Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

Maude, S. L., Frey, N., Shaw, P. A., Aplenc, R., Barrett, D. M., Bunin, N. J., Chew, A., Gonzalez, V. E., Zheng, Z., Lacey, S. F., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1407222 · Cited by 5,413 · see citing works

Chimeric antigen receptor–modified T cells in chronic lymphoid leukemia

Porter, D. L., Levine, B. L., Kalos, M., Bagg, A., & June, C. H. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103849 · Cited by 3,565 · see citing works

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

Grupp, S. A., Kalos, M., Barrett, D., Aplenc, R., Porter, D. L., Rheingold, S. R., Teachey, D. T., Chew, A., Hauck, B., Wright, J. F., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1215134 · Cited by 3,509 · see citing works

Current concepts in the diagnosis and management of cytokine release syndrome.

Lee, D. W., Gardner, R., Porter, D. L., Louis, C. U., Ahmed, N., Jensen, M., Grupp, S. A., & Mackall, C. L. (2014) · Blood · doi:10.1182/blood-2014-05-552729 · Cited by 2,806 · see citing works

International uniform response criteria for multiple myeloma

Durie, B. G. M., Harousseau, J.-L., Miguel, J. S., Bladé, J., Barlogie, B., Anderson, K., Gertz, M., Dimopoulos, M., Westin, J., Sonneveld, P., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404284 · Cited by 2,632 · see citing works

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Kalos, M. D., Levine, B. L., Porter, D. L., Katz, S. I., Grupp, S. A., Bagg, A., & June, C. H. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002842 · Cited by 2,389 · see citing works

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

Maus, M. V., Grupp, S. A., Porter, D., & June, C. H. (2014) · Blood · doi:10.1182/blood-2013-11-492231 · Cited by 617 · see citing works

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

Shalapour, S., Font-Burgada, J., Di Caro, G., Zhong, Z., Sanchez-Lopez, E., Dhar, D., Willimsky, G., Ammirante, M., Strasner, A., Hansel, D. E., et al. (2015) · Nature · doi:10.1038/nature14395 · Cited by 611 · see citing works

Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma

Leung-Hagesteijn, C., Erdmann, N., Cheung, G., Keats, J. J., Stewart, A. K., Reece, D. E., Chung, K. C., & Tiedemann, R. E. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.08.009 · Cited by 380 · see citing works

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

Affara, N. I., Ruffell, B., Medler, T. R., Gunderson, A. J., Johansson, M., Bornstein, S., Bergsland, E. K., Steinhoff, M. S., Li, Y., Gong, Q., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.026 · Cited by 305 · see citing works

Enhancement of clonogenicity of human multiple myeloma by dendritic cells

Kukreja, A., Hutchinson, A., Dhodapkar, K. M., Mazumder, A., Vesole, D. H., Angitapalli, R., Jagannath, S., & Dhodapkar, M. V. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052136 · Cited by 134 · see citing works

The Phenotypic Plasticity of Myeloma Plasma Cells as Expressed by Dedifferentiation into an Immature, Resilient, and Apoptosis-Resistant Phenotype

Yaccoby, S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0523 · Cited by 103 · see citing works

Flow cytometric differentiation of abnormal and normal plasma cells in the bone marrow in patients with multiple myeloma and its precursor diseases

Tembhare, P. R., Yuan, C. M., Venzon, D. J., et al. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.12.007 · Cited by 95 · see citing works

Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Rapoport, A. P., Stadtmauer, E. A., Aqui, N. A., Vogl, D. T., Chew, A., Fang, H., Janofsky, S., Yager, K., Veloso, E. A., Zheng, Z., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0418 · Cited by 90 · see citing works

Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma

Hájek, R., Okubote, S. A., & Šváchová, H. (2013) · British Journal of Haematology · doi:10.1111/bjh.12563 · Cited by 85 · see citing works

B cells and their mediators as targets for therapy in solid tumors

Gunderson, A. J., & Coussens, L. M. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.03.005 · Cited by 80 · see citing works

A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells

Hideshima, T., Mitsiades, C. S., Ikeda, H., Chauhan, D., Raje, N. S., Görgün, G., Hideshima, H., Munshi, N. C., Richardson, P. G. G., Carrasco, D. R., et al. (2010) · Blood · doi:10.1182/blood-2010-02-270082 · Cited by 52 · see citing works

Bone marrow stromal cell interaction reduces Syndecan-1 expression and induces kinomic changes in myeloma cells

