The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index; 4 of the 10 sources its claims cite were checked for support.
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma.
Open accessAbstract
BACKGROUND: Idecabtagene vicleucel (ide-cel, also called bb2121), a B-cell maturation antigen-directed chimeric antigen receptor (CAR) T-cell therapy, has shown clinical activity with expected CAR T-cell toxic effects in patients with relapsed and refractory multiple myeloma. METHODS: CAR-positive (CAR+) T cells. The primary end point was an overall response (partial response or better); a key secondary end point was a complete response or better (comprising complete and stringent complete responses). RESULTS: nucleated cells) was confirmed in 33 patients, representing 26% of all 128 patients who were treated and 79% of the 42 patients who had a complete response or better. The median progression-free survival was 8.8 months (95% confidence interval, 5.6 to 11.6). Common toxic effects among the 128 treated patients included neutropenia in 117 patients (91%), anemia in 89 (70%), and thrombocytopenia in 81 (63%). Cytokine release syndrome was reported in 107 patients (84%), including 7 (5%) who had events of grade 3 or higher. Neurotoxic effects developed in 23 patients (18%) and were of grade 3 in 4 patients (3%); no neurotoxic effects higher than grade 3 occurred. Cellular kinetic analysis confirmed CAR+ T cells in 29 of 49 patients (59%) at 6 months and 4 of 11 patients (36%) at 12 months after infusion. CONCLUSIONS: Ide-cel induced responses in a majority of heavily pretreated patients with refractory and relapsed myeloma; MRD-negative status was achieved in 26% of treated patients. Almost all patients had grade 3 or 4 toxic effects, most commonly hematologic toxic effects and cytokine release syndrome. (Funded by bluebird bio and Celgene, a Bristol-Myers Squibb company; KarMMa ClinicalTrials.gov number, NCT03361748.).
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Claims the paper makes
4 of 10 cited sources checked · 2 supported · 0 flagged · accuracy not yet measured
Every source the paper cites for this claim was checked and supports it.
In the paper
“The B-cell maturation antigen (BCMA)-directed CAR T cell idecabtagene vicleucel (ide-cel, also called bb2121) showed promising efficacy in a phase 1 study involving patients with relapsed or refractory myeloma.11”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > D
What the sources say
- Supportedcites [11] 11. Raje N, Berdeja J, Lin Y, et al. Anti- BCMA CAR T-cell therapy bb2121 in re- lapsed or refractory multiple myeloma. N Engl J Med 2019; 380: 1726-37. source
The Methods identify bb2121 as an anti-BCMA CAR T-cell therapy studied in a phase 1 trial involving patients with relapsed or refractory multiple myeloma. The Discussion reports an 85% clinical response rate, supporting the characterization of its efficacy as promising. (LLM, conf=0.94)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“These efficacy results compare favorably with results in similarly heavily pretreated patients with relapsed or refractory myeloma treated with two recently approved regimens, selinexor plus dexamethasone and belantamab mafodotin (median progression-free survival, 3.7 months and 2.9 months, respectively).5,17”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
What the sources say
- Supportedcites [5] 5. Chari A, Vogl DT, Gavriatopoulou M, et al. Oral selinexor-dexamethasone for triple-class refractory multiple myeloma. N Engl J Med 2019; 381: 727-38. source
The Methods and Discussion describe patients with triple-class refractory myeloma who were heavily pretreated, with a median of seven previous regimens. The Efficacy section reports median progression-free survival of 3.7 months with selinexor plus dexamethasone. This citation supports the selinexor result; the separate belantamab result is not attributed to this paper. (LLM, conf=0.92)
- Not checked — no full text of the sourcecites [17] 17. Lonial S, Lee HC, Badros A, et al. Belan- tamab mafodotin for relapsed or refracto- ry multiple myeloma (DREAMM-2): a two- arm, randomised, open-label, phase 2 study. Lancet Oncol 2020; 21: 207-21. source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: Cross-trial comparisons of progression-free survival between the KarMMa study and trials of selinexor plus dexamethasone or belantamab mafodotin are valid.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Observed toxic effects were consistent with those in previous reports.11”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
What the sources say
- Partly supportedcites [11] 11. Raje N, Berdeja J, Lin Y, et al. Anti- BCMA CAR T-cell therapy bb2121 in re- lapsed or refractory multiple myeloma. N Engl J Med 2019; 380: 1726-37. sourceExperimental — accuracy not yet measured
The Results (Safety; page unavailable) document the observed toxic effects. The Discussion compares them with previous studies, but reports a lower incidence of severe cytokine release syndrome with bb2121 and cautions that cross-study comparisons are complicated. It does not establish that the toxic effects were generally consistent with previous reports. (LLM, conf=0.82)
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Duration of undetectable sBCMA correlated with response duration, and clearance of sBCMA at month 2 was associated with longer progression-free survival (Fig. S5E and S5F).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Figure 2 (facing page). Progression-free Survival, Duration of Response, and Overall Survival.
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Rests on an assumption: Soluble BCMA is a serum-based universal marker of myeloma burden.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“with peak levels higher in patients having cytokine release syndrome of grade 3 or higher (Fig. S6).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“a somewhat higher frequency and somewhat greater depth of response were observed at the 450 × 10 6 dose (response in 81% of the pa-tients and complete response or better in 39%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At baseline, 110 of 112 tumor samples (98%) expressed BCMA, with 109 having at least 50% BCMA-positive plasma cells, and all the patients had detectable levels of sBCMA.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Figure 2 (facing page). Progression-free Survival, Duration of Response, and Overall Survival.
