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Crystal structure of saposin B reveals a dimeric shell for lipid binding
Open accessAbstract
Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from membranes, forming soluble protein-lipid complexes that are recognized by arylsulfatase A. The crystal structure of human saposin B reveals an unusual shell-like dimer consisting of a monolayer of α-helices enclosing a large hydrophobic cavity. Although the secondary structure of saposin B is similar to that of the known monomeric members of the saposin-like superfamily, the helices are repacked into a different tertiary arrangement to form the homodimer. A comparison of the two forms of the saposin B dimer suggests that extraction of target lipids from membranes involves a conformational change that facilitates access to the inner cavity.
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Citations
Cited by
Kolter, T., & Sandhoff, K. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120013 · Cited by 464
Sphingolipid metabolism diseases
Kolter, T., & Sandhoff, K. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.05.027 · Cited by 367
A saposin-lipoprotein nanoparticle system for membrane proteins
Frauenfeld, J., Löving, R., Armache, J.-P., Sonnen, A. F.-P., Guettou, F., Moberg, P., Zhu, L., Jegerschöld, C., Flayhan, A., Briggs, J. A. G., et al. (2016) · Nature Methods · doi:10.1038/nmeth.3801 · Cited by 293
Lysosomal degradation of membrane lipids
Kolter, T., & Sandhoff, K. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.10.021 · Cited by 275
Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone
Liu, B., Yang, Y., Qiu, Z., Staron, M., Hong, F., Li, Y., Wu, S., Li, Y., Hao, B., Bona, R., et al. (2010) · Nature Communications · doi:10.1038/ncomms1070 · Cited by 186
Metadata
- Authors
- Ahn, V. E., Faull, K. F., Whitelegge, J. P., Fluharty, A. L., & Privé, G. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-12-23
- Volume
- 100
- Issue
- 1
- Pages
- 38-43
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2041844634
- Cited by
- 182
- References
- 0
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Ahn, V. E., Faull, K. F., Whitelegge, J. P., Fluharty, A. L., & Privé, G. G. (2003). Crystal structure of saposin B reveals a dimeric shell for lipid binding. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0136947100
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