The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of IspH (LytB) protein
Open accessAbstract
Isopentenyl diphosphate and dimethylallyl diphosphate serve as the universal precursors for the biosynthesis of terpenes. Although their biosynthesis by means of mevalonate has been studied in detail, a second biosynthetic pathway for their formation by means of 1-deoxy- d -xylulose 5-phosphate has been discovered only recently in plants and certain eubacteria. Earlier in vivo experiments with recombinant Escherichia coli strains showed that exogenous 1-deoxy- d -xylulose can be converted into 1-hydroxy-2-methyl-2-( E )-butenyl 4-diphosphate by the consecutive action of enzymes specified by the xylB and ispCDEFG genes. This article describes the transformation of exogenous [U- 13 C 5 ]1-deoxy- d -xylulose into a 5:1 mixture of [U- 13 C 5 ]isopentenyl diphosphate and [U- 13 C 5 ]dimethylallyl diphosphate by an E. coli strain engineered for the expression of the ispH (lytB) gene in addition to recombinant xylB and ispCDEFG genes.
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Muehlbacher, M., & Poulter, C. D. (1988) · Biochemistry · doi:10.1021/bi00419a021 · Cited by 95
Cited by
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Eisenreich, W., Bacher, A., Arigoni, D., & Rohdich, F. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-3381-z · Cited by 668
Self-citationUnravelling the regulatory mechanisms that modulate the MEP pathway in higher plants
Cordoba, E., Salmi, M., & Leon, P. (2009) · Journal of Experimental Botany · doi:10.1093/jxb/erp190 · Cited by 346
Kasahara, H., Hanada, A., Kuzuyama, T., Takagi, M., Kamiya, Y., & Yamaguchi, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208659200 · Cited by 285
Isoprenoid drugs, biofuels, and Chemicals–Artemisinin, farnesene, and beyond
George, K. W., Alonso-Gutierrez, J., Keasling, J. D., & Lee, T. S. (2015) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2014_288 · Cited by 185
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Wächtershäuser, G. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03267.x · Cited by 176
Metadata
- Authors
- Rohdich, F., Hecht, S., Gärtner, K., Adam, P., Krieger, C., Amslinger, S., Arigoni, D., Bacher, A., & Eisenreich, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-01-29
- Volume
- 99
- Issue
- 3
- Pages
- 1158-1163
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2069030760
- Cited by
- 338
- References
- 1
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Rohdich, F., Hecht, S., Gärtner, K., Adam, P., Krieger, C., Amslinger, S., Arigoni, D., Bacher, A., & Eisenreich, W. (2002). Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of IspH (LytB) protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.032658999
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