Strength:plain· not yet calibratedn = 112Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A response was observed in 73% of the treated patients, and a complete response or better was observed in 33%;”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Baseline cytokine levels were not associated with higher-grade cytokine release syndrome or neurotoxic effects.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“with an incidence of response to bridging therapy of 4%”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes
- Probably not a substantial claim. 12
- It may state two separate claims as one. 32
- The quote only partly states this claim. 1
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In contrast, CD19 epitope loss is reported to be a relatively common escape mechanism after treatment with CD19-directed CAR T-cell therapy, especially in patients with acute leukemia.18,19”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
What the sources say
- Partly supportedcites [18] 18. Cheng J, Zhao L, Zhang Y, et al. Un- derstanding the mechanisms of resis- tance to CAR T-cell therapy in malignan- cies. Front Oncol 2019; 9: 1237. sourceExperimental — accuracy not yet measured
The Tumor Factors section reports that loss of the targeted CD19 epitope enabled escape after anti-CD19 CAR T-cell therapy in relapsed B-ALL. It also reports that target-antigen-negative relapse accounts for approximately 9–25% of B-ALL relapses, but does not establish that epitope loss specifically is relatively common or more common in acute leukemia than in other malignancies. (LLM, conf=0.82)
- Not checked — no full text of the sourcecites [19] 19. Badar T, Shah NN. Chimeric antigen receptor T cell therapy for acute lympho- blastic leukemia. Curr Treat Options On- col 2020; 21: 16. source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Among patients with persistent grade 3 or 4 neutropenia (52 patients) or thrombocytopenia (62 patients) 1 month after infusion, the median time to recovery to grade 2 or lower was 1.9 months (range, 1.2 to 5.6) and 2.1 months (range, 1.2 to 13.8), respectively”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Safety
Strength:plain· not yet calibratedn = 52Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The Kaplan-Meier estimated median progression-free survival was 8.8 months overall (95% CI, 5.6 to 11.6), 12.1 months (95% CI, 8.8 to 12.3) at the 450 × 10 6 dose, and 20.2 months (95% CI, 12.3 to could not be estimated) in patients having a complete or stringent complete response”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The 128 treated patients had received a median of 6 previous antimyeloma regimens (range, 3 to 16), and 120 (94%) had received previous autologous hematopoietic stem-cell transplants (Table 1).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Patients
Strength:plain· not yet calibratedn = 128Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although high interpatient variability was observed at all doses, upper quartiles of exposure (area under the curve of the transgene level from time of dose to 28 days [AUC 0-28 days ]) were observed more frequently at the 450 × 10 6 dose (Fig. 3B).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Cellular Pharmacokinetic Profile and Immunogenicity
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Among treated patients, 5 were positive for antidrug antibodies before infusion.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Cellular Pharmacokinetic Profile and Immunogenicity
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Baseline sBCMA levels were elevated in treated patients and de-creased rapidly after infusion in patients who had a response, with nadir values achieved within 3 months (Fig. 3A and Fig. S5B and S5C).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Soluble BCMA is a serum-based universal marker of myeloma burden.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Neurotoxic effects developed in 23 patients (18%) and were of grade 3 in 4 patients (3%); no neurotoxic effects higher than grade 3 occurred.”
- Also stated in: § Table 1. (Continued.) · plain
“Investigator-identified neurotoxic effects were reported in 23 patients (18%), of whom 4 (3%) had grade 3 events; no grade 4 or 5 neu-rotoxic effects were observed”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Abstract
Strength:plain· not yet calibratedn = 128Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Table 1. (Continued.) · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The median time to first response was 1.0 month (range, 0.5 to 8.8); the median time to a complete response or better was 2.8 months (range, 1.0 to 11.8).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At doses of 150 × 10 6 , 300 × 10 6 , and 450 × 10 6 CAR+ T cells, neurotoxic effects of any grade were reported in 0 of 4 patients, 12 of 70 patients (17%), and 11 of 54 patients (20%), respectively, with grade 3 events in 0 patients, 1 patient (1%), and 3 patients (6%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Table 1. (Continued.)
Strength:plain· not yet calibratedn = 54Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Antidrug antibodies had no effect on the incidence of response or of complete response or better and had no noticeable effect on progression-free survival.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Cellular Pharmacokinetic Profile and Immunogenicity
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The absence of a detectable effect of antidrug antibodies on efficacy is not due to insufficient statistical power.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The Kaplan-Meier estimated median overall survival was 19.4 months (95% CI, 18.2 to could not be estimated), with an overall survival of 78% at 12 months (Fig. 2D).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Exposures were higher in patients who had a response than in those who did not (Fig. S5A), and higher exposure was associated with deeper response and longer progression-free survival (Fig. 3C and 3D).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Cellular Pharmacokinetic Profile and Immunogenicity
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Achievement of undetectable sBCMA levels increased with depth of response (17 of 27 pa-”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesThe quote only partly states this claim.
- Rests on an assumption: Soluble BCMA is a serum-based universal marker of myeloma burden.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At doses of 150 × 10 6 , 300 × 10 6 , and 450 × 10 6 CAR+ T cells, cytokine release syndrome of any grade was observed in 2 of 4 patients (50%), 53 of 70 patients (76%), and 52 of 54 patients (96%), respectively, with cytokine release syndrome of grade 3 or higher observed in 0 patients, 4 patients (6%), and 3 patients (6%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Table 1. (Continued.)
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The Kaplan-Meier estimate for median duration of response was 10.7 months (95% CI, 9.0 to 11.3) overall and 11.3 months (95% CI, 10.3 to 11.4) at the 450 × 10 6 dose”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cytokine release syndrome was reported in 107 patients (84%), including 7 (5%) who had events of grade 3 or higher.”
- Also stated in: § Table 1. (Continued.) · plain
“Cytokine release syndrome occurred in 107 patients (84%) and was mostly of grade 1 or 2 (Table 2 and Table S10).Five patients (4%) had grade 3 cytokine release syndrome, 1 (<1%) had grade 4, and 1 (<1%) had grade 5 (300 × 10 6 dose level).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Abstract
Strength:plain· not yet calibratedn = 128Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Table 1. (Continued.) · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Infections occurred in 88 patients (69%) and were of grade 3 or 4 in 28 (22%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Safety
Strength:plain· not yet calibratedn = 88Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“including many with a high tumor burden, high-risk cytogenetic abnormalities, and extramedullary disease.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Common toxic effects among the 128 treated patients included neutropenia in 117 patients (91%), anemia in 89 (70%), and thrombocytopenia in 81 (63%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Abstract
Strength:plain· not yet calibratedn = 128Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After disease progression, 28 patients were retreated with ide-cel (Table S4).Six patients (21%) had a second response, with durations of response ranging from 1.9 to 6.8 months; all the patients who had a response were retreated at a dose higher than their initial dose.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Most grade 3 or 4 events were hematologic toxic effects, including neutropenia in 114 patients (89%), anemia in 77 (60%), and thrombocytopenia in 67 (52%), and were at least partially related to the lymphodepleting chemotherapy administered before ide-cel infusion.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Safety
Strength:plain· not yet calibratedn = 114Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“A total of 44 treated patients (34%) died during the study, with most deaths (27) attributed by the investigator to complications of myeloma progression (Table S12).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Table 1. (Continued.)
