The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Risks of testosterone-replacement therapy and recommendations for monitoring.
Abstract
Although some reports suggest that testosterone-replacement therapy may provide benefits for aging men, considerable controversy remains regarding indications for its use. Neither large-scale nor long-term studies have been initiated, in part because of theoretical concern regarding the risks associated with testosterone therapy, especially the possible stimulation of prostate cancer. This article discusses what is known (and not known) about the risks of testosterone-replacement therapy and provides recommendations for monitoring men who are receiving testosterone.
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In the citing paper
“Unfortunately, hormone replacement therapy is not a panacea, as it often results in various adverse events which outweigh its potential health benefits.”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [12]
In the citing paper
“preventing an age-related decline in hormones by exogenous replacement is associated with increased risk for adverse effects in older adults.11-13”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [12]
In the citing paper
“However, testosterone may have deleterious actions on prostate disease, sleep apnea, and possibly cardiovascular risk (35).”
From Low testosterone levels are common and associated with insulin resistance in men with diabetes (2008) · cites this paper as [35]
Citations
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Cited by
Sorted by citations
Molecular and Cellular Basis of Cardiovascular Gender Differences
Mendelsohn, M. E., & Karas, R. H. (2005) · Science · doi:10.1126/science.1112062 · Cited by 1,105
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
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Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai Pour, H. R., Aleman, A., Lock, T. M. T. W., Bosch, J. L. H. R., Grobbee, D. E., & van der Schouw, Y. T. (2008) · JAMA · doi:10.1001/jama.2007.51 · Cited by 518
“A stimulatory effect of testosterone on erythropoiesis has been documented in several studies.(73) This effect was confirmed in our study, but without apparent clinical consequences.”
Metadata
- Authors
- Rhoden, E. L., & Morgentaler, A.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- ORCID
- Morgentaler, Abraham
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2004-01-29
- Volume
- 350
- Issue
- 5
- Pages
- 482-492
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2120158027
- Cited by
- 705
- References
- 77
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 12 · 2023: 10 · 2022: 7 · 2021: 16 · 2020: 18 · 2019: 21 · 2018: 19 · 2017: 20 · 2016: 22 · 2015: 36 · 2014: 30 · 2013: 35 · 2012: 44
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- testosterone replacement therapy, risk, prostate cancer, older men, monitoring, androgen therapy, hypogonadism
- MeSH terms
- Cardiovascular Diseases, Humans, Hypogonadism, Lipids, Male, Polycythemia, Prostatic Diseases, Risk Factors, Testosterone, Drug Monitoring, Prostate-Specific Antigen, Age Distribution, Hormone Replacement Therapy
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