Catch me if you can: targeting the mitochondrial permeability transition pore in myocardial infarction
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Elevated interconnectivity of RCD subroutines (notably intrinsic apoptosis and MPT-driven necrosis) may have played a key role in the negative results of the CIRCUS trial.
“Although multiple caveats linked to the methods employed to measure infarct size and the use of a specific pharmacological CsA formulation can be invoked to explain the negative results of the CIRCUS trial [388], the elevated interconnectivity of RCD subroutines (notably, intrinsic apoptosis and MPT-driven necrosis) may have played a key role in this setting.”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [388]
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- Authors
- Linkermann, A., Konstantinidis, K., & Kitsis, R. N.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Johns Hopkins University (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Linkermann, A
- Kitsis, R N
- Venue
- Cell Death & Differentiation
- Published
- 2015-11-20
- Volume
- 23
- Issue
- 1
- Pages
- 1-2
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC4815971
- OpenAlex
- W2174715216
- Cited by
- 36
- References
- 17
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 14 · 2016: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Deutsche Forschungsgemeinschaft (EXC 306)
- Fondation Leducq
- Exzellenzclusters Entzündungsforschung
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL128071)
- National Cancer Institute (R01CA170911)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- mitochondrial permeability transition pore, myocardial infarction, ischemia-reperfusion injury, cyclosporine, myocardial necrosis, ST-elevation myocardial infarction, cell death mechanisms, cardioprotection
- MeSH terms
- Enzyme Inhibitors, Female, Humans, Male, Myocardial Infarction, Cyclosporine, Ventricular Remodeling, Cyclophilins, Percutaneous Coronary Intervention
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