Strength:plain· not yet calibratedn = 44Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Levels of proinflammatory markers, including cytokines, ferritin, and C-reactive protein, increased early after ide-cel infusion and decreased by month 1”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Biomarkers
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The response duration increased with the depth of response; the median response duration was 4.5 months (95% CI, 2.9 to 6.7), 10.4 months (95% CI, 5.1 to 11.3), and 19.0 months (95% CI, 11.3 to could not be estimated) in patients having a best response of partial response (27 patients), very good partial response (25 patients), and complete or stringent complete response (42 patients),”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“At the target doses of 150 × 10 6 , 300 × 10 6 , and 450 × 10 6 CAR+ T cells, a response was observed in 2 of 4 patients (50%), in 48 of 70 patients (69%), and in 44 of 54 patients (81%), respectively, and a complete response or better was observed in 1 of 4 patients (25%), in 20 of 70 patients (29%), and in 21 of 54 patients (39%).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Efficacy
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Five patients (4%) died after 6 months from unrelated adverse events, and an additional 8 patients (6%) died after disease progression.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Table 1. (Continued.)
Strength:plain· not yet calibratedn = 5Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Minimal residual disease (MRD)-negative status (<10 -5 nucleated cells) was confirmed in 33 patients, representing 26% of all 128 patients who were treated and 79% of the 42 patients who had a complete response or better.”
- Also stated in: § Efficacy · plain
“Of the 42 patients with a complete or stringent complete response, 33 (79%) also had MRDnegative status at a sensitivity level of 10 -5 , corresponding to 26% (95% CI, 19 to 34) of the treated population; the remaining 9 patients (21%) could not be evaluated for MRD”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Abstract
Strength:plain· not yet calibratedn = 33Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Also stated in: § Efficacy · plain
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“High-grade hematologic toxic effects were common but transient.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The fact that MRDnegative responses occurred in approximately a quarter of the patients highlights the depth of response induced by ide-cel.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: MRD negativity at a sensitivity of 10^-5 is a valid measure of depth of response and clinical benefit.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The study protocol was approved by local or independent institutional review boards or ethics committees at participating sites.All the patients provided written informed consent.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Study Oversight
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Nearly all tumors expressed BCMA, a finding that supports the use of ide-cel in relapsed and refractory myeloma without restriction based on tumor BCMA expression.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: BCMA expression is required for ide-cel efficacy, so lack of tumor BCMA expression would limit its use.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The primary efficacy analysis was performed in the population of patients treated with ide-cel (128 patients).”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Statistical Analysis
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Between December 13, 2017, and November 13, 2018, a total of 140 patients were enrolled and underwent leukapheresis, of whom 128 received ide-cel infusions.Twelve patients discontinued the study before ide-cel infusion (including 1 patient who discontinued after unsuccessful manufacture of the CAR T-cell product)”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Patients
Strength:plain· not yet calibratedn = 140Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The study was designed by the authors in conjunction with the sponsors and conducted in accordance with the International Council for Harmonisation guidelines for Good Clinical Practice and the principles of the Declaration of Helsinki.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Study Oversight
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The sample size for the primary end point (overall response) was based on a onesample binomial test with normal approximation, under the assumption of 15% dropout between the time of enrollment and ide-cel treatment.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Statistical Analysis
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Statistical tests were not performed on subgroup analyses.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Statistical Analysis
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The primary end point was an overall response (partial response or better), defined according to IMWG Uniform Response Criteria for Multiple Myeloma 12 as assessed by an independent review committee.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > End Points and Assessments
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“MRD negativity was evaluated in bone marrow aspirates by next-generation sequencing (clonoSEQ, Adaptive Biotechnologies) with a minimum cutoff of 10 -5 nucleated cells.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > End Points and Assessments
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The actual doses delivered were within 20% of the target doses.”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > Study Design and Patients
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Adverse events were graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE), version 4.03.Cytokine release syndrome was graded according to published criteria (Table S2).14”
§ Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma > End Points and Assessments
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
The paper relies on this without support.
Soluble BCMA is a serum-based universal marker of myeloma burden.
“Soluble BCMA was assessed as a serum-based universal marker of myeloma burden.”
The paper relies on this without support.
Cross-trial comparisons of progression-free survival between the KarMMa study and trials of selinexor plus dexamethasone or belantamab mafodotin are valid.
“These efficacy results compare favorably with results in similarly heavily pretreated patients with relapsed or refractory myeloma treated with two recently approved regimens, selinexor plus dexamethasone and belantamab mafodotin (median progression-free survival, 3.7 months and 2.9 months, respectively).5,17”
The paper relies on this without support.
MRD negativity at a sensitivity of 10^-5 is a valid measure of depth of response and clinical benefit.
“The fact that MRDnegative responses occurred in approximately a quarter of the patients highlights the depth of response induced by ide-cel.”
The paper relies on this without support.
BCMA expression is required for ide-cel efficacy, so lack of tumor BCMA expression would limit its use.
“Nearly all tumors expressed BCMA, a finding that supports the use of ide-cel in relapsed and refractory myeloma without restriction based on tumor BCMA expression.”
The paper relies on this without support.
The absence of a detectable effect of antidrug antibodies on efficacy is not due to insufficient statistical power.
