The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Multiple pathways process stalled replication forks
Open accessAbstract
Impairment of replication fork progression is a serious threat to living organisms and a potential source of genome instability. Studies in prokaryotes have provided evidence that inactivated replication forks can restart by the reassembly of the replication machinery. Several strategies for the processing of inactivated replication forks before replisome reassembly have been described. Most of these require the action of recombination proteins, with different proteins being implicated, depending on the cause of fork arrest. The action of recombination proteins at blocked forks is not necessarily accompanied by a strand-exchange reaction and may prevent rather than repair fork breakage. These various restart pathways may reflect different structures at stalled forks. We review here the different strategies of fork processing elicited by different kinds of replication impairments in prokaryotes and the variety of roles played by recombination proteins in these processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Unrepaired fork gaps can become frank DSB [24, 61, 62].”
From NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites (2013) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology
Neidhardt, F. C., & Ingraham, J. L. (1987) · Medical Entomology and Zoology · Cited by 4,089
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
Supercoiling of the DNA template during transcription.
Liu, L. F., & Wang, J. C. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.20.7024 · Cited by 1,877
Rupp, W. D., & Howard-flanders, P. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90445-2 · Cited by 1,093
Recombinational Repair of DNA Damage in Escherichia coli and Bacteriophage λ
Kuzminov, A. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.4.751-813.1999 · Cited by 897
Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects
Sogo, J. M., Lopes, M., & Foiani, M. (2002) · Science · doi:10.1126/science.1074023 · Cited by 824
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.060402.113540 · Cited by 793
RuvAB Acts at Arrested Replication Forks
Seigneur, M., Bidnenko, V., Ehrlich, S. D., & Michel, B. (1998) · Cell · doi:10.1016/s0092-8674(00)81772-9 · Cited by 538
Self-citationKogoma, T. (1997) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.61.2.212-238.1997 · Cited by 525
Maintenance of Genome Stability in Saccharomyces cerevisiae
Kolodner, R. D., Putnam, C. D., & Myung, K. (2002) · Science · doi:10.1126/science.1075277 · Cited by 470
PROCESSING OF RECOMBINATION INTERMEDIATES BY THE R uv ABC PROTEINS
West, S. C. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.213 · Cited by 450
A model for replication repair in mammalian cells
Higgins, N. P., Kato, K., & Strauss, B. S. (1976) · Journal of Molecular Biology · doi:10.1016/0022-2836(76)90156-x · Cited by 444
DNA double‐strand breaks caused by replication arrest
Michel, B., Ehrlich, S. D., & Uzest, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.430 · Cited by 426
Self-citationRecFOR Proteins Load RecA Protein onto Gapped DNA to Accelerate DNA Strand Exchange
Morimatsu, K., & Kowalczykowski, S. C. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00188-6 · Cited by 425
Single-strand interruptions in replicating chromosomes cause double-strand breaks
Kuzminov, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131009198 · Cited by 407
Recombinational repair and restart of damaged replication forks
McGlynn, P., & Lloyd, R. G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm951 · Cited by 397
Levine, C., Hiasa, H., & Marians, K. J. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00126-2 · Cited by 392
Collapse and repair of replication forks in Escherichia coli
Kuzminov, A. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02403.x · Cited by 363
Thymine Dimers and Inhibition of DNA Synthesis by Ultraviolet Irradiation of Cells
Setlow, R. B., Swenson, P. A., & Carrier, W. L. (1963) · Science · doi:10.1126/science.142.3598.1464 · Cited by 346
Rescue of arrested replication forks by homologous recombination
Michel, B., Flores, M. J., Viguera, E., Grompone, G., Seigneur, M., & Bidnenko, V. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111008798 · Cited by 292
Self-citationMcGlynn, P., & Lloyd, R. (2000) · Cell · doi:10.1016/s0092-8674(00)80621-2 · Cited by 288
Replication fork arrest and DNA recombination
Michel, B. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01560-7 · Cited by 247
Self-citationBreak-induced replication: A review and an example in budding yeast
Kraus, E., Leung, W.-Y., & Haber, J. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151008198 · Cited by 239
