroke · doi:10.1161/strokeaha.120.031063 · Cited by 8
The plasticity of late‐onset dementia: A nationwide cohort study in Denmark
Hegelund, E. R., Mehta, A. J., Mortensen, L. H., & Westendorp, R. G. J. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12469 · Cited by 8
Oughli, H. A., Nguyen, S. A., Siddarth, P., Fox, M. M., Milillo, M. M., Ercoli, L. M., & Lavretsky, H. (2022) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887221090216 · Cited by 8
Shaffer, J. (2022) · Journal of Ageing and Longevity · doi:10.3390/jal2030015 · Cited by 8
Ó’Caoimh, R., Molloy, D. W., Fitzgerald, C., van Velsen, L., Cabrita, M., Nassabi, M. H., de Vette, F., Weering, M. D.-V., Jansen-Kosterink, S. M., Kenter, W., et al. (2018) · Communications in computer and information science · doi:10.1007/978-3-319-93644-4_4 · Cited by 9
Neurobiological Mechanisms Involved in the Pathogenesis of Alzheimer’s Disease
Mir, F. A., & Rizvi, Z. A. (2019) · Springer eBooks · doi:10.1007/978-981-13-9636-6_13 · Cited by 8
Shen, K., Yang, Y., Ornstein, K. A., Shih, R. A., & Reckrey, J. M. (2025) · Health Affairs Scholar · doi:10.1093/haschl/qxae180 · Cited by 7
Sindi, S., Yerramalla, M. S., Barbera, M., Thunborg, C., Li, Y., Jönsson, L., Mangialasche, F., Qiu, C., & Kivipelto, M. (2025) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2025.100385 · Cited by 8
Lohner, V., Badhwar, A., Detcheverry, F. E., García, C. L., Gellersen, H. M., Khodakarami, Z., Lattmann, R., Li, R., Low, A., Mazo, C., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01815-6 · Cited by 7
You, W. (2025) · Health Science Reports · doi:10.1002/hsr2.71179 · Cited by 7
Ávila‐Villanueva, M., & Ávila, J. (2024) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2024.00090 · Cited by 7
Wang, N., Zhang, Q., Li, P., Guo, L., Wu, X., & Tu, Q. (2024) · Brain and Behavior · doi:10.1002/brb3.70170 · Cited by 7
Physical activity and incident dementia in older Japanese adults: The Okayama study
Liu, Y., Mitsuhashi, T., Yamakawa, M., Sasai, M., Tsuda, T., Doi, H., & Hamada, J. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5135 · Cited by 7
Commissioning social care for people with dementia living at home: Findings from a national survey
Davies, S., Hughes, J., Ahmed, S., Clarkson, P., Challis, D., & Members of the HoSt‐D (Home Support in Dementia) Programme Management Group (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5214 · Cited by 8
Secular Trends in Dementia Free Cognitive Function in Older Adults: A Systematic Review
Stephan, B. C. M., Tang, E. Y. H., Pakpahan, E., Biswas, B., Gupta, A., McGrattan, A., Bosco, A., Richardson, C. D., Robinson, L. A., & Siervo, M. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220162 · Cited by 7
Hershey, M. S., Sotos‐Prieto, M., Andrieu, S., Hofman, A., Magiatis, P., Martínez‐González, M. Á., Yannakoulia, M., Kales, S. N., & Scarmeas, N. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.99 · Cited by 7
Newman, A. B., Patel, S., Kizer, J. R., Lee, S., Bhasin, S., Cawthon, P. M., LeBrasseur, N. K., Tracy, R. P., Ganz, P., & Cummings, S. R. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad019 · Cited by 8
Development and validation of the Michigan Chronic Disease Simulation Model (MICROSIM)
Burke, J. F., Copeland, L. L., Sussman, J. B., Hayward, R. A., Gross, A. L., Briceño, E. M., Whitney, R. T., Giordani, B., Elkind, M. S. V., Manly, J. J., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300005 · Cited by 7
Alzheimer's disease prevention: A way forward
