The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist
Open accessAbstract
BACKGROUND: Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain. Elagolix, an oral, nonpeptide, gonadotropin-releasing hormone (GnRH) antagonist, produced partial to nearly full estrogen suppression in previous studies. METHODS: We performed two similar, double-blind, randomized, 6-month phase 3 trials (Elaris Endometriosis I and II [EM-I and EM-II]) to evaluate the effects of two doses of elagolix - 150 mg once daily (lower-dose group) and 200 mg twice daily (higher-dose group) - as compared with placebo in women with surgically diagnosed endometriosis and moderate or severe endometriosis-associated pain. The two primary efficacy end points were the proportion of women who had a clinical response with respect to dysmenorrhea and the proportion who had a clinical response with respect to nonmenstrual pelvic pain at 3 months. Each of these end points was measured as a clinically meaningful reduction in the pain score and a decreased or stable use of rescue analgesic agents, as recorded in a daily electronic diary. RESULTS: A total of 872 women underwent randomization in Elaris EM-I and 817 in Elaris EM-II; of these women, 653 (74.9%) and 632 (77.4%), respectively, completed the intervention. At 3 months, a significantly greater proportion of women who received each elagolix dose met the clinical response criteria for the two primary end points than did those who received placebo. In Elaris EM-I, the percentage of women who had a clinical response with respect to dysmenorrhea was 46.4% in the lower-dose elagolix group and 75.8% in the higher-dose elagolix group, as compared with 19.6% in the placebo group; in Elaris EM-II, the corresponding percentages were 43.4% and 72.4%, as compared with 22.7% (P<0.001 for all comparisons). In Elaris EM-I, the percentage of women who had a clinical response with respect to nonmenstrual pelvic pain was 50.4% in the lower-dose elagolix group and 54.5% in the higher-dose elagolix group, as compared with 36.5% in the placebo group (P<0.001 for all comparisons); in Elaris EM-II, the corresponding percentages were 49.8% and 57.8%, as compared with 36.5% (P=0.003 and P<0.001, respectively). The responses with respect to dysmenorrhea and nonmenstrual pelvic pain were sustained at 6 months. Women who received elagolix had higher rates of hot flushes (mostly mild or moderate), higher levels of serum lipids, and greater decreases from baseline in bone mineral density than did those who received placebo; there were no adverse endometrial findings. CONCLUSIONS: Both higher and lower doses of elagolix were effective in improving dysmenorrhea and nonmenstrual pelvic pain during a 6-month period in women with endometriosis-associated pain. The two doses of elagolix were associated with hypoestrogenic adverse effects. (Funded by AbbVie; Elaris EM-I and EM-II ClinicalTrials.gov numbers, NCT01620528 and NCT01931670 .).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In both trials, during the 6 months treatment, elagolix dramatically reduced dysmenorrhea and non-menstrual pelvic discomfort.”
From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [173]
In the citing paper
“The results of a study in which about 1700 women with moderate or severe pain in endometriosis participated played a part in the above decision. Doses of this drug—150 mg once a day or 200 mg twice a day—significantly reduced the most common types of endometrial pain: pelvic pain and sex-related pain.”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [117]
In the citing paper
“The latest drug to be approved by the Food and Drug Administration (FDA) is elagolix, a drug for the treatment of moderate to severe pain associated with endometriosis [117].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [117]
In the citing paper
“Recently, an oral GnRH antagonist (elagolix) was reported to be effective for reducing endometriosis‐related symptoms.”
