The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating γ-aminobutyric acid type A receptor membrane trafficking
Open accessAbstract
γ-Aminobutyric acid type A receptors (GABA A Rs) are the major sites of fast synaptic inhibition in the brain. An essential determinant for the efficacy of synaptic inhibition is the regulation of GABA A R cell surface stability. Here, we have examined the regulation of GABA A R endocytic sorting, a critical regulator of cell surface receptor number. In neurons, rapid constitutive endocytosis of GABA A Rs was evident. Internalized receptors were then either rapidly recycled back to the cell surface, or on a slower time scale, targeted for lysosomal degradation. This sorting decision was regulated by a direct interaction of GABA A Rs with Huntingtin-associated protein 1 (HAP1). HAP1 modulated synaptic GABA A R number by inhibiting receptor degradation and facilitating receptor recycling. Together these observations have identified a role for HAP1 in regulating GABA A R sorting, suggesting an important role for this protein in the construction and maintenance of inhibitory synapses.
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MACDONALD, M. (1993) · Cell · doi:10.1016/0092-8674(93)90585-e · Cited by 8,366
Trinucleotide repeat length instability and age of onset in Huntington's disease
Duyao, M., Ambrose, C., Myers, R., Novelletto, A., Persichetti, F., Frontali, M., Folstein, S., Ross, C., Franz, M., Abbott, M., et al. (1993) · Nature Genetics · doi:10.1038/ng0893-387 · Cited by 1,089
Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude
Nusser, Z., Cull-Candy, S., & Farrant, M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80382-7 · Cited by 449
Kittler, J. T., & Moss, S. J. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00064-3 · Cited by 301
Self-citationJovanovic, J. N., Thomas, P., Kittler, J. T., Smart, T. G., & Moss, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3606-03.2004 · Cited by 273
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Cited by
GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition
Jacob, T. C., Moss, S. J., & Jurd, R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2370 · Cited by 695
Self-citationGABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses
Luscher, B., Fuchs, T., & Kilpatrick, C. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.024 · Cited by 434
Tretter, V., Jacob, T. C., Mukherjee, J., Fritschy, J.-M., Pangalos, M. N., & Moss, S. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5050-07.2008 · Cited by 259
Self-citationPorcher, C., Hatchett, C., Longbottom, R. E., McAinch, K., Sihra, T. S., Moss, S. J., Thomson, A. M., & Jovanovic, J. N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.201582 · Cited by 91
Self-citationBogoch, Y., Biala, Y. N., Linial, M., & Weinstock, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04402.x · Cited by 74
Metadata
- Authors
- Kittler, J. T., Thomas, P., Tretter, V., Bogdanov, Y. D., Haucke, V., Smart, T. G., & Moss, S. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-08-13
- Volume
- 101
- Issue
- 34
- Pages
- 12736-12741
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1990567359
- Cited by
- 224
- References
- 5
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Kittler, J. T., Thomas, P., Tretter, V., Bogdanov, Y. D., Haucke, V., Smart, T. G., & Moss, S. J. (2004). Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating γ-aminobutyric acid type A receptor membrane trafficking. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0401860101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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