Mutations arising in the wave front of an expanding population
Open accessAbstract
The ability to infer the time and place of origin of a mutation can be very useful when reconstructing the evolutionary histories of populations and species. We use forward computer simulations of population growth, migration, and mutation in an analysis of an expanding population with a wave front that advances at a constant slow rate. A pronounced founder effect can be observed among mutations arising in this wave front where extreme population bottlenecks arise and are followed by major population growth. A fraction of mutations travel with the wave front and generate mutant populations that are on average much larger than those that remain stationary. Analysis of the diffusion of these mutants makes it possible to reconstruct migratory trajectories during population expansions, thus helping us better understand observed patterns in the evolution of species such as modern humans. Examination of some historical data supports our model.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
As hunter-gatherers spread over Europe, their Neanderthal introgression levels increased because of a combination of stochastic demographic and migratory processes related to gene dilution and gene surfing, which explain the spatial gradients of Neanderthal ancestry observed in hunter-gatherers.
“According to the expansion hypothesis (19), as HGs spread over Europe, their NE introgression levels increased because of a combination of stochastic demographic and migratory processes related to gene dilution (20, 31, 39) and gene surfing (22, 23), which explain the spatial gradients of NE ancestry observed in HGs (Fig. 5).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [22]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
THE WAVE OF ADVANCE OF ADVANTAGEOUS GENES
Fisher, R. A. (1937) · Annals of Eugenics · doi:10.1111/j.1469-1809.1937.tb02153.x · Cited by 5,071 · see citing works
The History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175 · see citing works
Self-citationRANDOM DISPERSAL IN THEORETICAL POPULATIONS
Skellam, J. G. (1951) · Biometrika · doi:10.1093/biomet/38.1-2.196 · Cited by 2,498 · see citing works
History and Geography of Human Genes
Piazza, A. (1994) · Advances in forensic haemogenetics · doi:10.1007/978-3-642-78782-9_1 · Cited by 1,639 · see citing works
Natural selection shaped regional mtDNA variation in humans
Mishmar, D., Ruiz‐Pesini, E., Golik, P., Macaulay, V. A., Clark, A. G., Hosseini, S., Brandon, M., Easley, K. A., Chen, E., Brown, M. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0136972100 · Cited by 1,040 · see citing works
The Neolithic Transition and the Genetics of Populations in Europe
Ammerman, A. J., & Cavalli-Sforza, L. L. (1984) · Princeton University Press eBooks · doi:10.1515/9781400853113 · Cited by 981 · see citing works
Self-citationThe phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
Underhill, P. A., Passarino, G., Lin, A. A., Shen, P., Lahr, M. M., Foley, R., Oefner, P. J., & Cavalli-Sforza, L. L. (2001) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2001.6510043.x · Cited by 782 · see citing works
Self-citationThe genetics of human populations
Cavalli-Sforza, L. L. (1974) · Journal of Human Evolution · doi:10.1016/0047-2484(74)90135-3 · Cited by 724 · see citing works
Self-citationThe application of molecular genetic approaches to the study of human evolution
Cavalli-Sforza, L. L., & Feldman, M. W. (2003) · Nature Genetics · doi:10.1038/ng1113 · Cited by 671 · see citing works
Self-citationParkington, J. E., & Klein, R. B. (1989) · Cited by 558 · see citing works
Zhivotovsky, L. A., Rosenberg, N. A., & Feldman, M. W. (2003) · The American Journal of Human Genetics · doi:10.1086/375120 · Cited by 300 · see citing works
Vlad, M. O., Morán, F., Tsuchiya, M., Cavalli-Sforza, L. L., Oefner, P. J., & Ross, J. (2002) · Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics · doi:10.1103/physreve.65.061110 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 9
- [1]Ammerman, A. A. & Cavalli-Sforza, L. L. (1984) The Neolithic Transition and the Population Genetics of Europe (Princeton Univ. Press, Princeton).
