Cited by 268DNA Repair MechanismsBacterial Genetics and BiotechnologyFungal and yeast genetics research

Replisome assembly and the direct restart of stalled replication forks

Heller, Ryan C., Marians, Kenneth J.·2006·Nature Reviews Molecular Cell Biology

Abstract

Failure to reactivate either stalled or collapsed replication forks is a source of genomic instability in both prokaryotes and eukaryotes. In prokaryotes, dedicated fork repair systems that involve both recombination and replication proteins have been identified genetically and characterized biochemically. Replication conflicts are solved through several pathways, some of which require recombination and some of which operate directly at the stalled fork. Some recent biochemical observations support models of direct fork repair in which the removal of the blocking template lesion is not always required for replication restart.

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Crossref · 10.1038/nrm2058

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Authors
Heller, R. C., & Marians, K. J.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Marians, Kenneth J.
Venue
Nature Reviews Molecular Cell Biology
Published
2006-11-08
Volume
7
Issue
12
Pages
932-943
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2083344047
Cited by
268
References
101
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 12 · 2020: 9 · 2019: 6 · 2018: 11 · 2017: 16 · 2016: 11 · 2015: 11 · 2014: 13 · 2013: 21 · 2012: 22
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (R37GM034557)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
replisome assembly, replication fork stalling, replication fork restart, replication fork collapse, genomic instability, DNA damage, recombination, replication restart
MeSH terms
Animals, DNA Repair, DNA Replication, DNA Helicases, DNA-Binding Proteins, Eukaryotic Cells, Humans, Prokaryotic Cells, Recombination, Genetic, Replicon

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