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Cited by 282

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease

Zhou, Yumin, Zhong, Nan-shan, Li, Xiaochen, Chen, Shuyun, Zheng, Jinping, Zhao, Dongxing, Yao, Weimin, Zhi, Rongchang, Wei, Liping, He, Bingwen, Zhang, Xiangyan, Yang, Changli, Li, Ying, Li, Fenglei, Du, Juan, Gui, Jianping, Hu, Bin, Bai, Chunxue, Huang, Ping, Chen, Gang, Xu, Yongjian, Wang, Changzheng, Liang, Biao, Li, Yinhuan, Hu, Guoping, Tan, Hui, Ye, Xianwei, Ma, Xitao, Chen, Yan, Hu, Xiwei, Tian, Jia, Zhu, Xiaodan, Shi, Zhe, Du, Xiufang, Li, Minjing, Liu, Shengming, Yu, Ronghuan, Zhao, Jianping, Ma, Qianli, Xie, Canmao, Li, Xiongbin, Chen, Tao, Lin, Yingxiang, Zeng, Lizhen, Ye, Changxiu, Ye, Weishu, Luo, Xiangwen, Zeng, Lingshan, Yu, Shuqing, Guan, Wei-jie, Ran, Pixin·2017·New England Journal of Medicine
DOI 10.1056/nejmoa1700228
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Abstract

BACKGROUND: Patients with mild or moderate chronic obstructive pulmonary disease (COPD) rarely receive medications, because they have few symptoms. We hypothesized that long-term use of tiotropium would improve lung function and ameliorate the decline in lung function in patients with mild or moderate COPD. METHODS: before and after bronchodilator use from day 30 to month 24. RESULTS: after bronchodilator use was significantly less in the tiotropium group than in the placebo group (29±5 ml per year vs. 51±6 ml per year; difference, 22 ml per year [95% CI, 6 to 37]; P=0.006). The incidence of adverse events was generally similar in the two groups. CONCLUSIONS: after bronchodilator use in patients with COPD of GOLD stage 1 or 2. (Funded by Boehringer Ingelheim and others; Tie-COPD ClinicalTrials.gov number, NCT01455129 .).

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Metadata

Authors
Zhou, Y., Zhong, N.-S., Li, X., Chen, S., Zheng, J., Zhao, D., Yao, W., Zhi, R., Wei, L., He, B., Zhang, X., Yang, C., Li, Y., Li, F., Du, J., Gui, J., Hu, B., Bai, C., Huang, P., Chen, G., Xu, Y., Wang, C., Liang, B., Li, Y., Hu, G., Tan, H., Ye, X., Ma, X., Chen, Y., Hu, X., Tian, J., Zhu, X., Shi, Z., Du, X., Li, M., Liu, S., Yu, R., Zhao, J., Ma, Q., Xie, C., Li, X., Chen, T., Lin, Y., Zeng, L., Ye, C., Ye, W., Luo, X., Zeng, L., Yu, S., Guan, W.-J., & Ran, P.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2017-09-07
Volume
377
Issue
10
Pages
923-935
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa1700228
OpenAlex
W2753810958
Cited by
282
References
23
FWCI
23.29
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1056/nejmoa1700228
The paper
Zhou, Y., Zhong, N.-S., Li, X., Chen, S., Zheng, J., Zhao, D., Yao, W., Zhi, R., Wei, L., He, B., Zhang, X., Yang, C., Li, Y., Li, F., Du, J., Gui, J., Hu, B., Bai, C., Huang, P., . . . Ran, P. (2017). Tiotropium in Early-Stage Chronic Obstructive Pulmonary Disease. New England Journal of Medicine. https://doi.org/10.1056/nejmoa1700228

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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