From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [97]
In the citing paper
“In Elaris EM-II, corresponding percentages were 49.8% and 57.8% (compared with 36.5% in the placebo group).”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“In the EM-I and -II trials, Taylor et al. [102] reported that mean decreases in BMD in the lumbar spine, femoral neck and total hip after six months of treatment were significantly greater in patients receiving elagolix than in those given a placebo (excluding femoral neck BMD at a dose of 150 mg in Elaris EM-I (Figure 3).”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“In Elaris EM-II, corresponding percentages were 43.4% and 72.4% (compared with 22.7% in the placebo group).”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“At 200 mg (twice daily), percentages were respectively 42.3%, 47.6%, 72% and 77% [102,103].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“Overall, alleviation of both dysmenorrhea and non-menstrual pelvic pain were sustained for six months (Table 1).”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“In both studies, only women treated with elagolix at a dose of 200 mg twice daily showed a statistically significant greater reduction in dyspareunia after three months of treatment (compared with the placebo).”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“In conclusion, use of elagolix 200 mg twice daily causes strong suppression of E2 and marked improvements in dysmenorrhea, non-menstrual pelvic pain and dyspareunia, albeit at the cost of more hot flushes and a more pronounced decrease in BMD (Figure 4).”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“The percentage of patients with a decrease of >5% from baseline in lumbar spine BMD was higher in the elagolix 200 mg twice daily group in all studies.”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“Overall, the pharmacokinetic properties of elagolix at 150 mg once daily and 200 mg twice daily do not appear to be affected, to a clinically meaningful extent, by body weight, body mass index, race/ethnicity or the presence of endometriosis [102,103,107].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“Elagolix causes a dose-dependent decrease in BMD.”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“Regarding side effects, the most frequently reported were hot flushes, depending on the dose.”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“Percentages of women experiencing hot flushes at a dose of 150 mg (once daily) were respectively 23.7%, 22.6%, 44% and 36% in Elaris-I, -II, -III and -IV.”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“In Elaris EM-I, the percentage of women who noted an improvement in non-menstrual pelvic pain was 50.4% with elagolix 150 mg once daily and 54.5% with elagolix 200 mg twice daily (compared with 36.5% in the placebo group).”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“The percentage of women who experienced a clinical improvement in dysmenorrhea was 46.4% with elagolix 150 mg once daily and 75.8% with elagolix 200 mg twice daily (compared with 19.6% in the placebo group).”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [102]
In the citing paper
“Even if the majority of patients were satisfied with this therapy, as many as 40% of patients indicated unsatisfactory improvement of pain symptoms ( 69 ).”
From Is intracrinology of endometriosis relevant in clinical practice? A systematic review on estrogen metabolism (2022) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Farrar, J. T., Young, J. P., LaMoreaux, L., Werth, J. L., & Poole, M. R. (2001) · Pain · doi:10.1016/s0304-3959(01)00349-9 · Cited by 5,808
Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924
Self-citationBulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772