Bermejo‐Pareja, F., Velasco, S. L., & Villarejo‐Galende, A. (2016) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2016.06.006 · Cited by 9
Risk Factors and Prevention in Alzheimer’s Disease and Dementia
Grande, G., Vetrano, D. L., & Mangialasche, F. (2018) · Springer eBooks · doi:10.1007/978-3-319-72938-1_6 · Cited by 7
Derby, C. A., Katz, M. J., Rozner, S., Lipton, R. B., & Hall, C. B. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181141 · Cited by 7
Application of Genome-Wide Association Studies in Coronary Artery Disease
Zheng, H., Zeng, Z., Wen, H., Wang, P., Huang, C., Huang, P., Chen, Q., Gong, D., & Qiu, X. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191105125148 · Cited by 7
Processing speed is affected by early impairment in kidney function in the general elder population
Månsson, T., & Elmståhl, S. (2021) · BMC Nephrology · doi:10.1186/s12882-021-02517-5 · Cited by 7
Future policy directions for planning of national responsibility for dementia care
Kim, S. H. (2017) · Journal of Korean Medical Association · doi:10.5124/jkma.2017.60.8.622 · Cited by 7
Conner, S. C., Benayoun, L., Himali, J. J., Adams, S. L., Yang, Q., DeCarli, C. S., Blusztajn, J. K., Beiser, A., Seshadri, S. S., & Delalle, I. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180977 · Cited by 7
Self-citationSantanasto, A. J., Marron, M. M., Boudreau, R. M., Feitosa, M. F., Wojczynski, M. K., Arbeev, K. G., Thyagarajan, B., Schupf, N., Stallard, E., Paola Sebastiani, B., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz124 · Cited by 7
Temporal changes in the likelihood of dementia and MCI over 18 years in a population sample
Rajan, K. B., Weuve, J., Wilson, R. S., Barnes, L. L., McAninch, E. A., & Evans, D. A. (2019) · Neurology · doi:10.1212/wnl.0000000000008731 · Cited by 7
Cui, Q., Wang, D., Zeng, M., Dong, J., Jin, H., Hu, Z.-F., Zhang, Y., Peng, Y., & Han, R. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-034657 · Cited by 7
Yan, Z., Zou, X., & Hou, X. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.02217 · Cited by 7
Murata, S., Ono, R., Yasuda, H., Tanemura, R., Kido, Y., & Kowa, H. (2021) · Physical Therapy Research · doi:10.1298/ptr.e10057 · Cited by 7
Androgen deprivation therapy for prostate cancer and risk of dementia
Robinson, D. S., Garmo, H., Hemelrijck, M. V., Damber, J. ‐., Ola Bratt, A., Holmberg, L., Wahlund, L., Stattin, P., & Adolfsson, J. (2018) · European Urology Supplements · doi:10.1016/s1569-9056(18)31582-3 · Cited by 7
Charisis, S., Lu, S., Melgarejo, J. D., Satizábal, C. L., Vasan, R. S., Beiser, A., & Seshadri, S. S. (2025) · Neurology · doi:10.1212/wnl.0000000000213715 · Cited by 6
Self-citationSocioeconomic patterns in health behaviours after disease onset
Mika Kivimaki, B., & Marmot, M. G. (2022) · The Lancet Public Health · doi:10.1016/s2468-2667(22)00162-1 · Cited by 6
Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife
Gonzales, M. M., Kojis, D. J., Spartano, N. L., Thibault, E. G., DeCarli, C. S., Fakhri, G. E., Johnson, K. A., Beiser, A., & Seshadri, S. S. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240322 · Cited by 6
Self-citationShort Sleep Duration and Hypertension: A Double Hit for the Brain
Yiallourou, S. R., Baril, A., Wiedner, C. D., Song, X., Bernal, R., Himali, D., Cavuoto, M. G., DeCarli, C. S., Beiser, A., Seshadri, S. S., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.035132 · Cited by 6
Self-citationExploring the Complex Relationship Between Antidepressants, Depression and Neurocognitive Disorders
