Risk factors for sleep-disordered breathing in pregnancy
Open accessAbstract
RATIONALE: Symptoms of sleep-disordered breathing (SDB) are common among pregnant women, and several studies link SDB symptoms with gestational hypertension and preeclampsia. However, few prospective studies objectively measuring SDB during pregnancy have been performed. OBJECTIVES: We performed a prospective cohort study examining risk factors for third trimester SDB in pregnant women. MEASUREMENTS AND METHODS: 105 pregnant women from the Hospital of the University of Pennsylvania obstetrics practices completed first and third trimester overnight polysomnography studies. We examined whether the number of SDB events per hour of sleep increased during pregnancy. We performed unadjusted and multivariable logistic regression analyses to estimate the effects of usual and pregnancy-specific characteristics on development of third trimester obstructive sleep apnoea (OSA). In secondary analyses, we examined the relationship between objectively measured SDB, hypertensive disorders of pregnancy, and other adverse maternal-fetal outcomes. MAIN RESULTS: Mean Apnoea-Hypopnoea Index increased from 2.07 (SD 3.01) events/h at baseline (first trimester) to 3.74 (SD 5.97) in the third trimester (p=0.009). 10.5% of women had OSA in the first trimester. By the third trimester, 26.7% of women had OSA. In multivariable analyses, first trimester body mass index (BMI) and maternal age were significantly associated with third trimester OSA. CONCLUSIONS: Third trimester OSA is common. Risk factors for third trimester OSA among women without baseline SDB include higher baseline BMI and maternal age.
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Other studies have identified similar risk factors for gestational obstructive sleep apnea.
“Other studies have identified similar risk factors for gestational OSA.1005,1006”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [1006]
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- Authors
- Pien, G. W., Pack, A. I., Jackson, N., Maislin, G., Macones, G. A., & Schwab, R. J.
- Affiliations
- Johns Hopkins University (US)
- University of Pennsylvania (US)
- Washington University in St. Louis (US)
- Corresponding author
- Pien, Grace W
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2013-11-21
- Volume
- 69
- Issue
- 4
- Pages
- 371-377
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- PMC
- PMC6994201
- OpenAlex
- W2123403550
- Semantic Scholar
- 48114c5f342fa4c1e38b4875ac1cfce0e01d07b8
- Cited by
- 281
- References
- 34
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 22 · 2023: 22 · 2022: 33 · 2021: 25 · 2020: 34 · 2019: 22 · 2018: 24 · 2017: 15 · 2016: 15 · 2015: 21 · 2014: 5 · 2013: 2
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- American Heart Association
- National Institutes of Health (P01HL94307)
- National Heart, Lung, and Blood Institute (P01HL94307, P01HL094307)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD041465, K23HD41465)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
- Keywords
- sleep-disordered breathing, obstructive sleep apnea, pregnancy, third trimester, risk factors, body mass index, maternal age, apnea-hypopnea index, hypertensive disorders of pregnancy, preeclampsia, gestational hypertension
- MeSH terms
- Adult, Female, Humans, Pennsylvania, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Third, Prospective Studies, Risk Factors, Sleep Apnea Syndromes, Cohort Studies, Logistic Models, Polysomnography, Young Adult
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