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Zika Virus Disease in Colombia — Preliminary Report

Pacheco, Oscar, Beltrán, Mauricio, Nelson, Christina A., Valencia, Diana, Tolosa, Natalia, Farr, Sherry L., Padilla, Ana V., Tong, Van T., Cuevas, Esther L., Espinosa-Bode, Andrés, Pardo, Lissethe, Rico, Angélica, Reefhuis, Jennita, González, Maritza, Mercado, Marcela, Chaparro, Pablo, Martínez Duran, Mancel, Rao, Carol Y., Muñoz, María M., Powers, Ann M., Cuéllar, Claudia, Helfand, Rita, Huguett, Claudia, Jamieson, Denise J., Honein, Margaret A., Ospina Martínez, Martha L.·2020·New England Journal of Medicine

Abstract

BACKGROUND: Colombia began official surveillance for Zika virus disease (ZVD) in August 2015. In October 2015, an outbreak of ZVD was declared after laboratory-confirmed disease was identified in nine patients. METHODS: Using the national population-based surveillance system, we assessed patients with clinical symptoms of ZVD from August 9, 2015, to April 2, 2016. Laboratory test results and pregnancy outcomes were evaluated for a subgroup of pregnant women. Concurrently, we investigated reports of microcephaly for evidence of congenital ZVD. RESULTS: By April 2, 2016, there were 65,726 cases of ZVD reported in Colombia, of which 2485 (4%) were confirmed by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay. The overall reported incidence of ZVD among female patients was twice that in male patients. A total of 11,944 pregnant women with ZVD were reported in Colombia, with 1484 (12%) of these cases confirmed on RT-PCR assay. In a subgroup of 1850 pregnant women, more than 90% of women who were reportedly infected during the third trimester had given birth, and no infants with apparent abnormalities, including microcephaly, have been identified. A majority of the women who contracted ZVD in the first or second trimester were still pregnant at the time of this report. Among the cases of microcephaly investigated from January 2016 through April 2016, four patients had laboratory evidence of congenital ZVD; all were born to asymptomatic mothers who were not included in the ZVD surveillance system. CONCLUSIONS: Preliminary surveillance data in Colombia suggest that maternal infection with the Zika virus during the third trimester of pregnancy is not linked to structural abnormalities in the fetus. However, the monitoring of the effect of ZVD on pregnant women in Colombia is ongoing. (Funded by Colombian Instituto Nacional de Salud and the Centers for Disease Control and Prevention.).

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Metadata

Authors
Pacheco, O., Beltrán, M., Nelson, C. A., Valencia, D., Tolosa, N., Farr, S. L., Padilla, A. V., Tong, V. T., Cuevas, E. L., Espinosa-Bode, A., Pardo, L., Rico, A., Reefhuis, J., González, M., Mercado, M., Chaparro, P., Martínez Duran, M., Rao, C. Y., Muñoz, M. M., Powers, A. M., Cuéllar, C., Helfand, R., Huguett, C., Jamieson, D. J., Honein, M. A., & Ospina Martínez, M. L.
Venue
New England Journal of Medicine
Published
2020-08-06
Volume
383
Issue
6
Pages
e44-e44
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2423421007
Cited by
312
References
10
FWCI
55.92
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Zika Virus Disease in Colombia — Preliminary Report. https://app.cochat.ai/papers/10.1056/nejmoa1604037
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Pacheco, O., Beltrán, M., Nelson, C. A., Valencia, D., Tolosa, N., Farr, S. L., Padilla, A. V., Tong, V. T., Cuevas, E. L., Espinosa-Bode, A., Pardo, L., Rico, A., Reefhuis, J., González, M., Mercado, M., Chaparro, P., Martínez Duran, M., Rao, C. Y., Muñoz, M. M., . . . Ospina Martínez, M. L. (2020). Zika Virus Disease in Colombia — Preliminary Report. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1604037

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