Neațu, M., Ioniță, I., Jugurt, A., Davidescu, E. I., & Popescu, B. O. (2024) · Biomedicines · doi:10.3390/biomedicines12122747 · Cited by 7
Walters, E. E., Luczak, S. E., Beam, C. R., Ericsson, M., Kremen, W. S., Krueger, R. F., Markon, K. E., McGue, M. K., Nygaard, M., Panizzon, M. S., et al. (2025) · European Journal of Epidemiology · doi:10.1007/s10654-025-01286-x · Cited by 6
Zheng, C., Qi, X., Shu, Y.-B., Bai, Y., & Wu, Y. (2018) · Blood Purification · doi:10.1159/000486846 · Cited by 6
Ostroumova, O. D., Cherniaeva, M. S., & Головина, О. В. (2018) · Kardiologiia · doi:10.18087/cardio.2018.9.10173 · Cited by 6
Rosas, A. G., Stögmann, E., & Lehrner, J. P. (2021) · Brain Disorders · doi:10.1016/j.dscb.2021.100028 · Cited by 6
Qipo, O., Debain, A., Bautmans, I., on behalf of the Gerontopole Brussels Study Group, Bautmans, I., Verté, D., Beyer, I., Petrović, M., Witte, N. D., Kardol, T., et al. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02247-0 · Cited by 6
Dementia and mild cognitive impairment in older people in Trøndelag
Gjøra, L., Strand, B. H., Engedal, K., Ernstsen, L., Myrstad, C., Skjellegrind, H. K., Thingstad, P., & Selbæk, G. (2023) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.22.0815 · Cited by 6
Ciciora, D., Vásquez, E., Valachovic, E. L., Hou, L., Zheng, Y., Xu, H., Jiang, X., Huang, K., Gabriel, K. P., Deng, H., et al. (2023) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2023.11.017 · Cited by 6
Wang, Y., Huang, J., Ang, T. F. A., Zhu, Y., Tao, Q., Mez, J., Alosco, M. L., Denis, G. V., Belkina, A. C., Gurnani, A. S., et al. (2024) · Exploration of Medicine · doi:10.37349/emed.2024.00216 · Cited by 6
Associations of cerebral amyloid beta and tau with cognition from midlife
Gonzales, M. M., O’Donnell, A., Ghosh, S., Thibault, E. G., Tanner, J. A., Satizábal, C. L., DeCarli, C. S., Fakhri, G. E., Johnson, K. A., Beiser, A., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14060 · Cited by 6
Self-citationThe effect of schooling on reported age of onset of cognitive decline: A collaborative study
Treves, T. A., Parmet, Y., Klimovitzky, S., & Korczyn, A. D. (2016) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2016.05.013 · Cited by 6
The Discrepancy of Neurological Diseases between China and Western Countries in Recent Two Decades
Ni, J., Han, F., Yuan, J., Wang, H., Shen, D., Xu, Y., & Cui, L. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.229905 · Cited by 6
Decreasing trend in the incidence and prevalence of dementia: a systematic review
Mayer, F., Remoli, G., Bacigalupo, I., Palazzesi, I., Piscopo, P., Bellomo, G., Canevelli, M., Corbo, M., Vanacore, N., & Lacorte, E. (2021) · Minerva Medica · doi:10.23736/s0026-4806.21.07454-1 · Cited by 6
Creating a research idea: steps and challenges
School, H. M., Lopes, F. O. D. A., Puerto, A. M. H., School, H. M., Moreno, H., School, H. M., Fregni, F., School, H. M., Falcão, D. P., (UnB), U. D. B., et al. (2016) · Geriatrics Gerontology and Aging · doi:10.5327/z2447-211520161600034 · Cited by 6
Grasset, L., Joly, P., Jacqmin‐Gadda, H., Letenneur, L., Wittwer, J., Amieva, H., Helmer, C., & Dartigues, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174950 · Cited by 7
Jiayaspathi, A., Chen, L. Y., Selvin, E., Gottesman, R. F., Knopman, D. S., Mosley, T. H., Norby, F. L., & Alonso, Á. (2021) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2021.11.005 · Cited by 6
Du, X. L., Simpson, L. M., Osani, M. C., Yama, J.-M., & Davis, B. R. (2022) · PubMed · Cited by 6
