Riluzole in the Treatment of Mood and Anxiety Disorders
Abstract
Recent advances implicate amino acid neurotransmission in the pathophysiology and treatment of mood and anxiety disorders. Riluzole, which is approved and marketed for the treatment of amyotrophic lateral sclerosis, is thought to be neuroprotective through its modulation of glutamatergic neurotransmission. Riluzole has multiple molecular actions in vitro; the two that have been documented to occur at physiologically realistic drug concentrations and are therefore most likely to be clinically relevant are inhibition of certain voltage-gated sodium channels, which can lead to reduced neurotransmitter release, and enhanced astrocytic uptake of extracellular glutamate.Although double-blind, placebo-controlled trials are lacking, several open-label trials have suggested that riluzole, either as monotherapy or as augmentation of standard therapy, reduces symptoms of obsessive-compulsive disorder, unipolar and bipolar depression, and generalized anxiety disorder. In studies of psychiatrically ill patients conducted to date, the drug has been quite well tolerated; common adverse effects include nausea and sedation. Elevation of liver function tests is common and necessitates periodic monitoring, but has been without clinical consequence in studies conducted to date in psychiatric populations. Case reports suggest utility in other conditions, including trichotillomania and self-injurious behaviour associated with borderline personality disorder. Riluzole may hold promise for the treatment of several psychiatric conditions, possibly through its ability to modulate pathologically dysregulated glutamate levels, and merits further investigation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Riluzole, felbamate, and cyclothiazide have been shown to modulate glutamatergic activity.
“These three identified drugs, riluzole, felbamate and cyclothiazide, have been shown to modulate glutamatergic activity.30”
From Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions (2021) · cites this paper as [30]
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744 · see citing works
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · see citing works
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,068 · see citing works
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
The Synaptic Organization of the Brain
(2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195159561.001.1 · Cited by 3,550 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043 · see citing works
Rothstein, J. D., Dykes-Hoberg, M., Pardo, C. A., Bristol, L. A., Jin, L., Kuncl, R. W., Kanai, Y., Hediger, M. A., Wang, Y., Schielke, J. P., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80086-0 · Cited by 2,534 · see citing works
The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency
Kim, S. W., Dysken, M. W., Pheley, A. M., & Hoover, K. M. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90039-6 · Cited by 2,361 · see citing works
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323 · see citing works
A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis
Bensimon, G., Lacomblez, L., & Meininger, V. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300901 · Cited by 2,239 · see citing works
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055 · see citing works
Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity
SCAHILL, L., RIDDLE, M. A., McSWIGGIN-HARDIN, M., ORT, S. I., KING, R. A., GOODMAN, W. K., CICCHETTI, D., & LECKMAN, J. F. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199706000-00023 · Cited by 2,045 · see citing works
Epilepsy and Exacerbation of Brain Injury in Mice Lacking the Glutamate Transporter GLT-1
Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., et al. (1997) · Science · doi:10.1126/science.276.5319.1699 · Cited by 1,755 · see citing works
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518 · see citing works
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works
Kirk, J., & Miller, M. L. (1986) · Sage eBooks · doi:10.4135/9781412985659.n2 · Cited by 1,376 · see citing works
Borderline personality disorder
Lieb, K., Zanarini, M. C., Schmahl, C., Linehan, M. M., & Bohus, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16770-6 · Cited by 1,369 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Dose-ranging study of riluzole in amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis/Riluzole Study Group II, Lacomblez, L., Bensimon, G., Meininger, V., Leigh, P. N., & Guillet, P. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91680-3 · Cited by 1,303 · see citing works
Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis
Rothstein, J. D., Martin, L. J., & Kuncl, R. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199205283262204 · Cited by 1,180 · see citing works
McShane, R., Areosa Sastre, A., & Minakaran, N. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003154.pub5 · Cited by 1,155 · see citing works
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
Miller, R. G., Mitchell, J. D., & Moore, D. H. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001447.pub3 · Cited by 1,123 · see citing works
The Time Course of Glutamate in the Synaptic Cleft
Clements, J. D., Lester, R. A. J., Tong, G., Jahr, C. E., & Westbrook, G. L. (1992) · Science · doi:10.1126/science.1359647 · Cited by 1,089 · see citing works
A multidimensional model of obsessive-compulsive disorder
Mataix-Cols, D., do Rosario-Campos, M. C., & Leckman, J. F. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.2.228 · Cited by 1,074 · see citing works
The Toxic Effect of Sodium L-Glutamate on the Inner Layers of the Retina
Lucas, D., & Newhouse, J. P. (1957) · Archives of Ophthalmology · doi:10.1001/archopht.1957.00940010205006 · Cited by 1,069 · see citing works
Excitotoxity and the NMDA receptor
Rothman, S. M., & Olney, J. W. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90177-9 · Cited by 1,052 · see citing works
Cole, A. J., Saffen, D. W., Baraban, J. M., & Worley, P. F. (1989) · Nature · doi:10.1038/340474a0 · Cited by 1,010 · see citing works
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease
HYND, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.03.007 · Cited by 938 · see citing works
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works
Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
Arundine, M., & Tymianski, M. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00141-6 · Cited by 827 · see citing works
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
Self-citationHippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787 · see citing works
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723 · see citing works
The pharmacology and mechanism of action of riluzole
Doble, A. (1996) · Neurology · doi:10.1212/wnl.47.6_suppl_4.233s · Cited by 700 · see citing works
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death
Sapolsky, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00971-9 · Cited by 699 · see citing works
Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634 · see citing works
Control of Glutamate Clearance and Synaptic Efficacy by Glial Coverage of Neurons
Oliet, S. H. R., Piet, R., & Poulain, D. A. (2001) · Science · doi:10.1126/science.1059162 · Cited by 623 · see citing works
The Yin and Yang of NMDA receptor signalling
Hardingham, G. E., & Bading, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00040-1 · Cited by 619 · see citing works
Gliogenesis and Glial Pathology in Depression
Rajkowska, G., & Miguel-Hidalgo, J. J. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780619326 · Cited by 612 · see citing works
Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors
Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 606 · see citing works
Self-citationGlutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553 · see citing works
Self-citationIs CREB a key to neuronal survival?
