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Cyclosporine before PCI in Patients with Acute Myocardial Infarction
Open accessAbstract
BACKGROUND: Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine would improve clinical outcomes and prevent adverse left ventricular remodeling. METHODS: In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation myocardial infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset and who had complete occlusion of the culprit coronary artery to receive a bolus injection of cyclosporine (administered intravenously at a dose of 2.5 mg per kilogram of body weight) or matching placebo before coronary recanalization. The primary outcome was a composite of death from any cause, worsening of heart failure during the initial hospitalization, rehospitalization for heart failure, or adverse left ventricular remodeling at 1 year. Adverse left ventricular remodeling was defined as an increase of 15% or more in the left ventricular end-diastolic volume. RESULTS: A total of 395 patients in the cyclosporine group and 396 in the placebo group received the assigned study drug and had data that could be evaluated for the primary outcome at 1 year. The rate of the primary outcome was 59.0% in the cyclosporine group and 58.1% in the control group (odds ratio, 1.04; 95% confidence interval [CI], 0.78 to 1.39; P=0.77). Cyclosporine did not reduce the incidence of the separate clinical components of the primary outcome or other events, including recurrent infarction, unstable angina, and stroke. No significant difference in the safety profile was observed between the two treatment groups. CONCLUSIONS: In patients with anterior STEMI who had been referred for primary PCI, intravenous cyclosporine did not result in better clinical outcomes than those with placebo and did not prevent adverse left ventricular remodeling at 1 year. (Funded by the French Ministry of Health and NeuroVive Pharmaceutical; CIRCUS ClinicalTrials.gov number, NCT01502774; EudraCT number, 2009-013713-99.).
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“with relatively deceiving results (despite multiple clinical trials, no drug based on this concept has ever been approved for use in humans by regulatory agencies) [387].”
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Authors Task Force Members, Steg, P. G., James, S. K., Atar, D., Badano, L. P., Lundqvist, C. B., Borger, M. A., Mario, C. D., Dickstein, K., Ducrocq, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs215 · Cited by 6,890
Self-citationYellon, D. M., & Hausenloy, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071667 · Cited by 3,797
Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature · doi:10.1038/nature03434 · Cited by 2,280
Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y. (2005) · Nature · doi:10.1038/nature03317 · Cited by 1,635
Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction
Piot, C. A., Croisille, P., Staat, P., Thibault, H., Rioufol, G., Mewton, N., Belghiti, R. E., Cung, T. T., Bonnefoy‐Cudraz, E., Angoulvant, D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa071142 · Cited by 1,339
Self-citationEvolving Therapies for Myocardial Ischemia/Reperfusion Injury
Ibáñez, B., Heusch, G., Ovize, M., & de Werf, F. V. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.02.032 · Cited by 1,014
Self-citationMitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion
Griffiths, E. J., & Halestrap, A. P. (1995) · Biochemical Journal · doi:10.1042/bj3070093 · Cited by 838
Randomized Trial of Primary PCI with or without Routine Manual Thrombectomy
Jolly, S. S., Cairns, J. A., Yusuf, S., Meeks, B., Pogue, J. M., Rokoss, M. J., Kedev, S. A., Thabane, L., Stankovic, G. R., Moreno, R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1415098 · Cited by 665
Self-citationSteg, P. G., Greenlaw, N., Tardif, J., Tendera, M., Ford, I., Kääb, S., Abergel, H., Fox, K. M., Ferrari, R., & on behalf of the CLARIFY Registry Investigators (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs289 · Cited by 653
Self-citationHausenloy, D. J. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00455-8 · Cited by 585
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Sun, P., Li, Y., Yu, W.-D., Chen, J., Wan, P., Wang, Z., Zhang, M., Wang, C., Fu, S., Mang, G., et al. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1749 · Cited by 45