Dementia Research—A Roadmap for the Next Decade
Traynor, B. J., & Rademakers, R. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.5004 · Cited by 6
Shen, J., Chen, H., Gong, Y., Huang, Y., Wu, M., Gu, Y., Wang, T., Fontana, L., Rong, S., Qian, S., et al. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100457 · Cited by 5
The effects of acupuncture on cognitive impairment of vascular dementia patients
Tang, Y., Shao, S., Zhou, Y., Xiong, B., Cao, J., Li, Z., Wu, J., & Wang, C. (2019) · Medicine · doi:10.1097/md.0000000000017648 · Cited by 5
Guo, Y., Zhao, T., Chu, X., & Cheng, Z. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1275793 · Cited by 5
Dyer, A. H., Dolphin, H., O’Connor, A., Morrison, L., Sedgwick, G., McFeely, A., Killeen, E., Gallagher, C., Davey, N., Connolly, E., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-077772 · Cited by 5
Ramos‐Cejudo, J., Scott, M. R., Tanner, J. A., Pase, M. P., McGrath, E. R., Ghosh, S., Osorio, R. S., Thibault, E. G., Fakhri, G. E., Johnson, K. A., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231320 · Cited by 5
Self-citationLeng, Y., Ding, H., Ang, T. F. A., Au, R., Doraiswamy, P. M., & Liu, C. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2024.100021 · Cited by 5
Li, J., Liu, C., Ang, T. F. A., & Au, R. (2025) · European Journal of Neurology · doi:10.1111/ene.70062 · Cited by 5
Inequalities in the Duration and Lifetime Risk of Dementia in the United States
Hudomiet, P., Hurd, M. D., & Rohwedder, S. (2025) · Demography · doi:10.1215/00703370-12175489 · Cited by 5
William M. Feinberg Award for Excellence in Clinical Stroke
Greenberg, S. M. (2017) · Stroke · doi:10.1161/strokeaha.117.017246 · Cited by 5
How many geriatricians should, at minimum, be staffing health regions in Australia?
Commerford, T. (2017) · Australian Journal on Ageing · doi:10.1111/ajag.12467 · Cited by 5
Metadata
- Authors
- Satizabal, C. L., Beiser, A. S., Chouraki, V., Chêne, G., Dufouil, C., & Seshadri, S.
- Affiliations
- Boston University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-02-11
- Volume
- 374
- Issue
- 6
- Pages
- 523-532
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4943081
- OpenAlex
- W2265553328
- Cited by
- 1,051
- References
- 37
- Citations by year
- 2026: 49 · 2025: 90 · 2024: 77 · 2023: 78 · 2022: 94 · 2021: 110 · 2020: 109 · 2019: 105 · 2018: 128 · 2017: 125 · 2016: 83
- FWCI
- 130.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1, HHSN268201500001I, N01-HC 25195)
- National Institute on Aging (P30AG010129, U01AG049505, N01-HC-25195, AG08122, R01AG054076, R01AG049607, AG033193, NS017950, R01AG033040, R01AG033193, R01AG008122)
- National Heart, Lung, and Blood Institute (N01‐HC25195, HHSN268201500001I, AG08122, HHSN268201500001C, N01-HC-025195, NS017950, AG033193)
- National Institute of Neurological Disorders and Stroke (NS017950, N01‐HC‐25195, HHSN268201500001I, R01NS017950)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- dementia incidence, temporal trends, age-specific incidence, older adults, APOE ε4, educational attainment, vascular risk factors, stroke, atrial fibrillation, heart failure, cardiovascular disease, dementia risk factors
- MeSH terms
- Aged, Aged, 80 and over, Atrial Fibrillation, Dementia, Educational Status, Female, Heart Failure, Humans, Longitudinal Studies, Male, Massachusetts, Middle Aged, Risk Factors, Dementia, Vascular, Incidence, Proportional Hazards Models, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
