Neutrophils: Linking Inflammation to Thrombosis and Unlocking New Treatment Horizons

Neutrophil Extracellular Traps Kill Bacteria

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Neutrophil recruitment and function in health and inflammation

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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

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Novel cell death program leads to neutrophil extracellular traps

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Neutrophils in the activation and regulation of innate and adaptive immunity

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Extracellular DNA traps promote thrombosis

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Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

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Progress and challenges towards targeted delivery of cancer therapeutics

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Mechanisms of Thrombus Formation

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Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

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Acute respiratory distress syndrome

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Platelets and the immune continuum

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Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

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PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

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Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

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Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

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Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

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Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

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Leukocyte Migration into Inflamed Tissues

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Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

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Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

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The Neutrophil's Role During Health and Disease.

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Neutrophil extracellular traps: Is immunity the second function of chromatin?

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Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms

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Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

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NETosis: how vital is it?

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Neutrophil extracellular traps promote deep vein thrombosis in mice

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CRISPR/Cas9 therapeutics: progress and prospects

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Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

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SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

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Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice

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Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation

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Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches

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Circulating Histones Are Mediators of Trauma-associated Lung Injury

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Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets

Kireev, D. A., Popenko, N. Y., Av, P., Panteleev, M. A., Krymskaya, O., Иноятович, А. Ф., & Sinauridze, E. I. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-06-0313 · Cited by 554 · see citing works

Dual-responsive biohybrid neutrobots for active target delivery

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Coronary Neutrophil Extracellular Trap Burden and Deoxyribonuclease Activity in ST-Elevation Acute Coronary Syndrome Are Predictors of ST-Segment Resolution and Infarct Size

Mangold, A., Alias, S., Scherz, T., Hofbauer, T. M., Jakowitsch, J., Panzenboeck, A., Simon, D., Laimer, D., Bangert, C., Kammerlander, A. A., et al. (2014) · Circulation Research · doi:10.1161/circresaha.116.304944 · Cited by 518 · see citing works

NETosis, complement, and coagulation: a triangular relationship

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Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G., & Kubes, P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.01.005 · Cited by 443 · see citing works

Histones induce rapid and profound thrombocytopenia in mice

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Release and activity of histone in diseases

Chen, R., Kang, R., Fan, X.-G., & Tang, D. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.337 · Cited by 418 · see citing works

The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke

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Extracellular histones increase plasma thrombin generation by impairing thrombomodulin‐dependent protein C activation

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Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenecity of human platelets

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HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4

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Neutrophil clearance: when the party is over, clean-up begins

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Neutrophils in the pathogenesis and manifestations of SLE

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Two-Way Interactions Between Inflammation and Coagulation

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Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Its Consequences for the Development of Atherosclerosis

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Functional significance of the platelet immune receptors GPVI and CLEC-2

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Tissue factor–positive neutrophils bind to injured endothelial wall and initiate thrombus formation

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The impact of the inflammatory response on coagulation

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Platelets in defense against bacterial pathogens

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Peculiarities of cell death mechanisms in neutrophils

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Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium

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Neutrophil extracellular traps are induced by Mycobacterium tuberculosis

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Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

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Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

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Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy

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Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

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Chemotaxis‐Guided Hybrid Neutrophil Micromotors for Targeted Drug Transport

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Platelet–neutrophil interactions as drivers of inflammatory and thrombotic disease

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Advances in Microfluidic Blood–Brain Barrier (BBB) Models

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The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

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TREM-1 ligand expression on platelets enhances neutrophil activation

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Platelet-Neutrophil Interplay: Insights Into Neutrophil Extracellular Trap (NET)-Driven Coagulation in Infection

Zucoloto, A. Z., & Jenne, C. N. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00085 · Cited by 208 · see citing works

Immune Cell Phenotype and Function in Sepsis

Rimmele, T. R., Payen, D. M., Cantaluppi, V., Marshall, J. C., Gómez, H., Gómez, A., Murray, P. T., & Kellum, J. A. (2015) · Shock · doi:10.1097/shk.0000000000000495 · Cited by 202 · see citing works

Ischaemic stroke: a thrombo‐inflammatory disease?