Nnoaham, K. E., Hummelshoj, L., Webster, P., d’Hooghe, T., de Cicco Nardone, F., de Cicco Nardone, C., Jenkinson, C., Kennedy, S. H., & Zondervan, K. T. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.090 · Cited by 1,584
Simoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., Brodszky, V., Canis, M., Colombo, G. L., DeLeire, T., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des073 · Cited by 1,070
Burney, R. O., Talbi, S., Hamilton, A. E., Vo, K. C., Nyegaard, M., Nezhat, C. R., Lessey, B. A., & Giudice, L. C. (2007) · Endocrinology · doi:10.1210/en.2006-1692 · Cited by 735
Self-citationRecurrence of endometriosis and its control
Guo, S.-W. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp007 · Cited by 719
Consensus on current management of endometriosis
Johnson, N. P., Hummelshoj, L., for the World Endometriosis Society Montpellier Consortium, Abrao, M. S., Adamson, G. D., Allaire, C., Amelung, V., Andersson, E., Becker, C., Birna Árdal, K. B., et al. (2013) · Human Reproduction · doi:10.1093/humrep/det050 · Cited by 558
Self-citationJacobson, T. A., Ito, M. K., Maki, K. C., Orringer, C. E., Bays, H. E., Jones, P. H., McKenney, J. M., Grundy, S. M., Gill, E. A., Wild, R. A., et al. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.07.007 · Cited by 469
Contribution of Bone Marrow-Derived Stem Cells to Endometrium and Endometriosis
Du, H., & Taylor, H. S. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0828 · Cited by 449
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- Brown J, 2010, Cochrane Database Syst Rev, CD008475
- Surrey ES, 2002, Obstet Gynecol, 99, 709
- Prentice A, 2000, Cochrane Database Syst Rev, CD000346
- Sagsveen M, 2003, Cochrane Database Syst Rev, CD001297
Cited by
Sorted by citations
Items 401–500 of 527
ESTRATÉGIAS DE PREVENÇÃO E MANEJO DA ENDOMETRIOSE: UMA REVISÃO BIBLIOGRÁFICA DE LITERATURA
Bezerra, L. M. R., Frazão, M. D. A., de Macedo, P. O. L., Araújo, I. M. Z. C., Rodrigues, H. M. D. S., Hélène, C. M., Silva, L. L. C., Coutinho, A. C. N. D. S. V., de Araújo, E. D. M. P. A., & de Castro, A. C. S. (2024) · RECIMA21 - Revista Científica Multidisciplinar · doi:10.47820/recima21.v5i3.5062 · Cited by 1
Leonardi, M., Singh, S. S., & Condous, G. S. (2019) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15986 · Cited by 1
What’s new on the horizon for polycystic ovarian syndrome? Exploring emerging drugs in phase II
D’Angelo, G., Ascione, M., Morra, I., Verrazzo, P., Bifulco, G., Giampaolino, P., & Corte, L. D. (2023) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2023.2260746 · Cited by 1
Taylor, H. S. (2025) · Fertility and Sterility · doi:10.1016/j.fertnstert.2025.03.025 · Cited by 1
Self-citationPharmacodynamic Evaluation: Endocrinology
Naafs, M. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-56637-5_35-1
Effects on the Skeleton from Medications Used to Treat Nonskeletal Disorders
Watts, N. B. (2018) · Wiley eBooks · doi:10.1002/9781119266594.ch61
Self-citationManage endometriosis-related pain with hormonal suppression therapies
Writers, A. M. (2019) · Drugs & Therapy Perspectives · doi:10.1007/s40267-019-00601-3
Endometriosis and Endometriosis-Associated Tumors
Simmen, R. C. M., Quick, C. M., Kelley, A. S., & Zheng, W. (2019) · Springer eBooks · doi:10.1007/978-981-13-3019-3_12
Pharmacologie des analogues de la GnRH
Sonigo, C., Peigné, M., Gronier, H., & Robin, G. (2019) · Elsevier eBooks · doi:10.1016/b978-2-294-75965-9.00018-0
Endometriosis - Review Of Current Therapeutic Aproaches For Disease Control
Spasova, V., Karamisheva, V., Staneva, R., Hadjidekova, S. P., Antonova, O., Koleva, L., & Toncheva, D. I. (2019) · Annual for Hospital Pharmacy · doi:10.14748/ahp.v5i1.5971
Treatment of scar endometriosis with elagolix
D'Amico, T. A., Bystry, L., & Kandel, S. M. (2020) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/2284026519901237
American Association for Cancer Research And American College of Obstetricians and Gynecologists.
