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The Pathogenesis of Rheumatoid Arthritis
Abstract
The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
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“Rheumatoid arthritis is a chronic autoimmune disease characterized by synovial inflammation that can result in damage to articular cartilage and bone.205”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [205]
In the citing paper
“Development of rheumatoid arthritis occurs largely through a loss of tolerance for proteins that have undergone citrullination (ie, posttranslational modification of a positively charged arginine into a neutral citrulline group).205”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [205]
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Schuerwegh, A. J., Ioan‐Facsinay, A., Dorjée, A. L., Roos, J. A. D. M. D., Bajema, I. M., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913054107 · Cited by 94
RetractedGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959
Evolving concepts of rheumatoid arthritis
Firestein, G. S. (2003) · Nature · doi:10.1038/nature01661 · Cited by 3,653
Gregersen, P. K., Silver, J., & WINCHESTER, R. J. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780301102 · Cited by 2,633
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623
Cytokines in the pathogenesis of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,576
Self-citationRantapää‐Dahlqvist, S., Jong, B. A. W. D., Berglin, E. H., Hallmans, G., Wadell, G., Stenlund, H. C., Sundin, U., & VENROOIJ, W. J. V. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,946
Klareskog, L., Stolt, P., Lundberg, K., Källberg, H., Bengtsson, C., Grünewald, J., Rönnelid, J., Harris, H. E., Ulfgren, A., Rantapää‐Dahlqvist, S., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21575 · Cited by 1,516
Research works printed but not linked: 5
- Scher JU, 2010, Arthritis Rheum, 62, 1390
- Szekanecz Z, 2009, Front Biosci (Elite Ed), 1, 44
- Aupperle KR, 1998, Am J Pathol, 152, 1091
- Gravallese EM, 1998, Am J Pathol, 152, 943
- Jacobsson LT, 2005, J Rheumatol, 32, 1213
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Self-citationSmolen, J. S., Aletaha, D., Barton, A. C., Burmester, G. R., Emery, P., Firestein, G. S., Kavanaugh, A., McInnes, I. B., Solomon, D. H., Strand, V., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.1 · Cited by 2,553
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Zhang, X., Zhang, D., Jia, H., Feng, Q., Wang, D., Liang, D., Wu, X., Li, J., Tang, L., Li, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3914 · Cited by 1,690
Harding, S. D., Sharman, J. L., Faccenda, E., Southan, C., Pawson, A. J., Ireland, S. M., Gray, A. J. G., Bruce, L., Alexander, S. P. H., Anderton, S. M., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1121 · Cited by 1,650
Zhang, F., Wei, K., Slowikowski, K., Fonseka, C. Y., Rao, D. A., Kelly, S., Goodman, S. M., Tabechian, D., Hughes, L. B., Salomon-Escoto, K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0378-1 · Cited by 1,372
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Zuo, L., Prather, E. R., Stetskiv, M., Garrison, D. E., Meade, J. R., Peace, T. I., & Zhou, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184472 · Cited by 560
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BackgroundInfluentialMechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions
Komatsu, N., & Takayanagi, H. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00793-5 · Cited by 574
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Wei, K., Korsunsky, I., Marshall, J. L., Gao, A., Watts, G. F. M., Major, T., Croft, A. P., Watts, J., BLAZAR, P. E., Lange, J. K., et al. (2020) · Nature · doi:10.1038/s41586-020-2222-z · Cited by 536
MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease
Juge, P., Lee, J. S., Ebstein, E., Furukawa, H., Dobrinskikh, E., Gazal, S., Kannengiesser, C., Ottaviani, S., Oka, S., Tohma, S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801562 · Cited by 521
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McInnes, I. B., Buckley, C. D., & Isaacs, J. D. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.171 · Cited by 504
Self-citationYang, Y., Guo, L., Wang, Z., Liu, P., Liu, X., Ding, J., & Zhou, W. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120390 · Cited by 503
Zhang, H., Lin, C., Zeng, C., Wang, Z., Wang, H., Lu, J., Liu, X., Shao, Y. X., Zhao, C. M., Pan, J., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213450 · Cited by 503
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Tajik, N., Frech, M., Schulz, O., Schälter, F., Lucas, S., Azizov, V., Dürholz, K., Steffen, F., Omata, Y., Rings, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15831-7 · Cited by 515
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Narasimhan, P. B., Marcovecchio, P., Hamers, A. A. J., & Hedrick, C. C. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053119 · Cited by 493
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O’Shea, J. J., Kontzias, A., Yamaoka, K., Tanaka, Y., & Laurence, A. D. J. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202576 · Cited by 470