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The role of neutrophils in thrombosis

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Neutrophil hitchhiking for drug delivery to the bone marrow

Luo, Z., Lu, Y., Shi, Y., Jiang, M., Shan, X., Li, X., Zhang, J., Qin, B., Liu, X., Guo, X., et al. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01374-7 · Cited by 190 · see citing works

DNA, histones and neutrophil extracellular traps exert anti-fibrinolytic effects in a plasma environment

Varjú, I., Longstaff, C., Szabó, L. F., Farkas, A. Z., Farkas, V. J., Tanka‐Salamon, A., Machovich, R., & Kolev, K. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-08-0669 · Cited by 174 · see citing works

Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

Wang, Y., Gao, H., Shi, C., Erhardt, P., Pavlovsky, A. G., Soloviev, D. A., Bledzka, K. M., Ustinov, V., Zhu, L., Qin, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15559 · Cited by 173 · see citing works

Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation

Mauler, M., Herr, N., Schönichen, C., Witsch, T., Marchini, T., Härdtner, C., Koentges, C., Kienle, K., Ollivier, V., Schell, M., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.033942 · Cited by 173 · see citing works

A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients

Abrams, S. T., Morton, B., Alhamdi, Y., Alsabani, M. H., Lane, S., Welters, I. D., Wang, G., & Toh, C. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201811-2111oc · Cited by 148 · see citing works

Immunothrombosis and thromboinflammation in host defense and disease

Martinod, K., & Deppermann, C. (2020) · Platelets · doi:10.1080/09537104.2020.1817360 · Cited by 143 · see citing works

Inflammatory bowel disease

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Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles

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Current concepts and novel targets for antiplatelet therapy

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Neutrophils Enable Local and Non‐Invasive Liposome Delivery to Inflamed Skeletal Muscle and Ischemic Heart

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tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?

Kim, J. S. (2019) · Journal of Stroke · doi:10.5853/jos.2019.00584 · Cited by 114 · see citing works

Piezo1 expression in neutrophils regulates shear-induced NETosis

Baratchi, S., Danish, H., Chheang, C., Zhou, Y., Huang, A., Lai, A., Khanmohammadi, M., Quinn, K. M., Khoshmanesh, K., & Peter, K. (2024) · Nature Communications · doi:10.1038/s41467-024-51211-1 · Cited by 109 · see citing works

“The NET effect”: Neutrophil extracellular traps—a potential key component of the dysregulated host immune response in sepsis

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Compromised Anti-inflammatory Action of Neutrophil Extracellular Traps in PAD4-Deficient Mice Contributes to Aggravated Acute Inflammation After Myocardial Infarction

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Neutrophil extracellular traps (NETs) and the role of platelets in infection

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Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

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Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation

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A Review on Lactoferrin and Central Nervous System Diseases

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Platelets in neutrophil recruitment to sites of inflammation

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The Reciprocal Relationship Between Inflammation and Coagulation

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Living Leukocyte‐Based Drug Delivery Systems

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Colchicine Inhibits NETs and Alleviates Cardiac Remodeling after Acute Myocardial Infarction

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Inhibition of NADPH oxidase blocks NETosis and reduces thrombosis in heparin-induced thrombocytopenia

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Platelet-Mediated NET Release Amplifies Coagulopathy and Drives Lung Pathology During Severe Influenza Infection

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Nanotechnology reinforced neutrophil-based therapeutic strategies for inflammatory diseases therapy

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Neutrophil Extracellular Traps and Thrombolysis Resistance: New Insights for Targeting Therapies

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Cellular Vehicles Based on Neutrophils Enable Targeting of Atherosclerosis

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Multiplatform Analyses Reveal Distinct Drivers of Systemic Pathogenesis in Adult Versus Pediatric COVID-19

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Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting

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Neutrophil extracellular trap components increase the expression of coagulation factors

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Cyclic stretch enhances neutrophil extracellular trap formation

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Tissue factor links inflammation, thrombosis, and senescence in COVID-19

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Secretomes of M1 and M2 macrophages decrease the release of neutrophil extracellular traps

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Leukocyte indicators and variations predict worse outcomes after intravenous thrombolysis in patients with acute ischemic stroke

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Neutrophil-mediated Delivery of Nanotherapeutics Across Blood Vessel Barrier

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Neutrophil as a Carrier for Cancer Nanotherapeutics: A Comparative Study of Liposome, PLGA, and Magnetic Nanoparticles Delivery to Tumors

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Stroke in 2015: the year of endovascular treatment

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Neutrophil hitchhiking for nanoparticle delivery to the central nervous system

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Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease

