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Cited by 1,674

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

Hutvágner, György, Zamore, Phillip D.·2002·Science
DOI 10.1126/science.1073827
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Abstract

In animals, the double-stranded RNA-specific endonuclease Dicer produces two classes of functionally distinct, tiny RNAs: microRNAs (miRNAs) and small interfering RNAs (siRNAs). miRNAs regulate mRNA translation, whereas siRNAs direct RNA destruction via the RNA interference (RNAi) pathway. Here we show that, in human cell extracts, the miRNA let - 7 naturally enters the RNAi pathway, which suggests that only the degree of complementarity between a miRNA and its RNA target determines its function. Human let - 7 is a component of a previously identified, miRNA-containing ribonucleoprotein particle, which we show is an RNAi enzyme complex. Each let - 7 –containing complex directs multiple rounds of RNA cleavage, which explains the remarkable efficiency of the RNAi pathway in human cells.

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Crossref · 10.1126/science.1073827

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2 of 2 references verified0 citation errors · 0 not checkable

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  • Base-pairing interactions between a miRNA and its mRNA target allow targeting of the mRNA for degradation or repression of translation.

    “Base-pairing interactions between the miRNA and mRNA target, allow for targeting of the mRNA for degradation or repression of translation42,46.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [46]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 33

  1. 10.1038/35053110 · DOI
  2. 10.1126/science.1062039 · DOI
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  7. 10.1101/gad.927801 · DOI · Paper page
  8. 10.1101/gad.1004402 · DOI
  9. 10.1126/science.1072148 · DOI
  10. 10.1038/35005107 · DOI
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  24. 10.1073/pnas.072190799 · DOI
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  33. 10.1105/tpc.003210 · DOI

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Metadata

Authors
Hutvágner, G., & Zamore, P. D.
Affiliations
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Lazare Research Building, Room 825, 364 Plantation Street, Worcester, MA 01605, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2002-09-20
Volume
297
Issue
5589
Pages
2056-2060
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1073827
Cited by
1,674
References
2
Language
en

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