The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
The Clustering of GABAAReceptor Subtypes at Inhibitory Synapses is Facilitated via the Direct Binding of Receptor α2 Subunits to Gephyrin
Open accessAbstract
Classical benzodiazepine sensitive GABA A receptor subtypes, the major mediators of fast synaptic inhibition in the brain are heteropentamers that can be assembled from α1–3/5, β1–3, and γ2 subunits, but how neurons orchestrate their selective accumulation at synapses remains obscure. We have identified a 10 amino acid hydrophobic motif within the intracellular domain of the α2 subunit that regulates the accumulation of GABA A receptors at inhibitory synaptic sites on both axon initial segments and dendrites in a mechanism dependent on the inhibitory scaffold protein gephyrin. This motif was sufficient to target CD4 (cluster of differentiation molecule 4) molecules to inhibitory synapses, and was also critical in regulating the direct binding of α2 subunits to gephyrin in vitro. Our results thus reveal that the specific accumulation of GABA A receptor subtypes containing α2 subunits at inhibitory synapses is dependent on their ability to bind gephyrin.
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Cites
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Self-citationSubunit Composition, Distribution and Function of GABA-A Receptor Subtypes
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Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin
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GABA-based therapeutic approaches: GABAA receptor subtype functions
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Loss of Postsynaptic GABAAReceptor Clustering in Gephyrin-Deficient Mice
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Cited by
GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition
Jacob, T. C., Moss, S. J., & Jurd, R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2370 · Cited by 695
Self-citationGABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses
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Regulation of GABAA Receptor Subunit Expression by Pharmacological Agents
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Gatto (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00004 · Cited by 204
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Metadata
- Authors
- Tretter, V., Jacob, T. C., Mukherjee, J., Fritschy, J.-M., Pangalos, M. N., & Moss, S. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-02-06
- Volume
- 28
- Issue
- 6
- Pages
- 1356-1365
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1969301568
- Cited by
- 259
- References
- 36
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tretter, V., Jacob, T. C., Mukherjee, J., Fritschy, J.-M., Pangalos, M. N., & Moss, S. J. (2008). The Clustering of GABAAReceptor Subtypes at Inhibitory Synapses is Facilitated via the Direct Binding of Receptor α2 Subunits to Gephyrin. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.5050-07.2008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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