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Remdesivir for the Treatment of Covid-19 — Final Report
Open accessAbstract
BACKGROUND: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious. METHODS: We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days. The primary outcome was the time to recovery, defined by either discharge from the hospital or hospitalization for infection-control purposes only. RESULTS: A total of 1062 patients underwent randomization (with 541 assigned to remdesivir and 521 to placebo). Those who received remdesivir had a median recovery time of 10 days (95% confidence interval [CI], 9 to 11), as compared with 15 days (95% CI, 13 to 18) among those who received placebo (rate ratio for recovery, 1.29; 95% CI, 1.12 to 1.49; P<0.001, by a log-rank test). In an analysis that used a proportional-odds model with an eight-category ordinal scale, the patients who received remdesivir were found to be more likely than those who received placebo to have clinical improvement at day 15 (odds ratio, 1.5; 95% CI, 1.2 to 1.9, after adjustment for actual disease severity). The Kaplan-Meier estimates of mortality were 6.7% with remdesivir and 11.9% with placebo by day 15 and 11.4% with remdesivir and 15.2% with placebo by day 29 (hazard ratio, 0.73; 95% CI, 0.52 to 1.03). Serious adverse events were reported in 131 of the 532 patients who received remdesivir (24.6%) and in 163 of the 516 patients who received placebo (31.6%). CONCLUSIONS: Our data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection. (Funded by the National Institute of Allergy and Infectious Diseases and others; ACTT-1 ClinicalTrials.gov number, NCT04280705.).
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Citations
Cites
Dexamethasone in Hospitalized Patients with Covid-19
The RECOVERY Collaborative Group (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2021436 · Cited by 11,477
Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Hú, Z., Zhong, W., & Xiao, G. (2020) · Cell Research · doi:10.1038/s41422-020-0282-0 · Cited by 6,994
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
Cao, B., Wang, Y., Wen, D., Liu, W., Wang, J., Fan, G., Ruan, L., Song, B., Cai, Y., Wei, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001282 · Cited by 5,258 · cited 4×
“The trial site in South Korea received funding from the Seoul National University Hospital.”
InfluentialWang, Y., Zhang, D., Du, G., Du, R., Zhao, J., Jin, Y., Fu, S., Gao, L., Cheng, Z., Lu, Q., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31022-9 · Cited by 3,442
Sheahan, T. P., Sims, A. M., Leist, S. R., Schäfer, A., Won, J. J., Brown, A. J., Montgomery, S. A., Hogg, A., Babusis, D. M., Clarke, M. O., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13940-6 · Cited by 1,757
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Sheahan, T. P., Sims, A. M., Graham, R. L., Menachery, V. D., Gralinski, L. E., Case, J. B., Leist, S. R., Pyrć, K., Feng, J. Y., Trantcheva, I., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3653 · Cited by 1,575 · cited 3×
“There were 60 trial sites and 13 subsites in the United States (45 sites), Denmark (8), the United Kingdom (5), Greece (4), Germany (3), Korea (2), Mexico (2), Spain (2), Japan (1), and Singapore (1).”
