CoChat
Sign Up
Cited by 360Preterm Birth and ChorioamnionitisInfant Development and Preterm CareMaternal and Perinatal Health Interventions

The preterm prediction study: prediction of preterm premature rupture of membranes through clinical findings and ancillary testing

Mercer, Brian M., Goldenberg, Robert L., Meis, Paul J., Moawad, Atef H., Shellhaas, Cynthia, Das, Anita, Menard, M.Kathryn, Caritis, Steve N. +5 more·2000·American Journal of Obstetrics and Gynecology
DOI 10.1067/mob.2000.106766
Open this paper in CoChat — free account

Abstract

Objective Our objective was to determine the relative importance of demographic characteristics, clinical risk factors, and ancillary screening tests in the prediction of preterm birth as a result of premature rupture of membranes.Study design A total of 2929 women were evaluated in 10 centers at 23 to 24 weeks' gestation. Demographic and clinical characteristics were ascertained. Cervicovaginal fetal fibronectin and bacterial vaginosis were evaluated. Cervical length was measured by vaginal ultrasonography. Patients were evaluated for spontaneous preterm birth caused by preterm premature rupture of membranes at <37 and <35 weeks' gestation. Multivariate analyses were performed separately for nulliparous women and multiparous women.Results Premature rupture of membranes at <37 weeks' gestation complicated 4.5% of pregnancies, accounting for 32.6% of preterm births. Univariate analysis revealed low body mass index, pulmonary disease, contractions within 2 weeks, short cervix (</=25 mm), positive results of fetal fibronectin screening, bacterial vaginosis, and a previous preterm birth caused by premature rupture of membranes (in multiparous women) to be significantly associated with preterm birth caused by premature rupture of membranes in the current gestation. Short cervix, previous preterm birth caused by premature rupture of membranes in multiparous women, and presence of fetal fibronectin were the strongest predictors for both preterm birth caused by premature rupture of membranes at <37 and <35 weeks' gestation. Women with positive fetal fibronectin screening results and a short cervix had greater risks both of preterm birth caused by premature rupture of membranes at <37 weeks' gestation (relative risk, 4.9) and of preterm birth caused by premature rupture of membranes at <35 weeks' gestation (relative risk, 13.5) than did those without these risk factors. Multiparous women with all three risk factors had a 31. 3-fold increased risk of preterm birth caused by premature rupture of membranes at <35 weeks' gestation.Conclusion The combination of short cervical length, previous preterm birth caused by preterm premature rupture of membranes, and positive fetal fibronectin screening results was highly associated with preterm delivery caused by preterm premature rupture of membranes in the current gestation.

Integrity signals

Registry

Crossref · 10.1067/mob.2000.106766

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Risk factors for PPROM are generally similar to those for preterm spontaneous labour with intact membranes, although infections and tobacco exposure play important parts.

    “Risk factors for PPROM are generally similar to those for preterm spontaneous labour with intact membranes, although infections and tobacco exposure play important parts.12”

    From Epidemiology and causes of preterm birth (2008) · cites this paper as [12]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Mercer, B. M., Goldenberg, R. L., Meis, P. J., Moawad, A. H., Shellhaas, C., Das, A., Menard, M. K., Caritis, S. N., Thurnau, G. R., Dombrowski, M. P., Miodovnik, M., Roberts, J. M., & McNellis, D.
Affiliations
National Institutes of Health (US)
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2000-09
Volume
183
Issue
3
Pages
738-745
ISSN
0002-9378 (ISSN-L)
DOI
10.1067/mob.2000.106766
OpenAlex
W1981121675
Cited by
360
References
27
Citations by year
2026: 8 · 2025: 7 · 2024: 7 · 2023: 18 · 2022: 12 · 2021: 17 · 2020: 19 · 2019: 18 · 2018: 16 · 2017: 71 · 2016: 13 · 2015: 14 · 2014: 15 · 2013: 17 · 2012: 16
FWCI
4.54
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD21434, HD-21414, [HD21410)
Topics
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
Keywords
preterm premature rupture of membranes, preterm birth prediction, fetal fibronectin, cervical length, bacterial vaginosis, short cervix, previous preterm birth, multiparous women, nulliparous women, risk factors, cervical ultrasonography
MeSH terms
Cervix Uteri, Female, Premature Rupture of Fetal Membranes, Fetus, Fibronectins, Gestational Age, Humans, Obstetric Labor, Premature, Parity, Pregnancy, Risk Factors, Ultrasonography, Vagina, Vaginosis, Bacterial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review