Cited by 667Diabetes Management and ResearchDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

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Insulin Analogues

Hirsch, Irl B.·2005·New England Journal of Medicine

DOI 10.1056/nejmra040832

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Abstract

In the 1990s, the value of glycemic control in the management of diabetes became incontrovertible. The interest in producing insulin formulations that are safer than previous formulations and that more closely duplicate the basal and mealtime components of endogenous insulin secretion has yielded insulin analogues with action profiles that afford more flexible treatment regimens and a lower risk of hypoglycemia. This article examines the use of these newer insulins in clinical practice.

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Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.
Yki‐Järvinen, H., Dressler, A., Ziemen, M., & HOE 901/300s Study Group (2000) · Diabetes Care · doi:10.2337/diacare.23.8.1130 · Cited by 573
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Authors: Hirsch, I. B.
Affiliations: University of Washington (US)
Corresponding author: Hirsch, Irl B.
ORCID: Hirsch, Irl B.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2005-01-13
Volume: 352
Issue: 2
Pages: 174-183
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra040832
OpenAlex: W4242554702
Cited by: 667
References: 62
Citations by year: 2026: 13 · 2025: 8 · 2024: 14 · 2023: 11 · 2022: 23 · 2021: 16 · 2020: 26 · 2019: 19 · 2018: 31 · 2017: 29 · 2016: 36 · 2015: 36 · 2014: 27 · 2013: 39 · 2012: 46
FWCI: 5.86
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: insulin analogues, glycemic control, diabetes mellitus, hypoglycemia risk, insulin formulations
MeSH terms: Insulin Glargine, Child, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Drug Administration Schedule, Female, Humans, Hypoglycemic Agents, Insulin, Pregnancy, Blood Glucose Self-Monitoring, Insulin, Long-Acting, Insulin Aspart, Insulin Lispro

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Insulin Analogues

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