Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725

Inflammation in atherosclerosis

Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315

Inflammation and Atherosclerosis

Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,996

Atherosclerosis

Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,094

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L., & Schwartz, D. A. (2000) · Nature Genetics · doi:10.1038/76048 · Cited by 2,024

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

Gu, L., Okada, Y., Clinton, S. K., Gerard, C. J., Sukhova, G. K., Libby, P., & Rollins, B. J. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80139-2 · Cited by 1,574

Toll-like receptors in innate immunity

Takeda, K. (2004) · International Immunology · doi:10.1093/intimm/dxh186 · Cited by 3,328

Sterile inflammation: sensing and reacting to damage

Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051

Macrophages in atherosclerosis: a dynamic balance

Moore, K. J., Sheedy, F. J., & Fisher, E. A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3520 · Cited by 2,559

The immune system in atherosclerosis

Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,389

The immune response in atherosclerosis: a double-edged sword

Hansson, G. K., & Libby, P. (2006) · Nature reviews. Immunology · doi:10.1038/nri1882 · Cited by 2,220

Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways

Tedgui, A., & Mallat, Z. (2006) · Physiological Reviews · doi:10.1152/physrev.00024.2005 · Cited by 1,751

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

Stewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1836 · Cited by 1,513

Negative regulation of Toll-like receptor-mediated immune responses

Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509

Immune and Inflammatory Mechanisms of Atherosclerosis

Galkina, E., & Ley, K. F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132620 · Cited by 1,480

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.043 · Cited by 1,356

Atherosclerotic Plaque Progression and Vulnerability to Rupture

Virmani, R., Kolodgie, F. D., BURKE, A. P., Finn, A. V., Gold, H. K., Tulenko, T. N., Wrenn, S. P., & Narula, J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000178991.71605.18 · Cited by 1,326

Human oral, gut, and plaque microbiota in patients with atherosclerosis

Koren, O., Spor, A., Felin, J., Fåk, F., Stombaugh, J., Tremaroli, V., Behre, C. J., Knight, R., Fagerberg, B., Ley, R. E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011383107 · Cited by 1,196

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

Kong, P., Cui, Z.-Y., Huang, X.-F., Zhang, D.-D., Guo, R.-J., & Han, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00955-7 · Cited by 1,183

Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes

Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180

Dietary lipids, gut microbiota and lipid metabolism

Schoeler, M., & Caesar, R. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09512-0 · Cited by 1,163

INFLAMMATION AND ATHEROSCLEROSIS

Hansson, G. K., Robertson, A.-K. L., & Söderberg‐Nauclér, C. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100100 · Cited by 1,082

Nutrient sensing and inflammation in metabolic diseases

Hotamisligil, G. S., & Erbay, E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2449 · Cited by 1,040

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

Rajamäki, K., Lappalainen, J., Öörni, K., Välimäki, E., Matikainen, S., Kovanen, P. T., & Eklund, K. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011765 · Cited by 1,039

The role of the gut microbiota in energy metabolism and metabolic disease

Cani, P., & Delzenne, N. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168164 · Cited by 974

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.026 · Cited by 960

Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer

Karin, M., Lawrence, T., & Nizet, V. (2006) · Cell · doi:10.1016/j.cell.2006.02.016 · Cited by 938

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926

Obesity, inflammation, and the gut microbiota

Cox, A. J., West, N. P., & Cripps, A. W. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70134-2 · Cited by 869

Scavenger receptors in homeostasis and immunity

Canton, J., Neculai, D., & Grinstein, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3515 · Cited by 838

Inflammation and plaque vulnerability

Hansson, G. K., Libby, P., & Tabas, I. A. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12406 · Cited by 809

Role of the Toll-like Receptor 4/NF-κB Pathway in Saturated Fatty Acid–Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages

Suganami, T., Tanimoto-Koyama, K., Nishida, J., Itoh, M., Yuan, X., Mizuarai, S., Kotani, H., Yamaoka, S., Miyake, K., Aoe, S., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000251608.09329.9a · Cited by 820

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

Abderrazak, A., Syrovets, T., Couchie, D., Hadri, K. E., Friguet, B., Simmet, T., & Rouis, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.008 · Cited by 749

Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?

