Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725

Inflammation in atherosclerosis

Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315

Inflammation and Atherosclerosis

Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986

Atherosclerosis

Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,094

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L., & Schwartz, D. A. (2000) · Nature Genetics · doi:10.1038/76048 · Cited by 2,024

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

Gu, L., Okada, Y., Clinton, S. K., Gerard, C. J., Sukhova, G. K., Libby, P., & Rollins, B. J. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80139-2 · Cited by 1,574

Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Overview

Romerio, A., & Peri, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01210 · Cited by 84

Rap1 induces cytokine production in pro-inflammatory macrophages through NFκB signaling and is highly expressed in human atherosclerotic lesions

Cai, Y., Sukhova, G. K., Wong, H. K., Xu, A., Tergaonkar, V., Vanhoutte, P. M., & Tang, E. H. C. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1100771 · Cited by 84

Effects of dyslipidaemia on monocyte production and function in cardiovascular disease

Rahman, M. S., Murphy, A. J., & Woollard, K. J. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.34 · Cited by 86

Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Wiciński, M., Socha, M. W., Walczak, M., Wódkiewicz, E., Malinowski, B., Rewerski, S., Górski, K. M., & Pawlak-Osińska, K. (2018) · Nutrients · doi:10.3390/nu10111813 · Cited by 86

Invited review: Vascular cells contribute to atherosclerosis by cytokine- and innate-immunity-related inflammatory mechanisms

Loppnow, H., Werdan, K., & Buerke, M. (2008) · Innate Immunity · doi:10.1177/1753425908091246 · Cited by 83

Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms

Alì, A., Boutjdir, M., & Aromolaran, A. S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01866 · Cited by 86

Chemokines and microRNAs in atherosclerosis

Hartmann, P., Schober, A., & Weber, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1925-z · Cited by 82

Effect of the Toll‐like receptor 4 (TLR‐4) variants on intima‐media thickness and monocyte‐derived macrophage response to LPS

Norata, G. D., Garlaschelli, K., Ongari, M., Raselli, S., Grigore, L., Benvenuto, F., Maggi, F. M., & Catapano, A. L. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01509.x · Cited by 81

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Koulis, C., Chen, Y., Hausding, C., Ahrens, I., Kyaw, T. S., Tay, C., Allen, T. J., Jandeleit-Dahm, K. A. M., Sweet, M. J., Akira, S., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302407 · Cited by 80

Pathogen-Mediated Inflammatory Atherosclerosis Is Mediated in Part via Toll-Like Receptor 2-Induced Inflammatory Responses

Hayashi, C., Madrigal, A. G., Liu, X., Ukai, T., Goswami, S., Gudino, C. V., Gibson, F. C., & Genco, C. A. (2010) · Journal of Innate Immunity · doi:10.1159/000314686 · Cited by 82

Platelet Innate Immune Receptors and TLRs: A Double-Edged Sword

Ebermeyer, T., Cognasse, F., Berthelot, P., Mismetti, P., Garraud, O., & Hamzeh‐Cognasse, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157894 · Cited by 80

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases

Yu, M., Zhou, H., Zhao, J., Xiao, N., Roychowdhury, S., Schmitt, D. C., Hu, B., Ransohoff, R. M., Harding, C. V., Hise, A. G., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131314 · Cited by 81

Toll-like receptors 2 and 4 mediate hyperglycemia induced macrovascular aortic endothelial cell inflammation and perturbation of the endothelial glycocalyx

Pahwa, R., Nallasamy, P., & Jialal, I. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.01.014 · Cited by 80

Genetically modified mouse models for the study of nonalcoholic fatty liver disease

Nagarajan, P. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i11.1141 · Cited by 83

STAT1-Dependent Signal Integration between IFNγ and TLR4 in Vascular Cells Reflect Pro-Atherogenic Responses in Human Atherosclerosis

Chmielewski, S., Olejnik, A., Sikorski, K., Pelisek, J., Błaszczyk, K., Aoqui, C., Nowicka, H., Zernecke, A., Heemann, U. W., Wesoły, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113318 · Cited by 84

Chemokine regulation of atherosclerosis

Barlic, J., & Murphy, P. M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1206761 · Cited by 80

Involvement of Innate and Adaptive Immunity in a Murine Model of Coronary Arteritis Mimicking Kawasaki Disease

Schulte, D. J., Yılmaz, A., Shimada, K., Fishbein, M. C., Lowe, E. L., Chen, S., Wong, M., Doherty, T. M., Lehman, T. J. A., Crother, T. R., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901395 · Cited by 79

Infection and atherosclerosis. An alternative view on an outdated hypothesis.