- [2]Cavalli-Sforza, L. L. & Feldman, M. W. (2003) Nat. Genet. Supp. 33, 266–275. [DOI] [PubMed] [Google Scholar]
- [4]Underhill, P. A., Passarino, G., Lin, A. A., Shen, P., Foley, R. A., Mirazón Lahr, M., Oefner, P. J. & Cavalli-Sforza, L. L. (2001) Ann. Hum. Genet. 65, 43–62. [DOI] [PubMed] [Google Scholar]
- [5]Mishmar, D., Ruiz-Pesini, E., Golik, P., Macaulay, V., Clark, A. G., Hosseini, S., Brandon, M., Easley, K., Chen, E., Brown, M. D., et al. (2003) Proc. Natl. Acad. Sci. USA 100, 171–176. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [6]Zhivotovsky, L. A., Rosenberg, N. A. & Feldman, M. W. (2003) Am. J. Hum. Genet. 72, 1171–1186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- [7]Fisher, R. A. (1937) Ann. Eugen. 7, 355–369. [Google Scholar]
- [8]Skellam, J. (1951) Biometrika 38, 196–218. [PubMed] [Google Scholar]
- [9]Rendine, S., Piazza, A. & Cavalli-Sforza, L. L. (1986) Am. Nat. 128, 762–768. [Google Scholar]
- [13]Vlad, M. O., Moran, F., Tsuchiya, M., Cavalli-Sforza, L. L., Oefner, P. J. & Ross, J. (2002) Phys. Rev. E. 65, 061110-1–061110-17. [DOI] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Genetic Consequences of Range Expansions
Excoffier, L., Foll, M., & Petit, R. J. (2009) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev.ecolsys.39.110707.173414 · Cited by 1,350 · see citing works
Capriotti, E., Calabrese, R., & Casadio, R. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl423 · Cited by 940 · see citing works
THE HIDDEN SIDE OF INVASIONS: MASSIVE INTROGRESSION BY LOCAL GENES
Currat, M., Ruedi, M., Petit, R. J., & Excoffier, L. (2008) · Evolution · doi:10.1111/j.1558-5646.2008.00413.x · Cited by 816 · see citing works
Genetic drift at expanding frontiers promotes gene segregation
Hallatschek, O., Hersen, P., Ramanathan, S., & Nelson, D. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710150104 · Cited by 712 · see citing works
Legendre, P., & Fortin, M. (2010) · Molecular Ecology Resources · doi:10.1111/j.1755-0998.2010.02866.x · Cited by 703 · see citing works
Functional annotations improve the predictive score of human disease-related mutations in proteins
Calabrese, R., Capriotti, E., Fariselli, P., Martelli, P. L., & Casadio, R. (2009) · Human Mutation · doi:10.1002/humu.21047 · Cited by 685 · see citing works
Surfing during population expansions promotes genetic revolutions and structuration
Excoffier, L., & Ray, N. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2008.04.004 · Cited by 671 · see citing works
Distinctive Paleo-Indian Migration Routes from Beringia Marked by Two Rare mtDNA Haplogroups
Perego, U. A., Achilli, A., Angerhofer, N., Accetturo, M., Pala, M., Olivieri, A., Kashani, B. H., Ritchie, K. H., Scozzari, R., Kong, Q., et al. (2009) · Current Biology · doi:10.1016/j.cub.2008.11.058 · Cited by 665 · see citing works
Paradigm shifts in marine fisheries genetics: ugly hypotheses slain by beautiful facts
Hauser, L., & Carvalho, G. R. (2008) · Fish and Fisheries · doi:10.1111/j.1467-2979.2008.00299.x · Cited by 640 · see citing works
The Fate of Mutations Surfing on the Wave of a Range Expansion
Klopfstein, S., Currat, M., & Excoffier, L. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msj057 · Cited by 641 · see citing works
Genetic Variation and Population Structure in Native Americans
Wang, S., Lewis, C. M., Jakobsson, M., Ramachandran, S., Ray, N., Bedoya, G., Rojas, W., Parra, M. V., Molina, J. A., Gallo, C., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030185 · Cited by 632 · see citing works
