Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 732

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

Open access
Whitlock, Richard P., Belley-Cote, Emilie P., Paparella, Domenico, Healey, Jeff S., Brady, Katheryn, Sharma, Mukul, Reents, Wilko, Budera, Petr, Baddour, Andony J., Fila, Petr, Devereaux, P.J., Bogachev-Prokophiev, Alexander, Boening, Andreas, Teoh, Kevin H.T., Tagarakis, Georgios I., Slaughter, Mark S., Royse, Alistair G., McGuinness, Shay, Alings, Marco, Punjabi, Prakash P., Mazer, C. David, Folkeringa, Richard J., Colli, Andrea, Avezum, Álvaro, Nakamya, Juliet, Balasubramanian, Kumar, Vincent, Jessica, Voisine, Pierre, Lamy, Andre, Yusuf, Salim, Connolly, Stuart J.·2021·New England Journal of Medicine
DOI 10.1056/nejmoa2101897
Open this paper in CoChat — free account

Abstract

BACKGROUND: Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedure can be performed during cardiac surgery undertaken for other reasons. METHODS: -VASc score of at least 2 (on a scale from 0 to 9, with higher scores indicating greater risk of stroke) who were scheduled to undergo cardiac surgery for another indication. The participants were randomly assigned to undergo or not undergo occlusion of the left atrial appendage during surgery; all the participants were expected to receive usual care, including oral anticoagulation, during follow-up. The primary outcome was the occurrence of ischemic stroke (including transient ischemic attack with positive neuroimaging) or systemic embolism. The participants, research personnel, and primary care physicians (other than the surgeons) were unaware of the trial-group assignments. RESULTS: -VASc score of 4.2. The participants were followed for a mean of 3.8 years. A total of 92.1% of the participants received the assigned procedure, and at 3 years, 76.8% of the participants continued to receive oral anticoagulation. Stroke or systemic embolism occurred in 114 participants (4.8%) in the occlusion group and in 168 (7.0%) in the no-occlusion group (hazard ratio, 0.67; 95% confidence interval, 0.53 to 0.85; P = 0.001). The incidence of perioperative bleeding, heart failure, or death did not differ significantly between the trial groups. CONCLUSIONS: Among participants with atrial fibrillation who had undergone cardiac surgery, most of whom continued to receive ongoing antithrombotic therapy, the risk of ischemic stroke or systemic embolism was lower with concomitant left atrial appendage occlusion performed during the surgery than without it. (Funded by the Canadian Institutes of Health Research and others; LAAOS III ClinicalTrials.gov number, NCT01561651.).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejmoa2101897

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 16 references

Cited by

See all 732

Metadata

Authors
Whitlock, R. P., Belley-Cote, E. P., Paparella, D., Healey, J. S., Brady, K., Sharma, M., Reents, W., Budera, P., Baddour, A. J., Fila, P., Devereaux, P. J., Bogachev-Prokophiev, A., Boening, A., Teoh, K. H. T., Tagarakis, G. I., Slaughter, M. S., Royse, A. G., McGuinness, S., Alings, M., Punjabi, P. P., Mazer, C. D., Folkeringa, R. J., Colli, A., Avezum, Á., Nakamya, J., Balasubramanian, K., Vincent, J., Voisine, P., Lamy, A., Yusuf, S., & Connolly, S. J.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
2021-06-03
Volume
384
Issue
22
Pages
2081-2091
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejmoa2101897
OpenAlex
W3161524032
Cited by
732
References
16
FWCI
73.63
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. https://app.cochat.ai/papers/10.1056/nejmoa2101897
The paper
Whitlock, R. P., Belley-Cote, E. P., Paparella, D., Healey, J. S., Brady, K., Sharma, M., Reents, W., Budera, P., Baddour, A. J., Fila, P., Devereaux, P. J., Bogachev-Prokophiev, A., Boening, A., Teoh, K. H. T., Tagarakis, G. I., Slaughter, M. S., Royse, A. G., McGuinness, S., Alings, M., . . . Connolly, S. J. (2021). Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. New England Journal of Medicine. https://doi.org/10.1056/nejmoa2101897

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.