Walton, M. R., & Dragunow, M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01500-3 · Cited by 520 · see citing works
Manji, H. K., Quiroz, J. A., Sporn, J., Payne, J. L., Denicoff, K. D., Gray, N. A., Zarate, C. A., & Charney, D. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00117-3 · Cited by 499 · see citing works
Glial cell abnormalities in major psychiatric disorders: the evidence and implications
Cotter, D. R., Pariante, C. M., & Everall, I. P. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00527-5 · Cited by 465 · see citing works
Roles of Nuclear Factor κB in Neuronal Survival and Plasticity
Mattson, M. P., Culmsee, C., Yu, Z., & Camandola, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740443.x · Cited by 449 · see citing works
Transporters for L‐glutamate: An update on their molecular pharmacology and pathological involvement
Beart, P., & O'Shea, R. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706949 · Cited by 419 · see citing works
Moran, M., McFarland, K., Meléndez, R. I., Kalivas, P. W., & Seamans, J. K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1007-05.2005 · Cited by 412 · see citing works
Axis I comorbidity in body dysmorphic disorder
Gunstad, J., & Phillips, K. A. (2003) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(03)00088-9 · Cited by 407 · see citing works
Sung, B., Lim, G., & Mao, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02899.2003 · Cited by 398 · see citing works
Riluzole inhibits the persistent sodium current in mammalian CNS neurons
Urbani, A., & Belluzzi, O. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00242.x · Cited by 381 · see citing works
Heninger, G. R., Delgado, P. L., & Charney, D. S. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979535 · Cited by 381 · see citing works
Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder
Arnold, P. D., Sicard, T., Burroughs, E., Richter, M. A., & Kennedy, J. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.769 · Cited by 357 · see citing works
Glutamatergic Dysfunction in OCD
Chakrabarty, K., Bhattacharyya, S., Christopher, R., & Khanna, S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300733 · Cited by 344 · see citing works
Chronic Unpredictable Stress Decreases Cell Proliferation in the Cerebral Cortex of the Adult Rat
Banasr, M., Valentine, G. W., Li, X., Gourley, S. L., Taylor, J. R., & Duman, R. S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.006 · Cited by 341 · see citing works
Self-citationExtracellular Glutamate Concentration in Hippocampal Slice
Herman, M. A., & Jahr, C. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3009-07.2007 · Cited by 331 · see citing works
An Open-Label Trial of Riluzole in Patients With Treatment-Resistant Major Depression
Zarate, C. A., Payne, J. L., Quiroz, J. A., Sporn, J., Denicoff, K. K., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.171 · Cited by 324 · see citing works
Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: An open-label trial
Coric, V., Taskiran, S., Pittenger, C., Wasylink, S., Mathalon, D. H., Valentine, G., Saksa, J., Wu, Y.-T., Gueorguieva, R., Sanacora, G., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.043 · Cited by 314 · see citing works
Antidepressant‐induced mania: an overview of current controversies
Goldberg, J. F., & Truman, C. J. (2003) · Bipolar Disorders · doi:10.1046/j.1399-5618.2003.00067.x · Cited by 310 · see citing works
Abnormal glutamate metabolism in amyotrophic lateral sclerosis
Plaitakis, A., & Caroscio, J. T. (1987) · Annals of Neurology · doi:10.1002/ana.410220503 · Cited by 306 · see citing works
Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin
Jabaudon, D., Shimamoto, K., Yasuda‐Kamatani, Y., Scanziani, M., Gähwiler, B. H., & Gerber, U. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8733 · Cited by 305 · see citing works
Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex
Genoud, C., Quairiaux, C., Steiner, P., Hirling, H., Welker, E., & Knott, G. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040343 · Cited by 304 · see citing works
Bhagwagar, Z., Wylezinska, M., Jezzard, P., Evans, J., Ashworth, F., Sule, A., Matthews, P. M., & Cowen, P. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.048 · Cited by 304 · see citing works
Zhang, S.-J., Steijaert, M. N., Lau, D., Schütz, G., Delucinge-Vivier, C., Descombes, P., & Bading, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.025 · Cited by 304 · see citing works
Bergles, D. E., & Jahr, C. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07709.1998 · Cited by 298 · see citing works
Beyond Monoamines: Glutamatergic Function in Mood Disorders
Kugaya, A., & Sanacora, G. (2005) · CNS Spectrums · doi:10.1017/s1092852900010403 · Cited by 291 · see citing works
Self-citationSystematic Review: Pharmacological and Behavioral Treatment for Trichotillomania
Bloch, M. H., Landeros-Weisenberger, A., Dombrowski, P., Kelmendi, B., Wegner, R., Nudel, J., Pittenger, C., Leckman, J. F., & Coric, V. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.019 · Cited by 280 · see citing works
Self-citationDickel, D. E., Veenstra-VanderWeele, J., Cox, N. J., Wu, X., Fischer, D. J., Van Etten-Lee, M., Himle, J. A., Leventhal, B. L., Cook, E. H., & Hanna, G. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.778 · Cited by 274 · see citing works
Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk
Piet, R., Vargová, L., Syková, E., Poulain, D. A., & Oliet, S. H. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308408100 · Cited by 272 · see citing works
Novel Neurotransmitters and Their Neuropsychiatric Relevance
Snyder, S. H., & Ferris, C. D. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1738 · Cited by 262 · see citing works
Obsessive-compulsive-related disorders
Hollander, E. (1993) · American Psychiatric Press eBooks · Cited by 262 · see citing works
Martin, D., Thompson, M. A., & Nadler, J. V. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90037-i · Cited by 259 · see citing works
Zarate, C. A., Quiroz, J. A., Singh, J. B., Denicoff, K. D., Jesus, G. D., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.023 · Cited by 257 · see citing works
The Neuroprotective Agent Riluzole Activates the Two P Domain K+ Channels TREK-1 and TRAAK
Duprat, F., Lesage, F., Patel, A. J., Fink, M., Romey, G., & Lazdunski, M. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26499-3 · Cited by 254 · see citing works
Yildiz-Yesiloglu, A., & Ankerst, D. P. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.012 · Cited by 253 · see citing works
Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins
Jackson, M. T., Song, W., Liu, M.-Y., Jin, L., Dykes‐Hoberg, M., Lin, C.-L., Bowers, W. J., Federoff, H. J., Sternweis, P. C., & Rothstein, J. D. (2001) · Nature · doi:10.1038/35065091 · Cited by 244 · see citing works
Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: A meta-analysis
Yildiz-Yesiloglu, A., & Ankerst, D. P. (2006) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2005.12.004 · Cited by 232 · see citing works
Acute decrease in net glutamate uptake during energy deprivation
Jabaudon, D., Scanziani, M., Gähwiler, B. H., & Gerber, U. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5610 · Cited by 232 · see citing works
Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18
Lin, C. G., Orlov, I., Ruggiero, A. M., Dykes‐Hoberg, M., Lee, A. C. H., Jackson, M. T., & Rothstein, J. D. (2001) · Nature · doi:10.1038/35065084 · Cited by 230 · see citing works
Svenningsson, P., Tzavara, E. T., Witkin, J. M., Fienberg, A. A., Nomikos, G. G., & Greengard, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052712799 · Cited by 229 · see citing works
Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre
Benoit, É., & Escande, D. (1991) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00370302 · Cited by 225 · see citing works
Pittenger, C., Krystal, J. H., & Coric, V. (2006) · NeuroRx · doi:10.1016/j.nurx.2005.12.006 · Cited by 223 · see citing works
Self-citationGene expression of the transcription factor NF-κ B in hippocampus: regulation by synaptic activity
Meberg, P. J., Kinney, W. R., Valcourt, E. G., & Routtenberg, A. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00229-l · Cited by 215 · see citing works
Riluzole Enhances Glutamate Uptake in Rat Astrocyte Cultures
Frizzo, M. E., Dall’Onder, L. P., Dalcin, K. B., & Souza, D. O. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000012717.37839.07 · Cited by 213 · see citing works
Stimulation of the receptor has a trophic effect on differentiating cerebellar granule cells
Balázs, R., Hack, N., & J�rgensen, O. S. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90149-8 · Cited by 212 · see citing works
Wang, S.-J., Wang, K., & Wang, W.-C. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.01.019 · Cited by 210 · see citing works
Debono, M.-W., Guern, J. L., Canton, T., Doble, A., & Pradier, L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90147-a · Cited by 210 · see citing works
Bénavidès, J. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90196-0 · Cited by 208 · see citing works
Du, J., Suzuki, K., Wei, Y., Wang, Y., Blumenthal, R., Chen, Z., Falke, C., Zarate, C. A., & Manji, H. K. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301178 · Cited by 208 · see citing works
The NMDA Receptor as a Therapeutic Target in Major Depressive Disorder
Pittenger, C., Sanacora, G., & Krystal, J. H. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363267 · Cited by 203 · see citing works
Self-citationSanacora, G., Kendell, S. F., Levin, Y., Simen, A. A., Fenton, L. R., Coric, V., & Krystal, J. H. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.037 · Cited by 199 · see citing works
Self-citationRivière, M., Meininger, V., Zeisser, P., & Munsat, T. L. (1998) · Archives of Neurology · doi:10.1001/archneur.55.4.526 · Cited by 198 · see citing works
Grant, P., Lougee, L., Hirschtritt, M., & Swedo, S. E. (2007) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2007.0021 · Cited by 197 · see citing works
Mizoule, J., Meldrum, B. S., Mazadier, M., Croucher, M. J., Ollat, C., Uzan, A., Legrand, J., Gueremy, C., & Fur, G. L. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90011-5 · Cited by 194 · see citing works
Perego, C., Vanoni, C., Bossi, M., Massari, S., Basudev, H., Longhi, R., & Pietrini, G. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751076.x · Cited by 193 · see citing works
Katoh, R., Asano, T., Ueda, H., Morishita, R., Takeuchi, I. K., Inaguma, Y., & Kato, K. (2002) · The FASEB Journal · doi:10.1096/fj.02-0143fje · Cited by 193 · see citing works
The Massachusetts General Hospital (MGH) hairpulling scale: 2. Reliability and validity
O’Sullivan, R. L., Keuthen, N. J., Hayday, C. F., Ricciardi, J. N., Buttolph, L., Jenike, M. A., & Baer, L. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000289004 · Cited by 191 · see citing works
Mechanisms of neurodegeneration in amyotrophic lateral sclerosis: Figure 1
Cluskey, S., & Ramsden, D. B. (2001) · Molecular Pathology · doi:10.1136/mp.54.6.386 · Cited by 183 · see citing works
Association of the <i>SLC1A1</i> glutamate transporter gene and obsessive‐compulsive disorder
Stewart, S. E., Fagerness, J. A., Platko, J., Smoller, J. W., Scharf, J. M., Illmann, C., Jenike, E., Chabane, N., Leboyer, M., Delorme, R., et al. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30533 · Cited by 182 · see citing works
Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole.
Hébert, T. E., Drapeau, P., Pradier, L., & Dunn, R. J. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10187-9 · Cited by 181 · see citing works
Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis
Gurney, M. E., Fleck, T. J., Himes, C. S., & Hall, E. D. (1998) · Neurology · doi:10.1212/wnl.50.1.62 · Cited by 178 · see citing works
Differential Action of Riluzole on Tetrodotoxin-Sensitive and Tetrodotoxin-Resistant Sodium Channels
Song, J.-H., Huang, C.-S., Nagata, K., Yeh, J. Z., & Narahashi, T. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36856-9 · Cited by 176 · see citing works
Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes
Azbill, R. D., Mu, X., & Springer, J. E. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02430-6 · Cited by 175 · see citing works
Bensimon, G., Lacomblez, L., Delumeau, J.-C., Bejuit, R., Truffinet, P., & Meininger, V. (2002) · Journal of Neurology · doi:10.1007/s004150200071 · Cited by 173 · see citing works
SAMUELS, J. F., Shugart, Y. Y., Grados, M. A., Willour, V. L., Bienvenu, O. J., Greenberg, B. D., Knowles, J. A., McCracken, J. T., Rauch, S. L., Murphy, D. L., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.493 · Cited by 165 · see citing works
Malgouris, C., Bardot, F., Daniel, M., Pellis, F., Rataud, J., Uzan, A., Blanchard, J. C., & Laduron, P. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03720.1989 · Cited by 165 · see citing works
Clinical Studies Implementing Glutamate Neurotransmission in Mood Disorders
Sanacora, G., Rothman, D. L., Mason, G. F., & Krystal, J. H. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.018 · Cited by 157 · see citing works
Self-citationRiluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo
Chéramy, A., Barbeito, L., Godeheu, G., & Glowinski, J. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90597-z · Cited by 157 · see citing works
Antidepressant-Like Effects of Ceftriaxone in Male C57BL/6J Mice
Mineur, Y. S., Picciotto, M. R., & Sanacora, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.037 · Cited by 150 · see citing works
Self-citationNeuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia
Pratt, J., Rataud, J., Bardot, F., Roux, M., Blanchard, J., Laduron, P. M., & Stutzmann, J. M. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90108-j · Cited by 149 · see citing works
Heurteaux, C., Laigle, C., Blondeau, N., Jarretou, G., & Lazdunski, M. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.083 · Cited by 148 · see citing works
Mizuta, I., Ohta, M., Ohta, K., Nishimura, M., Mizuta, E., & Kuno, S. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02098-5 · Cited by 145 · see citing works
Metabotropic Glutamate Receptors in the Control of Mood Disorders
Witkin, J. M., Marek, G. J., Johnson, B., & Schoepp, D. D. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363302 · Cited by 140 · see citing works
Stefani, A., Spadoni, F., & Bernardi, G. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6554 · Cited by 137 · see citing works
Open-Label Trial of Riluzole in Generalized Anxiety Disorder
Mathew, S. J., Amiel, J. M., Coplan, J. D., Fitterling, H. A., Sackeïm, H. A., & Gorman, J. M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.12.2379 · Cited by 134 · see citing works
Marini, A. M., Jiang, X., Wu, X., Tian, F., Zhu, D., Okagaki, P., & Lipsky, R. H. (2004) · PubMed · Cited by 129 · see citing works
Hubert, J., Delumeau, J.-C., Glowinski, J., Prémont, J., & Doble, A. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb16203.x · Cited by 127 · see citing works
Dunlop, J., McIlvain, H. B., She, Y., & Howland, D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01688.2003 · Cited by 124 · see citing works
Huang, C., Song, J. H., Nagata, K., Yeh, J. Z., & Narahashi, T. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36931-9 · Cited by 124 · see citing works
Roles and regulation of glutamate transporters in the central nervous system
O'Shea, R. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03770.x · Cited by 121 · see citing works
