Cited by 1,093DNA Repair MechanismsBacterial Genetics and BiotechnologyDNA and Nucleic Acid Chemistry

Discontinuities in the DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation

Rupp, W. Dean, Howard-flanders, Paul·1968·Journal of Molecular Biology

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Crossref · 10.1016/0022-2836(68)90445-2

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18 of 18 references verified0 citation errors · 0 not checkable

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  • Blocked polymerases can leave the lesion and PCNA behind and re-initiate downstream via re-priming, generating numerous ssDNA gaps behind forks that likely cause strong Mec1 activation during S phase in UV-irradiated cells.

    “Blocked polymerase can leave the lesion and PCNA behind and re-initiate downstream of the lesion via a re-priming mechanism, generating numerous ssDNA gaps behind the forks, which are likely responsible for the strong activation of Mec1 during S phase in UV-irradiated cells [51,82–85].”

    From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [82]

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Authors
Rupp, W. D., & Howard-flanders, P.
Affiliations
Yale University (US)
Venue
Journal of Molecular Biology
Publisher
Elsevier BV
Published
1968-01
Volume
31
Issue
2
Pages
291-304
ISSN
0022-2836 (ISSN-L)
OpenAlex
W1984459901
Cited by
1,093
References
18
Citations by year
2026: 6 · 2025: 6 · 2024: 3 · 2023: 9 · 2022: 4 · 2021: 11 · 2020: 6 · 2019: 18 · 2018: 11 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 15 · 2013: 15 · 2012: 15
FWCI
29.73
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords
pyrimidine dimers, UV irradiation, DNA synthesis, excision repair, Escherichia coli, DNA gaps, DNA molecular weight, 3H-thymidine incorporation
MeSH terms
Centrifugation, Density Gradient, Centrifugation, Zonal, Cesium, Chlorides, Coliphages, DNA, Bacterial, Escherichia coli, Models, Chemical, Molecular Weight, Pyrimidines, Radiation Effects, Sucrose, Thymidine, Tritium, Ultraviolet Rays

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