“Antidrug antibodies had no effect on the incidence of response or of complete response or better and had no noticeable effect on progression-free survival.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel) are newly approved CAR-T products targeting BCMA that are active in relapsed refractory myeloma.89,90”
From Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management (2024) · cites this paper as [89]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Safety of ide-cel remained consistent with the IA, with no parkinsonism, Guillain-Barré syndrome, or SPMs of T-cell origin reported. 13”
From Ide-cel vs standard regimens in triple-class-exposed relapsed and refractory multiple myeloma: updated KarMMa-3 analyses. (2024) · cites this paper as [18]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Common side effects such as CRS and immune effector cell-associated neurotoxicity syndrome (ICANS) were mostly low grade, indicating manageable toxicity.”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [243]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The median duration of response (mDOR) was 11 months in patients achieving CR and 19 months in those achieving stringent complete response (sCR).”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [243]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A number of BCMA-directed therapies, including belantamab mafodotin, idecabtagene vicleucel (ide-cel), ciltacabtagene autoleucel (cilta-cel) and teclistamab, have shown efficacy in clinical trials and are approved for the treatment of relapsed or refractory multiple myeloma4–9.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Median DOR and PFS were 10.7 months and 8.8 months, respectively, for ide-cel, and were both not reached for cilta-cel5,6.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Although follow-up is still ongoing, among patients with ≥CR, DOR and PFS at 15 months with elranatamab were comparable to those observed with other BCMA-targeted T-cell-redirecting therapies, suggesting similar outcomes once a deep response is achieved5,24,25.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“High response rates have been reported with the BCMA chimeric antigen receptor (CAR) T-cell therapies, ide-cel and cilta-cel, with responses reported in 73% and 97% of treated patients, respectively.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In comparison to other BCMA-targeted T-cell-redirecting therapies, the rate of hematologic AEs with elranatamab was similar or lower after a similar follow-up4–6.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“CAR-T therapy requires that patients have access to specialized care centers and can wait the minimum 4-week period for production, which can result in attrition rates of approximately 10 to 15%,6-8”
From Teclistamab in Relapsed or Refractory Multiple Myeloma (2022) · cites this paper as [6]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Among 128 patients with relapsed refractory myeloma treated on a phase II trial, ide-cel was associated with a response rate of 73%.89 Thirty three percent of patients had a complete response or better. The median PFS was 8.8 months.”
From Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management (2024) · cites this paper as [89]
The cited source says what the claim attributes to it.
In the citing paper
“Cytokine release syndrome was seen in 84%, and 5% were grade 3 or higher. Neurotoxicity was seen in 18%, and was grade 3 in 3%.”
From Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management (2024) · cites this paper as [89]
The cited source says what the claim attributes to it.
In the citing paper
“Chimeric antigen receptor (CAR) T-cell therapy has shown promising ef fi cacy in patients with TCE R/RMM. 13-21”
From Ide-cel vs standard regimens in triple-class-exposed relapsed and refractory multiple myeloma: updated KarMMa-3 analyses. (2024) · cites this paper as [18]
The cited source says what the claim attributes to it.
In the citing paper
“In the KarMMa study involving 128 patients with RRMM, the overall response rate (ORR) to a single infusion of Abecma was 73%, with a complete response (CR) rate of 33%.”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [243]
The cited source says what the claim attributes to it.
In the citing paper
“Abecma has demonstrated the ability to induce rapid, deep, and long-lasting remissions with just one infusion, providing a new and effective personalized therapy option for MM patients [227, 243, 258, 259].”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [243]
The cited source says what the claim attributes to it.
In the citing paper
“In contrast, higher-grade cytokine release syndrome and neurotoxic events have been described after CAR-T administration in patients with multiple myeloma.6,8”
From Teclistamab in Relapsed or Refractory Multiple Myeloma (2022) · cites this paper as [6]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Similarly, patients with advanced disease stage (R-ISS stage III) have consistently shown poorer outcomes irrespective of the therapy received4–6,19–22.”
From Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredIn the citing paper
“Recently approved therapies such as selinexor, 9 belantamab mafodotin, 10 idecabtagene vicleucel, 11 and ciltacabtagene autoleucel 12 have had clinical benefit in patients with relapsed or refractory multiple myeloma.”
From Talquetamab, a T-Cell–Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma (2022) · cites this paper as [11]
Citations
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CAR T-cell therapy in hematologic malignancies: a voyage in progress.
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Understanding the mechanisms of resistance to CAR T-cell therapy in malignancies.
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Items 1,301–1,400 of 2,535
Nakamura, N., Jo, T., Arai, Y., et al. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01373-5 · Cited by 6
Gonzalez, N. S., Marchese, P. V., Baraibar, I., Ros, J., Salvà, F., Rodrı́guez, M., Salvà, C., Vaghi, C., Alcaráz, A., García, A., et al. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2349287 · Cited by 6
“Initially, BsAbs involving T cells showed excellent results in several hematologic malignancies, such as by targeting CD19 in acute lymphoblastic leukemia [96], CD20 in B-cell non-Hodgkin lymphoma [97], and BCMA and GPRC5D in multiple myeloma [98].”
BackgroundPenack, O., Peczynski, C., Boreland, W., Wolff, D., Moiseev, I., Schoemans, H. M., Koenecke, C., Graham, C., & Perić, Z. (2024) · Haematologica · doi:10.3324/haematol.2023.284810 · Cited by 7
Novel treatment strategies for hematological malignancies in the immunotherapy era
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“As a result, two CAR T-cell therapies (idecabtagene vicleucel [ide-cel] and ciltacabtagene autoleucel [cilta-cel]) targeting the B-cell maturation antigen (BCMA) have been introduced and have shown robust clinical responses in relapsed/refractory disease [4, 5].”
A Review of CAR-T Combination Therapies for Treatment of Gynecological Cancers
Olifirenko, V., & Barlev, N. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126595 · Cited by 8
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“26,27 A simplified comparison of these three methods is shown in Figure S2.”
Shaver, J., Horton, D., & Halford, Z. (2024) · Annals of Pharmacotherapy · doi:10.1177/10600280241271192 · Cited by 6
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“Previously, various trials studying CD19-directed CAR-T cellular kinetics in patients with B-cell acute lymphoblastic leukemia and large B-cell lymphoma also observed that treatment with tocilizumab and/or corticosteroids were associated with higher C MAX [25, 28, 29, 32–34, 40, 41].”
Qureshi, Z. A., Jamil, A. R., Altaf, F., Siddique, R., & Ahmed, F. (2024) · Annals of Hematology · doi:10.1007/s00277-024-06078-z · Cited by 6
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Impact of TP53 mutations on the efficacy of CAR-T cell therapy in cancer
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Esquinas, E., Moreno-Sanz, A., Sandá, V., Stodulski, D., Borregón, J., Peña-Blanque, V., Fernández-Calles, J., Fernández‐Fuentes, N., Serrano‐López, J., Juan, M., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009485 · Cited by 7
Basic Concepts and Indications of CAR T Cells
van den Berg, J., Laubli, H. P., Khanna, N., Jeker, L. T., & Holbro, A. (2025) · Hämostaseologie · doi:10.1055/a-2491-3652 · Cited by 7
“6,38,61 Mechanisms involved includebut are not limited to tumor-intrinsic mechanisms such as antigen loss (e.g., CD19 antigen-negative escape), an immunosuppressive tumor microenvironment, and CAR T cell dysfunction including exhaustion.”