Coric, V., Milanovic, S. M., Wasylink, S., Patel, P., Malison, R. T., & Krystal, J. H. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1396-z · Cited by 118 · see citing works
Self-citationSchiefer, J., Landwehrmeyer, G. B., Lüesse, H., Sprünken, A., Puls, C., Milkereit, A., Milkereit, E., & Kosinski, C. M. (2002) · Movement Disorders · doi:10.1002/mds.10229 · Cited by 117 · see citing works
Time Course of Cerebral Edema after Traumatic Brain Injury in Rats: Effects of Riluzole and Mannitol
Bareyre, F. M., Wahl, F., McIntosh, T. K., & Stutzmann, J. M. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.839 · Cited by 115 · see citing works
Zona, C., Siniscalchi, A., Mercuri, N. B., & Bernardi, G. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00604-0 · Cited by 113 · see citing works
Saxena, S. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.380 · Cited by 110 · see citing works
Selective Depression of Low–Release Probability Excitatory Synapses by Sodium Channel Blockers
Prakriya, M., & Mennerick, S. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81203-9 · Cited by 108 · see citing works
Dosage effects of riluzole in Huntington’s disease
Huntington Study Group (2003) · Neurology · doi:10.1212/01.wnl.0000096019.71649.2b · Cited by 106 · see citing works
Zarate, C. A., Quiroz, J. A., Quiroz, J. A., Manji, H. K., Payne, J. L., Kornstein, S. G., Manji, A. H. K., & MD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4204 · Cited by 104 · see citing works
Coderre, T. J., Kumar, N., Lefebvre, C. D., & Yu, J. S. C. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04304.x · Cited by 103 · see citing works
Pro-survival signalling from the NMDA receptor
Hardingham, G. E. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340936 · Cited by 100 · see citing works
Protective Effects of Riluzole on Dopamine Neurons
Storch, A., Burkhardt, K., Ludolph, A. C., & Schwarz, J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752259.x · Cited by 98 · see citing works
Ionic mechanisms in glutamate-induced astrocyte swelling: Role of K+ influx
Bender, A. S., Schousboe, A., Reichelt, W., & Norenberg, M. D. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980501)52:3 · Cited by 94 · see citing works
Monti, B., & Contestabile, A. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00189.x · Cited by 92 · see citing works
NMDA Receptors, Glial Cells, and Clinical Medicine
Lipton, S. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.026 · Cited by 92 · see citing works
Translational Control of Glial Glutamate Transporter EAAT2 Expression
Tian, G., Lai, L., Guo, H., Lin, Y., Butchbach, M. E. R., Chang, Y., & Lin, C. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609822200 · Cited by 85 · see citing works
A double-blind, placebo-controlled and longitudinal study of riluzole in early Parkinson's disease
Jankovic, J. J., & Hunter, C. (2002) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(01)00040-2 · Cited by 83 · see citing works
Effect of riluzole on focal cerebral ischemia in rats
Wahl, F., Allix, M., Plotkine, M., & Boulu, R. G. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90804-q · Cited by 83 · see citing works
Riluzole Augmentation in Treatment-Refractory Obsessive-Compulsive Disorder
Pittenger, C., Kelmendi, B., Wasylink, S., Bloch, M. H., & Coric, V. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181727548 · Cited by 82 · see citing works
Self-citationEffects of riluzole on electrically evoked neurotransmitter release
Jehle, T., Bauer, J., Blauth, E., Hummel, A., Darstein, M., Freiman, T. M., & Feuerstein, T. J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703424 · Cited by 82 · see citing works
Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat
Barnéoud, P., Mazadier, M., Miquet, J.-M., Parmentier, S., Dubédat, P., Doble, A., & Boireau, A. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00249-7 · Cited by 81 · see citing works
Neuroprotective agent riluzole potentiates postsynaptic GABAA receptor function
He, Y., Benz, A. M., Fu, T., Wang, M., Covey, D. F., Zorumski, C. F., & Mennerick, S. J. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(01)00175-7 · Cited by 81 · see citing works
Doble, A., Hubert, J., & Blanchard, J. C. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90114-m · Cited by 79 · see citing works
Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse.
Bambrick, L. L., Yarowsky, P., & Krueger, B. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9692 · Cited by 79 · see citing works
Dietrich, D., Kral, T., Clusmann, H., Friedl, M., & Schramm, J. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(01)00193-9 · Cited by 79 · see citing works
The effect of riluzole on post-traumatic spinal cord injury in the rat
Stutzmann, J. M., Pratt, J., Boraud, T., & Gross, C. E. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00003 · Cited by 78 · see citing works
Wahl, F., Renou, E., Mary, V., & Stutzmann, J. M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00144-3 · Cited by 78 · see citing works
Riluzole in Huntington's disease (HD): an open label study with one year follow up
Seppi, K., Mueller, J., Bodner, T., Brandauer, E., Benke, T., Weirich‐Schwaiger, H., Poewe, W. H., & Wenning, G. K. (2001) · Journal of Neurology · doi:10.1007/s004150170071 · Cited by 75 · see citing works
McIntosh, T. K., Smith, D. H., Voddi, M., PERRI, B. R., & Stutzmann, J. M. (1996) · Journal of Neurotrauma · doi:10.1089/neu.1996.13.767 · Cited by 72 · see citing works
Riluzole Augmentation for Treatment-Resistant Depression
Sanacora, G., Kendell, S. F., Fenton, L. R., Coric, V., & Krystal, J. H. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2132 · Cited by 71 · see citing works
Self-citationRosenberg, D. R., MacMillan, S. N., & Moore, G. J. (2001) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145701002401 · Cited by 70 · see citing works
Hippocampal N-Acetylaspartate Concentration and Response to Riluzole in Generalized Anxiety Disorder
Mathew, S. J., Price, R. B., Mao, X., Smith, E. L., Coplan, J. D., Charney, D. S., & Shungu, D. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.012 · Cited by 68 · see citing works
Obinu, M. C., Reibaud, M., Blanchard, V., Moussaoui, S. M., & Impérato, A. (2002) · Movement Disorders · doi:10.1002/mds.1272 · Cited by 65 · see citing works
Modulation of AMPA receptors in spinal motor neurons by the neuroprotective agent riluzole
Albo, F., Pieri, M., & Zona, C. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20244 · Cited by 61 · see citing works
Anti-glutamatergic effect of riluzole: Comparison with valproic acid
Kim, J.-E., Kim, D.-S., Kwak, S., Choi, H.-C., Song, H.-K., Choi, S. Y., Kwon, O.-S., Kim, Y.-I., & Kang, T. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.018 · Cited by 56 · see citing works
Clinical trials of neuroprotection for Parkinson’s disease
LeWitt, P. A. (2004) · Neurology · doi:10.1212/wnl.63.7_suppl_2.s23 · Cited by 55 · see citing works
The tolerability of riluzole in the treatment of patients with amyotrophic lateral sclerosis
Bensimon, G., & Doble, A. (2004) · Expert Opinion on Drug Safety · doi:10.1517/14740338.3.6.525 · Cited by 55 · see citing works
Wu, J., Tang, T.-S., & Борисович, Б. И. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.036 · Cited by 55 · see citing works
Balázs, R. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606777323700 · Cited by 54 · see citing works
Advances in the treatment of anxiety: Targeting glutamate
Simon, A. B., & Gorman, J. M. (2006) · NeuroRx · doi:10.1016/j.nurx.2005.12.005 · Cited by 54 · see citing works
Biology of schizophrenia and affective disease
Watson, S. J., & Meeting, M. D. (1996) · American Psychiatric Press eBooks · Cited by 53 · see citing works