Stassen, F. R. M., Vainas, T., & Bruggeman, C. A. (2008) · PubMed · Cited by 79

Acute Brain Injury Triggers MyD88-Dependent, TLR2/4-Independent Inflammatory Responses

Koedel, U., Merbt, U. M., Schmidt, C., Angele, B., Popp, B., Wagner, H., Pfister, H.-W., & Kirschning, C. J. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060821 · Cited by 78

TLR4 antagonist reduces early-stage atherosclerosis in diabetic apolipoprotein E-deficient mice

Lu, Z., Zhang, X., Li, Y., Jin, J., & Huang, Y. Q. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0338 · Cited by 78

The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta‐Analysis of 35,317 Subjects

Xie, X., Shi, X., & Liu, M. (2017) · Scandinavian Journal of Immunology · doi:10.1111/sji.12560 · Cited by 77

The activation of CD14, TLR4, and TLR2 by mmLDL induces IL-1β, IL-6, and IL-10 secretion in human monocytes and macrophages

Chávez-Sanchéz, L., Chávez-Rueda, A. K., Legorreta-Haquet, M. V., Zenteno, E., Ledesma‐Soto, Y., Montoya-Díaz, E., Tesoro-Cruz, E., Madrid-Miller, A., & Blanco-Favela, F. A. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-117 · Cited by 77

High glucose induces and activates Toll-like receptor 4 in endothelial cells of diabetic retinopathy

Wang, L., Wang, J., Fang, J., Zhou, H., Liu, X., & Su, S. B. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0086-4 · Cited by 77

A combination of Lox-1 and Nox1 regulates TLR9-mediated foam cell formation

Lee, J., Lim, E., Park, D., Lee, S.-H., Kim, J.-R., & Baek, S. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.08.022 · Cited by 76

Myeloid Differentiation Primary Response Protein 88 Couples Reverse Cholesterol Transport to Inflammation

Smoak, K. A., Aloor, J. J., Madenspacher, J. H., Merrick, B. A., Collins, J. B., Zhu, X., Cavigiolio, G., Oda, M. N., Parks, J. S., & Fessler, M. B. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.006 · Cited by 81

Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease

Erridge, C. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.043 · Cited by 81

MyD88-dependent and independent pathways of Toll-Like Receptors are engaged in biological activity of Triptolide in ligand-stimulated macrophages

Premkumar, V., Dey, M., Dorn, R., & Raskin, I. (2010) · BMC Chemical Biology · doi:10.1186/1472-6769-10-3 · Cited by 76

Endogenous Inflammatory Molecules Engage Toll-Like Receptors in Cardiovascular Disease

Ionita, M. G., Arslan, F., de Kleijn, D. P. V., & Pasterkamp, G. (2010) · Journal of Innate Immunity · doi:10.1159/000314270 · Cited by 75

Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo

Hao, W., Frei, B. B., Beckman, J. S., & Zhang, W. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01299.2010 · Cited by 75

Increased Atherogenesis during Streptococcus mutans Infection in ApoE-null Mice

Kesavalu, L. N., Lucas, A., Verma, R. K., Liu, L., Dai, E., Sampson, E. M., & Progulske‐Fox, A. (2012) · Journal of Dental Research · doi:10.1177/0022034511435101 · Cited by 75

Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes

Wang, Y., Song, E., Bai, B., & Vanhoutte, P. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.12.005 · Cited by 77

Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis

Fairweather, D., Petri, M., Coronado, M. J., & Cooperr, L. T. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.12.10 · Cited by 75

Toll-like receptor 4 gene polymorphisms and myocardial infarction: no association in a Caucasian population

Koch, W., Hoppmann, P., Pfeufer, A., Schömig, A., & Kastrati, A. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl231 · Cited by 74

Lipopolysaccharide-binding protein (LBP) is associated with total and cardiovascular mortality in individuals with or without stable coronary artery disease – Results from the Ludwigshafen Risk and Cardiovascular Health Study (LURIC)

