The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques
Open accessAbstract
A polymorphism in the human serotonin transporter gene promoter ( 5-HTT LPR) is associated with anxiety and increased risk for developing depression in the face of adversity. Here, we report that among infant rhesus macaques, an orthologous polymorphism (rh 5-HTT LPR) interacts with adversity in the form of peer rearing to influence adrenocorticotropic hormone (ACTH) response to stress and, further, that this interaction is sexually dichotomous. ACTH responses to separation are higher in l / s than in l / l males. In females, however, it is only among those with a history of adversity that the s allele is associated with increased ACTH responses to stress. Of interest, peer-reared animals, in particular females carrying the s allele, also exhibit lower cortisol responses to stress, a pattern that has been recognized in association with certain stress-related neuropsychiatric disorders. By extension, our findings suggest the intriguing possibility that human females carrying the 5-HTT LPR s allele could be more vulnerable to the effects of early adversity. This interactive effect may underlie the increased incidence of certain stress-related disorders in women.
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Cites
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Serotonin transporter genetic variation and the response of the human amygdala.
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Self-citationGUNNAR, M. R., & VAZQUEZ, D. M. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003066 · Cited by 900
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Lower cortisol levels in depressed patients with comorbid post-traumatic stress disorder
Oquendo, M. A., Echavarria, G., Galfalvy, H. C., Grunebaum, M. F., Burke, A., Barrera, A., Cooper, T. B., Malone, K. M., & John Mann, J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300050 · Cited by 124
Cited by
Miller, G. E., Chen, E., & Zhou, E. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.25 · Cited by 2,467
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
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Gender differences in posttraumatic stress disorder.
Olff, M., Langeland, W., Draijer, N., & Gersons, B. P. R. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.2.183 · Cited by 1,058
The genetics of depression: A review
Levinson, D. F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.024 · Cited by 855
Metadata
- Authors
- Barr, C. S., Newman, T. K., Schwandt, M., Shannon, C., Dvoskin, R. L., Lindell, S. G., Taubman, J., Thompson, B., Champoux, M., Lesch, K. P., Goldman, D., Suomi, S. J., & Higley, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-08-09
- Volume
- 101
- Issue
- 33
- Pages
- 12358-12363
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2112307066
- Cited by
- 205
- References
- 6
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Barr, C. S., Newman, T. K., Schwandt, M., Shannon, C., Dvoskin, R. L., Lindell, S. G., Taubman, J., Thompson, B., Champoux, M., Lesch, K. P., Goldman, D., Suomi, S. J., & Higley, J. D. (2004). Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0403763101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