The Amino Terminus of the Glial Glutamate Transporter GLT-1 Interacts with the LIM Protein Ajuba
Marie, H., Billups, D., Bedford, F. K., Dumoulin, A., Goyal, R. K., Longmore, G. D., Moss, S. J., & Attwell, D. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1066 · Cited by 52 · see citing works
Sarro, G. D., Siniscalchi, A., Ferreri, G., Gallelli, L., & Sarro, A. D. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00709-3 · Cited by 51 · see citing works
Xu, L., Enyeart, J. A., & Enyeart, J. J. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29322-8 · Cited by 51 · see citing works
Effect of Riluzole on Dyskinesia and Duration of the ON State in Parkinson Disease Patients
Braz, C. A., Borges, V., & Ferraz, H. B. (2004) · Clinical Neuropharmacology · doi:10.1097/00002826-200401000-00008 · Cited by 50 · see citing works
Chronic Riluzole Treatment Increases Glucose Metabolism in Rat Prefrontal Cortex and Hippocampus
Chowdhury, G. M. I., Banasr, M., de Graaf, R. A., Rothman, D. L., Behar, K. L., & Sanacora, G. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.78 · Cited by 48 · see citing works
Self-citationSasso, D. A., Kalanithi, P. S. A., Trueblood, K. V., Pittenger, C., Kelmendi, B., Wayslink, S., Malison, R. T., Krystal, J. H., & Coric, V. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000245567.29531.d6 · Cited by 47 · see citing works
Self-citationLack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions
Galer, B. S., Twilling, L., Harle, J., Cluff, R. S., Friedman, E., & Rowbotham, M. C. (2000) · Neurology · doi:10.1212/wnl.55.7.971 · Cited by 46 · see citing works
Interaction of the neuroprotective drug riluzole with GABAA and glycine receptor channels
Mohammadi, B., Krampfl, K., Moschref, H., Dengler, R., & Bufler, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00847-0 · Cited by 46 · see citing works
Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model
Bézard, E., Stutzmann, J. M., Imbert, C., Boraud, T., Boireau, A., & Gross, C. E. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00537-8 · Cited by 44 · see citing works
Pittenger, C., Krystal, J. H., & Coric, V. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1121d · Cited by 42 · see citing works
Self-citationAnticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy
Romettino, S., Lazdunski, M., & Gottesmann, C. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90503-i · Cited by 41 · see citing works
Placebo‐controlled trial of riluzole in multiple system atrophy
Seppi, K., Peralta, C., Diem‐Zangerl, A., Puschban, Z., Mueller, J., Poewe, W. H., & Wenning, G. K. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01452.x · Cited by 39 · see citing works
Inter- and intraindividual variability of riluzole serum concentrations in patients with ALS
Groeneveld, G. J., van Kan, H. J. M., Toraño, J. S., Veldink, J. H., Guchelaar, H., Wokke, J. H. J., & van den Berg, L. H. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00613-x · Cited by 38 · see citing works
Ibotenic acid stimulates d-[3H]aspartate release from cultured cerebellar granule cells
Hubert, J., & Doble, A. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90403-5 · Cited by 37 · see citing works
Acute hepatitis after riluzole administration
Remy, A., Camu, W., Ramos, J., Blanc, P., & Larrey, D. G. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80115-9 · Cited by 34 · see citing works
Inhibition of the cloned delayed rectifier K+ channels, Kv1.5 and Kv3.1, by riluzole
Ahn, H. S., Choi, J., Choi, B. H., Kim, M.-J., Rhie, D.-J., Yoon, S. H., Jo, Y.-H., Kim, M.-S., Sung, K.-W., & Hahn, S. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.041 · Cited by 31 · see citing works
Glutamate release inhibition ineffective in Levodopa‐induced motor complications
Bara‐Jimenez, W., Dimitrova, T. D., Sherzai, A., Aksu, M., & Chase, T. N. (2006) · Movement Disorders · doi:10.1002/mds.20976 · Cited by 31 · see citing works
Kainate‐induced currents in rat cortical neurons in culture are modulated by riluzole
Zona, C., Cavalcanti, S., Sarro, G. D., Siniscalchi, A., Marchetti, C., Gaetti, C., Costa, N., Mercuri, N. B., & Bernardi, G. (2002) · Synapse · doi:10.1002/syn.10040 · Cited by 30 · see citing works
Risterucci, C., Coccurello, R., Banasr, M., Stutzmann, J. M., Amalric, M., & Nieoullon, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.054 · Cited by 29 · see citing works
Self-citationCoric, V., Kelmendi, B., Pittenger, C., Wasylink, S., Bloch, M. H., & Green, J. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0123f · Cited by 29 · see citing works
Self-citationEffect of MX-68 on airway inflammation and hyperresponsiveness in mice and guinea-pigs
Nagao, K., Akabane, H., Masuda, T., Komal, M., Tanaka, H., & Nagai, H. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357022548 · Cited by 29 · see citing works
Interaction of Riluzole with the Closed Inactivated State of Kv4.3 Channels
Ahn, H. S., Kim, S. E., Jang, H., Kim, M.-J., Rhie, D., Yoon, S.-H., Jo, Y., Kim, M.-S., Sung, K.-W., & Hahn, S. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.106724 · Cited by 28 · see citing works
Rőszer, T., Jenei, Z., Gáll, T., Nagy, O., Czimmerer, Z., Serfözö, Z., Elekes, K., & Bánfalvi, G. (2003) · Brain Behavior and Evolution · doi:10.1159/000073757 · Cited by 27 · see citing works
Neuroprotective Effects of Riluzole in Neurotrauma Models: A Review
Wahl, F., & Stutzmann, J. M. (1999) · Springer eBooks · doi:10.1007/978-3-7091-6391-7_18 · Cited by 26 · see citing works
Icteric toxic hepatitis associated with riluzole
Castells, L., Gámez, J., Cervera, C., & Guàrdia, J. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78431-2 · Cited by 25 · see citing works
Laboratory Standards in the Assessment of the Quality of Care
Aanstoot, H. (1998) · Hormone Research in Paediatrics · doi:10.1159/000053106 · Cited by 23 · see citing works
Borowicz, K. K., Sekowski, A., Drelewska, E., & Czuczwar, S. J. (2004) · PubMed · Cited by 21 · see citing works
Methemoglobinemia Due to Riluzole
Viallon, A., Page, Y., & Bertrand, J. C. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008313430918 · Cited by 17 · see citing works
Treatment of bipolar depression: current status, continued challenges, and the STEP-BD approach
Thase, M. E., Bhargava, M., & Sachs, G. S. (2003) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(03)00029-7 · Cited by 15 · see citing works
Huang, C.-S., Song, J. H., Nagata, K., TWOMBLY, D. A., Yeh, J. Z., & Narahashi, T. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00491-5 · Cited by 15 · see citing works
Effects of riluzole on the evolution of focal cerebral ischemia: a magnetic resonance imaging study
Mottet, I., Demeure, R., Rataud, J., Lucas, M., Wahl, F., Warscotte, V., Thiran, J., Goudemant, J., Maldague, B. E., Maloteaux, J., et al. (1997) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/bf02594581 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Inflammation, glutamate, and glia: a trio of trouble in mood disorders
Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584 · see citing works
Self-citationThe Neurobiology of Anxiety Disorders: Brain Imaging, Genetics, and Psychoneuroendocrinology
Martin, E. I., Ressler, K. J., Binder, E. B., & Nemeroff, C. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.05.004 · Cited by 132 · see citing works
Banasr, M., Chowdhury, G. M. I., Terwilliger, R., Newton, S. S., Duman, R. S., Behar, K. L., & Sanacora, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.106 · Cited by 458 · see citing works
Self-citationVoltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders
Mantegazza, M., Curia, G., Biagini, G., Ragsdale, D. S., & Avoli, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70059-4 · Cited by 457 · see citing works