Alexander, W. (2018) · Europe PMC (PubMed Central)
Khmil, S. V., Kulyk, I. I., & Підгайна, І. Я. (2020) · Актуальні питання педіатрії акушерства та гінекології · doi:10.11603/24116-4944.2019.2.10801
Yong, P. J. (2020) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2020.03.005
Medical management of symptomatic endometriosis: a new weapon in the arsenal?
Surrey, E. S. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.04.006
Self-citationEntwicklung oraler nichtpeptidischer GnRH-Antagonisten
Strowitzki, T. (2020) · Der Gynäkologe · doi:10.1007/s00129-020-04632-0
Neue Behandlungsoptionen mit GnRH-Antagonisten bei Endometriose und Uterus myomatosus
Küpker, W., Plathow, D., Bullerdiek, J., & Felberbaum, R. E. (2020) · Gynäkologische Endokrinologie · doi:10.1007/s10304-020-00329-8
Taney, J., & Tu, F. F. (2020) · Wiley eBooks · doi:10.1002/9781119482598.ch35
Khmil, S. V., & Kulyk, I. I. (2021) · Актуальні питання педіатрії акушерства та гінекології · doi:10.11603/24116-4944.2020.2.11846
Quality of life assessment and screening tool development for endometriosis
Verket, N. J. (2020) · NORA - Norwegian Open Research Archives
The role of the immune response in the etiopathogenesis of endometriosis
Stănică, C. D., Neacşu, A., Sima, R., & Ioan, R. G. (2021) · Romanian Medical Journal · doi:10.37897/rmj.2021.1.7
Optimize your treatment of endometriosis by using an FDA-approved hormonal medication
Barbieri, R. L. (2021) · OBG Management · doi:10.12788/obgm.0084
Casais, M., Zabala, A. S., & Rolla, E. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00119-5
Geraghty, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-85484-3_7
Ou, Z., Mo, Z.-W., & Ou, J. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_1055
Cieri‐Hutcherson, N. E., Carden, D., & Hutcherson, T. C. (2017) · The American Pharmacists Association eBooks · doi:10.21019/pharmacotherapyfirst.endometriosis_overview
Pharmacodynamic Evaluation: Endocrinology
Naafs, M. A. (2020) · Springer eBooks · doi:10.1007/978-3-319-68864-0_35
JOHNSON, N. P. (2018) · Wiley eBooks · doi:10.1002/9781119211457.ch53
Self-citationWu, C. Z., Klebanoff, J. S., & Moawad, G. (2020) · Wiley eBooks · doi:10.1002/9781119482598.ch34
Suplemento do IX Congresso SAMMG
(2021) · Revista Médica de Minas Gerais · doi:10.5935/2238-3182.v31supl.2
Ou, Z., Mo, Z.-W., & Ou, J. (2020) · Springer eBooks · doi:10.1007/978-3-319-69892-2_1055-1
Regulation of angiogenesis by microRNAs and long non-coding RNAs in endometriosis
Lu, R., Zhu, J., Li, F., & Xue, Q. (2022) · Reproductive and Developmental Medicine · doi:10.1097/rd9.0000000000000024
Lebovic, D. I., & Falcone, T. (2022) · Springer eBooks · doi:10.1007/978-3-030-99596-6_24
Gonadotropin-Releasing Hormone Antagonists Revolutionizing Gynecology
Esencan, E., & Taylor, H. S. (2022) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000005012
Self-citationThe use of combined oral contraceptives in patients with endometriosis
Kuznetsova, I. V. (2023) · Medical alphabet · doi:10.33667/2078-5631-2023-3-14-20
Elagolix: How far can it go in the world of gynecology?
Danis, R. B. (2023) · F&S Reports · doi:10.1016/j.xfre.2023.04.002
Elagolix và hiệu quả điều trị cơn đau trong bệnh lý Lạc nội mạc tử cung
Tran, N. Q. T., Lê, M. T., & Cao, N. T. (2023) · Tạp chí Phụ sản · doi:10.46755/vjog.2022.4.1558
Hao, Y., Feng, Z., Zhuang, X., Teng, H., & Zhang, G. (2023) · Journal of Chromatographic Science · doi:10.1093/chromsci/bmad038
Aktuelle Aspekte der endokrinen Therapie der Endometriose und der Adenomyose
Ebert, A. D., Felberbaum, R. E., & Küpker, W. (2023) · Gynäkologische Endokrinologie · doi:10.1007/s10304-023-00524-3
Gibt es neue Hoffnungsträger abseits der chirurgischen Endometriosetherapie?
Perricos, A., & Wenzl, R. J. (2023) · Die Gynäkologie · doi:10.1007/s00129-023-05158-x