Lepper, P. M., Kleber, M. E., Grammer, T. B., Hoffmann, K., Dietz, S., Winkelmann, B. R., Boehm, B. O., & März, W. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.06.001 · Cited by 77

TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates

Singh, R. K., Haka, A. S., Asmal, A., Barbosa-Lorenzi, V. C., Grosheva, I., Chin, H. F., Xiong, Y., Hla, T., & Maxfield, F. R. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313200 · Cited by 74

Vaccination against atherosclerosis? Induction of atheroprotective immunity

Hansson, G. K., & Nilsson, J. Å. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0151-x · Cited by 73

Protective effects of syringin against oxidative stress and inflammation in diabetic pregnant rats via TLR4/MyD88/NF-κB signaling pathway

Shen, Z., Yang, C., Zhu, P., Tian, C., & Liang, A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110681 · Cited by 73

Oxidized phospholipids as triggers of inflammation in atherosclerosis

Leitinger, N. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500086 · Cited by 73

Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of miR-26a-5p via inhibiting TLR4/NF-κB pathway in human endothelial cells

Zhong, X., Zhang, L., Li, Y., Li, P., Li, J., & Cheng, G. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.175 · Cited by 72

Toll-Like Receptor 4 Mediates Inflammatory Cytokine Secretion in Smooth Muscle Cells Induced by Oxidized Low-Density Lipoprotein

Yang, K., Zhang, X. J., Cao, L., Liu, X. H., Liu, Z. H., Wang, X. Q., Chen, Q. J., Lu, L., Shen, W. F., & Liu, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095935 · Cited by 77

Tissue-Specific RNA-Seq in Human Evoked Inflammation Identifies Blood and Adipose LincRNA Signatures of Cardiometabolic Diseases

Liu, Y., Ferguson, J. F., Xue, C., Ballantyne, R. L., Silverman, I. M., Gosai, S. J., Serfecz, J. C., Morley, M. P., Gregory, B. D., Li, M., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.303123 · Cited by 72

The Complex Interplay between Lipids, Immune System and Interleukins in Cardio-Metabolic Diseases

Bernardi, S., Marcuzzi, A., Piscianz, E., Tommasini, A., & Fabris, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124058 · Cited by 71

ABC Transporters, Cholesterol Efflux, and Implications for Cardiovascular Diseases

Wang, N., & Westerterp, M. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6082-8_6 · Cited by 71

Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: Effect of statins on let-7i and Toll-like receptor 4 signal

Satoh, M., Tabuchi, T., Minami, Y., Takahashi, Y., Itoh, T., & Nakamura, M. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.08.005 · Cited by 72

Inflammation‐induced foam cell formation in chronic inflammatory disease

Angelovich, T. A., Hearps, A. C., & Jaworowski, A. (2015) · Immunology and Cell Biology · doi:10.1038/icb.2015.26 · Cited by 72

Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II–Induced Atherosclerosis

Fukuda, D., Nishimoto, S., Aini, K., Tanaka, A., Nishiguchi, T., Kim‐Kaneyama, J., Lei, X., Masuda, K., Naruto, T., Tanaka, K., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010860 · Cited by 71

Myeloid cells in atherosclerosis: initiators and decision shapers

Soehnlein, O., & Weber, C. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0141-z · Cited by 70

Toll-Like Receptor-4 and Lipoprotein Accumulation in Macrophages

Miller, Y. I., Choi, S.-H., Fang, L., & Harkewicz, R. (2009) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.02.001 · Cited by 70

The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice

Kiouptsi, K., Jäckel, S., Pontarollo, G., Grill, A., Kuijpers, M. J. E., Wilms, E., Weber, C., Sommer, F., Nagy, M., Neideck, C., et al. (2019) · mBio · doi:10.1128/mbio.02298-19 · Cited by 70

Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation

Cheng, H. S., Njock, M.-S., Khyzha, N., Dang, L. T., & Fish, J. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00422 · Cited by 69

Absence of p55 TNF Receptor Reduces Atherosclerosis, but Has No Major Effect on Angiotensin II Induced Aneurysms in LDL Receptor Deficient Mice

Xanthoulea, S., Thelen, M., Pöttgens, C. C. H., Gijbels, M. J., Lutgens, E., & de Winther, M. P. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006113 · Cited by 69

Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response

Regidor, P., Mueller, A., Sailer, M., Santos, F. G., Rizo, J. M., & Egea, F. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010384 · Cited by 70

