The DOI matches its Crossref record; 90 of the 92 references it cites were found in a registry or an index, and 2 are not checked yet.
Nonalcoholic Fatty Liver Disease
Abstract
Alcohol abuse is the most common cause of fatty liver disease, but it is now apparent that fat deposition in the liver, and its consequences, may occur without alcohol abuse. The principal risk factors are obesity, non-insulin-dependent diabetes mellitus, and hyperlipidemia. The disorder has a wide clinical spectrum, ranging from asymptomatic steatosis to steatohepatitis, fibrosis, and cirrhosis. This article provides a broad overview of this increasingly recognized liver disease.
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In the citing paper
“Non-alcoholic fatty liver disease (NAFLD) is caused by the accumulation of fat within the hepatocytes (>5.5%) in the absence of significant alcohol intake [1].”
From Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells (2021) · cites this paper as [1]
In the citing paper
“Presently, non-alcoholic fatty liver disease (NAFLD) is by far the most common liver ailment (53).”
From Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation* (2010) · cites this paper as [53]
Citations
Cites
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Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions
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Cited by
Sorted by citations
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
Obesity in children and young people: a crisis in public health
Lobstein, T., Baur, L., & Uauy, R. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00133.x · Cited by 3,801
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
Bedogni, G., Bellentani, S., Miglioli, L., Masutti, F., Passalacqua, M., Castiglione, A., & Tiribelli, C. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-33 · Cited by 3,146
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Buzzetti, E., Pinzani, M., & Tsochatzis, E. A. (2016) · Metabolism · doi:10.1016/j.metabol.2015.12.012 · Cited by 3,119
Metadata
- Authors
- Angulo, P.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Angulo, Paul
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2002-04-18
- Volume
- 346
- Issue
- 16
- Pages
- 1221-1231
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2040109162
- Cited by
- 5,228
- References
- 90
- Citations by year
- 2026: 38 · 2025: 80 · 2024: 102 · 2023: 171 · 2022: 155 · 2021: 191 · 2020: 246 · 2019: 228 · 2018: 222 · 2017: 264 · 2016: 275 · 2015: 339 · 2014: 368 · 2013: 319 · 2012: 309
- FWCI
- 23.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- non-alcoholic fatty liver disease, hepatic steatosis, steatohepatitis, liver fibrosis, liver cirrhosis, obesity, type 2 diabetes, hyperlipidemia, risk factors, alcohol abuse
- MeSH terms
- Biopsy, Fatty Liver, Humans, Liver, Liver Function Tests, Radiography, Risk Factors, Ultrasonography, Weight Loss, Prevalence
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