Whitaker, L. H. R., Middleton, L., Priest, L., Odedra, S., Cheed, V., Nicholls, E. P., Williams, A. R. W., Roberts, N., Stubbs, C., Tryposkiadis, K., et al. (2023) · Efficacy and Mechanism Evaluation · doi:10.3310/fglq1687
Directive clinique no 445 : Gestion de la douleur pelvienne chronique
Allaire, C., Yong, P. J., Bajzak, K. I., Jarrell, J. F., Lemos, N. L. B. M., Miller, C., Morin, M., Nasr‐Esfahani, M., Singh, S. S., & Chen, I. (2024) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2023.102284
Endometriosis presents with massive hemorrhagic ascites and catamenial hemopneumothorax
Alikhanova, A., Gao, Y., Thompson, G., Duan, S., & Chujutall, R. (2023) · Open Journal of Clinical and Medical Case Reports · doi:10.52768/2379-1039/2149
Belchenko, U. D., Yakubova, E. E., Popovich, T. S., Agaeva, E. L., Kayalieva, E. Z., Khudaiberdiev, E.-S. S., Li, Y. R., Gasanov, S. R., Perederenko, N. I., Kadyrov, E. S., et al. (2024) · Obstetrics Gynecology and Reproduction · doi:10.17749/2313-7347/ob.gyn.rep.2024.534
Endometriosis: A Comprehensive and Concise Review of Potential Biomarkers and Treatment Therapies
Aziz, N., Wal, P., Pyne, C., Singh, S. K., Borkar, S. N., Pandey, S., & Sharma, M. C. (2024) · Current Drug Therapy · doi:10.2174/0115748855310120240819062459
Orale GnRH-Antagonisten in der kontrollierten ovariellen Stimulation: noch viele Fragen offen
Felberbaum, R. E., Küpker, W., & Diedrich, K. (2024) · Die Gynäkologie · doi:10.1007/s00129-024-05280-4
Updates in Endometriosis Management
Blackledge, K. T., Saad-Naguib, M. H., & McGovern, P. G. (2024) · Topics in Obstetrics & Gynecology · doi:10.1097/01.pgo.0001069572.69135.a0
Donnez, J., Becker, C. M., Taylor, H. S., Herrera, F. C., Petraglia, F., Renner, S. P., & Dolmans, M. (2024) · Human Reproduction · doi:10.1093/humrep/deae223
Self-citationEndometriosis: causes, diagnosis, and treatment options-review article for healthcare providers
Albogamy, . A., Alzaher, . A., Aljawad, . M., Aloula, . S. A., Alazmiy, . S., Bahaidarah, . A., Alharbi, M. S., Aljehani, M. R., & Alamri, F. H. (2018) · International Journal of Health Sciences · doi:10.53730/ijhs.v2ns1.15234
Wang, C., Nguyen, B. T., & Swerdloff, R. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00091-1
Mardero, O. D., Arruti, N., Coca-Robinot, J., Calvo, J. P., Montaño, V. E. F., Vallespín, E., & Martín, S. N. (2024) · European Journal of Ophthalmology · doi:10.1177/11206721241305244
Diagnostic Errors of Nodular Adenomyosis on the Example of a Clinical Case
Grigoryants, A. A., & Aksenenko, V. (2024) · Ural Medical Journal · doi:10.52420/umj.23.6.70
Neuroimmunology of Endometriosis-Associated Pain and Its Psychological Aspects
Lin, Y., & Wang, C. C. (2024) · Integrated science · doi:10.1007/978-3-031-72079-6_30
Nicely, T. M., Lim, L., Willette, A., Legiec, J. R., & Rawiji, H. (2025) · Cureus · doi:10.7759/cureus.80286
Metreveli, B., Gagua, D., Kepuladze, S., & Burkadze, G. (2025) · GEORGIAN SCIENTISTS · doi:10.52340/gs.2025.07.01.36
Clinical Guidance Paper VVOG: Pharmacological treatment of endometriosis-related pain
Remans, E., Bafort, C., Blank, C., Bongima, A., Geysenbergh, B., Hamerlynck, T. W. O., Page, G., Verguts, J., & Tomassetti, C. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology X · doi:10.1016/j.eurox.2025.100403
Endometriosis and Endometriosis-Associated Tumors
Simmen, R. C. M., Quick, C. M., & Zheng, W. (2025) · Springer eBooks · doi:10.1007/978-981-97-4822-8_12
Menstrual Suppression in Adolescents
Bolac, C. S., & Howell, J. O. (2025) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000001411
Surrey, E. S., Katz‐Jaffe, M. G., Kondapalli, L. A., Schoolcraft, W. B., & Makloski, R. (2025) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2025.105125
Self-citationJain, E., & Kalia, H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-12105-0.00006-9
Elagolix - a novel drug for management of endometriosis and uterine fibroids
Khan, F. (2025) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20252375