Agostini, M. L., Andres, E. L., Sims, A. M., Graham, R. L., Sheahan, T. P., Lu, X., Smith, E. C., Case, J. B., Feng, J. Y., Jordan, R., et al. (2018) · mBio · doi:10.1128/mbio.00221-18 · Cited by 1,418
Spinner, C. D., Gottlieb, R., Criner, G. J., Arribas, J. R., Cattelan, A. M., Soriano, À., Ogbuagu, O. E., Malhotra, P., Mullane, K. M., Castagna, A., et al. (2020) · JAMA · doi:10.1001/jama.2020.16349 · Cited by 1,234
Borba, M. G. S., Val, F. F. A., Sampaio, V. S., Alexandre, M. A. A., Melo, G. C., Brito, M., Mourão, M. P. G., Brito-Sousa, J. D., Baía-da-Silva, D., Guerra, M. V. F., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.8857 · Cited by 1,038
de Wit, E., Feldmann, F., Cronin, J., Jordan, R., Okumura, A., Thomas, T., Scott, D. P., Cihlář, T., & Feldmann, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922083117 · Cited by 888
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Items 801–900 of 1,018
Garibaldi, B. T., Wang, K., Robinson, M. L., Betz, J., Alexander, G. C., Andersen, K. M., Joseph, C., Mehta, H. B., Korwek, K. M., Sands, K., et al. (2021) · Clinical Infectious Diseases · doi:10.1093/cid/ciab1035 · Cited by 67
Senefeld, J. W., Johnson, P. W., Kunze, K. L., Bloch, E. M., van Helmond, N., Golafshar, M. A., Klassen, S. A., Klompas, A. M., Sexton, M. A., Soto, J. C. D., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003872 · Cited by 66
Antiviral cyclic peptides targeting the main protease of SARS-CoV-2
Johansen‐Leete, J., Ullrich, S., Fry, S. E., Frkic, R. L., Bedding, M. J., Aggarwal, A., Ashhurst, A. S., Ekanayake, K. B., Mahawaththa, M. C., Sasi, V. M., et al. (2022) · Chemical Science · doi:10.1039/d1sc06750h · Cited by 67
SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19
Kreuzberger, N., Hirsch, C., Chai, K. L., Piechotta, V., Valk, S. J., Estcourt, L. J., Salomon, S., Tomlinson, E., Monsef, I., Wood, E. M., et al. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013825 · Cited by 68
Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection
Heyer, A., Günther, T., Robitaille, A., Lütgehetmann, M., Addo, M. M., Jarczak, D., Kluge, S., Aepfelbacher, M., Wiesch, J. S. Z., Fischer, N., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100735 · Cited by 65
SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in CellsPreprint
Andres, A. D., Feng, Y., Campos, A. R., Yin, J., Yang, C.-C., James, B. P., Murad, R., Kim, H., Deshpande, A. J., Gordon, D. E., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.18.256776 · Cited by 67
Waghmare, A., Abidi, M. Z., Boeckh, M., Chemaly, R. F., Dadwal, S., Boghdadly, Z. E., Kamboj, M., Papanicolaou, G. A., Pergam, S. A., & Shahid, Z. (2020) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2020.07.027 · Cited by 65
Sung, H. K., Kim, J. Y., Heo, J., Seo, H., Jang, Y.-S., Kim, H., Koh, B. R., Jo, N., Oh, H. S., Baek, Y. M., et al. (2020) · Journal of Korean Medical Science · doi:10.3346/jkms.2020.35.e280 · Cited by 64
Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2
Rogstam, A., Nyblom, M., Christensen, S., Sèle, C., Talibov, V., Lindvall, T., Rasmussen, A. A., André, I., Fisher, S. Z., Knecht, W., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197375 · Cited by 59
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases
Lo, M. K., Albariño, C. G., Perry, J. K., Chang, S., Tchesnokov, E. P., Guerrero, L. W., Chakrabarti, A. K., Shrivastava-Ranjan, P., Chatterjee, P., McMullan, L. K., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012294117 · Cited by 65
Vivarelli, S., Falzone, L., Torino, F., Scandurra, G., Russo, G. L., Bordonaro, R., Pappalardo, F., Spandidos, D. A., Raciti, G., & Libra, M. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5159 · Cited by 64
Remdesivir Use in the Setting of Severe Renal Impairment: A Theoretical Concern or Real Risk?