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Shi, M., Su, F., Dong, Z., Shi, Y., Tian, X., Cui, Z., & Li, J. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.09.057 · Cited by 31
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Pavlović, N., Todorović, P., Maglica, M., Kumrić, M., Vukojević, K., Pogorelić, Z., & Božić, J. (2025) · Biomolecules · doi:10.3390/biom15111572 · Cited by 31
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Engstrøm, T., Nepper‐Christensen, L., Helqvist, S., Kløvgaard, L., Holmvang, L., Jørgensen, E. O., Pedersen, F., Saunamäki, K. I., Tilsted, H., Steensberg, A., et al. (2018) · Heart · doi:10.1136/heartjnl-2017-312774 · Cited by 31
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Zhang, L., Jiang, Y. Y., Jia, W., Le, W., Liu, J., Zhang, P., Yang, H., Liu, Z., & Liu, Y. (2024) · Cell Proliferation · doi:10.1111/cpr.13762 · Cited by 30
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Heusch, G. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv225 · Cited by 30
Campo, G. C., Morciano, G., Pavasini, R., Bonora, M., Sbano, L., Biscaglia, S., Bovolenta, M., Pinotti, M., Punzetti, S., Rizzo, P., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.07.125 · Cited by 30
Briston, T., Lewis, S., Koglin, M., Mistry, K., Shen, Y., Hartopp, N., Katsumata, R., Fukumoto, H., Duchen, M. R., Szabadkai, G., et al. (2016) · Scientific Reports · doi:10.1038/srep37798 · Cited by 30
Hwang, I., Kim, J., Kim, J.-H., Lee, J., Seo, J.-Y., Lee, J., Park, J., Yang, H., Kim, S.-H., Cho, H., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.09405 · Cited by 30
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Ure, D., Trepanier, D. J., Mayo, P., & Foster, R. T. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1703948 · Cited by 30
Chen, B., An, D., He, J., Wu, C., Yue, T., Wu, R., Shi, R., Eteer, K., Joseph, B., Hu, J., et al. (2020) · European Radiology · doi:10.1007/s00330-020-07117-9 · Cited by 30
Ma, L., Kong, F., Dong, Z., Xin, K., Wang, X., Sun, A., Zou, Y., & Ge, J. (2021) · Cell Proliferation · doi:10.1111/cpr.13051 · Cited by 30
Chun, N. H., Haddadin, A. S., Liu, J., Hou, Y. J., Wong, K., Lee, D. C., Rushbrook, J. I., Gulaya, K., Hines, R. L., Hollis, T., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179450 · Cited by 30
Ríos‐Navarro, C., Marcos‐Garcés, V., Bayés‐Genís, A., Hüsser, O., Núñez, J. E., & Bodı́, V. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111805 · Cited by 30
Campo, G. C., Pavasini, R., Morciano, G., Lincoff, A. M., Gibson, C. M., Kitakaze, M., Lønborg, J., Ahluwalia, A., Ishii, H., Frenneaux, M. P., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.06.040 · Cited by 29
Self-citationMa, L., Ding, Z., Yin, P., Wu, J., Hu, K., Sun, A., Zou, Y., & Ge, J. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101960 · Cited by 29
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Xu, X., Li, M., Yu, F., Qin, W. D., Liu, Y., Tong, J., & Yang, F. (2024) · Advanced Science · doi:10.1002/advs.202308727 · Cited by 28
Paillard, M., Abdellatif, M., Andreadou, I., Bär, C., Bertrand, L., Brundel, B. J. J. M., Chiva‐Blanch, G., Davidson, S. M., Dawson, D. K., Lisa, F. D., et al. (2025) · European Journal of Heart Failure · doi:10.1002/ejhf.3674 · Cited by 29
Lecour, S., du Pré, B. C., Bøtker, H. E., Brundel, B. J. J. M., Daiber, A., Davidson, S. M., Ferdinandy, P., Girão, H., Gollmann‐Tepeköylü, C., Gyöngyösi, M., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab293 · Cited by 29
Current knowledge on the role of P2Y receptors in cardioprotection against ischemia-reperfusion
Djerada, Z., Féliu, C., Richard, V. J., & Millart, H. G. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.08.009 · Cited by 28
Rahman, F. A., Abdullah, S. S., Manan, W. Z. A., Tan, L. T., Neoh, C. F., Ming, L. C., Chan, K., Lee, L., Goh, B. H., Salmasi, S., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00238 · Cited by 28
Huang, Y.-Y., Wu, J., Su, T., Zhang, S., & Lin, X. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01083 · Cited by 28
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Rozich, E., Ozkurede, U., Pakkiriswami, S., Gemilere, R., Azarin, S. M., & Liu, J. C. (2025) · The Journal of Physiology · doi:10.1113/jp287770 · Cited by 29
Yao, H., He, Q., Wei, S., Xiang, L., Luo, Y., Huang, C., Liu, W., Zheng, C., Li, X., & Gao, Y. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.06.014 · Cited by 29
Cardioprotection: Where to from here?