Goel, U., Zanwar, S., Cowan, A. J., Banerjee, R., Khouri, J., & Dima, D. (2025) · Cancer Management and Research · doi:10.2147/cmar.s510408 · Cited by 5
“7,8,10 These therapeutic indications were expanded in 2024, based on updated results from KarMMa-3 and CARTITUDE-4 trials.”
Wang, Y., Jiang, J., Shang, K., Xu, X., & Sun, J. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.02.028 · Cited by 6
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“…CAR-T cell), YESCARTA (axicabtagene ciloleucel, a CD19 CAR-T cell), TECARTUS (brexucabtagene autoleucel, a CD19 CAR-T cell), BREYANZI (lisocabtagene maraleucel, a CD19 CAR-T cell), ABECMA (idecabtagene vicleucel, a BCMA CAR-T cell) and CARVYKTI (ciltacabtagene autoleucel, a BCMA CAR-T cell) (7, 8).”
Kikuchi, T., Watanabe, M., Tsukada, N., Matsumoto, C., Nomura‐Yogo, M., Kunisada, K., Sawada, H., Sato, K., Takei, T., Ogura, M., et al. (2025) · Transplant Infectious Disease · doi:10.1111/tid.70040 · Cited by 6
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“These cytopenias are universally seen in patients with multiple myeloma undergoing CAR T cell therapy [4] and appear to be more pronounced due to a host of factors including heavily pretreated disease, use of prior alkylating agents (Cy, bendamustine, high-dose melphalan), prior autologous or allogeneic stem cell tran…”
BackgroundAdvances and Personalized Approaches in the Frontline Treatment of T-Cell Lymphomas
Angelos, M. G., Ballard, H. J., & Barta, S. K. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020267 · Cited by 6
“CAR-T therapy has since been expanded into treatment of other classes of hematological neoplasms, such as multiple myeloma, and has further been integrated as a standard of care option for chemotherapy-refractory patients [85].”
BackgroundOrmhøj, M., Abken, H., & Hadrup, S. R. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03163-y · Cited by 9
“Presence of humoral immunity against the CAR does not seem to correlate with notable effect on CAR T-cell efficacy but have been attributed to development of anaphylaxis in one patient receiving several doses of CAR T-cells [24, 70].”
BackgroundCurrent Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma
Claveau, J., Buadi, F. K., & Kumar, S. K. (2022) · Oncology and Therapy · doi:10.1007/s40487-022-00195-3 · Cited by 6
“More than 84% of the patients developed a cytokine release syndrome (CRS), mostly grade 1 or 2 [43].”
BackgroundSelinexor therapy for multiple myeloma and non-Hodgkin lymphomas
Goldsmith, S. R., Liu, L., & Shiah, K. (2022) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000866 · Cited by 6
Bispecific Antibodies for the Treatment of Multiple Myeloma
Goldsmith, S. R., Streeter, S., & Covut, F. (2022) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-022-00675-3 · Cited by 6
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BTK Inhibitors and Other Targeted Therapies in Waldenström Macroglobulinemia
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Intent Matters: Real-World Applicability of Idecabtagene Vicleucel Usage in the United States
Chakraborty, R., & Hadidi, S. A. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.23.00226 · Cited by 6
THE ROLE OF CAR T-CELL THERAPY IN THE ERA OF BISPECIFIC ANTIBODIES
Nath, K. D., Mailankody, S., & Usmani, S. Z. (2023) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2023.05.011 · Cited by 8
Noninfectious causes of fever in hematologic malignancies. Are antibiotics still indicated?
Shahid, Z., & Epstein, D. J. (2023) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000940 · Cited by 6
“BELINDA [6] N1⁄4162 KarMMa [10] N1⁄4128 CARTITUDE-2 [7] N1⁄420”
Țigu, A. B., Constantinescu, C. S., Teodorescu, P., Kegyes, D., Munteanu, R. A., Feder, R., Peters, M., Pralea, I.-E., Iuga, C. A., Cenariu, D., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17810 · Cited by 5
Wang, Y.-H., Zhang, K., Suo, X., et al. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14554 · Cited by 6
“1 Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor-modi fi ed T (CAR-T)-based cell therapy, which eliminates malignant plasma cells expressing BCMA ligand, has been developed as an innovative therapy for MM. 2 We conducted an investigator-initiated trial using humanized anti-BCMA CAR-T cells (produced in…”
BackgroundInfluentialLiao, Y., Hsu, S., & Chiou, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042416 · Cited by 7
Liu, R., Yang, R., Xu, X.-Z., Zhao, W.-H., Wang, F.-X., Zhang, W.-G., Lei, B., Yang, R.-Y., Wang, Y., He, A.-L., et al. (2024) · British Journal of Haematology · doi:10.1111/bjh.19340 · Cited by 9
“16 In addition, Chen et al. reported on 10 patients with PD after murine BCMA CAR-T therapy who received a second CAR-T, including a CD19-BCMA dual-targeting CAR-T and a human BCMA CAR-T; ORR was 20%, with both responses CR after the human BCMA CAR-T.”
BackgroundInfluentialTargeting GPRC5D in multiple myeloma
Elemian, S., & al Hadidi, S. (2024) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2024.2343114 · Cited by 7
“Specifically, Ide-cel gained approval based on results from the phase II KARMMA-1 trial, while Cilta-cel’s approval was supported by findings from the CARTITUDE-1 study [18,19].”
BackgroundFinding the Optimal Partner to Pair with Bispecific Antibody Therapy for Multiple Myeloma
Louvet, C., Nadeem, O., & Smith, E. L. (2021) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0073 · Cited by 6
Disease heterogeneity, prognostication and the role of targeted therapy in multiple myeloma
Zanwar, S., & Kumar, S. K. (2021) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2021.1957875 · Cited by 6
“In the subset of MM with high-risk cytogenetics (45/128), the ORR was close to 70% even in this refractory disease population [87].”