TLR4 signaling: A potential therapeutic target in ischemic coronary artery disease

Jia, S., Niu, P.-P., Cong, J.-Z., Zhang, B., & Zhao, M. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.08.011 · Cited by 70

Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress

Lei, Y., Yang, G., Hu, L., Piao, L., Inoue, A., Jiang, H., Sasaki, T., Zhao, G., Yisireyili, M., Yu, C., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.05.062 · Cited by 69

Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics

Heine, H., & Zamyatina, A. (2022) · Pharmaceuticals · doi:10.3390/ph16010023 · Cited by 72

Toll-like Receptors and Atherosclerosis: Key Contributors in Disease and Health?

Mullick, A. E., Tobias, P. S., & Curtiss, L. K. (2006) · Immunologic Research · doi:10.1385/ir:34:3:193 · Cited by 68

Islet Endothelial Activation and Oxidative Stress Gene Expression Is Reduced by IL-1Ra Treatment in the Type 2 Diabetic GK Rat

Lacraz, G., Giroix, M.-H., Kassis, N., Coulaud, J., Galinier, A., Noll, C., Cornut, M., Schmidlin, F., Paul, J., Janel, N., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006963 · Cited by 73

Sensitization of Human Aortic Endothelial Cells to Lipopolysaccharide via Regulation of Toll-Like Receptor 4 by Bacterial Fimbria-Dependent Invasion

Yumoto, H., Chou, H.-H., Takahashi, Y., Davey, M., Gibson, F. C., & Genco, C. A. (2005) · Infection and Immunity · doi:10.1128/iai.73.12.8050-8059.2005 · Cited by 68

Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis

Huang, Q., & Pope, R. M. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310126 · Cited by 69

Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis

Hamann, L., Glaeser, C., Hamprecht, A. G., Gross, M. C., Gomma, A., & Schumann, R. R. (2005) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.07.017 · Cited by 68

Toll-like receptor 2/4 links to free fatty acid-induced inflammation and β-cell dysfunction

Yin, J., Peng, Y., Wu, J., Wang, Y., & Yao, L. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313143 · Cited by 69

Endotoxin, Toll-like Receptor-4, and Atherosclerotic Heart Disease

Bowman, J. D., Surani, S., & Horseman, M. A. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666160901145313 · Cited by 67

Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation

Qu, D. C., Wang, L., Huo, M., Song, W., Lau, C., Xu, J., Xu, A., Yao, X., Chiu, J., Tian, X. Y., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz046 · Cited by 67

Protective Role for TLR4 Signaling in Atherosclerosis Progression as Revealed by Infection with a Common Oral Pathogen

Hayashi, C., Papadopoulos, G., Gudino, C. V., Weinberg, E. O., Barth, K., Madrigal, A. G., Chen, Y., Hua, N., LaValley, M. P., Gibson, F. C., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201541 · Cited by 67

Macrophage-Derived Myeloid Differentiation Protein 2 Plays an Essential Role in ox-LDL-Induced Inflammation and Atherosclerosis

Chen, T., Huang, W., Qian, J., Luo, W., Shan, P., Cai, Y., Lin, K., Wu, G., & Liang, G. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102706 · Cited by 67

Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms

Lin, Y.-T., Verma, A., & Hodgkinson, C. P. (2012) · Current Genomics · doi:10.2174/138920212803759712 · Cited by 68

Enhanced expression of TLR4 in smooth muscle cells in human atherosclerotic coronary arteries

Otsui, K., Inoue, N., Kobayashi, S., Shiraki, R., Honjo, T., Takahashi, M., Hirata, K., Kawashima, S., & Yokoyama, M. (2007) · Heart and Vessels · doi:10.1007/s00380-007-1001-1 · Cited by 66

The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4

Erridge, C. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003004 · Cited by 67

Microbiota, Immune Subversion, and Chronic Inflammation

Kramer, C. D., & Genco, C. A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00255 · Cited by 66

Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4

Doddapattar, P., Gandhi, C., Prakash, P., Dhanesha, N., Grumbach, I. M., Dailey, M. E., Lentz, S. R., & Chauhan, A. K. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.306474 · Cited by 67

Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease

Szeląg, M., Piaszyk-Borychowska, A., Plens-Gałąska, M., Wesoły, J., & Bluyssen, H. A. R. (2016) · Oncotarget · doi:10.18632/oncotarget.9195 · Cited by 66