Rehman, K., & Akash, M. S. H. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0303-y · Cited by 702

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

Libby, P., Lichtman, A. H., & Hansson, G. K. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.009 · Cited by 685

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

Miller, Y. I., Choi, S.-H., Wiesner, P., Fang, L., Harkewicz, R., Hartvigsen, K., Boullier, A., Gonen, A., Diehl, C. J., Que, X., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.223875 · Cited by 672

Role of gut microbiota in atherosclerosis

Jonsson, A. L., & Bäckhed, F. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.183 · Cited by 662

Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease

Schröder, N. W. J., & Schumann, R. R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)01308-3 · Cited by 638

Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

Glass, C. K., & Saijo, K. (2010) · Nature Reviews Immunology · doi:10.1038/nri2748 · Cited by 619

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

Spann, N. J., Garmire, L. X., McDonald, J. G., Myers, D. S., Milne, S. B., Shibata, N., Reichart, D. R., Fox, J. N., Shaked, I., Heudobler, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.054 · Cited by 630

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Depuydt, M. A. C., Prange, K. H. M., Slenders, L., Örd, T., Elbersen, D., Boltjes, A., de Jager, S. C. A., Asselbergs, F. W., de Borst, G. J., Aavik, E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.316770 · Cited by 608

Nuclear Factor κB Signaling in Atherogenesis

de Winther, M. P. J., Kanters, E., Kraal, G., & Hofker, M. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000160340.72641.87 · Cited by 586

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

Kim, F., Pham, M., Luttrell, I., Bannerman, D. D., Tupper, J., Thaler, J., Hawn, T. R., Raines, E. W., & Schwartz, M. W. (2007) · Circulation Research · doi:10.1161/circresaha.106.142851 · Cited by 584

Recent Advances on the Role of Cytokines in Atherosclerosis

Ait‐Oufella, H., Taleb, S., Mallat, Z., & Tedgui, A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207415 · Cited by 606

Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake

Moore, K. J., & Freeman, M. W. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000229218.97976.43 · Cited by 562

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

Wong, S. W., Kwon, M.-J., Choi, A. M. K., Kim, H.-P., Nakahira, K., & Hwang, D. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.044065 · Cited by 562

Monocyte and Macrophage Dynamics During Atherogenesis

Ley, K. F., Miller, Y. I., & Hedrick, C. C. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221127 · Cited by 570

Modulation of atherosclerosis in mice by Toll-like receptor 2

Mullick, A. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25482 · Cited by 549

MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages

Nazari-Jahantigh, M., Wei, Y., Noels, H., Akhtar, S., Zhou, Z., Koenen, R. R., Heyll, K., Gremse, F., Kiessling, F. M., Grommes, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61716 · Cited by 538

Inflammation and its Resolution as Determinants of Acute Coronary Syndromes

Libby, P., Tabas, I. A., Fredman, G., & Fisher, E. A. A. (2014) · Circulation Research · doi:10.1161/circresaha.114.302699 · Cited by 531

Translating molecular discoveries into new therapies for atherosclerosis

Rader, D. J., & Daugherty, A. (2008) · Nature · doi:10.1038/nature06796 · Cited by 515

Signalling networks regulating cyclooxygenase-2

Tsatsanis, C., Androulidaki, A., Venihaki, M., & Margioris, A. N. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.03.021 · Cited by 496

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

Vereecke, L., Beyaert, R., & Loo, G. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.007 · Cited by 490

Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress

Seimon, T. A., Nadolski, M. J., Liao, X., Magallon, J., Nguyen, M., Feric, N. T., Koschinsky, M. L., Harkewicz, R., Witztum, J. L., Tsimikas, S., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.010 · Cited by 457

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

Nardo, D. D., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2784 · Cited by 477

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages: Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions

Yvan-Charvet, L., Welch, C., Pagler, T. A., Ranalletta, M., Lamkanfi, M., Han, S., Ishibashi, M., Li, R., Wang, N., & Tall, A. R. (2008) · Circulation · doi:10.1161/circulationaha.108.793869 · Cited by 439

Molecular Biology of Atherosclerosis

Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 469

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

Engelen, S. E., Robinson, A., Zurke, Y.-X., & Monaco, C. G. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00668-4 · Cited by 455

Microbial modulation of cardiovascular disease

Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes

Dasu, M. R. K., Devaraj, S., Zhao, L., Hwang, D. H., & Jialal, I. (2008) · Diabetes · doi:10.2337/db08-0564 · Cited by 436

“ Gum Bug, Leave My Heart Alone !”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

Kebschull, M., Demmer, R. T., & Papapanou, P. N. (2010) · Journal of Dental Research · doi:10.1177/0022034510375281 · Cited by 429

NLRP3 inflammasomes link inflammation and metabolic disease

De Nardo, D., & Latz, E. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.004 · Cited by 425

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

Bae, Y. S., Lee, J. H., Choi, S. H., Kim, S. A., Almazan, F., Witztum, J. L., & Miller, Y. I. (2008) · Circulation Research · doi:10.1161/circresaha.108.181040 · Cited by 435

Innate sensing of oxidation-specific epitopes in health and disease

Binder, C. J., Papac-Milicevic, N., & Witztum, J. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.63 · Cited by 403

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease

Yang, J., Wise, L., & Fukuchi, K.-I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00724 · Cited by 387