BackgroundGene therapy. The legacy of Wacław Szybalski
Dulak, J. (2021) · Acta Biochimica Polonica · doi:10.18388/abp.2020_5805 · Cited by 7
Ojo, A. S., Araoye, M. O., Ali, A. S., & Sarma, R. (2023) · Journal of Cancer Survivorship · doi:10.1007/s11764-023-01332-1 · Cited by 6
Aiming for the cure in myeloma: Putting our best foot forward
Bar, N., Firestone, R., & Usmani, S. Z. (2023) · Blood Reviews · doi:10.1016/j.blre.2023.101116 · Cited by 6
SOHO State of the Art Updates and Next Questions: Will CAR-T Replace ASCT in NDMM
Jurgens, E. M., & Usmani, S. Z. (2024) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2024.01.001 · Cited by 6
Coopting T cell proximal signaling molecules enables Boolean logic-gated CAR T cell controlPreprint
Tousley, A. M., Rotiroti, M. C., Labanieh, L., Rysavy, L. W., Rietberg, S. P., de la Serna, E. L., Dalton, G. N., Klysz, D. D., Weber, E. W., Kim, W., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.17.496457 · Cited by 6
Singh, R., Jones, R. J., Shirazi, F., Li, Q., Zou, J., Hong, S., Wang, H., Lee, H. C., Patel, K. K., Wan, J., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3843028/v1 · Cited by 6
“…example, lower response rates were noted among high-risk patients in the pivotal trials of the ADC belantamab mafodotin (8), the bispeci�c teclistamab (9), and the CAR T-cell product idecabtagene vicleucel (10), which were the �rst drugs in each mechanistic category to achieve regulatory approvals.”
BackgroundRediscovering hemostasis abnormalities in multiple myeloma: The new era
Huang, Y., Wang, C., Wang, H., Liu, H., & Zhou, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34111 · Cited by 6
“Thrombocytopenia is one of the common toxic effects of CAR-T therapy [68,69].”
BackgroundLicense for a CAR T: Examining patient eligibility
Akkad, N., & Chihara, D. (2024) · Seminars in Hematology · doi:10.1053/j.seminhematol.2024.07.001 · Cited by 5
Trando, A., Ghamsari, F., Yeung, P., Costello, C. L., Saunders, I. M., & Jeong, A. (2024) · Biomedicines · doi:10.3390/biomedicines13010036 · Cited by 5
Costa, B. A., Dima, D., Mark, T. M., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14041316 · Cited by 5
“Based on results of the KarMMa and CARTITUDE trials [1,2], two commercial products are currently approved for routine use in patients with both early and later lines of treatment: idecabtagene vicleucel (ide-cel) and ciltacabtagene autoleucel (cilta-cel).”
Dykes, K. C., & Ball, E. D. (2025) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2025.2479014 · Cited by 5
Alsina, M., Dhakal, B., Pantin, J. M., et al. (2025) · Future Oncology · doi:10.1080/14796694.2025.2476382 · Cited by 5
“The relatively delayed time to onset of CRS and ICANS with cilta-cel compared to other therapies, such as idecabtagene vicleucel, supports this approach [15,18–20].”
Mol, I., Hu, Y., LeBlanc, T. W., Cappelleri, J. C., Chu, H., Nador, G., Aydin, D., Perez-Cruz, I., & Hlavacek, P. R. (2025) · Journal of Comparative Effectiveness Research · doi:10.57264/cer-2024-0236 · Cited by 5
“In recent years, novel treatment options have demonstrated promising efficacy for the treatment of patients with TCE / R MM in clinical trials, including chimeric antigen receptor T-cell therapies, as well as GPRC5D-targeted therapies [2–4] .”
Long, A. H., Aftandilian, C. C., Barmettler, S., & Alexander, S. W. (2025) · Pediatric Blood & Cancer · doi:10.1002/pbc.31779 · Cited by 7
Sadegh, R. K., Saleki, K., & Rezaei, N. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114837 · Cited by 5
Malignancies after Chimeric Antigen Receptor T Cell Therapy
Mohty, R., Halwani, A., Badar, T., Alkhateeb, H. B., Shah, M. V., Qin, H., & Kharfan‐Dabaja, M. A. (2025) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2025.06.001 · Cited by 6
Saha, T., Saha, R. P., Singh, M. K., Priya, K., Singh, S., Rajeev, M., Bhattacharya, D., Nag, M., & Lahiri, D. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10674-1 · Cited by 5
Beyond safety: suicide systems in cell-based cancer therapies
Chen, K., & Shah, K. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.06.003 · Cited by 5
Wu, F., Zheng, X., Burnett, J., et al. (2025) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.70075 · Cited by 5
Ng, S., Flaherty, P. W., Ancheta, M., Tindbaek, K., Sekhon, M. K., Huang, J. J., Portuguese, A. J., Albittar, A. A., Kopmar, N. E., Cowan, A. J., et al. (2025) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2025.07.022 · Cited by 5
Redefining multiple myeloma treatment: Advances, challenges, and future directions in immunotherapy
Fu, C., Zhai, Y., Yan, L., Jin, S. L., Shang, J., Shi, X., & Wu, D. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003655 · Cited by 8
“Studies like KarMMa [41] and CARTITUDE-1 [80] have provided strong evidence that CAR-T therapies can induce sustained MRD negativity even in heavily pretreated or high-risk genetic populations.”
