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The Pathogenesis of Rheumatoid Arthritis
Abstract
The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
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“Rheumatoid arthritis is a chronic autoimmune disease characterized by synovial inflammation that can result in damage to articular cartilage and bone.205”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [205]
In the citing paper
“Development of rheumatoid arthritis occurs largely through a loss of tolerance for proteins that have undergone citrullination (ie, posttranslational modification of a positively charged arginine into a neutral citrulline group).205”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [205]
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Metadata
- Authors
- McInnes, I. B., & Schett, G.
- Affiliations
- University of Glasgow (GB)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-12-08
- Volume
- 365
- Issue
- 23
- Pages
- 2205-2219
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2110826367
- Cited by
- 5,514
- References
- 100
- Citations by year
- 2026: 313 · 2025: 415 · 2024: 439 · 2023: 443 · 2022: 469 · 2021: 493 · 2020: 465 · 2019: 409 · 2018: 399 · 2017: 394 · 2016: 379 · 2015: 300 · 2014: 276 · 2013: 204 · 2012: 111
- FWCI
- 27.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- rheumatoid arthritis, pathogenesis, immune mechanisms, disease-modifying antirheumatic drugs, mortality reduction
- MeSH terms
- Arthritis, Rheumatoid, Humans, Antirheumatic Agents, Gene-Environment Interaction
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