Weight loss and health status 3 years after bariatric surgery in adolescents
Open accessAbstract
BACKGROUND: Bariatric surgery is increasingly considered for the treatment of adolescents with severe obesity, but few prospective adolescent-specific studies examining the efficacy and safety of weight-loss surgery are available to support clinical decision making. METHODS: We prospectively enrolled 242 adolescents undergoing weight-loss surgery at five U.S. centers. Patients undergoing Roux-en-Y gastric bypass (161 participants) or sleeve gastrectomy (67) were included in the analysis. Changes in body weight, coexisting conditions, cardiometabolic risk factors, and weight-related quality of life and postoperative complications were evaluated through 3 years after the procedure. RESULTS: The mean (±SD) baseline age of the participants was 17±1.6 years, and the mean body-mass index (the weight in kilograms divided by the square of the height in meters) was 53; 75% of the participants were female, and 72% were white. At 3 years after the procedure, the mean weight had decreased by 27% (95% confidence interval [CI], 25 to 29) in the total cohort, by 28% (95% CI, 25 to 30) among participants who underwent gastric bypass, and by 26% (95% CI, 22 to 30) among those who underwent sleeve gastrectomy. By 3 years after the procedure, remission of type 2 diabetes occurred in 95% (95% CI, 85 to 100) of participants who had had the condition at baseline, remission of abnormal kidney function occurred in 86% (95% CI, 72 to 100), remission of prediabetes in 76% (95% CI, 56 to 97), remission of elevated blood pressure in 74% (95% CI, 64 to 84), and remission of dyslipidemia in 66% (95% CI, 57 to 74). Weight-related quality of life also improved significantly. However, at 3 years after the bariatric procedure, hypoferritinemia was found in 57% (95% CI, 50 to 65) of the participants, and 13% (95% CI, 9 to 18) of the participants had undergone one or more additional intraabdominal procedures. CONCLUSIONS: In this multicenter, prospective study of bariatric surgery in adolescents, we found significant improvements in weight, cardiometabolic health, and weight-related quality of life at 3 years after the procedure. Risks associated with surgery included specific micronutrient deficiencies and the need for additional abdominal procedures. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; Teen-LABS ClinicalTrials.gov number, NCT00474318.).
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Bariatric surgery promotes weight loss in severe obesity and often leads to adjunctive remission of type 2 diabetes.
“Bariatric surgery supports weight loss in people with severe obesity, often with adjunctive remission of type 2 diabetes (129,130).”
From Psychosocial care for people with diabetes: a position statement of the American Diabetes Association (2016) · cites this paper as [129]
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- Authors
- Inge, T. H., Courcoulas, A. P., Jenkins, T. M., Michalsky, M. P., Helmrath, M. A., Brandt, M. L., Harmon, C. M., Zeller, M. H., Chen, M. K., Xanthakos, S. A., Horlick, M., & Buncher, C. R.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- University of Pittsburgh Medical Center (US)
- Nationwide Children's Hospital (US)
- Baylor College of Medicine (US)
- Women & Children's Hospital of Buffalo (US)
- University of Alabama at Birmingham (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- University of Cincinnati (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-01-14
- Volume
- 374
- Issue
- 2
- Pages
- 113-123
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4810437
- OpenAlex
- W2332505177
- Cited by
- 750
- References
- 25
- Citations by year
- 2026: 43 · 2025: 63 · 2024: 63 · 2023: 80 · 2022: 70 · 2021: 69 · 2020: 78 · 2019: 68 · 2018: 69 · 2017: 79 · 2016: 63 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 71.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001070, UL1TR001425, UL1TR000005, UL1TR000165, UL1TR001417, UL1TR000077)
- National Institute of Diabetes and Digestive and Kidney Diseases (UM1DK095710, U01DK066557, UM1DK072493, U01DK072493, P30DK078392)
- National Center for Research Resources (UL1RR025755, UL1RR024153, M01RR000188, M01 RR-00188)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Surgery › Body Contouring and Surgery
- Keywords
- adolescent obesity, Roux-en-Y gastric bypass, sleeve gastrectomy, weight loss, type 2 diabetes remission, prediabetes, cardiometabolic risk factors, hypoferritinemia, weight-related quality of life, postoperative complications, obesity surgery outcomes
- MeSH terms
- Adolescent, Female, Humans, Hypertension, Male, Obesity, Morbid, Postoperative Complications, Prospective Studies, Quality of Life, Reoperation, Risk Factors, Weight Loss, Body Mass Index, Prevalence, Malnutrition, Bariatric Surgery, Dyslipidemias, Young Adult
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