Toll‐like receptors, endogenous ligands, and systemic autoimmune disease

Rifkin, I. R., Leadbetter, E. A., Busconi, L., Viglianti, G. A., & Marshak‐Rothstein, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00239.x · Cited by 384

Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

Violi, F., Cammisotto, V., Bartimoccia, S., Pignatelli, P., Carnevale, R., & Nocella, C. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00737-2 · Cited by 400

Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways

Koushki, K., Shahbaz, S. K., Mashayekhi, K., Sadeghi, M., Zayeri, Z. D., Taba, M. Y., Banach, M., Al-Rasadi, K., Johnston, T. P., & Sahebkar, A. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08791-9 · Cited by 382

Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis

Gareus, R., Kotsaki, E., Xanthoulea, S., van der Made, I., Gijbels, M. J., Kardakaris, R., Polykratis, A., Kollias, G. A., de Winther, M. P. J., & Pasparakis, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.016 · Cited by 382

TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion

Quillard, T., Araújo, H. A., Franck, G., Shvartz, E., Sukhova, G. K., & Libby, P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv044 · Cited by 400

Increased Toll-Like Receptor (TLR) 2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Proinflammatory State

Devaraj, S., Dasu, M. R. K., Rockwood, J., Winter, W. E., Griffen, S. C., & Jialal, I. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2185 · Cited by 374

The Emerging Role of Innate Immunity in the Heart and Vascular System

Mann, D. L. (2011) · Circulation Research · doi:10.1161/circresaha.110.226936 · Cited by 369

Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics

Gao, W., Xiong, Y., Li, Q., & Yang, H. Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00508 · Cited by 372

Integration of B cell responses through Toll-like receptors and antigen receptors

Rawlings, D. J., Schwartz, M. A., Jackson, S. W., & Meyer‐Bahlburg, A. (2012) · Nature reviews. Immunology · doi:10.1038/nri3190 · Cited by 356

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

Zhu, X., Owen, J. S., Wilson, M. D., Li, H., Griffiths, G. L., Thomas, M. J., Hiltbold, E. M., Fessler, M. B., & Parks, J. S. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m006486 · Cited by 331

Mechanisms of Disease: Toll-like receptors in cardiovascular disease

Frantz, S., Ertl, G., & Bauersachs, J. K. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0938 · Cited by 314

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

Kawamoto, T., Ii, M., Kitazaki, T., Iizawa, Y., & Kimura, H. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.026 · Cited by 311

New role of PCSK9 in atherosclerotic inflammation promotion involving the TLR4/NF-κB pathway

Tang, Z.-H., Peng, J., Ren, Z., Yang, J., Li, T.-T., Li, T.-H., Wang, Z., Wei, D.-H., Liu, L.-S., Zheng, X.-L., et al. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.04.023 · Cited by 291

Toll-Like Receptor 4–Dependent and –Independent Cytokine Secretion Induced by Minimally Oxidized Low-Density Lipoprotein in Macrophages

Miller, Y. I., Viriyakosol, S., Worrall, D. S., Boullier, A., Butler, S. S., & Witztum, J. L. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000159891.73193.31 · Cited by 282

S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease

Șchiopu, A., & Cotoi, O. S. (2013) · Mediators of Inflammation · doi:10.1155/2013/828354 · Cited by 273

Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex

Youn, H. S., Lee, J. Y., Fitzgerald, K. A., Young, H. A., Akira, S., & Hwang, D. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3339 · Cited by 270

Platelets in atherosclerosis

von Hundelshausen, P., & Lievens, D. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-08-0592 · Cited by 282

Mechanisms That Regulate Macrophage Burden in Atherosclerosis

Randolph, G. J. (2014) · Circulation Research · doi:10.1161/circresaha.114.301174 · Cited by 271

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice

Wang, W., Liu, W., Fidler, T., Wang, Y., Tang, Y., Woods, B., Welch, C., Cai, B., Silvestre-Roig, C., Ai, D., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.313283 · Cited by 262

Vascular Lipid Accumulation, Lipoprotein Oxidation, and Macrophage Lipid Uptake in Hypercholesterolemic Zebrafish

Stoletov, K. V., Fang, L., Choi, S.-H., Hartvigsen, K., Hansen, L. F., Hall, C. J., Pattison, J., Juliano, J., Miller, E. R., Almazan, F., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.189803 · Cited by 261

Toll-like Receptors in the Vascular System: Sensing the Dangers Within

Goulopoulou, S., McCarthy, C. G., & Webb, R. C. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010090 · Cited by 267

MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4

Yang, K., He, Y. S., Wang, X. Q., Lu, L., Chen, Q., Liu, J., Sun, Z., & Shen, W. F. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.009 · Cited by 261

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

Erridge, C., & Samani, N. J. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194050 · Cited by 266

Innate immunity, macrophage activation, and atherosclerosis

Yan, Z., & Hansson, G. K. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00554.x · Cited by 258

Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism

Caesar, R., Fåk, F., & Bäckhed, F. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02270.x · Cited by 254

TLR4 and Insulin Resistance

Kim, J. J., & Sears, D. D. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/212563 · Cited by 260

Mechanisms of triglyceride accumulation in activated macrophages

Feingold, K. R., Shigenaga, J. K., Kazemi, M. R., McDonald, C. M., Patzek, S. M., Cross, A. S., Moser, A. H., & Grünfeld, C. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1111537 · Cited by 257

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome

Fessler, M. B., Rudel, L. L., & Brown, J. M. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832fa5c4 · Cited by 256

The role of Toll-like receptors in chronic inflammation

Drexler, S. K., & Foxwell, B. M. J. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.009 · Cited by 250

Nuclear Receptors Nur77, Nurr1, and NOR-1 Expressed in Atherosclerotic Lesion Macrophages Reduce Lipid Loading and Inflammatory Responses

Bonta, P. I., van Tiel, C. M., Vos, M., Pols, T. W. H., van Thienen, J. V., Ferreira, V., Arkenbout, E. K., Seppen, J., Spek, C. A., van der Poll, T., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000238346.84458.5d · Cited by 251

REVIEW: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways

Hayashi, C., Gudino, C. V., Gibson III, F. C., & Genco, C. A. (2010) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2010.00582.x · Cited by 244

Cholesterol Efflux Potential and Antiinflammatory Properties of High-Density Lipoprotein After Treatment With Niacin or Anacetrapib

Yvan‐Charvet, L., Kling, J., Pagler, T. A., Li, H., Hubbard, B. K., Fisher, T., Sparrow, C. P., Taggart, A. K. P., & Tall, A. R. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207142 · Cited by 242

Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4–Dependent Fluid Phase Uptake

Choi, S.-H., Harkewicz, R., Lee, J. H., Boullier, A., Almazan, F., Li, A. C., Witztum, J. L., Bae, Y. S., & Miller, Y. I. (2009) · Circulation Research · doi:10.1161/circresaha.108.192880 · Cited by 233

Emerging role of Toll-like receptors in atherosclerosis

Curtiss, L. K., & Tobias, P. S. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800056-jlr200 · Cited by 225

Mammalian Toll-like receptors: to immunity and beyond

Hopkins, P. A., & Sriskandan, S. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02801.x · Cited by 233

S100A8 and S100A9 in Cardiovascular Biology and Disease

Averill, M. M., Kerkhoff, C., & Bornfeldt, K. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.236927 · Cited by 219

Inducible Toll‐like Receptor and NF‐κB Regulatory Pathway Expression in Human Adipose Tissue

Vitseva, O. I., Tanrıverdi, K., Tchkonia, T., Kirkland, J. L., McDonnell, M. E., Apovian, C. M., Freedman, J. E., & Gokce, N. (2008) · Obesity · doi:10.1038/oby.2008.25 · Cited by 215

Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk

Neves, A. L., Coelho, J., Couto, L., Leite-Moreira, A., & Roncon-Albuquerque, R. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0079 · Cited by 211

TLR Signaling: An Emerging Bridge from Innate Immunity to Atherogenesis

Michelsen, K. S., Doherty, T. M., Shah, P. K., & Arditi, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.5901 · Cited by 211

Apolipoprotein E Enhances MicroRNA-146a in Monocytes and Macrophages to Suppress Nuclear Factor-κB–Driven Inflammation and Atherosclerosis

Li, K., Ching, D., Luk, F. S., & Raffaı̈, R. L. (2015) · Circulation Research · doi:10.1161/circresaha.117.305844 · Cited by 211

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Koulis, C., Chen, Y., Hausding, C., Ahrens, I., Kyaw, T. S., Tay, C., Allen, T. J., Jandeleit-Dahm, K. A. M., Sweet, M. J., Akira, S., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302407 · Cited by 80

Platelet Factor 4 and Toll-Like Receptor 2 are Expressed in Atherosclerotic Plaques of Apolipoprotein E~(-/-)Mice

Hai, J. (2007) · Chinese Journal of Arteriosclerosis

Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis

Chen, S., Shimada, K., Crother, T. R., Erbay, E., Shah, P. K., & Arditi, M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.01.072 · Cited by 32

Toll-like receptor signaling and atherosclerosis

Michelsen, K. S., & Arditi, M. (2006) · Current Opinion in Hematology · doi:10.1097/01.moh.0000219662.88409.7c · Cited by 42

Role of Toll-Like Receptor 4 in Intimal Foam Cell Accumulation in Apolipoprotein E–Deficient Mice

Higashimori, M., Tatro, J. B., Moore, K. J., Mendelsohn, M. E., Galper, J., & Beasley, D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.210971 · Cited by 125