Fuhler, G. M., Baanstra, M., Chesik, D., Somasundaram, R., Seckinger, A., Hose, D., Peppelenbosch, M. P., & Bos, N. A. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.03.013 · Cited by 44 · see citing works

Transfer of influenza vaccine–primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial

Stadtmauer, E. A., Vogl, D. T., Prak, E. T. L., et al. (2010) · Blood · doi:10.1182/blood-2010-07-296822 · Cited by 41 · see citing works

Car t cell immunotherapy for human cancer

June, C. H., O’Connor, R. S., Kawalekar, O. U., Ghassemi, S., & Milone, M. C. (2018) · Science · doi:10.1126/science.aar6711 · Cited by 3,207 · see citing works

Engineered T cells: the promise and challenges of cancer immunotherapy

Fesnak, A. D., June, C. H., & Levine, B. L. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.97 · Cited by 1,074 · see citing works

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

Qasim, W., Zhan, H., Samarasinghe, S., Adams, S., Amrolia, P., Stafford, S., Butler, K., Rivat, C., Wright, G., Somana, K., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaj2013 · Cited by 902 · see citing works

Driving CAR T-cells forward

Jackson, H. J., Rafiq, S., & Brentjens, R. J. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.36 · Cited by 613 · see citing works

Management of relapsed and refractory multiple myeloma: Novel agents, antibodies, immunotherapies and beyond

Chim, C. S., Kumar, S. K., Orlowski, R. Z., Cook, G., Richardson, P. G., Gertz, M. A., Giralt, S., Mateos, M. V., Leleu, X., & Anderson, K. C. (2018) · Leukemia · doi:10.1038/leu.2017.329 · Cited by 305 · see citing works

CAR T‐Cell‐Based gene therapy for cancers: new perspectives, challenges, and clinical developments

Jogalekar, M. P., Rajendran, R. L., Khan, F., Dmello, C., Gangadaran, P., & Ahn, B.-C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.925985 · Cited by 214 · see citing works

Effective targeting of multiple B-cell maturation antigen-expressing hematological malignances by anti-B-cell maturation antigen chimeric antigen receptor T cells.

Friedman, K. M., Garrett, T. E., Evans, J. W., Horton, H. M., Latimer, H. J., Seidel, S. L., Horvath, C. J., & Morgan, R. A. (2018) · Human Gene Therapy · doi:10.1089/hum.2018.001 · Cited by 205 · see citing works

Myeloid cells in peripheral blood mononuclear cell concentrates inhibit the expansion of chimeric antigen receptor T cells

Stroncek, D. F., Ren, J., Lee, D. W., Tran, M., Frodigh, S. E., Sabatino, M., Khuu, H., Merchant, M. S., & Mackall, C. L. (2016) · Cytotherapy · doi:10.1016/j.jcyt.2016.04.003 · Cited by 148 · see citing works

Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

Stroncek, D. F., Lee, D. W., Ren, J., Sabatino, M., Highfill, S., Khuu, H., Shah, N. N., Kaplan, R. N., Fry, T. J., & Mackall, C. L. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1160-5 · Cited by 80 · see citing works

Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials

Esensten, J. H., Bluestone, J. A., & Lim, W. A. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100304 · Cited by 62 · see citing works

Cell Fate Reprogramming in the Era of Cancer Immunotherapy

Zimmermannova, O., Caiado, I., Ferreira, A. G., & Pereira, C.-F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714822 · Cited by 56 · see citing works

Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy

Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Long, A. H., Haso, W. M., Shern, J. F., Wanhainen, K. M., Murgai, M., Ingaramo, M., Smith, J. P., Walker, A. J., Kohler, M. E., Venkateshwara, V. R., et al. (2015) · Nature Medicine · doi:10.1038/nm.3838 · Cited by 1,815 · see citing works

Tinkering in the garage — tuning CARs for safety

Salter, A. I., & Riddell, S. R. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0240-2

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Liu, E., Marin, D., Banerjee, P., Macapinlac, H. A., Thompson, P., Basar, R., Nassif Kerbauy, L., Overman, B., Thall, P., Kaplan, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1910607 · Cited by 2,217 · see citing works

Distribution Measurements of Chimeric Antigen Receptor-Modified T Cells Against CD19Preprint

Ying, Z., He, T., Wang, X., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-63462/v1

B cell targeting in CAR T cell therapy: Side effect or driver of CAR T cell function?

Chen, G. M., Melenhorst, J. J., & Tan, K. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn3353 · Cited by 21 · see citing works