Kloner, R. A., Hale, S. L., Dai, W., & Shi, J. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6691-0 · Cited by 27
Xu, S., Xu, C., Xu, J., Zhang, K., & Zhang, H. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s436560 · Cited by 27
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Soldozy, S., Dalzell, C. G., Skaff, A., Ali, Y. M., Norat, P., Yağmurlu, K., Park, M. S., & Kalani, M. Y. S. (2023) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2022.107574 · Cited by 28
Pan, Q., Liu, Y., Ma, W., Kan, R., Zhu, H., & Li, D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.685998 · Cited by 26
Pezel, T., de Horts, T. B., Schaaf, M., Croisille, P., Bière, L., García‐Dorado, D., Jossan, C., Roubille, F., Cung, T.-T., Prunier, F., et al. (2020) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2020.05.024 · Cited by 26
Self-citationSharp, T. E., Gong, Z., Scarborough, A. L., Goetzman, E. S., Ali, M. J., Spaletra, P. M., Lefer, D. J., Muzumdar, R. H., & Goodchild, T. T. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.04.015 · Cited by 25
Paccalet, A., Silva, C. C. D., Mechtouff, L., Amaz, C., Varillon, Y., de Bourguignon, C., Cartier, R., Prieur, C., Tomasevic, D., Génot, N., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.656928 · Cited by 25
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Self-citationSzulik, M. W., Valdez, S., Walsh, M., Davis, K., Bia, R. D., Horiuchi, E., O’Very, S., Laxman, A. K., Nicolova, L., Eberhardt, D., et al. (2023) · Basic Research in Cardiology · doi:10.1007/s00395-023-00991-6 · Cited by 26
Nakamura, E., Aoki, T., Endo, Y., Kazmi, J. S., Hagiwara, J., Kuschner, C. E., Yin, T., Kim, J. H., Becker, L. B., & Hayashida, K. (2024) · Life · doi:10.3390/life14040477 · Cited by 25
Metadata
- Authors
- Cung, T.-T., Morel, O., Cayla, G., Rioufol, G., Garcia-Dorado, D., Angoulvant, D., Bonnefoy-Cudraz, E., Guérin, P., Elbaz, M., Delarche, N., Coste, P., Vanzetto, G., Metge, M., Aupetit, J.-F., Jouve, B., Motreff, P., Tron, C., Labeque, J.-N., Steg, P. G., Cottin, Y., Range, G., Clerc, J., Claeys, M. J., Coussement, P., Prunier, F., Moulin, F., Roth, O., Belle, L., Dubois, P., Barragan, P., Gilard, M., Piot, C., Colin, P., De Poli, F., Morice, M.-C., Ider, O., Dubois-Randé, J.-L., Unterseeh, T., Le Breton, H., Béard, T., Blanchard, D., Grollier, G., Malquarti, V., Staat, P., Sudre, A., Elmer, E., Hansson, M. J., Bergerot, C., Boussaha, I., Jossan, C., Derumeaux, G., Mewton, N., & Ovize, M.
- Affiliations
- Centre Hospitalier Universitaire de Nantes (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Lyon 1 Université (FR)
- Centre Hospitalier De Pau (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Saint-Joseph Saint-Luc (FR)
- Centre Hospitalier Intercommunal Aix-Pertuis (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Hôpital Charles-Nicolle (FR)
- CHU Dijon Bourgogne (FR)
- Antwerp University Hospital (BE)
- AZ Sint-Jan (BE)
- Centre Hospitalier Universitaire d'Angers (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Centre Hospitalier de Mulhouse (FR)
- HUmani - CHU Charleroi-Chimay (BE)
- Clinique du Millénaire (FR)
- Hôpital Privé Jacques Cartier (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Lille’s Cardiology Hospital (FR)
- Lund University (SE)
- ORCID
- Morel, Olivier
- Cayla, Guillaume
- Rioufol, Gilles
- Angoulvant, Denis
- Guérin, Patrice
- Delarche, Nicolas
- Coste, Pierre
- Motreff, Pascal
- Tron, Christophe
- Cottin, Yves
- Claeys, Marc J.
- Prunier, Fabrice
- Barragan, Paul
- Gilard, Martine
- Piot, Christophe
- Unterseeh, Thierry
- Sudre, Arnaud
- Hansson, Magnus J.
- Bergerot, Cyrille
- Jossan, Claire
- Mewton, Nathan
- Ovize, Michel
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2015-09-10
- Volume
- 373
- Issue
- 11
- Pages
- 1021-1031
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2200357463
- Cited by
- 713
- References
- 34
- Citations by year
- 2026: 38 · 2025: 46 · 2024: 48 · 2023: 55 · 2022: 62 · 2021: 57 · 2020: 75 · 2019: 79 · 2018: 70 · 2017: 70 · 2016: 92 · 2015: 20
- FWCI
- 66.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Lunds Universitet
- Assistance publique-Hôpitaux de Paris
- Universitair Ziekenhuis Antwerpen
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- cyclosporine, ST-elevation myocardial infarction, percutaneous coronary intervention, left ventricular remodeling, ischemia-reperfusion injury, myocardial infarct size, heart failure, intravenous cyclosporine, primary percutaneous coronary intervention, drug safety
- MeSH terms
- Peptidyl-Prolyl Isomerase D, Aged, Combined Modality Therapy, Double-Blind Method, Electrocardiography, Enzyme Inhibitors, Female, Heart Failure, Humans, Injections, Intravenous, Male, Middle Aged, Mortality, Myocardial Infarction, Cyclosporine, Ventricular Remodeling, Cyclophilins, Kaplan-Meier Estimate, Percutaneous Coronary Intervention
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