Tuberculosis in Children
Abstract
In areas where it is endemic, tuberculosis remains a major, often unrecognized cause of disease and death among children. Symptoms are often subtle, and sputum smears have limited utility. This review summarizes the principles of diagnosis, treatment, and prevention.
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M. tuberculosis is often not detectable in paucibacillary paediatric specimens, and host biomarkers are not yet in place to reliably identify children with TB disease.
“Mycobacterium tuberculosis (M. tuberculosis) is often not detectable in paucibacillary paediatric specimens and host biomarkers are not yet in place to reliably identify children with TB disease [5, 6].”
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- Authors
- Perez-Velez, C. M., & Marais, B. J.
- Affiliations
- The University of Sydney (AU)
- ORCID
- Marais, Ben J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2012-07-26
- Volume
- 367
- Issue
- 4
- Pages
- 348-361
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2410129096
- Cited by
- 572
- References
- 48
- Citations by year
- 2026: 21 · 2025: 15 · 2024: 23 · 2023: 34 · 2022: 46 · 2021: 57 · 2020: 34 · 2019: 44 · 2018: 54 · 2017: 51 · 2016: 43 · 2015: 44 · 2014: 45 · 2013: 44 · 2012: 10
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- pediatric tuberculosis, tuberculosis diagnosis, tuberculosis treatment, tuberculosis prevention, sputum smear microscopy, tuberculosis endemic areas, child mortality
- MeSH terms
- Antitubercular Agents, Child, Humans, Tuberculosis, Tuberculosis, Pulmonary, HIV Infections, AIDS-Related Opportunistic Infections, Disease Progression, Disease Management, Directly Observed Therapy, Medication Adherence
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