Khan, M. A., Khan, F. H., Khan, A., et al. (2025) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2025.08.014 · Cited by 5
The role of stem cell transplantation in the modern management of multiple myeloma
Villar, S., Zapata, E., & Rifón, J. (2025) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000896 · Cited by 4
Pleitez, H. J. G., Saowapa, S., Maldonado, A., Kanitthamniyom, C., Bernal, D. A. O., & Tijani, L. (2025) · European Journal Of Haematology · doi:10.1111/ejh.70025 · Cited by 6
Chen, Z., Luo, W., Kang, Y. J., et al. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104969 · Cited by 5
Abuhelwa, Z., Amisha, F., Fan, W., Avila, G. D., Hansen, D. K., Grajales-Cruz, A., Blue, B. J., Castaneda, O., Liu, H. D., Freeman, C. L., et al. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1663814 · Cited by 6
Lin, P. Y., Acharya, S., Reyes-Silva, F., Başar, R., Uprety, N., Rueda, L. Y. M., Lin, P., Gilbert, A. L., Banerjee, P. P., Fang, D., et al. (2025) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-25-0130 · Cited by 7
Einsele, H., Moreau, P., Bahlis, N. J., Bhutani, M., Vincent, L., Karlin, L., Perrot, A., Goldschmidt, H., van de Donk, N. W. C. J., Ocio, E. M., et al. (2025) · Advances in Therapy · doi:10.1007/s12325-025-03409-y · Cited by 5
Self-citationDemystifying the diagnosis and management of ICUS, CHIP, and CCUS
Xie, Z., Lee, D. H., Hansen, D. K., & Loghavi, S. (2025) · Hematology · doi:10.1182/hematology.2025000766 · Cited by 6
Zhai, G., Bar, M., Cowan, A. J., Rubinstein, S. M., Shi, Q., Zhang, N., Xie, E., & Ma, W. (2025) · Frontiers in Artificial Intelligence · doi:10.3389/frai.2025.1683322 · Cited by 9
“…myeloma now have access to several approved therapeutic options - such as CAR-T cells, bispecific antibodies, and novel agent combination regimens (Munshi et al., 2021; Parrondo et al., 2024; Sheykhhasan et al., 2024) - which have led to significant improvements in outcomes (Turesson et al.,…”
Irfan, S., Ayoobkhan, F. S., Vojjala, N., Qureshi, R., Rahman, R. L., Kamboj, I., Abdallah, A.-O. A., McGuirk, J. P., Mahmoudjafari, Z., Lutfi, F. U., et al. (2025) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2025.12.947 · Cited by 6
CAR-T in resource-limited regions
Clé, D. V., Donadel, C. D., & Calado, R. T. (2025) · Blood Global Hematology · doi:10.1016/j.bglo.2025.100051 · Cited by 9
Dong, J., Nikolenko, D. A., Boymuradov, S., Garifulina, L., & Khodabandehloo, E. (2026) · Clinical & Translational Oncology · doi:10.1007/s12094-025-04185-5 · Cited by 6
Engineering Immunity: Current Progress and Future Directions of CAR-T Cell Therapy
Sioud, M., & Casey, N. P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020909 · Cited by 9
Maheswaran, S., Gordon, C., Chen, E. C., & Patel, S. A. (2026) · European Journal Of Haematology · doi:10.1111/ejh.70120 · Cited by 5
Jordana-Urriza, L., Serrano, G., Camara-Peña, S., Calleja-Cervantes, M. E., Martín‐Úriz, P. S., Zabaleta, A., Oliver‐Caldés, A., Español‐Rego, M., Alignani, D., Lozano, T., et al. (2026) · Blood Neoplasia · doi:10.1016/j.bneo.2026.100203 · Cited by 6
Cryopreservation and Storage Patterns of Hematopoietic Progenitor Stem Cells for Multiple Myeloma
Benjamin, C. L., Desai, S., Pereira, D. L., Beitinjaneh, A., Jiménez, A., Goodman, M. S., Lekakis, L. J., Spiegel, J. Y., Komanduri, K. V., & Wang, T. P. (2023) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2023.103731 · Cited by 5
Lee, J. H., Choi, J., Min, C., Park, S., Jo, J., Lee, Y. J., Kim, J. S., Eom, H., Jung, J., Moon, J. H., et al. (2024) · Haematologica · doi:10.3324/haematol.2024.285534 · Cited by 6
Zhou, S., Yang, Y., Jing, Y., & Zhu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1435635 · Cited by 5
Measurable Residual Disease Testing in Multiple Myeloma Following T-Cell Redirecting Therapies
Shim, K. G., & Fonseca, R. (2024) · Cancers · doi:10.3390/cancers16193288 · Cited by 6
“All 33 patients evaluable for MRD were found to be MRD-negative [53].”
BackgroundTranscriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumours
Srinivasan, S., Armitage, J. D., Nilsson, J. A., & Waithman, J. C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1412731 · Cited by 5
Are we there yet? CAR ‐T therapy in multiple myeloma
Mirvis, E., & Benjamin, R. (2024) · British Journal of Haematology · doi:10.1111/bjh.19896 · Cited by 8
“19 In one of the cases, homozygous deletion of TNFRSF17 (BCMA) on chromosome 16 was subsequently confirmed.”
The characteristics of patients with multiple myeloma surviving over 10 years
Huang, B., Zhang, H., Liu, J., Gu, J., Chen, M.-L., Kuang, L., Li, X., & Li, J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1490630 · Cited by 5
Radiation for Multiple Myeloma in the Era of Novel Agents: Indications, Safety, and Dose Selection
Zhang, S. C., & Ballas, L. (2024) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2024.10.004 · Cited by 6
Ram, M., Fraser, M., Santos, J. V. D., Tasakis, R. N., Islam, A., Abo-Donia, J. U., Parekh, S. S., & Laganà, A. (2024) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s350238 · Cited by 8
Li, M., Zheng, R., Liu, Z., Zhang, P., Zhu, T., Xin, X., Zhao, H., Chen, W.-Y., Zheng, B., Zhao, A., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1502936 · Cited by 5
Cardle, I. I., Scherer, D. R., Jensen, M. C., Pun, S. H., & Sellers, D. L. (2025) · ACS Nano · doi:10.1021/acsnano.4c16824 · Cited by 5
Extramedullary myeloma in the era of CAR T-cell and bispecific antibody therapies.
Sanchez, L. J., & Richard, S. (2025) · Seminars in hematology (Print) · doi:10.1053/j.seminhematol.2025.02.001 · Cited by 6
Pan, D., Mouhieddine, T. H., Sheng, T.-X., Fu, W.-J., Moshier, E., Richter, J., Parekh, S., Jagannath, S., Rossi, A. C., Sanchez, L. J., et al. (2025) · Bone Marrow Transplantation · doi:10.1038/s41409-025-02593-3 · Cited by 8
Anagnostopoulos, I., Lakić, T., Balagué, O., van den Brand, M., Dirnhofer, S., Gašljević, G., Laurent, C., Ponzoni, M., Quintanilla‐Martínez, L., Sander, B., et al. (2025) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-025-04197-0 · Cited by 6
Keyer, V. V., Kydyrbayeva, A., Kulatay, T., Zauatbayeva, G., Bazhenov, D. O., Ingirbay, B., Shakhmanova, Z., Zhumabekova, M., Ospanova, M. E., & Shustov, A. V. (2025) · Biomolecules · doi:10.3390/biom15081166 · Cited by 5
“CAR-T therapy has gained regulatory approval for treating hematologic malignancies, including B-cell leukemias, lymphomas, and multiple myeloma, showcasing unprecedented clinical efficacy in relapsed or refractory (r/r) cases where conventional therapies fail [4,5].”