The Biology of Atherosclerosis: General Paradigms and Distinct Pathogenic Mechanisms Among HIV-Infected Patients

Lo, J., & Plutzky, J. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis201 · Cited by 64

Red yeast rice ameliorates high-fat diet-induced atherosclerosis in Apoe −/− mice in association with improved inflammation and altered gut microbiota composition

Dong, Y., Cheng, H., Liu, Y., Xue, M., & Liang, H. W. (2019) · Food & Function · doi:10.1039/c9fo00583h · Cited by 64

Tanshinone IIA Exerts Anti-Inflammatory and Immune-Regulating Effects on Vulnerable Atherosclerotic Plaque Partially via the TLR4/MyD88/NF-κB Signal Pathway

Chen, Z., Gao, X., Jiao, Y., Qiu, Y. L., Wang, A., Yu, M., Che, F., Li, S., Liu, J. L., Li, J., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00850 · Cited by 64

Functional Role of B Cells in Atherosclerosis

Ma, S. D., Mußbacher, M., & Galkina, E. (2021) · Cells · doi:10.3390/cells10020270 · Cited by 65

TB, or not TB: that is the question – does TLR signaling hold the answer?

Doherty, T. M., & Arditi, M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci23867 · Cited by 64

Oxidized Low-Density Lipoprotein Induces Inflammatory Responses in Cultured Human Mast Cells Via Toll-Like Receptor 4

Meng, Z., Yan, C., Deng, Q., Dong, X., Duan, Z.-M., Gao, D., & Niu, X.-L. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350102 · Cited by 63

Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells

Yang, X. T., Murthy, V., Schultz, K., Tatro, J. B., Fitzgerald, K. A., & Beasley, D. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00252.2006 · Cited by 63

Local Overexpression of Toll-Like Receptors at the Vessel Wall Induces Atherosclerotic Lesion Formation

Shinohara, M., Hirata, K., Yamashita, T., Takaya, T., Sasaki, N., Shiraki, R., Ueyama, T., Emoto, N., Inoue, N., Yokoyama, M., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.139253 · Cited by 64

Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2

Bai, Y., Min, R., Chen, P., Mei, S., Deng, F., Zheng, Z., Jiang, C., Miao, R., Wu, Z., Zhang, P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306399120 · Cited by 64

EPA and DHA Exposure Alters the Inflammatory Response but not the Surface Expression of Toll‐like Receptor 4 in Macrophages

Honda, K. L., Lamon‐Fava, S., Matthan, N. R., Wu, D., & Lichtenstein, A. H. (2014) · Lipids · doi:10.1007/s11745-014-3971-y · Cited by 62

Diverse Bacteria Promote Macrophage Foam Cell Formation Via Toll-Like Receptor-Dependent Lipid Body Biosynthesis

Nicolaou, G., Goodall, A. H., & Erridge, C. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.10249 · Cited by 63

Decoding inflammation, its causes, genomic responses, and emerging countermeasures

Hawiger, J., & Zienkiewicz, J. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12812 · Cited by 62

Vascular cell responsiveness to Toll‐like receptor ligands in carotid atheroma

Erridge, C., Burdess, A., Jackson, A., Murray, C., Riggio, M. P., Lappin, D. F., Milligan, S., Spickett, C. M., & Webb, D. J. (2008) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.02010.x · Cited by 62

Toll-like receptors as targets for immune disorders

Keogh, B., & Parker, A. E. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.03.008 · Cited by 61

STAT1 as a central mediator of IFNγ and TLR4 signal integration in vascular dysfunction

Sikorski, K., Chmielewski, S., Olejnik, A., Wesoły, J., Heemann, U. W., Baumann, M., & Bluyssen, H. A. R. (2012) · JAK-STAT · doi:10.4161/jkst.22469 · Cited by 65

Toll-like receptors in atherosclerosis: a ‘Pandora's box’ of advances and controversies

Cole, J. E., Kassiteridi, C., & Monaco, C. G. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.09.008 · Cited by 61

Toll-Like Receptor, Lipotoxicity and Chronic inflammation: The Pathological Link Between Obesity and Cardiometabolic Disease

Eguchi, K., & Manabe, I. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.22533 · Cited by 63

