The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated I h channels
Open accessAbstract
The hyperpolarization-activated cation current ( I h ) plays an important role in determining membrane potential and firing characteristics of neurons and therefore is a potential target for regulation of intrinsic excitability. Here we show that an increase in AMPA-receptor-dependent synaptic activity induced by α-latrotoxin or glutamate application as well as direct depolarization results in an increase in I h recorded from cell-attached patches in hippocampal CA1 pyramidal neurons. This mechanism requires Ca 2+ influx but not increased levels of cAMP. Artificially increasing I h by using a dynamic clamp during whole-cell current clamp recordings results in reduced firing rates in response to depolarizing current injections. We conclude that modulation of somatic I h represents a previously uncharacterized mechanism of homeostatic plasticity, allowing a neuron to control its excitability in response to changes in synaptic activity on a relatively short-term time scale.
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Cites
Graded persistent activity in entorhinal cortex neurons
Egorov, A. V., Hamam, B. N., Fransén, E., Hasselmo, M. E., & Alonso, A. A. (2002) · Nature · doi:10.1038/nature01171 · Cited by 769
Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons
Magee, J. C. (1999) · Nature Neuroscience · doi:10.1038/9158 · Cited by 617
Burrone, J., O'Byrne, M., & Murthy, V. N. (2002) · Nature · doi:10.1038/nature01242 · Cited by 487
Cited by
Tononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356
Cortical firing and sleep homeostasis
Vyazovskiy, V. V., Olcese, U., Lazimy, Y. M., Faraguna, U., Esser, S. K., Williams, J. C., Cirelli, C., & Tononi, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.024 · Cited by 740
Spatiotemporal dynamics of continuum neural fields
Bressloff, P. C. (2012) · Journal of Physics A: Mathematical and Theoretical · doi:10.1088/1751-8113/45/3/033001 · Cited by 414
Activity-dependent decrease of excitability in rat hippocampal neurons through increases in Ih
Fan, Y., Fricker, D., Brager, D. H., Chen, X., Lu, H.-C., Chitwood, R. A., & Johnston, D. (2005) · Nature Neuroscience · doi:10.1038/nn1568 · Cited by 388
Neurophysiology of HCN channels: From cellular functions to multiple regulations
He, C., Chen, F., Li, B., & Hu, Z. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.001 · Cited by 353
Metadata
- Authors
- van Welie, I., van Hooft, J. A., & Wadman, W. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-03-29
- Volume
- 101
- Issue
- 14
- Pages
- 5123-5128
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2022442596
- Cited by
- 180
- References
- 3
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- green
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- van Welie, I., van Hooft, J. A., & Wadman, W. J. (2004). Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated I h channels. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0307711101
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