The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae
Open accessAbstract
A high-density transposon mutagenesis strategy was applied to the Haemophilus influenzae genome to identify genes required for growth or viability. This analysis detected putative essential roles for the products of 259 ORFs of unknown function. Comparisons between complete genomes defined a subset of these proteins in H. influenzae having homologs in Mycobacterium tuberculosis that are absent in Saccharomyces cerevisiae , a distribution pattern that favors their use in development of antimicrobial therapeutics. Three genes within this set are essential for viability in other bacteria. Interfacing the set of essential gene products in H. influenzae with the distribution of homologs in other microorganisms can detect components of unrecognized cellular pathways essential in diverse bacteria. This genome-scale phenotypic analysis identifies potential roles for a large set of genes of unknown function.
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Cites
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Cited by
Genes required for mycobacterial growth defined by high density mutagenesis
Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544
Self-citationExtreme genome reduction in symbiotic bacteria
McCutcheon, J. P., & Moran, N. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2670 · Cited by 1,464
The BDGP Gene Disruption Project
Bellen, H. J., Levis, R. W., Liao, G., He, Y., Carlson, J. W., Tsang, G., Evans-Holm, M., Hiesinger, P. R., Schulze, K. L., Rubin, G. M., et al. (2004) · Genetics · doi:10.1534/genetics.104.026427 · Cited by 873
Comparative genomics, minimal gene-sets and the last universal common ancestor
Koonin, E. V. (2003) · Nature Reviews Microbiology · doi:10.1038/nrmicro751 · Cited by 661
Determination of the Core of a Minimal Bacterial Gene Set
Gil, R., Silva, F. J., Peretó, J., & Moya, A. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.3.518-537.2004 · Cited by 573
Metadata
- Authors
- Akerley, B. J., Rubin, E. J., Novick, V. L., Amaya, K., Judson, N., & Mekalanos, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-01-22
- Volume
- 99
- Issue
- 2
- Pages
- 966-971
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1974299093
- Cited by
- 358
- References
- 1
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Akerley, B. J., Rubin, E. J., Novick, V. L., Amaya, K., Judson, N., & Mekalanos, J. J. (2002). A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.012602299
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