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Miller, M. A., Zheng, Y.-R., Gadde, S., Pfirschke, C., Zope, H., Engblom, C., Kohler, R. H., Iwamoto, Y., Yang, K. S., Askevold, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms9692 · Cited by 441
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Tardito, S., Martinelli, G., Soldano, S., Paolino, S., Pacini, G., Patanè, M., Alessandri, E., Smith, V. M., & Cutolo, M. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102397 · Cited by 441
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Wang, J., & Jia, H. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.83 · Cited by 429
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Gupta, S., & Kaplan, M. J. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.71 · Cited by 443
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Ross, E. A., Devitt, A., & Johnson, J. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708186 · Cited by 450
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Forbes, J. D., Domselaar, G. V., & Bernstein, C. N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01081 · Cited by 444
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Bantug, G. R., Galluzzi, L., Kroemer, G., & Hess, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.99 · Cited by 436
Hu, F., Jiang, X. W., Guo, C., Li, Y., Chen, S., Zhang, W., Du, Y., Wang, P., Zheng, X., Fang, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15700-3 · Cited by 419
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Scott, L. J. (2017) · Drugs · doi:10.1007/s40265-017-0829-7 · Cited by 419
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Francisco, V., Pino, J., Campos-Cabaleiro, V., Ruiz-Fernández, C., Mera, A., Gonzalez-Gay, M. A., Gómez, R., & Gualillo, O. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00640 · Cited by 411
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Gibofsky, A. (2012) · PubMed · Cited by 409
Pianta, A., Arvikar, S. L., Strle, K., Drouin, E. E., Wang, Q., Costello, C. E., & Steere, A. C. (2016) · Arthritis & Rheumatology · doi:10.1002/art.40003 · Cited by 411
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Holbrook, J. A., Reyna, S. J. L., Jarosz-Griffiths, H., & McDermott, M. (2019) · F1000Research · doi:10.12688/f1000research.17023.1 · Cited by 389
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Dejaco, C., Duftner, C., Buttgereit, F., Matteson, E. L., & Dasgupta, B. (2016) · Lara D. Veeken · doi:10.1093/rheumatology/kew273 · Cited by 369
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Self-citationNavegantes-Lima, K. C., Gomes, R. D. S., Pereira, P. A. T., Czaikoski, P. G., Azevedo, C. H. M., & Monteiro, M. C. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1141-8 · Cited by 369
Chowdhury, C. S., Giaglis, S., Walker, U. A., Buser, A. S., Hahn, S., & Hasler, P. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4579 · Cited by 366
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Crowson, C. S., Liao, K. P., Davis, J. M., Solomon, D. H., Matteson, E. L., Knutson, K. L., Hlatky, M. A., & Gabriel, S. E. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.07.010 · Cited by 368
Kehrer, J. P., & Klotz, L. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1074159 · Cited by 359
Kadura, S., & Raghu, G. (2021) · European Respiratory Review · doi:10.1183/16000617.0011-2021 · Cited by 368
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Derksen, V. F. A. M., Huizinga, T. W. J., & van der Woude, D. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0627-z · Cited by 330
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Li, R., He, Y., Zhu, Y., Jiang, L., Zhang, S., Qin, J., Wu, Q., Dai, W., Shen, S., Pang, Z., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b03439 · Cited by 327
Kleyer, A., Finzel, S., Rech, J., Manger, B., Krieter, M., Faustini, F., Araujo, E., Hueber, A. J., Steffen, U., Engelke, K., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202958 · Cited by 328
Self-citationHorta‐Baas, G., Romero-Figueroa, M. D. S., Montiel-Jarquín, Á. J., Pizano-Zárate, M. L., Garcı́a-Mena, J., & Ramírez‐Durán, N. (2017) · Journal of Immunology Research · doi:10.1155/2017/4835189 · Cited by 337
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Sharif, Κ., Watad, ., Bragazzi, N. L., Lichtbroun, M., Amital, H., & Shoenfeld, Y. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.11.010 · Cited by 342
Pfeifle, R., Rothe, T., Ipseiz, N., Scherer, H. U., Culemann, S., Steffen, U., Ackermann, J. A., Seefried, M., Kleyer, A., Uderhardt, S., et al. (2016) · Nature Immunology · doi:10.1038/ni.3579 · Cited by 320
Self-citationCrosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases
Jiao, Y., Wu, L., Huntington, N. D., & Zhang, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00282 · Cited by 321
“Monocytes/Macrophages are also considered to mediate the inflammation of synovitis via other pathways and produce inflammatory cytokines including IL-6/12/15/18/23, reactive oxygen and nitrogen besides TNF-α and IL-1 (136).”