Positive Torsional Strain Causes the Formation of a Four-way Junction at Replication Forks
Postow, L., Ullsperger, C., Keller, R. W., Bustamante, C., Vologodskii, A. V., & Cozzarelli, N. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006736200 · Cited by 237
RecBCD enzyme is a bipolar DNA helicase
Dillingham, M. S., Spies, M., & Kowalczykowski, S. C. (2003) · Nature · doi:10.1038/nature01673 · Cited by 224
RecBCD enzyme is a DNA helicase with fast and slow motors of opposite polarity
Taylor, A. F., & Smith, G. R. (2003) · Nature · doi:10.1038/nature01674 · Cited by 223
Uncoupling of Leading- and Lagging-Strand DNA Replication During Lesion Bypass in Vivo
Pagès, V., & Fuchs, R. P. (2003) · Science · doi:10.1126/science.1083964 · Cited by 221
Courcelle, J., Carswell-Crumpton, C., & Hanawalt, P. C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3714 · Cited by 218
Role of PriA in Replication Fork Reactivation in Escherichia coli
Sandler, S. J., & Marians, K. J. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.1.9-13.2000 · Cited by 213
Analysis of topoisomerase function in bacterial replication fork movement: Use of DNA microarrays
Khodursky, A. B., Peter, B. J., Schmid, M. B., DeRisi, J. L., Botstein, D., Brown, P. O., & Cozzarelli, N. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.17.9419 · Cited by 212
RecA-Dependent Recovery of Arrested DNA Replication Forks
Courcelle, J., & Hanawalt, P. C. (2003) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.142616 · Cited by 210
Ira, G., & Haber, J. E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6384-6392.2002 · Cited by 195
Spies, M., Bianco, P. R., Dillingham, M. S., Handa, N., Baskin, R. J., & Kowalczykowski, S. C. (2003) · Cell · doi:10.1016/s0092-8674(03)00681-0 · Cited by 181
PriA-directed replication fork restart in Escherichia coli
Marians, K. J. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01565-6 · Cited by 180
Kogoma, T., Cadwell, G. W., Barnard, K. G., & Asai, T. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1258-1264.1996 · Cited by 180
Sandler, S. J., Samra, H. S., & Clark, A. J. (1996) · Genetics · doi:10.1093/genetics/143.1.5 · Cited by 173
RecA protein promotes the regression of stalled replication forks in vitro
Robu, M. E., Inman, R. B., & Cox, M. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131022698 · Cited by 153
McGlynn, P., Lloyd, R. G., & Marians, K. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121007798 · Cited by 151
Higuchi, K., Katayama, T., Iwai, S., Hidaka, M., Horiuchi, T., & Maki, H. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00646.x · Cited by 140
Khidhir, M. A., Casarégola, S., & Holland, I. B. (1985) · Molecular and General Genetics MGG · doi:10.1007/bf00327522 · Cited by 137
Control of recA gene RNA in E. coli: Regulatory and signal genes
McPartland, A., Green, L., & Echols, H. (1980) · Cell · doi:10.1016/0092-8674(80)90319-0 · Cited by 137
Inhibition of bacterial DNA replication by zinc mobilization during nitrosative stress
Schapiro, J. M., Libby, S. J., & Fang, F. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1033133100 · Cited by 133
Whitby, M. C., Vincent, S. D., & Lloyd, R. G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06853.x · Cited by 133
A model for SOS-lesion-targeted mutations in Escherichia coli
Pham, P., Bertram, J. G., O’Donnell, M. E., Woodgate, R., & Goodman, M. F. (2001) · Nature · doi:10.1038/35053116 · Cited by 127
RuvABC‐dependent double‐strand breaks in dnaBts mutants require RecA
Seigneur, M., Ehrlich, S. D., & Michel, B. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02152.x · Cited by 118
Self-citationSpecific RecA amino acid changes affect RecA–UmuD′C interaction
Sommer, S., Boudsocq, F., Devoret, R., & Bailone, A. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00803.x · Cited by 113
Replication fork collapse at replication terminator sequences
Bidnenko, V., Ehrlich, S., & Michel, B. (2002) · EMBO Journal · doi:10.1093/emboj/cdf369 · Cited by 112
Self-citationPriA Mediates DNA Replication Pathway Choice at Recombination Intermediates
Xu, L., & Marians, K. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00061-3 · Cited by 111
Role for radA/sms in Recombination Intermediate Processing in Escherichia coli
Beam, C. E., Saveson, C. J., & Lovett, S. T. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.24.6836-6844.2002 · Cited by 108
Wang, T. V., & Smith, K. C. (1983) · Journal of Bacteriology · doi:10.1128/jb.156.3.1093-1098.1983 · Cited by 108
Simmons, L. A., Breier, A. M., Cozzarelli, N. R., & Kaguni, J. M. (2004) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03842.x · Cited by 108