The Origins of Lactase Persistence in Europe
Itan, Y., Powell, A., Beaumont, M. A., Burger, J., & Thomas, M. G. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000491 · Cited by 569 · see citing works
Evolution of lactase persistence: an example of human niche construction
Gerbault, P., Liebert, A., Itan, Y., Powell, A., Currat, M., Bürger, J., Swallow, D. M., & Thomas, M. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0268 · Cited by 528 · see citing works
Recent and ongoing selection in the human genome
Nielsen, R., Hellmann, I., Hubisz, M. J., Bustamante, C. D., & Clark, A. G. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2187 · Cited by 501 · see citing works
Use of Y Chromosome and Mitochondrial DNA Population Structure in Tracing Human Migrations
Underhill, P. A., & Kivisild, T. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130407 · Cited by 465 · see citing works
Founder takes all: density-dependent processes structure biodiversity
Waters, J. M., Fraser, C. I., & Hewitt, G. M. (2012) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2012.08.024 · Cited by 441 · see citing works
Absence of the lactase-persistence-associated allele in early Neolithic Europeans
Bürger, J., Kirchner, M., Bramanti, B., Haak, W., & Thomas, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607187104 · Cited by 447 · see citing works
What we still don't know about invasion genetics
Bock, D. G., Caseys, C., Cousens, R. D., Hahn, M. A., Heredia, S. M., Hübner, S., Turner, K. G., Whitney, K. D., & Rieseberg, L. H. (2014) · Molecular Ecology · doi:10.1111/mec.13032 · Cited by 443 · see citing works
Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities
Haak, W., Balanovsky, O. P., Sánchez, J. J., Михайлович, К. С., Владимирович, З. В., Adler, C. J., Sarkissian, C. S. I. D., Brandt, G., Schwarz, C., Nicklisch, N., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000536 · Cited by 437 · see citing works
The role of geography in human adaptation
Coop, G., Pickrell, J. K., Novembre, J., Kudaravalli, S., Li, J., Absher, D., Myers, R. M., Cavalli-Sforza, L. L., Feldman, M. W., & Pritchard, J. K. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000500 · Cited by 412 · see citing works
Self-citationThe Human Genome Diversity Project: past, present and future
Cavalli-Sforza, L. L. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1596 · Cited by 409 · see citing works
Self-citationIs There a Genetic Paradox of Biological Invasion?
Estoup, A., Ravigné, V., Hufbauer, R. A., Vitalis, R., Gautier, M., & Facon, B. (2016) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-121415-032116 · Cited by 399 · see citing works
Sengupta, S., Анатольевич, Ж. Л., King, R., Mehdi, S. Q., Edmonds, C. A., Chow, C. T., Lin, A. A., Mitra, M., Sil, S. K., Ramesh, A., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/499411 · Cited by 392 · see citing works
Self-citationGene surfing in expanding populations
Hallatschek, O., & Nelson, D. R. (2007) · Theoretical Population Biology · doi:10.1016/j.tpb.2007.08.008 · Cited by 391 · see citing works
On the accumulation of deleterious mutations during range expansions
Peischl, S., Dupanloup, I., Kirkpatrick, M., & Excoffier, L. (2013) · Molecular Ecology · doi:10.1111/mec.12524 · Cited by 304 · see citing works
Chikhi, L., Sousa, V. C., Luisi, P., Goossens, B., & Beaumont, M. (2010) · Genetics · doi:10.1534/genetics.110.118661 · Cited by 309 · see citing works
Genome scan methods against more complex models: when and how much should we trust them?