BackgroundC-reactive protein and implications in rheumatoid arthritis and associated comorbidities
Pope, J. E., & Choy, E. H. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.11.005 · Cited by 320
“Proinflammatory pathways result in localized joint and systemic inflammation, [1] with cytokines, such as interleukin-6 (IL-6), tumour”
BackgroundNociceptive neurons detect cytokines in arthritis
Schaible, H. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0470-8 · Cited by 317
Early Diagnosis and Treatment of Rheumatoid Arthritis
Littlejohn, E., & Monrad, S. U. (2018) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2018.02.010 · Cited by 315
The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function
Lasica, A. M., Ksiazek, M., Madej, M., & Potempa, J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00215 · Cited by 312
Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity
Brown, E., Kenny, D. J., & Xavier, R. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041841 · Cited by 318
Murdaca, G., Tonacci, A., Negrini, S., Greco, M., Borro, M., Puppo, F., & Gangemi, S. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102350 · Cited by 320
Emerging cell and cytokine targets in rheumatoid arthritis
Burmester, G. R., Feist, E., & Dörner, T. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.168 · Cited by 308
Puhm, F., Afonyushkin, T., Resch, U., Obermayer, G., Rohde, M., Penz, T., Schuster, M., Wagner, G., Rendeiro, A. F., Melki, I., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314601 · Cited by 306
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
Boyle, D. L., Soma, K., Hodge, J., Kavanaugh, A., Mandel, D. R., Mease, P. J., Shurmur, R., Singhal, A. K., Wei, N., Rosengren, S., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206028 · Cited by 302
Wollenhaupt, J., Silverfield, J. C., Lee, E. B., Curtis, J. R., Wood, S. P., Soma, K., Nduaka, C. I., Benda, B., Gruben, D. C., Nakamura, H., et al. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.130683 · Cited by 301
Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction
Boissier, M., Semerano, L., Challal, S., Saidenberg-Kermanac’h, N., & Falgarone, G. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.05.021 · Cited by 299
Liu, B., Wang, J., Li, Y., Li, K., & Zhang, Q. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03018-6 · Cited by 306
Schett, G. A., Emery, P., Tanaka, Y., Burmester, G. R., Pisetsky, D. S., Naredo, E., Fautrel, B., & van Vollenhoven, R. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209201 · Cited by 297
Self-citationCell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases
Duvvuri, B., & Lood, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00502 · Cited by 282
“Rheumatoid Arthritis RA is, similar to SLE, an autoimmune rheumatic disease primarily affecting joints, with severe and disabling erosion (174).”
Background
Metadata
- Authors
- McInnes, I. B., & Schett, G.
- Affiliations
- University of Glasgow (GB)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2011-12-08
- Volume
- 365
- Issue
- 23
- Pages
- 2205-2219
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2110826367
- Cited by
- 5,514
- References
- 100
- Citations by year
- 2026: 313 · 2025: 415 · 2024: 439 · 2023: 443 · 2022: 469 · 2021: 493 · 2020: 465 · 2019: 409 · 2018: 399 · 2017: 394 · 2016: 379 · 2015: 300 · 2014: 276 · 2013: 204 · 2012: 111
- FWCI
- 27.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Keywords
- rheumatoid arthritis, pathogenesis, immune mechanisms, disease-modifying antirheumatic drugs, mortality reduction
- MeSH terms
- Arthritis, Rheumatoid, Humans, Antirheumatic Agents, Gene-Environment Interaction
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