The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females
Open accessAbstract
Osteoarthritis (OA) is a leading cause of disability in Western society with multiple risk factors, including a complex genetic pattern. Identifying loci involved in the heredity of OA might lead to insights into the molecular pathogenesis of this common disorder. A previous genome scan mapped a primary hip OA susceptibility locus to chromosome 2q with a maximum multipoint logarithm of odds score of 1.6 in 378 affected sibling pair families. Here, microsatellite targeting of eight candidate genes in this region from 2q23-2q32 demonstrated significant associations with the tumor necrosis factor α-induced protein 6 gene in all probands and the integrin α 6 and frizzled motif associated with bone development(FRZB) genes in female probands. However, genotyping showed lack of association for a nonsynonymous single-nucleotide polymorphism in tumor necrosis factor α-induced protein 6, whereas a single-nucleotide polymorphism in FRZB resulting in an Arg324Gly substitution at the carboxyl terminus was associated with hip OA in the female probands (P= 0.04). This association was confirmed in an independent cohort of female hip cases (n= 338;P= 0.04). In addition, a haplotype coding for substitutions of two highly conserved arginine residues (Arg200Trp and Arg324Gly) in FRZB was a strong risk factor for primary hip OA, with an odds ratio of 4.1 (P= 0.004). FRZB encodes secreted frizzled-related protein 3, which is a soluble antagonist of wingless (wnt) signaling. Variant secreted frizzled-related protein 3 with the Arg324Gly substitution had diminished ability to antagonize wnt signaling in vitro. Hence, functional polymorphisms within FRZB confer susceptibility for hip OA in females and implicate the wnt signaling pathway in the pathogenesis of this disease.
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Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235
A high-resolution recombination map of the human genome
Kong, A., Gudbjartsson, D. F., Sainz, J., Jonsdottir, G. M., Gudjonsson, S. A., Richardsson, B., Sigurdardottir, S., Barnard, J., Hallbeck, B., Masson, G., et al. (2002) · Nature Genetics · doi:10.1038/ng917 · Cited by 1,736
Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly
Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., & Polakis, P. (1996) · Science · doi:10.1126/science.272.5264.1023 · Cited by 1,422
Little, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282
Yost, C., Torres, M., Miller, J. R., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,165
Monte Carlo tests for associations between disease and alleles at highly polymorphic loci
SHAM, P. C., & CURTIS, D. (1995) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1995.tb01608.x · Cited by 914
Specificities of heparan sulphate proteoglycans in developmental processes
Perrimon, N., & Bernfield, M. (2000) · Nature · doi:10.1038/35008000 · Cited by 714
Risk factors for osteoarthritis: genetics
Spector, T. D., & MacGregor, A. J. (2004) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2003.09.005 · Cited by 519
Hartmann, C., & Tabin, C. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00222-7 · Cited by 490
Cited by
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179
Ding, D.-C., Shyu, W.-C., & Lin, S.-Z. (2011) · Cell Transplantation · doi:10.3727/096368910x · Cited by 894
Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms
Xia, B., Chen, D., Zhang, J., Hu, S., Jin, H., & Tong, P. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9917-9 · Cited by 543
Metadata
- Authors
- Loughlin, J., Dowling, B., Chapman, K., Marcelline, L., Mustafa, Z., Southam, L., Ferreira, A., Ciesielski, C., Carson, D. A., & Corr, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-06-21
- Volume
- 101
- Issue
- 26
- Pages
- 9757-9762
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2013064709
- Cited by
- 400
- References
- 28
- FWCI
- 15.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Loughlin, J., Dowling, B., Chapman, K., Marcelline, L., Mustafa, Z., Southam, L., Ferreira, A., Ciesielski, C., Carson, D. A., & Corr, M. (2004). Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0403456101
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