de Villemereuil, P., Frichot, É., Bazin, É., François, O., & Gaggiotti, O. E. (2014) · Molecular Ecology · doi:10.1111/mec.12705 · Cited by 306 · see citing works
Serial Founder Effects During Range Expansion: A Spatial Analog of Genetic Drift
Slatkin, M., & Excoffier, L. (2012) · Genetics · doi:10.1534/genetics.112.139022 · Cited by 301 · see citing works
Adaptive Genetic Variation on the Landscape: Methods and Cases
Schoville, S. D., Bonin, A., François, O., Lobréaux, S., Melodelima, C., & Manel, S. (2012) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-110411-160248 · Cited by 298 · see citing works
Expanding population edges: theories, traits, and trade‐offs
Chuang, A., & Peterson, C. R. (2015) · Global Change Biology · doi:10.1111/gcb.13107 · Cited by 273 · see citing works
A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe
Myres, N. M., Rootsi, S., Lin, A. A., Järve, M., King, R., Kutuev, I. A., Cabrera, V. M., Хуснутдинова, Э. К., Pshenichnov, A., Yunusbayev, B., et al. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.146 · Cited by 270 · see citing works
The influence of numbers on invasion success
Blackburn, T. M., Lockwood, J. L., & Cassey, P. (2015) · Molecular Ecology · doi:10.1111/mec.13075 · Cited by 269 · see citing works
A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus
Biek, R., Henderson, J., Waller, L. A., Rupprecht, C. E., & Real, L. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700741104 · Cited by 268 · see citing works
LIFE AT THE FRONT OF AN EXPANDING POPULATION
Hallatschek, O., & Nelson, D. R. (2009) · Evolution · doi:10.1111/j.1558-5646.2009.00809.x · Cited by 266 · see citing works
Going the distance: human population genetics in a clinal world
Handley, L. L., Manica, A., Goudet, J., & Balloux, F. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.07.002 · Cited by 229 · see citing works
Gamble, C., Davies, W., Pettitt, P., Hazelwood, L. D., & Richards, M. B. (2005) · Cambridge Archaeological Journal · doi:10.1017/s0959774305000107 · Cited by 225 · see citing works
A Predominantly Neolithic Origin for European Paternal Lineages
Balaresque, P. L., Bowden, G. R., Adams, S. M., Leung, H.-Y., King, T. E., Rosser, Z. H., Goodwin, J., Moisan, J., Richard, C., Millward, A. B., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000285 · Cited by 220 · see citing works
Deleterious Mutations Can Surf to High Densities on the Wave Front of an Expanding Population
Travis, J. M. J., Münkemüller, T., Burton, O. J., Best, A., Dytham, C., & Johst, K. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm167 · Cited by 214 · see citing works
The effect of the Neolithic expansion on European molecular diversity
Currat, M., & Excoffier, L. (2005) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2004.2999 · Cited by 210 · see citing works
The Human Genome Diversity Project: past, present and future
Cavalli-Sforza, L. L. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1579 · Cited by 209 · see citing works
Self-citationSpatial patterns of variation due to natural selection in humans
Novembre, J., & Di Rienzo, A. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2632 · Cited by 205 · see citing works
The reach of gene–culture coevolution in animals
Whitehead, H., Laland, K. N., Rendell, L. E., Thorogood, R., & Whiten, A. (2019) · Nature Communications · doi:10.1038/s41467-019-10293-y · Cited by 204 · see citing works
Rapid evolution of dispersal ability makes biological invasions faster and more variable
Ochocki, B. M., & Miller, T. E. X. (2017) · Nature Communications · doi:10.1038/ncomms14315 · Cited by 202 · see citing works
DETECTING RANGE EXPANSIONS FROM GENETIC DATA
Peter, B. M., & Slatkin, M. (2013) · Evolution · doi:10.1111/evo.12202 · Cited by 173 · see citing works
Allee effect promotes diversity in traveling waves of colonization
Roques, L., Jimmy Garnier, A., François Hamel, A., & Klein, E. K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201695109 · Cited by 189 · see citing works
