Acute respiratory distress syndrome
Abstract
This month marks the 50th anniversary of the first description of the condition now termed the acute respiratory distress syndrome, or ARDS. The authors of this review discuss our current understanding of the pathobiology and treatment of ARDS.
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ARDS with a cytokine storm occurs in viral infections such as MERS-CoV, influenza virus and sepsis.
“ARDS with a cytokine storm occurs in viral infections such as MERS-CoV, influenza virus and sepsis.”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [334]
ARDS with a cytokine storm also occurs due to lung damage caused by gastric acid or inappropriate operation of a ventilator, like aspiration pneumonia.
“Furthermore, it also occurs due to lung damage caused by gastric acid or inappropriate operation of a ventilator, like aspiration pneumonia (334).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [334]
Cites
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Driving pressure and survival in the acute respiratory distress syndrome.
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Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
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Early versus late parenteral nutrition in critically ill adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Van Cromphaut, S., Ingels, C., Meersseman, P., Muller, J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102662 · Cited by 1,696 · see citing works
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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
Ackermann, M., Verleden, S. E., Kuehnel, M., Haverich, A., Welte, T., Laenger, F., Vanstapel, A., Werlein, C., Stark, H., Tzankov, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2015432 · Cited by 5,613 · see citing works
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
Combes, A., Hajage, D., Capellier, G., Demoule, A., Lavoué, S., Guervilly, C., Da Silva, D., Zafrani, L., Tirot, P., Veber, B., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1800385 · Cited by 2,380 · see citing works
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works
“Furthermore, it also occurs due to lung damage caused by gastric acid or inappropriate operation of a ventilator, like aspiration pneumonia (334).”
BackgroundYang, Y., Shen, C., Li, J., Yuan, J., Wei, J., Huang, F., Wang, F., Li, G., Li, Y., Xing, L., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.04.027 · Cited by 872 · see citing works
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I. L., Mittermaier, M., Mache, C., Chua, R. L., Knoll, R., Timm, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.033 · Cited by 528 · see citing works
Could Vitamins Help in the Fight Against COVID-19?
Jovic, T. H., Ali, S. R., Ibrahim, N., Jessop, Z. M., Tarassoli, S. P., Dobbs, T. D., Holford, P., Thornton, C. A., & Whitaker, I. S. (2020) · Nutrients · doi:10.3390/nu12092550 · Cited by 234 · see citing works
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Tarazan, N., Alshehri, M., Sharif, S., Al Duhailib, Z., Møller, M. H., Belley-Cote, E., Alshahrani, M., Centofanti, J., McIntyre, L., Baw, B., et al. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00348-6 · Cited by 52 · see citing works
Personalized Therapy Approach for Hospitalized Patients with Coronavirus Disease 2019
Garcia-Vidal, C., Moreno-García, E., Hernández-Meneses, M., Puerta-Alcalde, P., Chumbita, M., Garcia-Pouton, N., Linares, L., Rico, V., Cardozo, C., Martínez, J. A., et al. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa964 · Cited by 48 · see citing works
Neutrophils: Linking Inflammation to Thrombosis and Unlocking New Treatment Horizons
Li, H., Shan, W., Zhao, X., & Sun, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051965 · Cited by 32 · see citing works
- Authors
- Thompson, B. T., Chambers, R. C., & Liu, K. D.
- Affiliations
- Harvard University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-08-10
- Volume
- 377
- Issue
- 6
- Pages
- 562-572
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W4237939525
- Cited by
- 1,807
- References
- 5
- Citations by year
- 2026: 147 · 2025: 177 · 2024: 188 · 2023: 221 · 2022: 286 · 2021: 311 · 2020: 276 · 2019: 102 · 2018: 88 · 2017: 9 · 2015: 1
- FWCI
- 23.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- acute respiratory distress syndrome, pathobiology, ARDS treatment, lung injury
- MeSH terms
- Combined Modality Therapy, Fluid Therapy, Humans, Lung, Radiography, Respiration, Artificial, Respiratory Distress Syndrome, Risk Factors
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