Effect of simvastatin or its combination with ezetimibe on Toll-like receptor expression and lipopolysaccharide – Induced cytokine production in monocytes of hypercholesterolemic patients

Moutzouri, E., Tellis, C. C., Rousouli, K., Liberopoulos, E. N., Milionis, H. J., Elisaf, M., & Tselepis, A. D. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.08.037 · Cited by 62

Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216

Kumazoe, M., Nakamura, Y., Yamashita, M., Suzuki, T., Takamatsu, K., Huang, Y., Bae, J., Yamashita, S., Murata, M., Yamada, S., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.755959 · Cited by 62

Combined Therapy of Dietary Fish Oil and Stearoyl-CoA Desaturase 1 Inhibition Prevents the Metabolic Syndrome and Atherosclerosis

Brown, J. M., Chung, S., Sawyer, J. K., Degirolamo, C., Alger, H. M., Nguyen, T. M., Zhu, X., Duong, M., Brown, A. L., Lord, C. C., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.198036 · Cited by 61

Comprehensive Analysis of the Candidate Genes CCL2,CCR2, and TLR4 in Age-Related Macular Degeneration

Despriet, D. D. G., Bergen, A. A. B., Merriam, J. E., Zernant, J., Barile, G. R., Smith, R. T., Barbazetto, I. A., van Soest, S., Bakker, A., de Jong, P. T. V. M., et al. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0656 · Cited by 60

Elevation of markers of endotoxemia in women with polycystic ovary syndrome

Banaszewska, B., Siakowska, M., Chudzicka-Strugała, I., Chang, R. J., Pawelczyk, L. A., Zwoździak, B., Spaczyński, R., & Dulęba, A. J. (2020) · Human Reproduction · doi:10.1093/humrep/deaa194 · Cited by 61

C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis

Park, I., Goddard, M. E., Cole, J. E., Zanin, N., Lyytikäinen, L., Lehtimäki, T. J., Andreakos, E., Feldmann, M., Udalova, I. A., Drozdov, I. A., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27862-9 · Cited by 61

Targeting Immune Senescence in Atherosclerosis

Vellasamy, D. M., Lee, S.-J., Goh, K. W., Goh, B. H., Tang, Y.-Q., Ming, L. C., & Yap, W. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113059 · Cited by 63

Innate Immunity System in Patients With Cardiovascular and Kidney Disease

Zoccali, C., & Mallamaci, F. (2023) · Circulation Research · doi:10.1161/circresaha.122.321749 · Cited by 61

Serum Lipopolysaccharide‐Binding Protein Levels and the Incidence of Cardiovascular Disease in a General Japanese Population: The Hisayama Study

Asada, M., Oishi, E., Sakata, S., Hata, J., Yoshida, D., Honda, T., Furuta, Y., Shibata, M., Suzuki, K., Watanabe, H., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013628 · Cited by 60

Lipopolysaccharide Stimulation of Human Aortic Valve Interstitial Cells Activates Inflammation and Osteogenesis

Babu, A. N., Meng, X., Zou, N., Yang, X., Wang, M., Song, Y., Cleveland, J. C., Weyant, M. J., Banerjee, A. M., & Fullerton, D. A. (2008) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2008.03.008 · Cited by 60

The Roles of Toll-Like Receptors in Atherosclerosis

Erridge, C. (2009) · Journal of Innate Immunity · doi:10.1159/000191413 · Cited by 59

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Koulis, C., Chen, Y., Hausding, C., Ahrens, I., Kyaw, T. S., Tay, C., Allen, T. J., Jandeleit-Dahm, K. A. M., Sweet, M. J., Akira, S., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302407 · Cited by 80

Platelet Factor 4 and Toll-Like Receptor 2 are Expressed in Atherosclerotic Plaques of Apolipoprotein E~(-/-)Mice

Hai, J. (2007) · Chinese Journal of Arteriosclerosis

Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis

Chen, S., Shimada, K., Crother, T. R., Erbay, E., Shah, P. K., & Arditi, M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.01.072 · Cited by 32

Toll-like receptor signaling and atherosclerosis

Michelsen, K. S., & Arditi, M. (2006) · Current Opinion in Hematology · doi:10.1097/01.moh.0000219662.88409.7c · Cited by 42

Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice

Higashimori, M., Tatro, J. B., Moore, K. J., Mendelsohn, M. E., Galper, J., & Beasley, D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.210971 · Cited by 125