The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
ADHD Drugs and Cardiovascular Risk
Abstract
On February 9, the Drug Safety and Risk Management Advisory Committee of the FDA voted to recommend a “black-box” warning describing the cardiovascular risks of stimulant drugs used to treat ADHD. Dr. Steven Nissen explains why the advisory committee took decisive action.
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“The median of these published sudden death rates in children is at 1.2–1.3/100,000/year.”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
In the citing paper
“Sudden death rates range from 0.8 to 8.5/100,000 patient-years [20, 30, 98, 99, 159].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
In the citing paper
“In contrast to adults, sudden death occurs only rarely in the general paediatric population.”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
In the citing paper
“the frequency of reported sudden death per year of ADHD therapy with methylphenidate, atomoxetine or amfetamines among children was 0.2–0.5/100,000 patient-years [99].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
In the citing paper
“QTc prolongation (and sudden death and increased heart rate) have been reported with methylphenidate and dexamfetamine [99] and atomoxetine [34].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [99]
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Self-citationThe Relative Safety of Ephedra Compared with Other Herbal Products
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Metadata
- Authors
- Nissen, S. E.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Nissen, Steven E.
- ORCID
- Nissen, Steven E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2006-04-06
- Volume
- 354
- Issue
- 14
- Pages
- 1445-1448
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2032285255
- Cited by
- 331
- References
- 6
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 14 · 2014: 19 · 2013: 25 · 2012: 28
- FWCI
- 26.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- attention deficit hyperactivity disorder, stimulants, cardiovascular risk, black box warning, drug safety, cardiovascular adverse events
- MeSH terms
- Adult, Central Nervous System Stimulants, Appetite Depressants, Attention Deficit Disorder with Hyperactivity, Cardiovascular Diseases, Child, Death, Sudden, Drug and Narcotic Control, Female, Humans, Male, Phenylpropanolamine, Sympathomimetics, United States, United States Food and Drug Administration, Ephedra
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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