The DOI matches its Crossref record.
Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk
Abstract
Interactions between separate synaptic inputs converging on the same target appear to contribute to the fine-tuning of information processing in the central nervous system. Intersynaptic crosstalk is made possible by transmitter spillover from the synaptic cleft and its diffusion over a distance to neighboring synapses. This is the case for glutamate, which inhibits γ-aminobutyric acid (GABA)ergic transmission in several brain regions through the activation of presynaptic receptors. Such heterosynaptic modulation depends on factors that influence diffusion in the extracellular space (ECS). Because glial cells represent a physical barrier to diffusion and, in addition, are essential for glutamate uptake, we investigated the physiological contribution of the astrocytic environment of neurons to glutamate-mediated intersynaptic communication in the brain. Here we show that the reduced astrocytic coverage of magnocellular neurons occurring in the supraoptic nucleus of lactating rats facilitates diffusion in the ECS, as revealed by tortuosity and volume fraction measurements. Under these conditions, glutamate spillover, monitored through metabotropic glutamate receptor-mediated depression of GABAergic transmission, is greatly enhanced. Conversely, impeding diffusion with dextran largely prevents crosstalk between glutamatergic and GABAergic afferent inputs. Astrocytes, therefore, by hindering diffusion in the ECS, regulate intersynaptic communication between neighboring synapses and, probably, overall volume transmission in the brain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Insulin upregulates LPL activity in glial cells at the same time point where the lowest Angptl4 expression is detected, suggesting Angptl4 may play a role in LPL activity in glial cells.
“Importantly, insulin upregulates LPL activity in glial cells at the same time point where the lowest Angptl4 expression was detected, suggesting that Angptl4 may play a role in LPL activity in glial cells and perhaps in the interplay known to exist between glial cells and neurons [34,35].”
From Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2015) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 31
- 10.1016/S0166-2236(96)20050-5 · DOI
- 10.1016/S0166-2236(99)01425-3 · DOI
- 10.1016/S0960-9822(00)00448-6 · DOI
- 10.1038/35006649 · DOI
- 10.1016/S0896-6273(00)81068-5 · DOI
- 10.1073/pnas.96.17.9932 · DOI
- 10.1038/75718 · DOI
- 10.1073/pnas.96.3.1118 · DOI
- 10.1023/A:1022397704922 · DOI
- 10.1016/S0166-2236(98)01261-2 · DOI · Paper page
- 10.1002/(SICI)1098-1136(199910)28:1<40::AID-GLIA5>3.0.CO;2-6 · DOI
- 10.1016/S0079-6123(01)32087-3 · DOI
- 10.1016/0306-4522(93)90002-W · DOI
- 10.1146/annurev.neuro.20.1.375 · DOI
- 10.1126/science.1059162 · DOI
- 10.1111/j.1469-7793.1999.00815.x · DOI
- 10.1113/jphysiol.1981.sp013981 · DOI
- 10.1152/jn.1998.79.3.1508 · DOI
- 10.1111/j.1365-2826.1993.tb00357.x · DOI
- 10.1152/jn.1997.78.2.912 · DOI · Paper page
- 10.1152/jn.1997.77.2.527 · DOI
- 10.1046/j.1460-9568.2003.02611.x · DOI
- 10.1038/346177a0 · DOI
- 10.1016/S0896-6273(00)80566-8 · DOI
- 10.1046/j.1460-9568.2000.00957.x · DOI
- 10.1002/(SICI)1096-9861(19961209)376:2<188::AID-CNE2>3.0.CO;2-# · DOI
- 10.1523/JNEUROSCI.18-17-06641.1998 · DOI
- 10.1113/jphysiol.1995.sp021073 · DOI
- 10.1016/S0149-7634(99)00080-9 · DOI
- Syková, E., Mazel, T., Hasenöhrl, R. U., Harvey, A. R., Simonová, Z., Mulders, W. H. A. M. & Huston, J. P. (2002) Hippocampus 12, 469-479.
- 10.1016/S0079-6123(00)25030-9 · DOI
Cited by
Sorted by citations
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393
Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory
Panatier, A., Theodosis, D. T., Mothet, J.-P., Touquet, B., Pollegioni, L., Poulain, D. A., & Oliet, S. H. R. (2006) · Cell · doi:10.1016/j.cell.2006.02.051 · Cited by 934
Self-citationDelivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies
Chauhan, V. P., Stylianopoulos, T., Boucher, Y., & Jain, R. K. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114300 · Cited by 597
Activity-dependent structural and functional plasticity of astrocyte-neuron interactions
Theodosis, D. T., Poulain, D. A., & Oliet, S. H. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00036.2007 · Cited by 531
Self-citationEmerging role for astroglial networks in information processing: from synapse to behavior
Pannasch, U., & Rouach, N. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.004 · Cited by 251
Riluzole in the Treatment of Mood and Anxiety Disorders
Pittenger, C., Coric, V., Banasr, M., Bloch, M., Krystal, J. H., & Sanacora, G. (2008) · CNS Drugs · doi:10.2165/00023210-200822090-00004 · Cited by 177
Neural circuitry for maternal oxytocin release induced by infant cries
Valtcheva, S., Issa, H. A., Bair-Marshall, C. J., Martin, K. A., Jung, K., Zhang, Y., Kwon, H.-B., & Froemke, R. C. (2023) · Nature · doi:10.1038/s41586-023-06540-4 · Cited by 115
Araya-Callís, C., Hiemke, C., Abumaria, N., & Flugge, G. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2741-x · Cited by 109
Lambe, E. K., & Aghajanian, G. K. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300944 · Cited by 75
Fleming, T. M., Scott, V., Naskar, K., Joe, N., Brown, C. H., & Stern, J. E. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.207340 · Cited by 73
de Kloet, A. D., Liu, M., Rodríguez, V., Krause, E. G., & Sumners, C. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00078.2015 · Cited by 64
Xu, Z.-Q., Zhang, W.-J., Su, D.-F., Zhang, G.-Q., & Miao, C.-Y. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-273 · Cited by 60
Vienberg, S. G., Kleinridders, A., Suzuki, R., & Kahn, C. R. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2014.11.003 · Cited by 33
Heterodimer of A2A and oxytocin receptors regulating glutamate release in adult striatal astrocytes
Amato, S., Averna, M., Guidolin, D., Pedrazzi, M., Pelassa, S., Capraro, M., Passalacqua, M., Bozzo, M., Gatta, E., Anderlini, D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042326 · Cited by 23
Metadata
- Authors
- Piet, R., Vargová, L., Syková, E., Poulain, D. A., & Oliet, S. H. R.
- Affiliations
- Institut National de la Santé et de la Recherche Médicale Unité 378, Institut François Magendie, Université Victor Segalen Bordeaux 2, 33077 Bordeaux, France; Department of Neuroscience, Second Medical Faculty, Institute of Experimental Medicine and Charles University, Videnská 1083, 142 20 Prague 4, Czech Republic; and Center for Cell Therapy and Tissue Repair, Second Medical Faculty, Charles University, V Úvalu 84, 150 18 Prague 5, Czech Republic
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-02-06
- Volume
- 101
- Issue
- 7
- Pages
- 2151-2155
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 248
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