Rangarajan, S., Woodgate, R., & Goodman, M. F. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02747.x · Cited by 107
Mitotic recombination in Saccharomyces cerevisiae
Prado, F., Cortés‐Ledesma, F., Huertas, P., & Aguilera, A. (2003) · Current Genetics · doi:10.1007/s00294-002-0346-3 · Cited by 101
Chow, K.-H., & Courcelle, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311012200 · Cited by 99
Flores, M. J., Bierne, H., Ehrlich, S. D., & Michel, B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.619 · Cited by 87
Self-citationChromosomal elements conferring epigenetic inheritance
Lyko, F., & Paro, R. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199910)21:10 · Cited by 79
RecA protein in the SOS response: milestones and mysteries
Witkin, E. M. (1991) · Biochimie · doi:10.1016/0300-9084(91)90196-8 · Cited by 75
The S-phase checkpoint and its regulation in Saccharomyces cerevisiae
Longhese, M. P., Clerici, M., & Lucchini, G. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.009 · Cited by 74
Supercoiling, knotting and replication fork reversal in partially replicated plasmids
Olavarrieta, L. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.3.656 · Cited by 73
Situational Repair of Replication Forks
Robu, M. E., Inman, R. B., & Cox, M. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312184200 · Cited by 62
Replication fork reversal in DNA polymerase III mutants of Escherichia coli: a role for the β clamp
Grompone, G., Seigneur, M., Ehrlich, S. D., & Michel, B. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02962.x · Cited by 61
Self-citationCheckpoint responses to replication stalling: inducing tolerance and preventing mutagenesis
Kai, M., & Wang, T. S. ‐. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.010 · Cited by 61
Replication restart in gyrB Escherichia coli mutants
Grompone, G., Ehrlich, S. D., & Michel, B. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03480.x · Cited by 56
Self-citationWang, T. V., & Smith, K. C. (1986) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(86)90007-6 · Cited by 53
Donaldson, J. R., Courcelle, C. T., & Courcelle, J. (2004) · Genetics · doi:10.1534/genetics.166.4.1631 · Cited by 49
Flores, M. J., Ehrlich, S. D., & Michel, B. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02913.x · Cited by 47
Self-citationTatsumi, K., & Strauss, B. S. (1978) · Nucleic Acids Research · doi:10.1093/nar/5.2.331 · Cited by 37
Grigorian, A., Lustig, R. B., Guzmán, E. C., Mahaffy, J. M., & Zyskind, J. W. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.2.630-644.2003 · Cited by 36
Cells defective for replication restart undergo replication fork reversal
Grompone, G., Ehrlich, S. D., & Michel, B. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400167 · Cited by 31
Self-citationThe replication–recombination connection: insights from genomics
Gruss, A. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00256-3 · Cited by 14
Research works printed but not linked: 2
- Wang, T. C. & Smith, K. C. (1986) Mutat. Res. 165, 39–44.3510373
- 10.1093/genetics/166.4.1631 · DOI
Cited by
Sorted by citations
Oxidative Stress Resistance in Deinococcus radiodurans
Slade, D., & Radman, M. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-10 · Cited by 761
Mechanism of homologous recombination: mediators and helicases take on regulatory functions
Sung, P., & Klein, H. L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2008 · Cited by 744
RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks
Dillingham, M. S., & Kowalczykowski, S. C. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00020-08 · Cited by 586
Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance
Cirz, R. T., Chin, J. K., Andes, D. R., de Crécy‐Lagard, V., Craig, W. A., & Romesberg, F. E. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030176 · Cited by 583
SSB as an Organizer/Mobilizer of Genome Maintenance Complexes
Shereda, R. D., Kozlov, A. G., Lohman, T. M., Cox, M. M., & Keck, J. L. (2008) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230802341296 · Cited by 558
Metadata
- Authors
- Michel, B., Grompone, G., Florès, M.-J., & Bidnenko, V.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-08-24
- Volume
- 101
- Issue
- 35
- Pages
- 12783-12788
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC516472
- OpenAlex
- W2114809602
- Cited by
- 322
- References
- 71
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 13 · 2015: 8 · 2014: 18 · 2013: 13 · 2012: 16
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- replication fork restart, stalled replication forks, recombination proteins, genomic instability, strand exchange
- MeSH terms
- Bacteria, DNA, DNA Repair, DNA Replication, Mutation, DNA Gyrase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
