The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Lysosomal degradation of membrane lipids
Open accessAbstract
The constitutive degradation of membrane components takes place in the acidic compartments of a cell, the endosomes and lysosomes. Sites of lipid degradation are intralysosomal membranes that are formed in endosomes, where the lipid composition is adjusted for degradation. Cholesterol is sorted out of the inner membranes, their content in bis(monoacylglycero)phosphate increases, and, most likely, sphingomyelin is degraded to ceramide. Together with endosomal and lysosomal lipid‐binding proteins, the Niemann–Pick disease, type C2‐protein, the GM2‐activator, and the saposins sap‐A, ‐B, ‐C, and ‐D, a suitable membrane lipid composition is required for degradation of complex lipids by hydrolytic enzymes.
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Cited by
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Lipid sorting and multivesicular endosome biogenesis
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Ceramide synthases: Reflections on the impact of Dr. Lina M. Obeid
Kim, J. L., Mestre, B., Shin, S.-H., & Futerman, A. H. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109958 · Cited by 25
Metadata
- Authors
- Kolter, T., & Sandhoff, K.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-10-15
- Volume
- 584
- Issue
- 9
- Pages
- 1700-1712
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1984579655
- Cited by
- 275
- References
- 13
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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