Levey, D. F., Stein, M. B., Wendt, F. R., Pathak, G. A., Zhou, H., Aslan, M., Quaden, R., Harrington, K. M., Nuñez, Y. Z., Overstreet, C., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00860-2 · Cited by 422 · see citing works
Self-citationPittenger, C., Bloch, M. H., & Williams, K. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.006 · Cited by 426 · see citing works
Self-citationBellingham, M. C. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00116.x · Cited by 388 · see citing works
Neurological perspectives on voltage-gated sodium channels
Eijkelkamp, N., Linley, J. E., Baker, M. D., Minett, M. S., Cregg, R., Werdehausen, R., Rugiero, F., & Wood, J. (2012) · Brain · doi:10.1093/brain/aws225 · Cited by 359 · see citing works
Mathew, S. J., Murrough, J. W., Rot, M. A. H., Collins, K. A., Reich, D. L., & Charney, D. S. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000169 · Cited by 296 · see citing works
Duncan, W. C., Sarasso, S., Ferrarelli, F., Selter, J., Riedner, B. A., Hejazi, N. S., Yuan, P., Brutsche, N., Manji, H. K., Tononi, G., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000545 · Cited by 256 · see citing works
An astroglial basis of major depressive disorder? An overview
Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222 · see citing works
Sanacora, G., & Banasr, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.032 · Cited by 239 · see citing works
Self-citationPharmacological Treatment of Obsessive-Compulsive Disorder
Pittenger, C., & Bloch, M. H. (2014) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2014.05.006 · Cited by 222 · see citing works
Self-citationRomano, S., Coarelli, G., Marcotulli, C., Leonardi, L., Piccolo, F., Spadaro, M., Frontali, M., Ferraldeschi, M., Vulpiani, M. C., Ponzelli, F., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00201-x · Cited by 212 · see citing works
Grant, P., Lougee, L., Hirschtritt, M., & Swedo, S. E. (2007) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2007.0021 · Cited by 197 · see citing works
Ristori, G., Romano, S., Visconti, A., Cannoni, S., Spadaro, M., Frontali, M., Pontieri, F. E., Vanacore, N., & Salvetti, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d31e23 · Cited by 193 · see citing works
Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies
Averill, L. A., Purohit, P., Averill, C. L., Boesl, M. A., Krystal, J. H., & Abdallah, C. G. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.064 · Cited by 184 · see citing works
Self-citationPharmacological treatment of anxiety disorders: Current treatments and future directions
Farach, F. J., Pruitt, L. D., Jun, J. J., Jerud, A. B., Zoellner, L. A., & Roy‐Byrne, P. (2012) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2012.07.009 · Cited by 183 · see citing works
Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists
Krystal, J. H., Mathew, S. J., DʼSouza, D. C., Garakani, A., Gunduz-Bruce, H., & Charney, D. S. (2010) · CNS Drugs · doi:10.2165/11533230-000000000-00000 · Cited by 180 · see citing works
Self-citationNew perspectives in glutamate and anxiety
Riaza Bermudo-Soriano, C., Perez-Rodriguez, M. M., Vaquero-Lorenzo, C., & Baca-Garcia, E. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.010 · Cited by 207 · see citing works
Recent Advances in the Chemistry and Biology of Benzothiazoles
Gill, R. K., Rawal, R. K., & Bariwal, J. B. (2015) · Archiv der Pharmazie · doi:10.1002/ardp.201400340 · Cited by 176 · see citing works
Wilkinson, S. T., & Sanacora, G. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2018.11.007 · Cited by 173 · see citing works
Self-citationThe neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology.
Martin, E. I., Ressler, K., Binder, E., & Nemeroff, C. (2010) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2010.07.006 · Cited by 494 · see citing works
The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development
Blasco, H., Mavel, S., Corcia, P., & Gordon, P. H. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140916120118 · Cited by 165 · see citing works
Vallée, A., & Lecarpentier, Y. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00459 · Cited by 144 · see citing works
Ketamine as a new treatment for depression: A review of its efficacy and adverse effects
Katalinic, N., Lai, R., Somogyi, A. A., Mitchell, P. B., Glue, P., & Loo, C. K. A. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413486842 · Cited by 129 · see citing works
Antidepressants act directly on astrocytes: Evidences and functional consequences
Czéh, B., & Benedetto, B. D. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.04.017 · Cited by 129 · see citing works
Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder
Ting, J. T., & Feng, G. (2008) · Current Chemical Genomics · doi:10.2174/1875397300802010062 · Cited by 124 · see citing works
Pharmacotherapy of obsessive–compulsive disorder: evidence-based treatment and beyond
Fineberg, N. A., Reghunandanan, S., Brown, A., & Pampaloni, I. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412461958 · Cited by 122 · see citing works
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
Gourley, S. L., Swanson, A. M., Jacobs, A. M., Howell, J. L., Mo, M., Dileone, R., Koleske, A. J., & Taylor, J. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208342109 · Cited by 118 · see citing works
Uezato, A., Meador‐Woodruff, J. H., & McCullumsmith, R. E. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00752.x · Cited by 106 · see citing works
Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission
Montanari, M., Martella, G., Bonsi, P., & Meringolo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073861 · Cited by 105 · see citing works
Roles of glutamate signaling in preclinical and/or mechanistic models of depression
Tokita, K., Yamaji, T., & Hashimoto, K. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.016 · Cited by 103 · see citing works
CO-OCCURRENCE OF ANXIETY AND BIPOLAR DISORDERS: CLINICAL AND THERAPEUTIC OVERVIEW
Vázquez, G. H., Baldessarini, R. J., & Tondo, L. (2014) · Depression and Anxiety · doi:10.1002/da.22248 · Cited by 93 · see citing works
An update on the role of glutamate in the pathophysiology of depression
Mitchell, N. D., & Baker, G. B. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01529.x · Cited by 91 · see citing works
Targeting glial physiology and glutamate cycling in the treatment of depression
Valentine, G. W., & Sanacora, G. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.008 · Cited by 87 · see citing works
Self-citationNasir, M., Trujillo, D., Levine, J. L. S., Dwyer, J. B., Rupp, Z. W., & Bloch, M. H. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.548505 · Cited by 89 · see citing works
Self-citationHunsberger, H. C., Weitzner, D. S., Rudy, C. C., Hickman, J. E., Libell, E. M., Speer, R. R., Gerhardt, G. A., & Reed, M. N. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13230 · Cited by 87 · see citing works
Gosselin, R., O’Connor, R. M., Tramullas, M., Julio‐Pieper, M., Dinan, T. G., & Cryan, J. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.003 · Cited by 87 · see citing works
Grant, P., Song, J. Y., & Swedo, S. E. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2010.0009 · Cited by 84 · see citing works
Hughes, Z. A., Neal, S. J., Smith, D. L., Rizzo, S. J. S., Pulicicchio, C. M., Lotarski, S. M., Lu, S.-P., Dwyer, J. M., Brennan, J. A., Olsen, M. A., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.007 · Cited by 85 · see citing works
Gourley, S. L., Espitia, J. W., Sanacora, G., & Taylor, J. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2403-4 · Cited by 85 · see citing works
Self-citationThe PSD-95/nNOS complex: New drugs for depression?
