The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants
Abstract
Posttranscriptional gene silencing (PTGS) is a nucleotide sequence–specific defense mechanism that can target both cellular and viral mRNAs. Here, three types of transgene-induced PTGS and one example of virus-induced PTGS were analyzed in plants. In each case, antisense RNA complementary to the targeted mRNA was detected. These RNA molecules were of a uniform length, estimated at 25 nucleotides, and their accumulation required either transgene sense transcription or RNA virus replication. Thus, the 25-nucleotide antisense RNA is likely synthesized from an RNA template and may represent the specificity determinant of PTGS.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Cited by
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 4,892
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 3,345
Metadata
- Authors
- Hamilton, A. J., & Baulcombe, D. C.
- Venue
- Science
- Published
- 1999-10-29
- Volume
- 286
- Issue
- 5441
- Pages
- 950-952
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091070751
- Cited by
- 3,041
- References
- 1
- FWCI
- 151.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamilton, A. J., & Baulcombe, D. C. (1999). A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants. Science. https://doi.org/10.1126/science.286.5441.950
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
