The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Influenza Vaccine Effectiveness in the United States during the 2015–2016 Season
Open accessAbstract
BACKGROUND: The A(H1N1)pdm09 virus strain used in the live attenuated influenza vaccine was changed for the 2015-2016 influenza season because of its lack of effectiveness in young children in 2013-2014. The Influenza Vaccine Effectiveness Network evaluated the effect of this change as part of its estimates of influenza vaccine effectiveness in 2015-2016. METHODS: We enrolled patients 6 months of age or older who presented with acute respiratory illness at ambulatory care clinics in geographically diverse U.S. sites. Using a test-negative design, we estimated vaccine effectiveness as (1-OR)×100, in which OR is the odds ratio for testing positive for influenza virus among vaccinated versus unvaccinated participants. Separate estimates were calculated for the inactivated vaccines and the live attenuated vaccine. RESULTS: Among 6879 eligible participants, 1309 (19%) tested positive for influenza virus, predominantly for A(H1N1)pdm09 (11%) and influenza B (7%). The effectiveness of the influenza vaccine against any influenza illness was 48% (95% confidence interval [CI], 41 to 55; P<0.001). Among children 2 to 17 years of age, the inactivated influenza vaccine was 60% effective (95% CI, 47 to 70; P<0.001), and the live attenuated vaccine was not observed to be effective (vaccine effectiveness, 5%; 95% CI, -47 to 39; P=0.80). Vaccine effectiveness against A(H1N1)pdm09 among children was 63% (95% CI, 45 to 75; P<0.001) for the inactivated vaccine, as compared with -19% (95% CI, -113 to 33; P=0.55) for the live attenuated vaccine. CONCLUSIONS: Influenza vaccines reduced the risk of influenza illness in 2015-2016. However, the live attenuated vaccine was found to be ineffective among children in a year with substantial inactivated vaccine effectiveness. Because the 2016-2017 A(H1N1)pdm09 strain used in the live attenuated vaccine was unchanged from 2015-2016, the Advisory Committee on Immunization Practices made an interim recommendation not to use the live attenuated influenza vaccine for the 2016-2017 influenza season. (Funded by the Centers for Disease Control and Prevention and the National Institutes of Health.).
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Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Walter, E. B., Fry, A. M., & Jernigan, D. B. (2018) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6703a1 · Cited by 1,632
Self-citationEfficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults
DiazGranados, C. A., Dunning, A. J., Kimmel, M., Kirby, D., Treanor, J., Collins, A., Pollak, R., Christoff, J., Earl, J., Landolfi, V., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1315727 · Cited by 876
Self-citationLive Attenuated versus Inactivated Influenza Vaccine in Infants and Young Children
Belshe, R. B., Edwards, K. M., Vesikari, T., Black, S. V., Walker, R. E., Hultquist, M., Kemble, G., & Connor, E. M. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065368 · Cited by 811
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Olsen, S. J., Karron, R. A., Jernigan, D. B., & Bresee, J. S. (2016) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6505a1 · Cited by 593
The test-negative design for estimating influenza vaccine effectiveness
Jackson, M. L., & Nelson, J. C. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.02.053 · Cited by 510
Self-citationOhmit, S. E., Thompson, M. G., Petrie, J. G., Thaker, S. N., Jackson, M. L., Belongia, E. A., Zimmerman, R. K., Gaglani, M., Lamerato, L., Spencer, S. M., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/cit736 · Cited by 343
Self-citationSullivan, S. G., Tchetgen Tchetgen, E. J., & Cowling, B. J. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww064 · Cited by 319
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Self-citationMcLean, H. Q., Thompson, M. G., Sundaram, M. E., Kieke, B. A., Gaglani, M., Murthy, K., Piedra, P. A., Zimmerman, R. K., Nowalk, M. P., Raviotta, J. M., et al. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu647 · Cited by 281
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Lopez Bernal, J., Andrews, N., Gower, C., Robertson, C., Stowe, J., Tessier, E., Simmons, R., Cottrell, S., Roberts, R., O’Doherty, M., et al. (2021) · BMJ · doi:10.1136/bmj.n1088 · Cited by 1,389
Ranzani, O. T., Hitchings, M. D. T., Dorion, M., D’Agostini, T. L., de Paula, R. C., de Paula, O. F. P., Villela, E. F. D. M., Torres, M. S. S., de Oliveira, S. B., Schulz, W., et al. (2021) · BMJ · doi:10.1136/bmj.n2015 · Cited by 348
Bernal, J. L., Andrews, N., Gower, C., Stowe, J., Robertson, C., Tessier, E., Simmons, R., Cottrell, S., Roberts, R., O’Doherty, M., et al. (2021) · doi:10.1101/2021.03.01.21252652 · Cited by 1,389
Metadata
- Authors
- Jackson, M. L., Chung, J. R., Jackson, L. A., Phillips, C. H., Benoit, J., Monto, A. S., Martin, E. T., Belongia, E. A., McLean, H. Q., Gaglani, M., Murthy, K., Zimmerman, R., Nowalk, M. P., Fry, A. M., & Flannery, B.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-08-10
- Volume
- 377
- Issue
- 6
- Pages
- 534-543
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2744482235
- Cited by
- 283
- References
- 26
- FWCI
- 27.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jackson, M. L., Chung, J. R., Jackson, L. A., Phillips, C. H., Benoit, J., Monto, A. S., Martin, E. T., Belongia, E. A., McLean, H. Q., Gaglani, M., Murthy, K., Zimmerman, R., Nowalk, M. P., Fry, A. M., & Flannery, B. (2017). Influenza Vaccine Effectiveness in the United States during the 2015–2016 Season. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1700153
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