Pettit, N. N., Pisano, J. C., Nguyen, C. T., Lew, A. K., Hazra, A., Sherer, R. D., & Mullane, K. M. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1851 · Cited by 65
Roozbeh, F., Saeedi, M., Alizadeh‐Navaei, R., Hedayatizadeh‐Omran, A., Merat, S., Wentzel, H., Levi, J., Hill, A. M., & Shamshirian, A. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa501 · Cited by 65
Canakinumab as treatment for COVID-19-related pneumonia: A prospective case-control study
Generali, D., Bosio, G., Malberti, F., Antonio, C., Testa, S., Romanini, L., Fioravanti, A., Morandini, A., Pianta, L., Giannotti, G., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.12.073 · Cited by 65
Rapid resolution of COVID-19 after faecal microbiota transplantation
Biliński, J., Winter, K., Jasiński, M., Szczęś, A., Bilinska, N., Mullish, B. H., Malecka-Panas, E. I., & Basak, G. W. (2021) · Gut · doi:10.1136/gutjnl-2021-325010 · Cited by 65
Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study
IMPACC Manuscript Writing Team, Rouphael, N., Maecker, H. T., Montgomery, R. R., Diray‐Arce, J., Kleinstein, S. H., Altman, M. C., Bosinger, S. E., Eckalbar, W. L., Guan, L., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abf3733 · Cited by 58
Biswas, P., Hasan, M. M., Dey, D., Costa, A. C. D. S., Polash, S. A., Bibi, S., Ferdous, N., Kaium, M. A., Rahman, M. H., Jeet, F. K., et al. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16096-3 · Cited by 65
COVID-19 in Pediatric Patients: A Systematic Review
Jackson, W. M., Price, J. C., Eisler, L. D., Sun, L. S., & Lee, J. (2021) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0000000000000803 · Cited by 65
Troxel, A. B., Petkova, E., Goldfeld, K. S., Liu, M., Tarpey, T., Wu, Y., Wu, D., Agarwal, A., Avendaño, C., Bainbridge, E. D., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.47331 · Cited by 66
Mackman, R. L., Kalla, R. V., Babusis, D. M., Pitts, J., Barrett, K. T., Chun, K., Pont, V. D., Rodriguez, L., Moshiri, J., Xu, Y., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00750 · Cited by 65
Houston, B. L., Lawler, P. R., Goligher, E. C., Farkouh, M. E., Bradbury, C. A., Carrier, M., Džavík, V., Fergusson, D. A., Fowler, R., Galanaud, J. ‐., et al. (2020) · Clinical Trials · doi:10.1177/1740774520943846 · Cited by 64
Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework
Pirofski, L., & Casadevall, A. (2020) · mBio · doi:10.1128/mbio.01175-20 · Cited by 63
Tzou, P. L., Tao, K., Nouhin, J., Rhee, S., Hu, B. D., Pai, S., Parkin, N. T., & Shafer, R. W. (2020) · Viruses · doi:10.3390/v12091006 · Cited by 62
Pulmonary cavitation: an under-recognized late complication of severe COVID-19 lung disease
Zoumot, Z., Bonilla, M.-F., Wahla, A. S., Shafiq, I., Uzbeck, M. H., El-Lababidi, R. M., Hamed, F., Abuzakouk, M., & El-Kaissi, M. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-01379-1 · Cited by 64
Machitani, M., Yasukawa, M., Nakashima, J., Furuichi, Y., & Masutomi, K. (2020) · Cancer Science · doi:10.1111/cas.14618 · Cited by 61
Choudhry, N., Zhao, X., Xu, D., Zanin, M., Chen, W., Yang, Z., & Chen, J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00626 · Cited by 64
Kaye, A. G., & Siegel, R. (2020) · PeerJ · doi:10.7717/peerj.10322 · Cited by 62
Abubakar, A. R., Sani, I. H., Godman, B., Kumar, S., Islam, S., Jahan, I., & Haque, M. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s289037 · Cited by 65
Brunaugh, A. D., Seo, H., Warnken, Z. N., Ding, L., Seo, S. H., & Smyth, H. D. C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246803 · Cited by 76
Focosi, D., Maggi, F., McConnell, S. A., & Casadevall, A. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105247 · Cited by 59
Rattanaumpawan, P., Jirajariyavej, S., Lerdlamyong, K., Palavutitotai, N., & Saiyarin, J. (2022) · Antibiotics · doi:10.3390/antibiotics11060805 · Cited by 64
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
Jalloh, S., Olejnik, J., Berrigan, J. L., Nisa, A., Suder, E. L., Akiyama, H., Lei, M., Ramaswamy, S., Tyagi, S., Bushkin, Y., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010479 · Cited by 69
“Treatment of COVID-19 patients with remdesivir has been shown to significantly shorten recovery time and reduce lower respiratory tract infections, despite having minimal impact on viremia [95,96].”