ENDOMETRIOSE: AVANÇOS DIAGNÓSTICOS E TERAPÊUTICOS NA ÚLTIMA DÉCADA
Souza, C. P. D. O., Ferrari, A. C. B., Gomes, A. C. B. D. S., Souza, A. C. V., Parra, M. R., Guerra, T. A., Veiga, F. C., de Macedo, D. B., lago, M. S. V., & de Camargo, R. R. (2025) · Asclepius International Journal of Scientific Health Science · doi:10.70779/aijshs.v4i10.350
The crystal structure of 2,2′-difluoro-3,3′-dimethoxy-1,1′-biphenyl, C 14 H 12 F 2 O 2
Wang, J., & Li, Y. (2025) · Zeitschrift für Kristallographie - New Crystal Structures · doi:10.1515/ncrs-2025-0374
Alexander, K. G., Nordahl, E. J. B., Newton, T. I. J., & Georgiou, C. (2025) · Academia Mental Health and Well-Being · doi:10.20935/mhealthwellb7938
Pathogenetic therapy of endometriosis: Updated data on the use of buserelin acetate (depot form)
Yakushevskaya, O. V. (2025) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2025-464
Recent Advances in Drug Treatment for Endometriosis in Adolescents
孔, 文. (2025) · Journal of Clinical Personalized Medicine · doi:10.12677/jcpm.2025.46490
Bae, S. H., Kang, J., Jeon, S., Kim, S. M., Kim, H.-T., Han, S., & Han, S. (2025) · Clinical Pharmacokinetics · doi:10.1007/s40262-025-01595-0
Osuga, Y., Seki, Y., Tanimoto, M., Kusumoto, T., Kudou, K., & Terakawa, N. (2021) · Figshare · doi:10.6084/m9.figshare.14821132
Osuga, Y., Seki, Y., Tanimoto, M., Kusumoto, T., Kudou, K., & Terakawa, N. (2021) · Figshare · doi:10.6084/m9.figshare.14821126
Abrao, M. S., Surrey, E. S., Gordon, K., Snabes, M. C., Wang, H., Ijacu, H., & Taylor, H. S. (2021) · Figshare · doi:10.6084/m9.figshare.14795093
Self-citationOsuga, Y., Seki, Y., Tanimoto, M., Kusumoto, T., Kudou, K., & Terakawa, N. (2021) · Figshare · doi:10.6084/m9.figshare.14821141
Osuga, Y., Seki, Y., Tanimoto, M., Kusumoto, T., Kudou, K., & Terakawa, N. (2021) · Figshare · doi:10.6084/m9.figshare.14821129
Osuga, Y., Seki, Y., Tanimoto, M., Kusumoto, T., Kudou, K., & Terakawa, N. (2021) · Figshare · doi:10.6084/m9.figshare.14821135
Parke, S., Gude, K., Roth, K., & Messina, F. (2024) · Figshare · doi:10.6084/m9.figshare.26061474
Prise en charge ostéopathique des douleurs pelviennes chroniques de la femme. Série de cas traités
Malexieux, A., Saujot, J., Contreras, S., & Crépin, A. (2025) · La Revue de l Ostéopathie · doi:10.65071/rev.osteo2025.01.31.31
Эффективность и безопасность диеногеста в терапии эндометриоза у женщин репродуктивного возраста
Гутикова, Л. В. (2025) · Репродуктивное здоровье Восточная Европа · doi:10.34883/pi.2025.15.6.003
Short-term Use of GnRH Antagonist for Severe Pain in Endometriosis
Begum, M. R., Rashid, F., Ehsan, N., Ehsan, M., Khan, F. I., Parveen, N., Farhana, N., Tamanna, T., & Sharmin, N. (2026) · Journal of South Asian Federation of Obstetrics and Gynaecology · doi:10.5005/jp-journals-10006-2809
Hormonal Treatment for Endometriosis, Adenomyosis, and Fibromatosis
Silvestri, C., Baronti, A., Ferraro, G., Papini, F., Cela, Giannini, A., Simoncini, T., & Luisi, S. V. (2026) · Reproductive medicine for clinicians · doi:10.1007/978-3-032-07322-8_13
Li, Y., Tan, H., Xie, J., Deng, K., Wu, Q., Yang, S. C., Yang, X., Li, J., Jia, X., Tong, J., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178639
Shim, J. Y., Scatoni, A., Laufer, M. R., & Boskey, E. R. (2026) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2026.02.008
Advances in Metabolic Syndrome and Endometriosis: Emerging Insights and Therapeutic Horizons
Baloyi, S. M.-A. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1013379
Mamillapalli, R., Pyneni, K., Watson, K., Habata, S., Gawde, N., & Taylor, H. S. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01442-3
Self-citationMunir, S. I., Nasir-ud-din, A., Iqbal, S., Irshad, H., & Hussain, U. (2026) · Journal of College of Physicians And Surgeons Pakistan · doi:10.29271/jcpsp.2026.03.303
Li, Y., & Wang, W. (2026) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s586408