A new FST‐based method to uncover local adaptation using environmental variables
de Villemereuil, P., & Gaggiotti, O. E. (2015) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12418 · Cited by 189 · see citing works
Expansion load: recessive mutations and the role of standing genetic variation
Peischl, S., & Excoffier, L. (2015) · Molecular Ecology · doi:10.1111/mec.13154 · Cited by 178 · see citing works
Hofer, T., Ray, N., Wegmann, D., & Excoffier, L. (2008) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2008.00489.x · Cited by 170 · see citing works
Renaut, S., & Rieseberg, L. H. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv106 · Cited by 167 · see citing works
Accelerating invasion rates result from the evolution of density-dependent dispersal
Travis, J. M. J., Mustin, K., Benton, T. G., & Dytham, C. (2009) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2009.03.008 · Cited by 163 · see citing works
Y-chromosomal evidence of the cultural diffusion of agriculture in southeast Europe
Battaglia, V., Fornarino, S., Al-Zahery, N., Olivieri, A., Pala, M., Myres, N. M., King, R., Rootsi, S., Marjanović, D., Primorac, D., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.249 · Cited by 156 · see citing works
Deciphering the routes of invasion of Drosophila suzukii by means of ABC random forest
Fraimout, A., Debat, V., Fellous, S., Hufbauer, R. A., Foucaud, J., Pudlo, P., Marin, J., Price, D. K., Cattel, J., Chen, X., et al. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx050 · Cited by 155 · see citing works
Principal Component Analysis under Population Genetic Models of Range Expansion and Admixture
François, O., Currat, M., Ray, N., Han, E., Excoffier, L., & Novembre, J. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq010 · Cited by 149 · see citing works
White, T. A., Perkins, S. E., Heckel, G., & Searle, J. B. (2013) · Molecular Ecology · doi:10.1111/mec.12343 · Cited by 152 · see citing works
Namouchi, A., Didelot, X., Schöck, U., Gicquel, B., & Rocha, E. P. C. (2012) · Genome Research · doi:10.1101/gr.129544.111 · Cited by 145 · see citing works
Valdiosera, C. E., Garcı́a, N., Anderung, C., Dalén, L., Crégut-Bonnoure, É., Kahlke, R., Stiller, M., Durling, M. B., Thomas, M., Arsuaga, J. L., et al. (2007) · Molecular Ecology · doi:10.1111/j.1365-294x.2007.03590.x · Cited by 148 · see citing works
Y chromosome diversity, human expansion, drift, and cultural evolution
Chiaroni, J., Underhill, P. A., & Cavalli-Sforza, L. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910803106 · Cited by 147 · see citing works
Self-citationRapid trait evolution drives increased speed and variance in experimental range expansions
Weiss‐Lehman, C., Hufbauer, R. A., & Melbourne, B. A. (2017) · Nature Communications · doi:10.1038/ncomms14303 · Cited by 133 · see citing works
Currat, M., Excoffier, L., Maddison, W. P., Otto, S. P., Ray, N., Whitlock, M. C., & Yeaman, S. (2006) · Science · doi:10.1126/science.1122712 · Cited by 133 · see citing works
Allele surfing promotes microbial adaptation from standing variation
Gralka, M., Stiewe, F., Farrell, F., Möbius, W., Waclaw, B., & Hallatschek, O. (2016) · Ecology Letters · doi:10.1111/ele.12625 · Cited by 132 · see citing works
Eco‐evolutionary dynamics of range expansion
Miller, T. E. X., Angert, A. L., Brown, C. D., Lee‐Yaw, J. A., Lewis, M. A., Lutscher, F., Marculis, N. G., Melbourne, B. A., Shaw, A. K., Szűcs, M., et al. (2020) · Ecology · doi:10.1002/ecy.3139 · Cited by 128 · see citing works
Hallatschek, O., Datta, S. S., Drescher, K., Dunkel, J., Elgeti, J., Waclaw, B., & Wingreen, N. S. (2023) · Nature Reviews Physics · doi:10.1038/s42254-023-00593-0 · Cited by 126 · see citing works
Fusco, D., Gralka, M., Kayser, J., Anderson, A. S., & Hallatschek, O. (2016) · Nature Communications · doi:10.1038/ncomms12760 · Cited by 123 · see citing works
Insights into invasive species from whole‐genome resequencing
North, H. L., McGaughran, A., & Jiggins, C. D. (2021) · Molecular Ecology · doi:10.1111/mec.15999 · Cited by 123 · see citing works