Zhu, L., Nawaz, M. A., Zuo, Y., & Zeng, P. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104913 · Cited by 5
Hoda, D., Richards, R., Faber, E. A., et al. (2022) · Future Oncology · doi:10.2217/fon-2022-0162 · Cited by 5
Krohn, S., Boje, A. S., Gehlert, C. L., Lutz, S., Darzentas, N., Knecht, H., Herrmann, D., Brüggemann, M., Scheidig, A. J., Weisel, K. C., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.908093 · Cited by 5
“Antibodies like #55, which was together with the CD38 binding antibody #5 the most frequent antibody (≥10%) after two rounds of panning, may target low expressed antigens on myeloma cells, which can be – comparable to BCMA – suitable targets for highly potent immunotherapeutic approaches (4, 5).”
BackgroundSelf-citationCAR T Cells Contend with Myeloma in the Bone Marrow Microenvironment
Graham, C., & Maus, M. V. (2022) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-22-0126 · Cited by 4
Understanding the Etiology of Pancytopenias in the CAR T-Cell Therapy Setting
Yassine, F., Murthy, H. S., Ghabashi, E., Kharfan‐Dabaja, M. A., & Iqbal, M. (2022) · Hematology/Oncology and Stem Cell Therapy · doi:10.56875/2589-0646.1047 · Cited by 5
“MM KarMMA [8] Ide-cel 128 Anemia 89 (70%) 77 (60%) All-grade: 88 (69%)”
Taking a step forward in CAR T-cell therapy for acute myeloid leukaemia and myelodysplastic syndrome
Chua, C. C., & Cheok, K. P. L. (2023) · The Lancet Haematology · doi:10.1016/s2352-3026(23)00002-9 · Cited by 5
Pomalidomide combinations are a safe and effective option after daratumumab failure
Brioli, A., Gengenbach, L., Mancuso, K., Binder, M., Ernst, T., Heidel, F. H., Stauch, T., Zamagni, E., Hilgendorf, I., Hochhaus, A., et al. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04637-x · Cited by 5
Determinants of response and resistance to T cell-engaging therapies in multiple myeloma
Midha, S., & Anderson, K. C. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00775-w · Cited by 5
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Evidence-based mechanisms of synergy with IMiD agent-based combinations in multiple myeloma
Neri, P. E., & Nijhof, I. S. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104041 · Cited by 7
Recomendações do Grupo Português do Mieloma Múltiplo para Tratamento do Mieloma Múltiplo
Joao, C. M., Bergantim, R., Santos, J., Afonso, C., Bernardo, P. A. V. D. C., Coelho, H. G. B., Costa, C. M. A., Esteves, G. V., de Freitas, J. G., Gerivaz, R., et al. (2023) · Acta Médica Portuguesa · doi:10.20344/amp.19037 · Cited by 6
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Self-citation
Metadata
- Authors
- Munshi, N. C., Anderson, L. D., Shah, N., Madduri, D., Berdeja, J., Lonial, S., Raje, N., Lin, Y., Siegel, D., Oriol, A., Moreau, P., Yakoub-Agha, I., Delforge, M., Cavo, M., Einsele, H., Goldschmidt, H., Weisel, K., Rambaldi, A., Reece, D., Petrocca, F., Massaro, M., Connarn, J. N., Kaiser, S., Patel, P., Huang, L., Campbell, T. B., Hege, K., & San-Miguel, J.
- Affiliations
- Harvard University (US)
- Mayo Clinic (US)
- Hackensack University Medical Center (US)
- From the Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute (N.C.M.), the Veterans Affairs Boston Healthcare System, Harvard Medical School (N.C.M.), and Massachusetts General Hospital (N.R.), Boston, and bluebird bio, Cambridge (F.P., M.M.) — all in Massachusetts; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas (L.D.A.); the University of California, San Francisco, San Francisco (N.S.); Icahn School of Medicine at Mount Sinai, New York ...
- ORCID
- Munshi, Nikhil C.
- Anderson, Larry D.
- Shah, Nina
- Madduri, Deepu
- Berdeja, Jesús
- Lonial, Sagar
- Raje, Noopur
- Lin, Yi
- Siegel, David
- Oriol, Albert
- Moreau, Philippe
- Yakoub-Agha, Ibrahim
- Delforge, Michel
- Einsele, Hermann
- Goldschmidt, Hartmut
- Weisel, Katja
- Rambaldi, Alessandro
- Reece, Donna
- Petrocca, Fabio
- Connarn, Jamie N.
- Kaiser, Shari
- Patel, Payal
- Huang, Liping
- Campbell, Timothy B.
- Hege, Kristen
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-02-25
- Volume
- 384
- Issue
- 8
- Pages
- 705-716
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3133229959
- Semantic Scholar
- fd96e2f87dff7d1153a17b78b56fbbab69cb714e
- Cited by
- 2,560
- References
- 17
- Citations by year
- 2026: 411 · 2025: 486 · 2024: 540 · 2023: 493 · 2022: 436 · 2021: 186
- FWCI
- 150.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
- Lirias (KU Leuven) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Keywords
- idecabtagene vicleucel, CAR T-cell therapy, relapsed/refractory multiple myeloma, BCMA, minimal residual disease, cytokine release syndrome, neurotoxicity, CAR T cell persistence, progression-free survival, complete response, neutropenia, anemia, thrombocytopenia, chimeric antigen receptor T cells
- MeSH terms
- Receptors, Chimeric Antigen, Progression-Free Survival, Cytokine Release Syndrome, Adult, Aged, Female, Hematologic Diseases, Humans, Male, Middle Aged, Multiple Myeloma, Recurrence, Biomarkers, Immunotherapy, Adoptive, Drug Resistance, Neoplasm
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