Yuan, S., Chan, C. C.-Y., Chik, K. K., Tsang, J. O., Liang, R., Cao, J., Tang, K., Cai, J., Ye, Z., Yin, F., et al. (2020) · Viruses · doi:10.3390/v12060628 · Cited by 63
Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System
Sparks, M. A., South, A. M., Badley, A. D., Baker-Smith, C. M., BATLLE, D. C., Bozkurt, B., Cattaneo, R., Crowley, S. D., Dell’Italia, L. J., Ford, A. L., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15948 · Cited by 62
Repurposing Nucleoside Analogs for Human Coronaviruses
Zandi, K., Amblard, F., Musall, K., Downs-Bowen, J. A., Kleinbard, R., Oo, A., Cao, D., Liang, B., Russell, O. O., McBrayer, T. R., et al. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01652-20 · Cited by 63
Kamran, S. M., Mirza, Z.-E.-H., Naseem, A., Liaqat, J., Fazal, I., Alamgir, W., Saeed, F., Azam, R., Hussain, M., Yousaf, M. A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244853 · Cited by 63
COVID-19 and Its Implications for Thrombosis and Anticoagulation
Berkman, S. A., & Tapson, V. F. (2021) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0041-1722992 · Cited by 64
Rai, H., Barik, A., Singh, Y. P., Suresh, A., Singh, L., Singh, G., Nayak, U. Y., Dubey, V. K., & Modi, G. P. (2021) · Molecular Diversity · doi:10.1007/s11030-021-10188-5 · Cited by 63
Bian, H., Zheng, Z., Wei, D., Wen, A., Zhang, Z., Lian, J., Kang, W., Hao, C.-Q., Wang, J., Rong-hua, X., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00603-6 · Cited by 65
Dan, T. N., Donckers, K., Vangeel, L., Chatterjee, A. K., Gallay, P. A., Bobardt, M. D., Bilello, J. P., Cihlář, T., Jonghe, S. D., Neyts, J. H., et al. (2021) · Antiviral Research · doi:10.1016/j.antiviral.2021.105122 · Cited by 61
Nhean, S., Varela, M. E., Nguyen, Y.-N., Juarez, A., Huynh, T., Udeh, D., & Tseng, A. L.-I. (2021) · Journal of Pharmacy Practice · doi:10.1177/08971900211048139 · Cited by 68
Pharmacological treatment of COVID-19: an opinion paper
García‐Lledó, A., Gómez‐Pavón, J., del Castillo, J. M. G., Hernández‐Sampelayo, T., Delgado, M. C. M., Martín‐Sánchez, F. J., Martínez‐Sellés, M., Molero, J., Guillén, S. M., Rodríguez‐Artalejo, F., et al. (2021) · Revista Española de Quimioterapia · doi:10.37201/req/158.2021 · Cited by 63
Yin, J., Li, C., Ye, C., Ruan, Z., Liang, Y., Li, Y., Wu, J., & Luo, Z. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.01.026 · Cited by 66
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection
Cui, Z., Zeng, C., Huang, F., Yuan, F., Yan, J., Zhao, Y., Zhou, Y., Hankey, W., Jin, V. X., Huang, J., et al. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01094-4 · Cited by 65
A computational approach to drug repurposing using graph neural networks
Doshi, S., & Chepuri, S. P. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105992 · Cited by 66
Andrews, H. S., Herman, J. D., & Gandhi, R. T. (2023) · Annual Review of Medicine · doi:10.1146/annurev-med-052422-020316 · Cited by 64
Review of Burden, Clinical Definitions, and Management of COVID-19 Cases
McArthur, L., Sakthivel, D., Ataíde, R., Chan, F., Richards, J. S., & Narh, C. A. (2020) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.20-0564 · Cited by 68
Sharma, A., Sharma, S. K., Shi, Y., Bucci, E. M., Carafoli, E., Melino, G., Bhattacherjee, A., & Das, G. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2720-9 · Cited by 65
Fernandez‐Ruiz, R., Masson, M., Kim, M., Myers, B., Haberman, R. H., Castillo, R., Scher, J. U., Guttmann, A., Carlucci, P. M., Deonaraine, K., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41450 · Cited by 62