Kurt, M., Gromadzki, N., Jałoszyński, G., Konecki, S., Marciniak, O., Bylak, N., Makowski, B. G., Makarewicz, M., Barbachowski, M. P., Gwizdek, A., et al. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.1(49).2026.4988
Perelmuter, S. (2026) · Preprints.org · doi:10.20944/preprints202604.0081.v1
Kumar, S., Khuroo, A. H., Quadros, R. R., Dharmadhikari, S. K., Khandhedia, C., Puppalwar, G., & Mane, A. (2026) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.70053
Tandulwadkar, S. R., Mukherjee, B., Ganpule, C., Patel, M., Mallya, S., Gopinath, P., & Tiwari, B. (2026) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2026.115115
D’Hooghe, T. (2026) · Human Reproduction Open · doi:10.1093/hropen/hoag031
PREDICTORS OF DRUG RESISTANCE DEVELOPMENT IN HORMONE THERAPY FOR ENDOMETRIOSIS
Trubnikova, L. I., Antoneeva, I. I., Iglina, M. A., Klykova, A. V., & Dimitrienko, E. A. (2026) · Ulyanovsk Medico-biological Journal · doi:10.34014/2227-1848-2026-1-18-30
Kale, A., Kale, A., Sarkar, A., Das, A., & Samal, S. S. (2026) · The Journal of Obstetrics and Gynecology of India · doi:10.1007/s13224-025-02328-w
Monago, I. N., Nzereogu, C. S., Mbakwe, F. K., Olopade, E. O., Monago, C. K., Mbakwe, M., Obasi, S. I., & Agboola, A. O. (2026) · International Journal of Biological and Pharmaceutical Sciences Archive · doi:10.53771/ijbpsa.2026.11.2.0036
Wang, H., Gou, Y., Zhang, H., Wang, H., Wang, B., Liu, J., Cao, Y., Bai, R., Zhao, Y., Han, X., et al. (2026) · Advanced Science · doi:10.1002/advs.75442
Morphological modulation of ovarian endometrioma with elagolix: a case report
Maladkar, M. N., Patani, N., Tekchandani, C. M., & Patil, R. (2026) · International Journal of Reproduction Contraception Obstetrics and Gynecology · doi:10.18203/2320-1770.ijrcog20261297
Bhoir, S., Patel, J. N., Palve, T., Dash, M. K., Saigal, S., Kamilya, G., Srivastava, S., Savalia, K., Gupta, T., Choudhary, D., et al. (2026) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.70256
Langer, G., Bräuer, N., Walter, D. S., Flanagan, S., Barbeau, O. R., Yau, W. T., Jenkins, J., Wegener, D., Fearon, D., Coelho, A.-M., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00488
Li, F., Wang, H. J., Zhang, Y., Nan, F., Xu, L., Liu, Z. Y., & Shi, W. (2026) · Seminars in Immunopathology · doi:10.1007/s00281-026-01077-w
Marzec, U., Giza, A., Rajca, E., Cyrkler, A., Cieślak, N., Paulina, G. I. Z. A., Chodkowska, A., Czyżak, K., Dąbek, K., & Wymoczył, K. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.2(50).2026.5080
Metadata
- Authors
- Taylor, H. S., Giudice, L. C., Lessey, B. A., Abrao, M. S., Kotarski, J., Archer, D. F., Diamond, M. P., Surrey, E., Johnson, N. P., Watts, N. B., Gallagher, J. C., Simon, J. A., Carr, B. R., Dmowski, W. P., Leyland, N., Rowan, J. P., Duan, W. R., Ng, J., Schwefel, B., Thomas, J. W., Jain, R. I., & Chwalisz, K.
- Affiliations
- Creighton University (US)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-07-06
- Volume
- 377
- Issue
- 1
- Pages
- 28-40
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2616333165
- Cited by
- 511
- References
- 36
- Citations by year
- 2026: 53 · 2025: 56 · 2024: 62 · 2023: 53 · 2022: 42 · 2021: 67 · 2020: 74 · 2019: 45 · 2018: 40 · 2017: 18
- FWCI
- 56.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Creighton Digital Repository (CDR) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, elagolix, GnRH antagonist, dysmenorrhea, estrogen suppression, rescue analgesic consumption, pain management, dose comparison, chronic pelvic pain
- MeSH terms
- Adolescent, Adult, Dose-Response Relationship, Drug, Double-Blind Method, Dysmenorrhea, Endometriosis, Estrogen Antagonists, Female, Humans, Hydrocarbons, Fluorinated, Gonadotropin-Releasing Hormone, Lipids, Middle Aged, Pyrimidines, Bone Density, Premenopause, Pelvic Pain, Hot Flashes, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
