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Cited by 349

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis

Open access
Corcione, Anna, Casazza, Simona, Ferretti, Elisa, Giunti, Debora, Zappia, Emanuela, Pistorio, Angela, Gambini, Claudio, Mancardi, Giovanni Luigi, Uccelli, Antonio, Pistoia, Vito·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0402455101
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Abstract

Clonally expanded populations of B cells carrying somatic mutations of Ig variable (V) region genes have been detected in the CNS of subjects with multiple sclerosis (MS), suggesting that a process of B cell affinity maturation with ensuing production of potentially pathogenic autoantibodies may occur inside the CNS. Here, we have characterized the B cell subsets present in the cerebrospinal fluid (CSF) of MS patients and of individuals with other inflammatory neurological disorders by flow cytometry. CD19+CD38 high+CD77+, Ki67+, Bcl-2–centroblasts, i.e., a B cell subset found exclusively in secondary lymphoid organs, were detected in the CSF but not in paired peripheral blood from both patient groups. CD27+IgD–memory B cells, i.e., cells with hyper-mutated IgV genes, were significantly increased in the CSF vs. paired peripheral blood and displayed up-regulation of the CD80 and CD86 costimulatory molecules and of CC chemokine receptor (CCR) 1, CCR2, and CCR4 in both patient groups. Lymphotoxin-α, CXC ligand (CXCL) 12, and CXCL13, key mediators of lymphoid neogenesis, were present in the CSF from patients with MS and other inflammatory neurological disorders and were expressed in MS brain tissue, with selective localization in the outer layer of the capillary vessel wall. In conclusion, this study suggests that a compartmentalized B cell response occurs within the CNS during an ongoing inflammatory reaction, through a recapitulation of all stages of B cell differentiation observed in secondary lymphoid organs. The presence of lymphotoxin-α, CXCL12, and CXCL13 in the CNS may provide favorable microenvironmental conditions for these events.

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Metadata

Authors
Corcione, A., Casazza, S., Ferretti, E., Giunti, D., Zappia, E., Pistorio, A., Gambini, C., Mancardi, G. L., Uccelli, A., & Pistoia, V.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2004-07-19
Volume
101
Issue
30
Pages
11064-11069
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0402455101
OpenAlex
W1972442533
Cited by
349
References
47
FWCI
18.60
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. https://app.cochat.ai/papers/10.1073/pnas.0402455101
The paper
Corcione, A., Casazza, S., Ferretti, E., Giunti, D., Zappia, E., Pistorio, A., Gambini, C., Mancardi, G. L., Uccelli, A., & Pistoia, V. (2004). Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0402455101

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.