Carothers, C., Birrer, K. L., & Vo, M. (2020) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2464 · Cited by 62
Association between biomarkers and COVID-19 severity and mortality: a nationwide Danish cohort study
Hodges, G. W., Pallisgaard, J. L., Olsen, A. S., McGettigan, P., Andersen, M. P., Krogager, M. L., Kragholm, K. H., Køber, L., Gislason, G., Torp-Pedersen, C. T., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-041295 · Cited by 61
Ackley, T. W., McManus, D. S., Topal, J. E., Cicali, B., & Shah, S. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02290-20 · Cited by 63
Ibrahim, M. A. A., Abdelrahman, A. H. M., Allemailem, K. S., Almatroudi, A., Moustafa, M., & Hegazy, M. F. (2021) · The Protein Journal · doi:10.1007/s10930-020-09945-6 · Cited by 65
Current treatment in COVID-19 disease: a rapid review
Guerra, M. A. R., Jadhav, P., & Vittorio, T. J. (2021) · Drugs in Context · doi:10.7573/dic.2020-10-3 · Cited by 62
New drug approvals for 2020: Synthesis and clinical applications
Yuan, S., Luo, Y.-Q., Zuo, J.-H., Liu, H., Li, F., & Yu, B. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113284 · Cited by 62
Illouz, T., Biragyn, A., Iulita, M. F., Aguilar, L. F., Dierssen, M., Toma, I. D., Antonarakis, S. E., Yu, E. Y., Hérault, Y., Potier, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.621440 · Cited by 65
Izcovich, A., Siemieniuk, R. A. C., Bartoszko, J. J., Ge, L., Zeraatkar, D., Kum, E., Qasim, A., Khamis, A. M., Rochwerg, B. N., Agoritsas, T., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2020-048502 · Cited by 62
Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance
Ajmeera, D., & Ajumeera, R. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.12.013 · Cited by 67
Mozaffari, E., Chandak, A. N., Gottlieb, R., Chima-Melton, C., Read, S. H., Jiang, H., Chiang, M., Lee, E., Gupta, R. S., Berry, M., et al. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad460 · Cited by 65
Lauriola, M., Pani, A., Ippoliti, G., Mortara, A., Milighetti, S., Marjieh, M., Perseghin, G., Pastori, D., Grosso, P., & Scaglione, F. (2020) · Clinical and Translational Science · doi:10.1111/cts.12860 · Cited by 68
COVID-19 update: The race to therapeutic development
Twomey, J. D., Luo, S., Dean, A. Q., Bozza, W. P., Nalli, A. D., & Zhang, B. (2020) · Drug Resistance Updates · doi:10.1016/j.drup.2020.100733 · Cited by 62
Timing of Intubation and In-Hospital Mortality in Patients With Coronavirus Disease 2019
Hyman, J. B., Leibner, E. S., Tandon, P., Egorova, N., Bassily‐Marcus, A., Kohli-Seth, R. D., Arvind, V., Chang, H. L., Lin, H., & Levin, M. A. (2020) · Critical Care Explorations · doi:10.1097/cce.0000000000000254 · Cited by 61
Lopinavir/ritonavir: Repurposing an old drug for HIV infection in COVID-19 treatment
Magro, P., Zanella, I., Pescarolo, M., Castelli, F., & Quirós-Roldán, E. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.11.005 · Cited by 61
Chen, P., Lee, N., Cia, C.-T., Ko, W., & Hsueh, P. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.584956 · Cited by 62
Sheinson, D. M., Dang, J., Shah, A., Meng, Y., Elsea, D., & Kowal, S. L. (2021) · Advances in Therapy · doi:10.1007/s12325-021-01654-5 · Cited by 59
Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model
Cáceres, C. J., Garcia, S. C., Carnaccini, S., Seibert, B., Rajão, D. S., Wang, J., & Perez, D. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-89013-w · Cited by 64
Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality
Casadevall, A., Dragotakes, Q., Johnson, P. W., Senefeld, J. W., Klassen, S. A., Wright, R. S., Joyner, M. J., Paneth, N., & Carter, R. E. (2021) · eLife · doi:10.7554/elife.69866 · Cited by 61