Friedlaender, J. S., Friedlaender, F. R., Hodgson, J. A., Stoltz, M., Koki, G., Horvat, G., Zhadanov, S. I., Schurr, T. G., & Merriwether, D. A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000248 · Cited by 124 · see citing works
Liebert, A., López, S., Jones, B. L., Montalva, N., Gerbault, P., Lau, W., Thomas, M., Bradman, N., Maniatis, N., & Swallow, D. M. (2017) · Human Genetics · doi:10.1007/s00439-017-1847-y · Cited by 120 · see citing works
Rapid increase in dispersal during range expansion in the invasive ladybird Harmonia axyridis
Lombaert, É., Estoup, A., Facon, B., Joubard, B., Grégoire, J., Jannin, A., Blin, A., & Guillemaud, T. (2014) · Journal of Evolutionary Biology · doi:10.1111/jeb.12316 · Cited by 118 · see citing works
Gagnaire, P., & Gaggiotti, O. E. (2016) · Current Zoology · doi:10.1093/cz/zow088 · Cited by 118 · see citing works
Acceleration of evolutionary spread by long-range dispersal
Hallatschek, O., & Fisher, D. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404663111 · Cited by 116 · see citing works
Knowles, L. L., & Alvarado‐Serrano, D. F. (2010) · Molecular Ecology · doi:10.1111/j.1365-294x.2010.04702.x · Cited by 113 · see citing works
The evolution of lactase persistence in Europe. A synthesis of archaeological and genetic evidence
Leonardi, M., Gerbault, P., Thomas, M., & Bürger, J. (2011) · International Dairy Journal · doi:10.1016/j.idairyj.2011.10.010 · Cited by 112 · see citing works
Keller, S. R., Olson, M. S., Silim, S. N., Schroeder, W. R., & Tiffin, P. (2010) · Molecular Ecology · doi:10.1111/j.1365-294x.2010.04546.x · Cited by 112 · see citing works
Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands
Arenzana‐Seisdedos, F., & Parmentier, M. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.07.007 · Cited by 111 · see citing works
Dyken, J. D. V., Müller, M. J. I., Mack, K. M. L., & Desai, M. M. (2013) · Current Biology · doi:10.1016/j.cub.2013.04.026 · Cited by 107 · see citing works
Deep Human Genealogies Reveal a Selective Advantage to Be on an Expanding Wave Front
Moreau, C., Bhérer, C., Vézina, H., Jomphe, M., Labuda, D., & Excoffier, L. (2011) · Science · doi:10.1126/science.1212880 · Cited by 107 · see citing works
The Limits of Natural Selection in a Nonequilibrium World
Brandvain, Y. J., & Wright, S. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.01.004 · Cited by 98 · see citing works
Caujapé‐Castells, J. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511844270.013 · Cited by 105 · see citing works
Klein, E. K., Lavigne, C., & Gouyon, P. (2006) · BMC Ecology · doi:10.1186/1472-6785-6-3 · Cited by 103 · see citing works
On the post-glacial spread of human commensal Arabidopsis thaliana
Lee, C., Svardal, H., Farlow, A., Expósito‐Alonso, M., Ding, W., Novikova, P. Y., Alonso‐Blanco, C., Weigel, D., & Nordborg, M. (2017) · Nature Communications · doi:10.1038/ncomms14458 · Cited by 99 · see citing works
Bieker, V. C., & Martin, M. D. (2018) · Botany Letters · doi:10.1080/23818107.2018.1458651 · Cited by 102 · see citing works
Bürger, J., Link, V., Blöcher, J., Schulz, A., Sell, C., Pochon, Z., Diekmann, Y., Žegarac, A., Hofmanová, Z., Winkelbach, L., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.033 · Cited by 103 · see citing works
Canestrelli, D., Cimmaruta, R., Costantini, V., & Nascetti, G. (2006) · Molecular Ecology · doi:10.1111/j.1365-294x.2006.03055.x · Cited by 99 · see citing works
Kumar, S., Bellis, C., Zlojutro, M., Melton, P. E., Blangero, J., & Curran, J. E. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-293 · Cited by 98 · see citing works
Front acceleration by dynamic selection in Fisher population waves
Bénichou, O., Calvez, V., Meunier, N., & Voituriez, R. (2012) · Physical Review E · doi:10.1103/physreve.86.041908 · Cited by 91 · see citing works
Genomics at the origins of agriculture, part one
Armelagos, G. J., & Harper, K. N. (2005) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.20047 · Cited by 95 · see citing works
Population genomics of human adaptation
