The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gram-positive bacteria are a major reservoir of Class 1 antibiotic resistance integrons in poultry litter
Open accessAbstract
Reversing the spread of antibiotic multiresistant bacteria is hampered by ignorance of the natural history of resistance genes, the mobile elements carrying them, and the bacterial hosts harboring them. Using traditional cultivation and cultivation-independent molecular techniques, we quantified antibiotic resistance genes and mobile elements called integrons in poultry house litter from commercial poultry farms. Unexpectedly, the major reservoir for Class 1 integrons in poultry litter is not their previously identified hosts, Gram-negative Enterobacteriaceae such as Escherichia coli . Rather, integrons and associated resistance genes abound in several genera of Gram-positive bacteria that constitute >85% of the litter community compared with Enterobacteriaceae that comprise <2% of this ecosystem. This finding warrants reexamination of our assumptions about the persistence and spread of antibiotic resistance genes.
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Citations
Cites
Detection of a Streptomycin/Spectinomycin Adenylyltransferase Gene ( aadA ) in Enterococcus faecalis
Clark, N. C., Olsvik, Ø., Swenson, J. M., Spiegel, C. A., & Tenover, F. C. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.1.157 · Cited by 202
Cited by
Origins and evolution of antibiotic resistance
Davies, J., & Davies, D. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-10 · Cited by 5,784
Mobile Genetic Elements Associated with Antimicrobial Resistance
Partridge, S. R., Kwong, S. M., Firth, N., & Jensen, S. O. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00088-17 · Cited by 2,751
Rizzo, L., Manaia, C., Merlin, C., Schwartz, T., Dagot, C., Ploy, M. C., Michael, I., & Fatta-Kassinos, D. (2013) · Science of The Total Environment · doi:10.1016/j.scitotenv.2013.01.032 · Cited by 2,493
Cabello, F. C. (2006) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01054.x · Cited by 2,329
Environmental pollution by antibiotics and by antibiotic resistance determinants
Martinez, J. L. (2009) · Environmental Pollution · doi:10.1016/j.envpol.2009.05.051 · Cited by 1,912
Metadata
- Authors
- Nandi, S., Maurer, J. J., Hofacre, C., & Summers, A. O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-04-23
- Volume
- 101
- Issue
- 18
- Pages
- 7118-7122
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1988740874
- Cited by
- 300
- References
- 1
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Nandi, S., Maurer, J. J., Hofacre, C., & Summers, A. O. (2004). Gram-positive bacteria are a major reservoir of Class 1 antibiotic resistance integrons in poultry litter. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0306466101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