Zhou, S., Feng, J., Xie, Q., Huang, T., Xu, X., Zhou, D., Zhang, W., Sun, S., Liu, X., Wu, X., et al. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153612 · Cited by 61
Qomara, W. F., Primanissa, D. N., Amalia, S. H., Purwadi, F. V., & Zakiyah, N. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s332458 · Cited by 61
Severe Infections Due to Respiratory Viruses
Cillóniz, C., Pericàs, J. M., Rojas, J. R., & Torres, A. (2022) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0041-1740982 · Cited by 61
The Immunobiology of Nipah Virus
Liew, Y. J. M., Ibrahim, P. A. S., Ong, H. M., Chong, C. N., Tan, C. T., Schee, J. P., Román, R. G., Cherian, N. G., Wong, W. F., & Chang, L. (2022) · Microorganisms · doi:10.3390/microorganisms10061162 · Cited by 67
Dalamaga, Μ., Karampela, Ι., & Mantzoros, C. S. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154282 · Cited by 61
Jassat, W., Mudara, C., Ozougwu, L., Tempia, S., Blumberg, L. H., Davies, M., Pillay, Y. G., Carter, T., Morewane, R., Wolmarans, M., et al. (2021) · medRxiv · doi:10.1101/2021.03.09.21253184 · Cited by 61
Pau, A. K., Aberg, J. A., Baker, J., Belperio, P. S., Coopersmith, C., Crew, P. E., Grund, B., Gulick, R. M., Harrison, C., Kim, A. Y., et al. (2020) · Annals of Internal Medicine · doi:10.7326/m20-6448 · Cited by 60
Gorman, E. A., Millar, J. E., McAuley, D. F., & O’Kane, C. M. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1848555 · Cited by 60
van Halem, K., Bruyndonckx, R., van der Hilst, J. C. H., Cox, J., Driesen, P., Opsomer, M., Steenkiste, E. V., Stessel, B., Dubois, J., & Messiaen, P. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05605-3 · Cited by 61
CRISPR systems: Novel approaches for detection and combating COVID-19
Safari, F., Afarid, M., Rastegari, B., Borhani‐Haghighi, A., Barekati‐Mowahed, M., & Behzad‐Behbahani, A. (2021) · Virus Research · doi:10.1016/j.virusres.2020.198282 · Cited by 61
Khairallah, P., Aggarwal, N., Awan, A. A., Vangala, C., Airy, M., Pan, J. S.-C., Murthy, B. V. R., Winkelmayer, W. C., & Ramanathan, V. (2021) · Transplant International · doi:10.1111/tri.13840 · Cited by 65
Lack of Effectiveness of Repurposed Drugs for COVID-19 Treatment
Martínez, M. Á. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635371 · Cited by 62
COVID-19: Immunology, Immunopathogenesis and Potential Therapies
Bhardwaj, A., Sapra, L., Saini, C., Azam, Z., Mishra, P. K., Verma, B., Mishra, G. C., & Srivastava, R. K. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1883600 · Cited by 65
Villanego, F., Mazuecos, A., Pérez-Flores, I., Moreso, F., Andrés, A., Jiménez-Martín, C., Molina, M., Canal, C., Sánchez-Cámara, L., Zárraga, S., et al. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16579 · Cited by 60
Amantadine Inhibits SARS-CoV-2 In Vitro
Fink, K., Nitsche, A., Neumann, M., Grossegesse, M., Eisele, K., & Danysz, W. (2021) · Viruses · doi:10.3390/v13040539 · Cited by 60
Autoimmunity and COVID-19 – The microbiotal connection
Katz-Agranov, N. S., & Zandman‐Goddard, G. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102865 · Cited by 64
LaVange, L. M., Adam, S. J., Currier, J. S., Higgs, E. S., Reineck, L. A., Hughes, E., & Read, S. W. (2021) · Annals of Internal Medicine · doi:10.7326/m21-1269 · Cited by 60
Martins‐Filho, P. R., Ferreira, L. C., Heimfarth, L., Araújo, A. A. D. S., & Quintans‐Júnior, L. J. (2021) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2021.100062 · Cited by 61
RETRACTED: Remdesivir Efficacy in COVID-19 Treatment: A Randomized Controlled Trial