Lachance, J., & Tishkoff, S. A. (2013) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-110512-135833 · Cited by 95 · see citing works
Du, F., Peng, X. L., Liu, J. Q., Lascoux, M., Hu, F. S., & Petit, R. J. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2011.03853.x · Cited by 94 · see citing works
The ecoimmunology of invasive species
White, T. A., & Perkins, S. E. (2012) · Functional Ecology · doi:10.1111/1365-2435.12012 · Cited by 92 · see citing works
Pierce, A. A., Zalucki, M. P., Bangura, M., Udawatta, M., Kronforst, M. R., Altizer, S., Haeger, J. F., & de Roode, J. C. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.2230 · Cited by 91 · see citing works
HIV and the CCR5-Δ32 resistance allele
de Silva, E., & Stumpf, M. P. H. (2004) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2004.09.040 · Cited by 90 · see citing works
Haplotypic Background of a Private Allele at High Frequency in the Americas
Schroeder, K. B., Jakobsson, M., Crawford, M. H., Schurr, T. G., Boca, S. M., Conrad, D. F., Tito, R. Y., Osipova, L. P., Tarskaia, L. A., Жаданов, С. И., et al. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp024 · Cited by 87 · see citing works
Causes and Consequences of Spatial Within-Host Viral Spread
Gallagher, M., Brooke, C. B., Ke, R., & Koelle, K. (2018) · Viruses · doi:10.3390/v10110627 · Cited by 86 · see citing works
Storytelling and story testing in domestication
Gerbault, P., Allaby, R. G., Boivin, N. L., Rudzinski, A., Grimaldi, I. M., Pires, J. C., Vigueira, C. C., Dobney, K. M., Gremillion, K. J., Barton, L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400425111 · Cited by 85 · see citing works
Detecting adaptive evolution based on association with ecological gradients: Orientation matters!
Frichot, É., Schoville, S. D., de Villemereuil, P., Gaggiotti, O. E., & François, O. (2015) · Heredity · doi:10.1038/hdy.2015.7 · Cited by 84 · see citing works
Colonization of the Tibetan Plateau by the homoploid hybrid pine Pinus densata
Wang, B., Mao, J., Gao, J., Zhao, W., & WANG, X. (2011) · Molecular Ecology · doi:10.1111/j.1365-294x.2011.05157.x · Cited by 84 · see citing works
Javal, M., Lombaert, É., Tsykun, T., Courtin, C., Kerdelhué, C., Prospero, S., Alain Roques, B., & Roux, G. (2019) · Molecular Ecology · doi:10.1111/mec.15030 · Cited by 83 · see citing works
Evolution in structured populations: beyond the kin versus group debate
Lion, S., Jansen, V. A. A., & Day, T. (2011) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2011.01.006 · Cited by 82 · see citing works
Spatial sorting promotes the spread of maladaptive hybridization
Lowe, W. H., Muhlfeld, C. C., & Allendorf, F. W. (2015) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2015.05.008 · Cited by 81 · see citing works
Genes, language, and culture history in the Southwest Pacific
Friedlaender, J. S. (2007) · Oxford University Press eBooks · Cited by 80 · see citing works
Paz‐Vinas, I., Quéméré, E., Chikhi, L., Loot, G., & Blanchet, S. (2013) · Molecular Ecology · doi:10.1111/mec.12321 · Cited by 79 · see citing works
- Authors
- Edmonds, C. A., Lillie, A. S., & Cavalli-Sforza, L. L.
- Affiliations
- Stanford Medicine (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-01-19
- Volume
- 101
- Issue
- 4
- Pages
- 975-979
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC327127
- OpenAlex
- W2051334294
- Cited by
- 429
- References
- 12
- Citations by year
- 2026: 6 · 2025: 24 · 2024: 13 · 2023: 19 · 2022: 17 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 38 · 2017: 21 · 2016: 29 · 2015: 22 · 2014: 22 · 2013: 24 · 2012: 27
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (28428)
- National Institute of General Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- mutation origin, founder effect, population growth, wavefronts, population bottleneck, migration, migratory trajectories, human evolution, population genetics, forward modeling
- MeSH terms
- Biological Evolution, Mutation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