Doucet, M. V., Harkin, A., & Dev, K. K. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.005 · Cited by 82 · see citing works
Pittenger, C., Bloch, M. H., Wasylink, S., Billingslea, E., Simpson, R., Jakubovski, E., Kelmendi, B., Sanacora, G., & Coric, V. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09123 · Cited by 80 · see citing works
Poupon-Bejuit, L., Lamoine, S., Pereira, V., Barrière, D. A., Lolignier, S., Giraudet, F., Aissouni, Y., Méleine, M., Prival, L., Richard, D., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.026 · Cited by 76 · see citing works
How Oxidative Stress Induces Depression?
Ji, N., Lei, M., Chen, Y., Tian, S., Li, C., & Zhang, B. (2023) · ASN NEURO · doi:10.1177/17590914231181037 · Cited by 82 · see citing works
Drug therapy for pain in amyotrophic lateral sclerosis or motor neuron disease
Brettschneider, J., Kurent, J. E., & Ludolph, A. C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005226.pub3 · Cited by 66 · see citing works
Chemical-Genetic Screen Identifies Riluzole as an Enhancer of Wnt/β-catenin Signaling in Melanoma
Biechele, T. L., Camp, N. D., Fass, D. M., Kulikauskas, R. M., Robin, N. C., White, B. D., Taraska, C. M., Moore, E. C., Muster, J., Karmacharya, R., et al. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.08.012 · Cited by 66 · see citing works
Abdallah, C. G., Coplan, J. D., Jackowski, A. P., Sato, J. R., Mao, X., Shungu, D. C., & Mathew, S. J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.009 · Cited by 66 · see citing works
Anand, A., Gunn, A. D., Barkay, G., Karne, H. S., Nürnberger, J. I., Mathew, S. J., & Ghosh, S. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00971.x · Cited by 66 · see citing works
Verma, S. K., Arora, I., Javed, K., Akhtar, M., & Samim, M. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01776 · Cited by 63 · see citing works
Lecarpentier, Y., & Vallée, A. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00100 · Cited by 60 · see citing works
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue
Elsayed, M., & Magistretti, P. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00468 · Cited by 59 · see citing works
Trujillo, K. A., Smith, M. L., Sullivan, B., Heller, C. Y., Garcia, C., & Bates, M. L. S. (2011) · ILAR Journal · doi:10.1093/ilar.52.3.366 · Cited by 59 · see citing works
Update on GPCR-based targets for the development of novel antidepressants
Mantas, I., Saarinen, M., Xu, Q., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01040-1 · Cited by 59 · see citing works
Glutamatergic agents for OCD and related disorders
Pittenger, C. (2015) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-015-0051-8 · Cited by 62 · see citing works
Self-citationEmamzadehfard, S., Kamaloo, A., Paydary, K., Ahmadipour, A., Zeinoddini, A., Ghaleiha, A., Mohammadinejad, P., Zeinoddini, A., & Akhondzadeh, S. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12394 · Cited by 55 · see citing works
Salardini, E., Zeinoddini, A., Mohammadinejad, P., Ardakani, M. R. K., Zahraei, N., Zeinoddini, A., & Akhondzadeh, S. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.01.003 · Cited by 53 · see citing works
Targeting the Modulation of Neural Circuitry for the Treatment of Anxiety Disorders
Farb, D. H., & Ratner, M. H. (2014) · Pharmacological Reviews · doi:10.1124/pr.114.009126 · Cited by 55 · see citing works
Riluzole: a therapeutic strategy in Alzheimer’s disease by targeting the WNT/β-catenin pathway
Vallée, A., Vallée, J.-N., Guillevin, R., & Lecarpentier, Y. (2020) · Aging · doi:10.18632/aging.102830 · Cited by 50 · see citing works
Pharmacotherapeutic Strategies and New Targets in OCD
Pittenger, C. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_204 · Cited by 51 · see citing works
Self-citationRiluzole activates TRPC5 channels independently of PLC activity
Richter, J. M., Schaefer, M., & Hill, K. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12436 · Cited by 50 · see citing works
Chronic Riluzole Treatment Increases Glucose Metabolism in Rat Prefrontal Cortex and Hippocampus
Chowdhury, G. M. I., Banasr, M., de Graaf, R. A., Rothman, D. L., Behar, K. L., & Sanacora, G. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.78 · Cited by 48 · see citing works
Self-citationKarpinski, M., Mattina, G. F., & Steiner, M. S. (2016) · Neuroendocrinology · doi:10.1159/000453664 · Cited by 47 · see citing works
Mokhtari, Z., Baluchnejadmojarad, T., Nikbakht, F., Mansouri, M., & Roghani, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.067 · Cited by 48 · see citing works
Mathew, S. J., Gueorguieva, R. V., Brandt, C., D, M. F. M., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.106 · Cited by 47 · see citing works
Self-citationSepulveda-Orengo, M. T., Healey, K. L., Kim, R., Auriemma, A. C., Rojas, J. M., Woronoff, N., Hyppolite, R., & Reissner, K. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.244 · Cited by 45 · see citing works
Wachtel, L. E., Griffin, M., & Reti, I. M. (2010) · Journal of Ect · doi:10.1097/yct.0b013e3181a744ec · Cited by 45 · see citing works
Femenía, T., Magara, S., DuPont, C. M., & Lindskog, M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv032 · Cited by 43 · see citing works
Zwanzger, P., Zavorotnyy, M., Gencheva, E., Diemer, J., Kugel, H., Heindel, W. L., Ruland, T., Ohrmann, P., Arolt, V., Domschke, K., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.61 · Cited by 41 · see citing works
Lemmon, M. E., Grados, M. A., Kline, T., Thompson, C. B., Ali, S. F., & Singer, H. S. (2015) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2015.02.002 · Cited by 41 · see citing works
Lesuis, S. L., Kaplick, P. M., Lucassen, P. J., & Krugers, H. J. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.023 · Cited by 40 · see citing works
Obsessive-compulsive disorder and related disorders: a comprehensive survey
Fornaro, M., Gabrielli, F., Albano, C., Fornaro, S., Rizzato, S., Mattei, C., Solano, P., Vinciguerra, V., & Fornaro, P. (2009) · Annals of General Psychiatry · doi:10.1186/1744-859x-8-13 · Cited by 41 · see citing works
Rodrigues, N., Bennis, K., Vivier, D., Pereira, V., Chatelain, F. C., Chapuy, E., Deokar, H. S., Busserolles, J., Lesage, F., Eschalier, A., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.01.049 · Cited by 39 · see citing works