Abd-Elsalam, S. M., Salama, M., Soliman, S., Naguib, A. M., Ibrahim, I. S., Torky, M., Ghafar, M. S. A. E., Abdul‐Baki, E. A., & Elhendawy, M. (2021) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.21-0606 · Cited by 60
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Eroglu, B., Nuwarda, R. F., Ramzan, I. M., & Kayser, V. (2021) · Vaccines · doi:10.3390/vaccines10010062 · Cited by 59
Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis
Pitre, T., Alstine, R. V., Chick, G., Leung, G., Mikhail, D., Cusano, E., Khalid, F., & Zeraatkar, D. (2022) · Canadian Medical Association Journal · doi:10.1503/cmaj.220471 · Cited by 58
Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites
Iketani, S., Hong, S. J., Sheng, J., Bahari, F., Culbertson, B., Atanaki, F. F., Aditham, A. K., Kratz, A., Luck, M. I., Tian, R., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.08.003 · Cited by 59
Polatoğlu, İ., Öner, T. Ö., Dalman, I., & Ozdogan, S. (2023) · MedComm · doi:10.1002/mco2.228 · Cited by 68
Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19
Bai, X., Hippensteel, J. A., Leavitt, A., Maloney, J. P., Beckham, J. D., Garcia, C., Li, Q., Freed, B. M., Ordway, D. J., Sandhaus, R. A., et al. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110394 · Cited by 61
Gu, C., Wu, Y., Guo, H., Zhu, Y., Xu, W., Wang, Y., Zhou, Y., Sun, Z., Cai, X., Li, Y., et al. (2020) · 中国科学通报：英文版 · doi:10.1016/j.scib.2020.12.005 · Cited by 60
Czuppon, P., Débarre, F., Gonçalves, A., Tenaillon, O., Perelson, A. S., Guedj, J., & Blanquart, F. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008752 · Cited by 60
Wang, X., Sahu, K. K., & Černý, J. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02297-z · Cited by 62
High versus standard doses of corticosteroids in severe COVID-19: a retrospective cohort study
Monreal, E., de la Maza, S. S., Natera‐Villalba, E., Beltrán‐Corbellini, Á., Rodríguez‐Jorge, F., Fernández-Velasco, J. I., Walo-Delgado, P. E., Muriel, A., Zamora, J., Cánovas, A. A., et al. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-04078-1 · Cited by 60
SARS-CoV-2: Targeted managements and vaccine development
Bakhiet, M., & Taurin, S. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.11.001 · Cited by 65
Classical and alternative receptors for SARS‐CoV‐2 therapeutic strategy
Masre, S. F., Jufri, N. F., Ibrahim, F. W., & Raub, S. H. A. (2020) · Reviews in Medical Virology · doi:10.1002/rmv.2207 · Cited by 62
Mortality Benefit of Remdesivir in COVID-19: A Systematic Review and Meta-Analysis
Bansal, V., Mahapure, K. S., Bhurwal, A., Gupta, I., Hassanain, S., Makadia, J., Madas, N., Armaly, P., Singh, R., Mehra, I., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.606429 · Cited by 59
Juul, S., Nielsen, E. E., Feinberg, J. B., Siddiqui, F., Kamp, C. B., Barot, E., Holgersson, J., Nielsen, N., Bentzer, P., Veroniki, A. A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248132 · Cited by 57
Chen, J., & Lu, H. (2021) · BioScience Trends · doi:10.5582/bst.2021.01092 · Cited by 58
Metadata
- Authors
- Beigel, J. H., Tomashek, K. M., Dodd, L. E., Mehta, A. K., Zingman, B. S., Kalil, A. C., Hohmann, E., Chu, H. Y., Luetkemeyer, A., Kline, S., Lopez de Castilla, D., Finberg, R. W., Dierberg, K., Tapson, V., Hsieh, L., Patterson, T. F., Paredes, R., Sweeney, D. A., Short, W. R., Touloumi, G., Lye, D. C., Ohmagari, N., Oh, M.-D., Ruiz-Palacios, G. M., Benfield, T., Fätkenheuer, G., Kortepeter, M. G., Atmar, R. L., Creech, C. B., Lundgren, J., Babiker, A. G., Pett, S., Neaton, J. D., Burgess, T. H., Bonnett, T., Green, M., Makowski, M., Osinusi, A., Nayak, S., & Lane, H. C.
