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Cited by 257Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNeural dynamics and brain function

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits

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Gao, Wen-Jun, Krimer, Leonid S., Goldman-Rakic, Patricia S.·2001·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.98.1.295PMC PMC14584
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Abstract

The prefrontal cortex plays a fundamental role in the working memory functions of the cerebral cortex and is also the site of dysfunction in several neurological and psychiatric disorders, including schizophrenia. Prefrontal neurons are distinguished by their capacity for sustained activity during the time a stimulus is held in memory, and this mnemonic response is considered a substrate for a variety of cognitive functions. The neuronal basis for sustained activity in prefrontal neurons is unknown but is thought to involve recurrent excitation among pyramidal neurons. Recent studies in awake behaving monkeys have demonstrated that the persistent activity in prefrontal neurons is modulated by dopamine. To examine the mechanisms by which dopamine might modulate transmission in local excitatory circuits, we have performed dual whole-cell recordings in connected pyramidal cell pairs with and without dopamine application. We find that dopamine reduces the efficacy of unitary excitatory neurotransmission in layer V pyramidal cells by decreasing its reliability. These effects, which are reproduced by a selective D1 agonist and blocked by a D1 antagonist, are independent of voltage changes and are not attenuated by blockade of sodium and potassium channels in the postsynaptic neurons. We conclude that attenuation of local horizontal excitatory synaptic transmission in layer V pyramidal neurons by dopamine is through D1 actions at a presynaptic site.

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Research works printed but not linked: 2

  1. C R Yang, J K Seamans, N Gorelova Neuropharmacology 21, 161–194 (1999).
  2. S Tanaka Prog Neuropsychopharmacol Biol Psychiatry 25, 1–23 (2000).

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Metadata

Authors
Gao, W.-J., Krimer, L. S., & Goldman-Rakic, P. S.
Affiliations
  • Yale University (US)
  • Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510
ORCID
Gao, Wen-Jun
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2000-12-26
Volume
98
Issue
1
Pages
295-300
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.98.1.295
PMC
PMC14584
OpenAlex
W2154397718
Cited by
257
References
37
Citations by year
2026: 3 · 2025: 8 · 2024: 8 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 15 · 2012: 7
FWCI
5.29
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH038546, P50 MH44866, R01 MH38546, R37MH038546, P50MH044866, R01MH085666)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
dopamine D1 receptor, presynaptic modulation, recurrent excitation, prefrontal cortex, layer 5 pyramidal neurons, persistent neuronal activity, working memory, synaptic reliability, schizophrenia
MeSH terms
Animals, Benzazepines, Dopamine, Ferrets, Synaptic Transmission, Schizophrenia, Wakefulness, Potassium Channels, Sodium Channels, Prefrontal Cortex, Receptors, Dopamine D1, Presynaptic Terminals, Pyramidal Cells, Patch-Clamp Techniques, Dopamine Agonists, Dopamine Antagonists, Excitatory Postsynaptic Potentials, Raclopride, In Vitro Techniques

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CoChat. (2026). Citation check: Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits. https://app.cochat.ai/papers/10.1073/pnas.98.1.295
The paper
Gao, W.-J., Krimer, L. S., & Goldman-Rakic, P. S. (2001). Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.1.295