Sugiyama, A., Saitoh, A., Iwai, T., Takahashi, K., Yamada, M., Sasaki-Hamada, S., Oka, J.-I., Inagaki, M., & Yamada, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.012 · Cited by 38 · see citing works
de Boer, J. N., Vingerhoets, C., Hirdes, M., McAlonan, G. M., Amelsvoort, T. V., & Zinkstok, J. R. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.06.020 · Cited by 38 · see citing works
Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology
Data-Franco, J., Singh, A., Popovic, D., Ashton, M., Berk, M., Vieta, E., Figueira, M. L., & Dean, O. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.004 · Cited by 38 · see citing works
Glutamate Modulators in the Treatment of Obsessive-Compulsive Disorder
Pittenger, C. (2015) · Psychiatric Annals · doi:10.3928/00485713-20150602-06 · Cited by 40 · see citing works
Self-citationSullivan, K. G., & Levin, M. G. (2016) · Journal of Anatomy · doi:10.1111/joa.12467 · Cited by 34 · see citing works
Araminia, B., Shalbafan, M., Mortezaei, A., Shirazi, E., Ghaffari, S., Sahebolzamani, E., Mortazavi, S. H., Shariati, B., Ardebili, M. E., Aqamolaei, A., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.020 · Cited by 32 · see citing works
Riluzole increases glutamate uptake by cultured C6 astroglial cells
Dall'Igna, O. P. P., Bobermin, L. D., Souza, D. O., & Quincozes‐Santos, A. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.06.002 · Cited by 31 · see citing works
Strzelecki, D., Tabaszewska, A., Barszcz, Z., Józefowicz, O., Kropiwnicki, P., & Rabe‐Jabłońska, J. (2013) · Psychiatry Investigation · doi:10.4306/pi.2013.10.4.421 · Cited by 29 · see citing works
Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator
Joseph, A., Thủy, T. T. T., Thanh, L. T., & Okada, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201092 · Cited by 29 · see citing works
van Weperen, V. Y. H., Vos, M. A., & Ajijola, O. A. (2021) · Clinical Autonomic Research · doi:10.1007/s10286-021-00823-4 · Cited by 28 · see citing works
Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells
Sperling, S., Aung, T., Martin, S., Rohde, V., & Ninković, M. (2017) · Oncotarget · doi:10.18632/oncotarget.18043 · Cited by 28 · see citing works
Pain and the Brain: Diabetic Neuropathic Pain
Jain, R. K. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.0808e22 · Cited by 27 · see citing works
The Pharmacological Treatment of Obsessive-Compulsive Disorder
Pittenger, C. (2023) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2022.11.005 · Cited by 25 · see citing works
Self-citationMor, S., Mohil, R., Nagoria, S., Kumar, A., Lal, K., Kumar, D., & Singh, V. (2016) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.2710 · Cited by 24 · see citing works
Design, Synthesis and Biological Activities of (Thio)Urea Benzothiazole Derivatives
Mendieta‐Wejebe, J. E., Rosales‐Hernández, M. C., Martínez, I. I. P., Garcı́a-Báez, E. V., & Cruz, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119488 · Cited by 23 · see citing works
Ortí, J. E. D. L. R., Cuerda‐Ballester, M., Sanchis-Sanchis, C. E., Lajara-Romance, J. M., Navarro-Illana, E., & García-Pardo, M. P. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1227431 · Cited by 24 · see citing works
Theiss, R., Hornby, T. G., Rymer, W. Z., & Schmit, B. D. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00570.2010 · Cited by 23 · see citing works
Longer-term open-label study of adjunctive riluzole in treatment-resistant depression
Sakurai, H., Dording, C., Yeung, A., Foster, S., Jain, F., Chang, T., Trinh, N.-H., Bernard, R., Boyden, S., Iqbal, S. Z., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.065 · Cited by 20 · see citing works
“Its mechanism of action is thought to be inhibition of presynaptic release of glutamate via inactivation of voltage-dependent sodium channels on glutamatergic nerve terminals (Pittenger et al., 2008; Doble, 1996).”
BackgroundPhillips, R. S., & Rubin, J. E. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006938 · Cited by 22 · see citing works
Garcı́a-Báez, E. V., Martínez, I. I. P., Cach, F. T., & Cruz, A. (2021) · Molecules · doi:10.3390/molecules26216518 · Cited by 22 · see citing works
dos Santos, K. C., Borges, T. V., Olescowicz, G., Ludka, F. K., Santos, C. A. D. M., & Molz, S. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12512 · Cited by 21 · see citing works
Inflammation Effects on Glutamate as a Pathway to Neuroprogression in Mood Disorders
Haroon, E., & Miller, A. H. (2017) · Modern trends in psychiatry · doi:10.1159/000470805 · Cited by 21 · see citing works
Subramaniapillai, M., Carmona, N. E., Rong, C., & McIntyre, R. S. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.1/rmcintyre · Cited by 20 · see citing works
Okada‐Tsuchioka, M., Hisaoka, K., Yano, R., Shibasaki, C., Kajiatani, N., & Takebayashi, M. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.100 · Cited by 21 · see citing works
Teaching Students With Obsessive-Compulsive Disorder
Leininger, M., Dyches, T. T., Prater, M. A., & Heath, M. A. (2010) · Intervention in School and Clinic · doi:10.1177/1053451209353447 · Cited by 20 · see citing works
- Authors
- Pittenger, C., Coric, V., Banasr, M., Bloch, M., Krystal, J. H., & Sanacora, G.
- Affiliations
- Yale University (US)
- Corresponding author
- Pittenger, Christopher
- Venue
- CNS Drugs
- Published
- 2008
- Volume
- 22
- Issue
- 9
- Pages
- 761-786
- ISSN
- 1172-7047 (ISSN-L)
- OpenAlex
- W1967308562
- Cited by
- 177
- References
- 205
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 12 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 17 · 2015: 12 · 2014: 9 · 2013: 13 · 2012: 13
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Drugs (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (T32 MH 19961, T32MH019961)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- riluzole, mood disorders, anxiety disorders, obsessive-compulsive disorder, depression, bipolar disorder, generalized anxiety disorder, glutamatergic neurotransmission, voltage-gated sodium channel inhibition, neuroprotection, trichotillomania, self-harm, borderline personality disorder, drug tolerability, liver function monitoring
- MeSH terms
- Animals, Anxiety Disorders, Humans, Models, Biological, Nervous System Diseases, Receptors, Glutamate, Excitatory Amino Acid Antagonists, Riluzole, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