- Affiliations
- National Institutes of Health (US)
- From the National Institute of Allergy and Infectious Diseases, National Institutes of Health (J.H.B., K.M.T., L.E.D., S.N., H.C.L.), and the Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences (T.H.B.), Bethesda, the Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick (T. Bonnett), and Emmes, Rockville (M.G., M.M.) — all in Maryland; Emory University, Atlanta (A.K.M.); Montefiore Medical...
- Corresponding author
- Beigel, John H.
- ORCID
- Beigel, John H.
- Dodd, Lori E.
- Mehta, Aneesh K.
- Zingman, Barry S.
- Kalil, Andre C.
- Hohmann, Elizabeth
- Chu, Helen Y.
- Luetkemeyer, Annie
- Kline, Susan
- Finberg, Robert W.
- Dierberg, Kerry
- Tapson, Victor
- Patterson, Thomas F.
- Paredes, Roger
- Short, William R.
- Touloumi, Giota
- Lye, David Chien
- Ohmagari, Norio
- Oh, Myoung-don
- Ruiz-Palacios, Guillermo M.
- Benfield, Thomas
- Fätkenheuer, Gerd
- Atmar, Robert L.
- Creech, C. Buddy
- Lundgren, Jens
- Babiker, Abdel G.
- Pett, Sarah
- Neaton, James D.
- Burgess, Timothy H.
- Bonnett, Tyler
- Makowski, Mat
- Nayak, Seema
- Lane, H. Clifford
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2020-11-05
- Volume
- 383
- Issue
- 19
- Pages
- 1813-1826
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC7262788
- OpenAlex
- W3027630905
- Cited by
- 7,267
- References
- 22
- Citations by year
- 2026: 146 · 2025: 324 · 2024: 518 · 2023: 901 · 2022: 1447 · 2021: 2475 · 2020: 1451
- FWCI
- 206.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- Figshare (submittedVersion, cc-by)
- Sussex Research Online (University of Sussex) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion, other-oa)
- eScholarship@McGill (McGill) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, other-oa)
- Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Cancer Institute (HHSN261200800001E, HHSN261201500003I)
- National Institute of Allergy and Infectious Diseases (UM1AI148450, UM1AI148452, UM1AI148573, UM1AI148575, UM1AI148576, UM1AI148684, UM1AI148685, UM1AI148689)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- remdesivir, COVID-19 pandemic, SARS-CoV-2, antiviral therapy, hospitalized patients, lower respiratory tract infection, time to recovery, mortality, serious adverse events, clinical improvement, treatment efficacy, SARS-CoV-2 RNA load, viral load reduction, disease severity, prognostic factors, prognostic score
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Adenosine Monophosphate, Adult, Aged, Alanine, Antiviral Agents, Double-Blind Method, Female, Humans, Male, Middle Aged, Oxygen Inhalation Therapy, Pneumonia, Viral, Respiration, Artificial, Time Factors, Extracorporeal Membrane Oxygenation, Coronavirus Infections, Kaplan-Meier Estimate, Young Adult, Pandemics, Administration, Intravenous
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