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Higher fibrinogen and neutrophil-to-lymphocyte ratio are associated with the early poor response to intravenous thrombolysis in acute ischemic stroke

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The fundamentals of neutrophil antigen and antibody investigations

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Elevated systemic inflammation response index is associated with poor outcomes in minor ischemic stroke

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Musa paradisiaca L. Inflorescence Abrogates Neutrophil Activation by Downregulating TLR4/NF-KB Signaling Pathway in LPS-Induced Acute Lung Injury Model

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Abstract TP71: One-twentieth of Acute Ischemic Stroke With Anticoagulation Therapy for Venous Thromboembolism Have Hemorrhagic Complications

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Immunothrombosis in Sepsis: Cellular Crosstalk, Molecular Triggers, and Therapeutic Opportunities—A Review

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The Role of Neutrophil Extracellular Networks in Cardiovascular Pathology

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Hijacking the helpers: platelet and neutrophil trafficking in AML and therapeutic exploitation

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Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review

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Immunology of atherosclerosis as an inflammatory disease: rethinking the dynamic immunoinflammatory activity beneath stability

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3D-printable hyaluronic acid/gelatin double-network hydrogels for stretchable and adhesive wound patches

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The Interplay Between Inflammation and Malnutrition in Acute Ischemic Stroke: A Narrative Review

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Pulmonary Embolism in Acute Ischaemic Stroke: Evolving Evidence, Diagnostic Challenges, and a Novel Thromboinflammatory Axis Hypothesis

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Inflammation and Necrosis Syndrome in Young Piglets—A Longitudinal Study

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Unraveling neutrophil extracellular traps: A new frontier in kidney disease therapy

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Nanomedicine for thrombotic disorders: advancing toward safer and more effective theranostics

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High-Dose Tranexamic Acid Enhances Circulating Neutrophil Extracellular Traps and Thrombus in Thrombosis Mouse Model

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Advances in Drug Research Targeting Neutrophils for the Treatment of Rheumatoid Arthritis

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The Prognostic Gender-Related Value of the Systemic Immune-Inflammation Index in Patients With Acute Coronary Syndrome

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Inflammatory Markers and Stroke Outcomes: Lessons From Neutrophil Counts and Antiplatelet Therapy

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Chlamydia psittacosis infection complicating cerebral infarction: A case report and literature review

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Gingival Crevicular Fluid Proteomic Shift: From Gingivitis to Periodontitis

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Peptidylarginine deiminase 4-mediated citrullination in human disease: molecular mechanisms and therapeutic targeting

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Serotonin as a Regulator of Innate and Adaptive Immunity: Mechanisms and Clinical Relevance in Inflammatory Disease

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Deciphering conundrums on heparins and circulating histones: hype or hope?

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Risk Factors for Pulmonary Embolism in Patients with Acute Exacerbation of COPD: A Systematic Review and Meta-analysis

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Role of lipid peroxidation and chronic inflammation in development of post-thrombotic syndrome

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A U-shaped association between the systemic immune-inflammation index and refractory Mycoplasma pneumoniae pneumonia in children: A retrospective cohort study

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Epigenetic Regulation of the NET Formation–Blood–Brain Barrier Axis in Ischemic Stroke: Mechanisms, Therapeutic Targets and Translational Perspectives

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Polyphenols and inflammation in wound healing

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Immune–coagulation activation and mitochondrial shape the transcriptomic landscape of gestational diabetes mellitus and highlight SERPINE1-associated endothelial stress

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The association between body mass index and lower extremity deep venous abnormalities identified by computed tomography venography

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Fulminant Thromboinflammatory Syndrome Following an Influenza-like Illness in an Adolescent: Clinical Insights from a Case Report

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Activation of Inflammatory and Coagulation Pathways in Patients with Graft-Versus-Host Disease

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Spatiotemporally stratified nanoassemblies for precisely halting the immunothrombotic vicious cycle in acute lung inflammation

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Inflammatory and cardiac-stress biomarkers in Moyamoya disease: the role of GDF-15

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Neutrophil-Mediated Effects on Hemostasis and Thrombosis: Unraveling Their Complex Interaction in Thrombotic Events

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The coming of age of neutrophil extracellular traps in thrombosis: Where are we now and where are we headed?

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Pathological roles of NETs-platelet synergy in thrombotic diseases: From molecular mechanisms to therapeutic targeting

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